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PT2215119E - Anticorpos monoclonais que se ligam a hgm-csf e composições médicas que os compreendem - Google Patents

Anticorpos monoclonais que se ligam a hgm-csf e composições médicas que os compreendem

Info

Publication number
PT2215119E
PT2215119E PT88486964T PT08848696T PT2215119E PT 2215119 E PT2215119 E PT 2215119E PT 88486964 T PT88486964 T PT 88486964T PT 08848696 T PT08848696 T PT 08848696T PT 2215119 E PT2215119 E PT 2215119E
Authority
PT
Portugal
Prior art keywords
hgm
csf
bind
same
monoclonal antibodies
Prior art date
Application number
PT88486964T
Other languages
English (en)
Inventor
Kenzo Takada
Kantou Nakajima
Barbara Kistler
John Park
Original Assignee
Boehringer Ingelheim Int
Evec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Evec Inc filed Critical Boehringer Ingelheim Int
Publication of PT2215119E publication Critical patent/PT2215119E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT88486964T 2007-11-13 2008-11-12 Anticorpos monoclonais que se ligam a hgm-csf e composições médicas que os compreendem PT2215119E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007294945 2007-11-13
JP2008052471 2008-02-14

Publications (1)

Publication Number Publication Date
PT2215119E true PT2215119E (pt) 2013-02-11

Family

ID=40329216

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88486964T PT2215119E (pt) 2007-11-13 2008-11-12 Anticorpos monoclonais que se ligam a hgm-csf e composições médicas que os compreendem

Country Status (31)

Country Link
US (2) US8679502B2 (pt)
EP (3) EP2535353A1 (pt)
KR (1) KR20100102108A (pt)
CN (2) CN101970489B (pt)
AR (1) AR069290A1 (pt)
AU (1) AU2008321429A1 (pt)
BR (1) BRPI0820530A2 (pt)
CA (1) CA2705539A1 (pt)
CL (1) CL2008003361A1 (pt)
CO (1) CO6382188A2 (pt)
DK (1) DK2215119T3 (pt)
EC (1) ECSP10010251A (pt)
ES (1) ES2401536T3 (pt)
HR (1) HRP20130204T1 (pt)
IL (1) IL205576A0 (pt)
MA (1) MA31899B1 (pt)
ME (1) ME01005B (pt)
MX (1) MX2010005291A (pt)
NZ (2) NZ586027A (pt)
PE (1) PE20091420A1 (pt)
PL (1) PL2215119T3 (pt)
PT (1) PT2215119E (pt)
RS (1) RS52713B (pt)
RU (2) RU2517596C2 (pt)
SG (1) SG176499A1 (pt)
SI (1) SI2215119T1 (pt)
TN (1) TN2010000210A1 (pt)
TW (2) TW201206955A (pt)
UY (1) UY31466A1 (pt)
WO (1) WO2009064399A1 (pt)
ZA (1) ZA201003467B (pt)

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PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
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WO2009062238A1 (en) * 2007-11-12 2009-05-22 Crc For Asthma And Airways Ltd Epitope for neutralizing antibodies
PT2215119E (pt) 2007-11-13 2013-02-11 Boehringer Ingelheim Int Anticorpos monoclonais que se ligam a hgm-csf e composições médicas que os compreendem
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
MX2011002558A (es) 2008-09-10 2011-04-26 Boehringer Ingelheim Int Terapia de combinacion para el tratamiento de diabetes y estados relacionados.
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PL2376121T5 (pl) 2008-12-22 2021-09-27 The University Of Melbourne Leczenie zapalenia kości i stawów
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AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
JP2014520784A (ja) 2011-07-06 2014-08-25 モルフォシス・アー・ゲー 抗ｃｄ２０抗体と抗ｇｍ−ｃｓｆ抗体との治療的組合せおよびその使用
MY175388A (en) * 2012-09-20 2020-06-23 Morphosys Ag Treatment for rheumatoid arthritis
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WO2014138862A1 (en) * 2013-03-14 2014-09-18 John Schrader Human monoclonal antibodies that neutralize bioactivity of granulocyte macrophage colony-stimulating factor and methods and uses thereof
WO2015028657A1 (en) 2013-08-30 2015-03-05 Takeda Gmbh Antibodies neutralizing gm-csf for use in the treatment of rheumatoid arthritis or as analgesics
ES2974895T3 (es) 2014-05-07 2024-07-02 Takeda Pharmaceuticals Co Formulación líquida que comprende un compuesto neutralizante de GM-CSF
EP3368561B1 (en) * 2015-10-30 2025-09-17 Medimmune Limited Prevention of n-terminal truncation in igg light chains
KR101953706B1 (ko) 2016-09-19 2019-03-05 아이-맵 항-gm-csf 항체 및 이것의 사용
JP7399852B2 (ja) * 2017-06-25 2023-12-18 システィミューン， インク． 多重特異性抗体とその作製及び使用方法
AU2018396964C1 (en) * 2017-12-28 2024-10-03 Nanjing Legend Biotech Co., Ltd. Antibodies and variants thereof against PD-L1
EP3623382A1 (en) * 2018-09-14 2020-03-18 Universität Zürich Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct
US11655293B2 (en) * 2018-02-22 2023-05-23 Universitat Zurich Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT
JP7686563B2 (ja) * 2019-02-08 2025-06-02 ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド 皮膚、毛髪、爪および／または粘膜の処置および／またはケアに有用な化合物
WO2025221669A1 (en) * 2024-04-18 2025-10-23 Promab Biotechnologies, Inc. Fusion protein comprising il-12 and gm-csf
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Also Published As

Publication number Publication date
CN104072613A (zh) 2014-10-01
HK1146729A1 (en) 2011-07-08
EP2535353A8 (en) 2013-04-03
US20110182905A1 (en) 2011-07-28
SG176499A1 (en) 2011-12-29
NZ597023A (en) 2013-07-26
BRPI0820530A2 (pt) 2015-06-16
CN101970489A (zh) 2011-02-09
EP2535353A1 (en) 2012-12-19
HRP20130204T1 (hr) 2013-04-30
TN2010000210A1 (en) 2011-11-11
MX2010005291A (es) 2010-11-12
CO6382188A2 (es) 2012-02-15
EP2215119B1 (en) 2012-12-26
AU2008321429A1 (en) 2009-05-22
NZ586027A (en) 2012-01-12
TW200927760A (en) 2009-07-01
WO2009064399A1 (en) 2009-05-22
AR069290A1 (es) 2010-01-13
RU2517596C2 (ru) 2014-05-27
RS52713B (sr) 2013-08-30
KR20100102108A (ko) 2010-09-20
RU2010123693A (ru) 2011-12-20
TWI434854B (zh) 2014-04-21
CL2008003361A1 (es) 2010-02-05
MA31899B1 (fr) 2010-12-01
US8679502B2 (en) 2014-03-25
PL2215119T3 (pl) 2013-06-28
UY31466A1 (es) 2009-07-17
CN101970489B (zh) 2014-06-11
ES2401536T3 (es) 2013-04-22
ZA201003467B (en) 2012-01-25
US20140205611A1 (en) 2014-07-24
CA2705539A1 (en) 2009-05-22
SI2215119T1 (sl) 2013-04-30
IL205576A0 (en) 2010-11-30
PE20091420A1 (es) 2009-10-17
RU2013141223A (ru) 2015-03-20
ME01005B (me) 2012-10-20
TW201206955A (en) 2012-02-16
ECSP10010251A (es) 2010-08-31
DK2215119T3 (da) 2013-02-04
EP2215119A1 (en) 2010-08-11
EP2559706A1 (en) 2013-02-20

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