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PE20180798A1 - Constructos de anticuerpos biespeficos que se unen a mesotelina y cd3 - Google Patents

Constructos de anticuerpos biespeficos que se unen a mesotelina y cd3

Info

Publication number
PE20180798A1
PE20180798A1 PE2018000148A PE2018000148A PE20180798A1 PE 20180798 A1 PE20180798 A1 PE 20180798A1 PE 2018000148 A PE2018000148 A PE 2018000148A PE 2018000148 A PE2018000148 A PE 2018000148A PE 20180798 A1 PE20180798 A1 PE 20180798A1
Authority
PE
Peru
Prior art keywords
antibody construct
polynucleotide
binds
binding domain
biespefic
Prior art date
Application number
PE2018000148A
Other languages
English (en)
Inventor
Tobias Raum
Peter Kufer
Doris Rau
Jonas Anlahr
Claudia Bluemel
Patrick Hoffmann
Elisabeth Nahrwold
Julie Bailis
Original Assignee
Amgen Res Munich Gmbh
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh, Amgen Inc filed Critical Amgen Res Munich Gmbh
Publication of PE20180798A1 publication Critical patent/PE20180798A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Referido a un constructo de anticuerpo biespecifico que comprende un primer dominio de union que se une a mesotelina (MSLN) humana en la superficie de una celula diana y un segundo dominio de union que se une a CD3 humano en la superficie de una celula T, en donde el primer dominio de union se une a un epitope de MSLN el cual esta comprendido dentro de la region como se describe en SEQ ID NO: 245. Tambien se refiere a un polinucleotido que codifica para el constructo de anticuerpo, un vector que comprende dicho polinucleotido y una celula hospedante transformada o transfectada con dicho polinucleotido o vector; a un procedimiento para la produccion del constructo de anticuerpo; y un kit que comprende dicho constructo de anticuerpo; en donde, son utiles en la prevencion, tratamiento o mejora de una enfermedad de tumores solidos o enfermedad de cancer metastasico.
PE2018000148A 2015-07-31 2016-08-01 Constructos de anticuerpos biespeficos que se unen a mesotelina y cd3 PE20180798A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562199939P 2015-07-31 2015-07-31
US201662290861P 2016-02-03 2016-02-03

Publications (1)

Publication Number Publication Date
PE20180798A1 true PE20180798A1 (es) 2018-05-09

Family

ID=56801501

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000148A PE20180798A1 (es) 2015-07-31 2016-08-01 Constructos de anticuerpos biespeficos que se unen a mesotelina y cd3

Country Status (33)

Country Link
US (3) US11884720B2 (es)
EP (2) EP4327885A3 (es)
JP (1) JP7026610B2 (es)
CN (1) CN109476736B (es)
AU (1) AU2016302575B2 (es)
BR (1) BR112018001638A8 (es)
CL (2) CL2018000268A1 (es)
CO (1) CO2018000885A2 (es)
DK (1) DK3328893T5 (es)
EA (1) EA201890383A8 (es)
ES (1) ES2964897T3 (es)
FI (1) FI3328893T3 (es)
HR (1) HRP20231410T1 (es)
HU (1) HUE064248T2 (es)
IL (1) IL256873B2 (es)
JO (1) JO3747B1 (es)
LT (1) LT3328893T (es)
MD (1) MD3328893T2 (es)
MX (1) MX2018001157A (es)
MY (1) MY198199A (es)
PE (1) PE20180798A1 (es)
PH (1) PH12018500107A1 (es)
PL (1) PL3328893T3 (es)
PT (1) PT3328893T (es)
RS (1) RS64938B1 (es)
SG (1) SG10202000828TA (es)
SI (1) SI3328893T1 (es)
SM (1) SMT202300446T1 (es)
TN (1) TN2017000552A1 (es)
TW (1) TWI796283B (es)
UA (1) UA125580C2 (es)
WO (1) WO2017021356A1 (es)
ZA (1) ZA201707816B (es)

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