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PE20190633A1 - Anticuerpos anti-gm-csf y usos de los mismos - Google Patents

Anticuerpos anti-gm-csf y usos de los mismos

Info

Publication number
PE20190633A1
PE20190633A1 PE2019000664A PE2019000664A PE20190633A1 PE 20190633 A1 PE20190633 A1 PE 20190633A1 PE 2019000664 A PE2019000664 A PE 2019000664A PE 2019000664 A PE2019000664 A PE 2019000664A PE 20190633 A1 PE20190633 A1 PE 20190633A1
Authority
PE
Peru
Prior art keywords
seq
same
antibody
cdr1
cdr2
Prior art date
Application number
PE2019000664A
Other languages
English (en)
Inventor
Zhengyi Wang
Lei Fang
Bingshi Guo
Jingwu Zang
Original Assignee
I Mab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201610832677.0A external-priority patent/CN107840886B/zh
Priority claimed from CN201610831525.9A external-priority patent/CN107840885B/zh
Application filed by I Mab filed Critical I Mab
Publication of PE20190633A1 publication Critical patent/PE20190633A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/53—Colony-stimulating factor [CSF]
    • G01N2333/535—Granulocyte CSF; Granulocyte-macrophage CSF

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)

Abstract

SE REFIERE A UN ANTICUERPO HUMANIZADO AISLADO O FRAGMENTO DEL MISMO, EL CUAL TIENE ESPECIFICIDAD A UNA PROTEINA GM-CSF HUMANA Y COMPRENDE UNA VH CDR1 DE SEC ID NO: 1; UNA VH CDR2 DE SEC ID NO: 2; UNA VH CDR3 DE SEC ID NO: 3; UNA VL CDR1 DE SEC ID NO: 4; UNA VL CDR2 DE SEC ID NO: 5; Y UNA VL CDR3 DE SEC ID NO: 6; EN DONDE LA REGION VARIABLE DE CADENA PESADA DE DICHO ANTICUERPO COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 14 Y LA REGION VARIABLE DE CADENA LIVIANA COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEC ID NO: 22. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE DICHO ANTICUERPO LA CUAL ES UTIL PARA EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, LA ENFERMEDAD DE ADDISON, ESPONDILITIS ANQUILOSANTE
PE2019000664A 2016-09-19 2017-09-18 Anticuerpos anti-gm-csf y usos de los mismos PE20190633A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610832677.0A CN107840886B (zh) 2016-09-19 2016-09-19 Gm-csf抗体及其用途
CN201610831525.9A CN107840885B (zh) 2016-09-19 2016-09-19 Gm-csf抗体及其用途

Publications (1)

Publication Number Publication Date
PE20190633A1 true PE20190633A1 (es) 2019-04-26

Family

ID=61618639

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019000664A PE20190633A1 (es) 2016-09-19 2017-09-18 Anticuerpos anti-gm-csf y usos de los mismos

Country Status (25)

Country Link
US (3) US10647767B2 (es)
EP (1) EP3328887B1 (es)
JP (1) JP7256116B2 (es)
KR (3) KR101953706B1 (es)
CN (1) CN109219616B (es)
AU (1) AU2017328383B2 (es)
BR (1) BR112019005274A2 (es)
CA (1) CA3036509C (es)
CL (1) CL2019000702A1 (es)
CO (1) CO2019002550A2 (es)
DK (1) DK3328887T3 (es)
ES (1) ES2887343T3 (es)
HU (1) HUE056238T2 (es)
IL (1) IL265331B2 (es)
MX (1) MX2019003019A (es)
MY (1) MY190021A (es)
NZ (1) NZ750976A (es)
PE (1) PE20190633A1 (es)
PH (1) PH12019500434A1 (es)
PL (1) PL3328887T3 (es)
PT (1) PT3328887T (es)
SG (1) SG11201901789WA (es)
UA (1) UA126565C2 (es)
WO (1) WO2018050111A1 (es)
ZA (2) ZA201901835B (es)

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JP2025539457A (ja) * 2022-12-01 2025-12-05 アイ－エムエービー バイオファーマ （ハンジョウ） カンパニー リミテッド 抗ｇｍ－ｃｓｆ抗体の液体医薬品製剤及びその用途
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Publication number Publication date
CA3036509A1 (en) 2018-03-22
IL265331A (en) 2019-05-30
HUE056238T2 (hu) 2022-02-28
MY190021A (en) 2022-03-22
EP3328887A1 (en) 2018-06-06
AU2017328383A1 (en) 2019-03-14
US10647767B2 (en) 2020-05-12
KR20190035790A (ko) 2019-04-03
US20180362632A1 (en) 2018-12-20
JP2019534850A (ja) 2019-12-05
ZA201901835B (en) 2021-09-29
US10889641B2 (en) 2021-01-12
EP3328887B1 (en) 2021-08-18
PH12019500434A1 (en) 2019-05-20
CN109219616B (zh) 2022-10-21
AU2017328383B2 (en) 2022-10-27
BR112019005274A2 (pt) 2019-06-04
ES2887343T3 (es) 2021-12-22
UA126565C2 (uk) 2022-11-02
PL3328887T3 (pl) 2021-12-27
NZ750976A (en) 2023-01-27
US11926662B2 (en) 2024-03-12
CO2019002550A2 (es) 2019-05-21
KR20210007041A (ko) 2021-01-19
EP3328887A4 (en) 2019-04-03
CL2019000702A1 (es) 2019-06-21
MX2019003019A (es) 2019-09-19
WO2018050111A1 (en) 2018-03-22
PT3328887T (pt) 2021-10-19
JP7256116B2 (ja) 2023-04-11
IL265331B2 (en) 2024-01-01
KR20180039742A (ko) 2018-04-18
ZA202005792B (en) 2021-09-29
SG11201901789WA (en) 2019-03-28
IL265331B1 (en) 2023-09-01
CN109219616A (zh) 2019-01-15
US20210079085A1 (en) 2021-03-18
US20190002549A1 (en) 2019-01-03
KR102356187B1 (ko) 2022-02-08
KR101953706B1 (ko) 2019-03-05
CA3036509C (en) 2022-10-25
DK3328887T3 (da) 2021-09-20

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