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PE20180926A1 - Anticuerpos contra el miembro 4 de la superfamilia del receptor del factor de necrosis tumoral (ox40) y sus usos - Google Patents

Anticuerpos contra el miembro 4 de la superfamilia del receptor del factor de necrosis tumoral (ox40) y sus usos

Info

Publication number
PE20180926A1
PE20180926A1 PE2017002483A PE2017002483A PE20180926A1 PE 20180926 A1 PE20180926 A1 PE 20180926A1 PE 2017002483 A PE2017002483 A PE 2017002483A PE 2017002483 A PE2017002483 A PE 2017002483A PE 20180926 A1 PE20180926 A1 PE 20180926A1
Authority
PE
Peru
Prior art keywords
seq
antibodies against
necrosis factor
tumor necrosis
factor receptor
Prior art date
Application number
PE2017002483A
Other languages
English (en)
Inventor
Zhehong Cai
Indrani Chakraborty
Marie-Michelle Navarro GARCIA
Thomas D Kempe
Alan J Korman
Alexander T Kozhich
Hadia LEMAR
Mark Maurer
Christina Maria Milburn
Michael Quigley
Maria Rodriguez
Xiang Shao
Mohan Srinivasan
Brenda L Stevens
Kent Thudium
Susan Chien-Szu Wong
Jochem Gokemeijer
xi-tao Wang
Han Chang
Christine Huang
Maria Jure-Kunkel
Zheng Yang
Yan Feng
Patrick Guirnalda
Nils Lonberg
Bryan C Barnhart
Aaron P Yamniuk
Karla A Henning
Michelle Minhua Han
Ming Lei
Liang Schweizer
Sandra V Hatcher
Arvind Rajpal
Praveen Aanur
Mark J Selby
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20180926A1 publication Critical patent/PE20180926A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/3038—Kidney, bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • G01N33/575—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4

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Abstract

SE REFIERE A UN ANTICUERPO AISLADO QUE SE FIJA A OX40 HUMANA QUE COMPRENDE LAS SECUENCIAS CDR1 DE SEQ ID N°: 87, CDR2 DE SEQ ID N°: 88 Y CDR3 DE SEQ ID N°: 89 DE CADENA PESADA, Y LAS SECUENCIAS CDR1 DE SEQ ID N°: 90, CDR2 DE SEQ ID N°: 91 Y CDR3 DE SEQ ID N°: 92 DE CADENA LIGERA, CUYA SECUENCIA DE REGION VARIABLE DE CADENA PESADA ES LA SEQ ID N°: 318 Y LA SECUENCIA DE REGION VARIABLE DE CADENA LIGERA ES LA SEQ ID N°: 94. TAMBIEN SE REFIERE A UN ACIDO NUCLEICO QUE CODIFICA LAS REGIONES VARIABLES DE CADENA PESADA Y LIGERA, UN VECTOR DE EXPRESION Y UNA COMPOSICION FARMACEUTICA. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE CANCER
PE2017002483A 2015-05-29 2016-05-26 Anticuerpos contra el miembro 4 de la superfamilia del receptor del factor de necrosis tumoral (ox40) y sus usos PE20180926A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562168377P 2015-05-29 2015-05-29
US201562239574P 2015-10-09 2015-10-09
US201562264691P 2015-12-08 2015-12-08
US201662327140P 2016-04-25 2016-04-25
US201662333556P 2016-05-09 2016-05-09

Publications (1)

Publication Number Publication Date
PE20180926A1 true PE20180926A1 (es) 2018-06-08

Family

ID=56121193

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017002483A PE20180926A1 (es) 2015-05-29 2016-05-26 Anticuerpos contra el miembro 4 de la superfamilia del receptor del factor de necrosis tumoral (ox40) y sus usos

Country Status (31)

Country Link
US (5) US20180237534A1 (es)
EP (1) EP3303396B1 (es)
JP (3) JP6797137B2 (es)
KR (1) KR20180010264A (es)
CN (1) CN108137687B (es)
AU (1) AU2016271111B2 (es)
BR (1) BR112017025191A2 (es)
CA (1) CA2987410A1 (es)
CO (1) CO2017013235A2 (es)
DK (1) DK3303396T5 (es)
EA (1) EA035412B1 (es)
ES (1) ES2936317T3 (es)
FI (1) FI3303396T3 (es)
HR (1) HRP20230060T1 (es)
HU (1) HUE061253T2 (es)
IL (1) IL255949B2 (es)
LT (1) LT3303396T (es)
MX (1) MX2017015041A (es)
MY (1) MY188049A (es)
PE (1) PE20180926A1 (es)
PH (1) PH12017502129A1 (es)
PL (1) PL3303396T3 (es)
PT (1) PT3303396T (es)
RS (1) RS63897B1 (es)
SG (1) SG10202008304TA (es)
SI (1) SI3303396T1 (es)
SM (1) SMT202300013T1 (es)
TN (2) TN2019000101A1 (es)
TW (1) TWI732760B (es)
UY (1) UY36687A (es)
WO (1) WO2016196228A1 (es)

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