PT3348264T - Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para abaixamento da pressão intraocular - Google Patents

Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para abaixamento da pressão intraocular

Info

Publication number: PT3348264T
Authority: PT; Portugal
Prior art keywords: imidazol; methylphenyl; drugs; methanol; ethyl
Prior art date: 2010-09-16

Application number

PT181601741T

Other languages

English (en)

Original Assignee

Allergan Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-16

Filing date

2011-09-16

Publication date

2020-04-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44675870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3348264(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-09-16 Application filed by Allergan Inc filed Critical Allergan Inc

2020-04-02 Publication of PT3348264T publication Critical patent/PT3348264T/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PT181601741T 2010-09-16 2011-09-16 Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para abaixamento da pressão intraocular PT3348264T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US38337010P	2010-09-16	2010-09-16

Publications (1)

Publication Number	Publication Date
PT3348264T true PT3348264T (pt)	2020-04-02

Family

ID=44675870

Family Applications (7)

Application Number	Title	Priority Date	Filing Date
PT16161922T PT3053576T (pt)	2010-09-16	2011-09-16	Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para redução da pressão intraocular
PT117609628T PT2616068T (pt)	2010-09-16	2011-09-16	Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para abaixamento da pressão intraocular
PT181601741T PT3348264T (pt)	2010-09-16	2011-09-16	Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para abaixamento da pressão intraocular
PT181571472T PT3338777T (pt)	2010-09-16	2011-09-16	Pró-fármacos ésteres de [3-(1-(1h-imidazol-4- il)etil)-2-metilfenil]metanol para tratamento de doenças retinianas
PT16161920T PT3050563T (pt)	2010-09-16	2011-09-16	Pró-fármacos de éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil] metanol para o tratamento de doenças e afeções da pele
PT117609636T PT2616069T (pt)	2010-09-16	2011-09-16	Pró-fármacos éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol
PT161619234T PT3050564T (pt)	2010-09-16	2011-09-16	Pró-fármacos éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
PT16161922T PT3053576T (pt)	2010-09-16	2011-09-16	Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para redução da pressão intraocular
PT117609628T PT2616068T (pt)	2010-09-16	2011-09-16	Pró-fármacos ésteres de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol para abaixamento da pressão intraocular

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
PT181571472T PT3338777T (pt)	2010-09-16	2011-09-16	Pró-fármacos ésteres de [3-(1-(1h-imidazol-4- il)etil)-2-metilfenil]metanol para tratamento de doenças retinianas
PT16161920T PT3050563T (pt)	2010-09-16	2011-09-16	Pró-fármacos de éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil] metanol para o tratamento de doenças e afeções da pele
PT117609636T PT2616069T (pt)	2010-09-16	2011-09-16	Pró-fármacos éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol
PT161619234T PT3050564T (pt)	2010-09-16	2011-09-16	Pró-fármacos éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol

Country Status (28)

Country	Link
US (9)	US8492422B2 (pt)
EP (13)	EP3053576B1 (pt)
JP (4)	JP6073229B2 (pt)
KR (7)	KR20140005154A (pt)
CN (5)	CN103209694A (pt)
AR (4)	AR083018A1 (pt)
AU (4)	AU2011301856C1 (pt)
BR (4)	BR112013006352A2 (pt)
CA (8)	CA2812191C (pt)
CL (4)	CL2013000733A1 (pt)
CY (3)	CY1121024T1 (pt)
DK (9)	DK3338777T3 (pt)
ES (10)	ES2760920T3 (pt)
HU (5)	HUE047476T2 (pt)
IL (4)	IL225280A0 (pt)
MX (4)	MX2013003009A (pt)
MY (4)	MY161607A (pt)
NZ (1)	NZ608751A (pt)
PL (7)	PL3050563T3 (pt)
PT (7)	PT3053576T (pt)
RU (4)	RU2612351C2 (pt)
SG (4)	SG188573A1 (pt)
SI (5)	SI3050563T1 (pt)
TR (1)	TR201909249T4 (pt)
TW (4)	TWI591058B (pt)
UA (1)	UA112973C2 (pt)
WO (4)	WO2012037453A1 (pt)
ZA (4)	ZA201302194B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK3566703T3 (da) *	2009-02-13	2021-07-05	Allergan Inc	Farmaceutiske sammensætninger omfattende (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
ES2762113T3 (es)	2010-01-11	2020-05-22	Nalpropion Pharmaceuticals Inc	Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor
US8492422B2 (en) *	2010-09-16	2013-07-23	Allergan, Inc.	Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions
MX2014000871A (es) *	2011-07-22	2014-06-23	Allergan Inc	Moduladores adrenergicos alfa-2 para el tratamiento de trastornos visuales mediados por proyecciones visuales centrales desde el ojo.
AU2012340806B2 (en)	2011-11-21	2017-10-19	Allergan, Inc.	Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
USD794650S1 (en)	2014-11-28	2017-08-15	Samsung Electronics Co., Ltd.	Display screen or portion thereof with a graphical user interface
CN108310442B (zh) *	2017-01-17	2021-08-27	台北科技大学	眼科用组合物
KR102050506B1 (ko)	2017-06-20	2019-11-29	한국식품연구원	망막 질환 예방, 개선, 완화 또는 치료용 조성물
CN108872431B (zh) *	2018-07-09	2021-03-23	成都倍特药业股份有限公司	一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法
US20240287093A1 (en) *	2018-08-24	2024-08-29	Adlai Nortye Biopharma Co., Ltd.	High activity sting protein agonist
WO2022221071A1 (en) *	2021-04-16	2022-10-20	Ads Therapeutics Llc	Alpha2 adrenergic agonist codrugs conjugated with muscarinic agonist drugs
KR20250141793A (ko) *	2023-02-08	2025-09-29	보슈 롬 아일랜드 리미티드	시력을 개선시키기 위한 알파-2-아드레날린성 효능제
WO2025179071A1 (en) *	2024-02-20	2025-08-28	Bausch + Lomb Ireland Limited	Sustained-release drug delivery compositions for treating ocular diseases

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0642332B1 (en)	1992-05-13	1997-01-15	Sandoz Ltd.	Ophthalmic compositions containing a cyclosporin
US5459133A (en) *	1992-06-05	1995-10-17	Telor Ophthalmic Pharmaceuticals, Inc.	Methods and products for treating presbyopia
ES2188649T3 (es)	1993-11-15	2003-07-01	Schering Corp	Fenil-alquil-imidazoles como antagonistas del receptor h3.
US5474979A (en)	1994-05-17	1995-12-12	Allergan, Inc.	Nonirritating emulsions for sensitive tissue
EP0957073A1 (en) *	1998-05-12	1999-11-17	Schwarz Pharma Ag	Novel derivatives of 3,3-diphenylpropylamines
US20040214829A1 (en) *	2000-07-14	2004-10-28	Allergan, Inc.	Compositions containing alpha-2-adrenergic agonist components
US20020198209A1 (en)	2001-05-03	2002-12-26	Allergan Sales Inc.	Compositions having enhanced pharmacokinetic characteristics
US7439241B2 (en) *	2003-05-27	2008-10-21	Galderma Laboratories, Inc.	Compounds, formulations, and methods for treating or preventing rosacea
EA010392B1 (ru) *	2003-05-27	2008-08-29	Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.)	Производные имидазолов, способ их получения и их применение в качестве лекарственного средства
KR20060052809A (ko) *	2003-07-14	2006-05-19	코닌클리케 필립스 일렉트로닉스 엔.브이.	프로젝션 디바이스
JP5165242B2 (ja)	2003-09-12	2013-03-21	アラーガン、インコーポレイテッド	疼痛およびα２アドレナリン受容体が関与する他の状態の処置のための方法および組成物
US20050059583A1 (en)	2003-09-15	2005-03-17	Allergan, Inc.	Methods of providing therapeutic effects using cyclosporin components
US20050244463A1 (en) *	2004-04-30	2005-11-03	Allergan, Inc.	Sustained release intraocular implants and methods for treating ocular vasculopathies
CN104490884A (zh)	2004-05-25	2015-04-08	桑斯罗萨医药发展公司	治疗或预防炎症性皮肤疾病的化合物、制剂及方法
US20050277584A1 (en)	2004-06-09	2005-12-15	Allergan, Inc.	Pharmaceutical compositions comprising cyclosporins
WO2006036480A1 (en) *	2004-09-24	2006-04-06	Allergan, Inc.	4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
US7931909B2 (en)	2005-05-10	2011-04-26	Allergan, Inc.	Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates
US20070015691A1 (en)	2005-07-13	2007-01-18	Allergan, Inc.	Cyclosporin compositions
US7297679B2 (en)	2005-07-13	2007-11-20	Allergan, Inc.	Cyclosporin compositions
US20070082070A1 (en) *	2005-10-11	2007-04-12	Stookey Evangeline L	Treating skin disorders
US7902247B2 (en)	2008-01-09	2011-03-08	Allergan, Inc.	Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
EP2393800B1 (en)	2009-02-06	2014-10-08	Allergan, Inc.	Pyridine compounds as subtype selective modulators of alpha2b and/or alpha 2c adrenergic receptors
DK3566703T3 (da) *	2009-02-13	2021-07-05	Allergan Inc	Farmaceutiske sammensætninger omfattende (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
US8394800B2 (en) *	2009-11-19	2013-03-12	Galderma Laboratories, L.P.	Method for treating psoriasis
US8492422B2 (en) *	2010-09-16	2013-07-23	Allergan, Inc.	Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions

2011
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- 2011-09-16 KR KR1020137009505A patent/KR20140005154A/ko not_active Withdrawn
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2013
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EP2616069A1 (en)	2013-07-24
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SI3053576T1 (sl)	2018-11-30
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