[go: up one dir, main page]

PE20180673A1 - Tratamiento contra el cancer por manipulacion de la microflora comensal - Google Patents

Tratamiento contra el cancer por manipulacion de la microflora comensal

Info

Publication number
PE20180673A1
PE20180673A1 PE2017002514A PE2017002514A PE20180673A1 PE 20180673 A1 PE20180673 A1 PE 20180673A1 PE 2017002514 A PE2017002514 A PE 2017002514A PE 2017002514 A PE2017002514 A PE 2017002514A PE 20180673 A1 PE20180673 A1 PE 20180673A1
Authority
PE
Peru
Prior art keywords
microflora
manipulating
comensal
against cancer
treatment against
Prior art date
Application number
PE2017002514A
Other languages
English (en)
Inventor
Thomas F Gajewski
Ayelet Sivan
Leticia Corrales
Original Assignee
Univ Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57441608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20180673(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Chicago filed Critical Univ Chicago
Publication of PE20180673A1 publication Critical patent/PE20180673A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Se refiere a metodos de tratamiento y/o prevencion del cancer por manipulacion de la microflora comensal. En particular, la cantidad, identidad, presencia y/o relacion de la microflora (por ejemplo, microflora del intestino) en un sujeto se manipula para facilitar uno o mas co-tratamientos
PE2017002514A 2015-06-01 2016-06-01 Tratamiento contra el cancer por manipulacion de la microflora comensal PE20180673A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562169112P 2015-06-01 2015-06-01
US201562248741P 2015-10-30 2015-10-30

Publications (1)

Publication Number Publication Date
PE20180673A1 true PE20180673A1 (es) 2018-04-19

Family

ID=57441608

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017002514A PE20180673A1 (es) 2015-06-01 2016-06-01 Tratamiento contra el cancer por manipulacion de la microflora comensal

Country Status (18)

Country Link
US (4) US9855302B2 (es)
EP (2) EP4541361A3 (es)
JP (2) JP2018521013A (es)
KR (2) KR20240059639A (es)
CN (1) CN107847530A (es)
AU (1) AU2016270750B2 (es)
BR (1) BR112017025813A2 (es)
CA (1) CA2987129A1 (es)
CL (1) CL2017003024A1 (es)
HK (1) HK1253064A1 (es)
IL (1) IL255940A (es)
MX (1) MX2017015473A (es)
PE (1) PE20180673A1 (es)
RU (1) RU2017141448A (es)
TW (1) TW201717975A (es)
UY (1) UY36701A (es)
WO (1) WO2016196605A1 (es)
ZA (2) ZA201707986B (es)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2623127T3 (es) 2010-02-01 2017-07-10 Mikrobex Bacterioterapia para la colitis por Clostridium difficile
US9730967B2 (en) 2011-02-04 2017-08-15 Katherine Rose Kovarik Method and system for treating cancer cachexia
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US10314865B2 (en) 2011-02-04 2019-06-11 Katherine Rose Kovarik Method and system for treating cancer and other age-related diseases by extending the healthspan of a human
US12533312B2 (en) 2011-02-04 2026-01-27 Seed Health, Inc. Method and system for preventing sore throat in humans
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
US10034939B2 (en) * 2012-10-26 2018-07-31 The University Of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
HUE037476T2 (hu) 2014-12-23 2018-08-28 4D Pharma Res Ltd Pirin polipeptid és immunmodulálás
PE20171138A1 (es) 2014-12-23 2017-08-09 4D Pharma Res Ltd Modulacion inmunitaria
CA2984975A1 (en) 2015-05-06 2016-11-10 Snipr Technologies Limited Altering microbial populations & modifying microbiota
US10828340B2 (en) 2015-06-09 2020-11-10 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
RS59308B1 (sr) 2015-06-15 2019-10-31 4D Pharma Res Ltd Kompozicije koje sadrže bakterijske sojeve
TW202223083A (zh) 2015-06-15 2022-06-16 英商4D製藥研究有限公司 包含細菌菌株之組合物之用途
EA038405B1 (ru) 2015-06-15 2021-08-24 4Д Фарма Рисёрч Лимитед ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ШТАММЫ БАКТЕРИИ Bifidobacterium breve, ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЯ ИЛИ ПАТОЛОГИЧЕСКОГО СОСТОЯНИЯ, ОПОСРЕДОВАННОГО IL-17 ИЛИ Th17
PT3209310T (pt) 2015-11-20 2018-04-20 4D Pharma Res Ltd Composições compreendendo estirpes bacterianas
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
US10675347B2 (en) 2015-11-30 2020-06-09 Joseph E. Kovarik Method and system for protecting honey bees from fipronil pesticides
US10568916B2 (en) 2015-11-30 2020-02-25 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US10933128B2 (en) 2015-11-30 2021-03-02 Joseph E. Kovarik Method and system for protecting honey bees from pesticides
US10086024B2 (en) 2015-11-30 2018-10-02 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US11529412B2 (en) 2015-11-30 2022-12-20 Seed Health, Inc. Method and system for protecting honey bees from pesticides
US12239706B2 (en) 2015-11-30 2025-03-04 Seed Health, Inc. Method and system for protecting monarch butterflies from pesticides
FR3045383B1 (fr) 2015-12-18 2019-06-14 Maat Pharma Procede de lyophilisation d'un echantillon de microbiote fecal
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
TW201733601A (zh) 2016-03-04 2017-10-01 ４Ｄ製藥有限公司 包含細菌菌株之組合物
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
TW201821093A (zh) 2016-07-13 2018-06-16 英商４Ｄ製藥有限公司 包含細菌菌株之組合物
WO2018064165A2 (en) 2016-09-27 2018-04-05 Board Of Regents, The University Of Texas System Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
US11617771B2 (en) 2016-12-15 2023-04-04 The Regents Of The University Of California Oral composition comprising lactic acid bacteria for regulating immune responses and methods related thereto
CA3047029A1 (en) * 2016-12-22 2018-06-28 Institut Gustave Roussy Microbiota composition, as a marker of responsiveness to anti-pd1/pd-l1/pd-l2 antibodies and use of microbial modulators for improving the efficacy of an anti-pd1/pd-l1/pd-l2 ab-based treatment
MX2019007648A (es) 2016-12-23 2020-02-07 Univ Keio Composiciones y metodos para la induccion de celulas t cd8+.
EP3560513A4 (en) * 2016-12-26 2020-10-14 National University Corporation Kobe University ANTICANCER THERAPY USING A COMBINATION OF AN ORAL TUMOR VACCINE AND AN IMMUNOSUPPRESSION INHIBITOR
WO2018136617A2 (en) * 2017-01-18 2018-07-26 Evelo Biosciences, Inc. Methods of treating cancer
US11723935B2 (en) * 2017-02-06 2023-08-15 New York University Methods and compositions for treating and diagnosing pancreatic cancers
WO2018171555A1 (en) * 2017-03-20 2018-09-27 Crown Bioscience Inc. (Taicang) Use of gut microbiota composition in immunotherapy
MA48939B1 (fr) 2017-05-22 2021-06-30 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
JP6978514B2 (ja) 2017-05-24 2021-12-08 フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited 細菌株を含む組成物
WO2018226690A1 (en) 2017-06-05 2018-12-13 The University Of Chicago Microbiome biomarkers of immunotherapy responsiveness: diagnostic, prognostic and therapeutic uses thereof
TW201919670A (zh) 2017-06-14 2019-06-01 英商4D製藥研究有限公司 包含細菌品系之組成物
CA3066557A1 (en) 2017-06-14 2018-12-20 4D Pharma Research Limited Compositions comprising bacterial strains
DK3600363T3 (da) 2017-06-14 2021-01-25 4D Pharma Res Ltd Sammensætninger omfattende bakteriestammer
BR112019028301A2 (pt) * 2017-07-05 2020-07-14 Evelo Biosciences, Inc. composições e métodos para tratar câncer com o uso de bifidobacterium animalis ssp. lactis
JP2020530297A (ja) * 2017-08-11 2020-10-22 ジェネンテック， インコーポレイテッド 抗ｃｄ８抗体及びその使用
WO2019109074A1 (en) * 2017-12-01 2019-06-06 Shepherd Therapeutics, Inc. Mebendazole cancer therapies and methods of use
US20210060038A1 (en) * 2018-01-17 2021-03-04 Reponex Pharmaceuticals A/S Compositions for eliminating bacterial promotors of colorectal cancer by intraluminal application
CA3088338A1 (en) * 2018-01-19 2019-07-25 4D Pharma Research Limited Combination therapy for treating or preventing cancer
TW201938179A (zh) * 2018-01-19 2019-10-01 英商4D製藥研究有限公司 用於治療或預防癌症之組合療法
TW201934138A (zh) * 2018-01-19 2019-09-01 英商4D製藥研究有限公司 用於治療或預防癌症之組合療法
TW201938180A (zh) * 2018-01-19 2019-10-01 英商4D製藥研究有限公司 用於治療或預防癌症之組合療法
CN110090230B (zh) * 2018-01-30 2022-07-12 青岛东海药业有限公司 凝结芽孢杆菌在制备预防或治疗胆管癌制剂中的应用
WO2019149859A1 (en) * 2018-01-31 2019-08-08 Universität Basel Gut commensal bacteria for treatment of human colorectal cancer
US11723934B2 (en) 2018-02-09 2023-08-15 Keio University Compositions and methods for the induction of CD8+ T-cells
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
JP2021519299A (ja) * 2018-03-28 2021-08-10 セレス セラピューティクス インコーポレイテッド 微生物叢モジュレーションによる癌の治療
KR101980525B1 (ko) * 2018-04-12 2019-05-21 주식회사 지놈앤컴퍼니 락토코커스 락티스 gen3013 균주, 및 이를 포함하는 암의 예방 또는 치료용 조성물
CN113164532A (zh) * 2018-05-30 2021-07-23 进化生物系统股份有限公司 H5功能性长双歧杆菌婴儿亚种的组合物和使用方法
CN112334141B (zh) * 2018-06-14 2024-12-13 株式会社明治 用于促进免疫检查点抑制疗法的组合物
US20210283197A1 (en) * 2018-07-17 2021-09-16 Ferring B.V. Microbiota restoration therapy (mrt) compositions and methods of manufacture
EP3597202A1 (en) * 2018-07-20 2020-01-22 Maat Pharma Fecal microbiota composition, for use in reducing treatment-induced inflammation
EP3829637A1 (en) * 2018-08-05 2021-06-09 Da Volterra Method for improving anticancer agent efficacy
US12150967B2 (en) 2018-08-18 2024-11-26 Seed Health, Inc. Methods and compositions for honey bee health
EP3858368B1 (en) 2018-09-25 2023-11-29 National Cerebral and Cardiovascular Center Antitumor effect potentiator
CN109266766B (zh) * 2018-10-10 2021-10-19 中国人民解放军第三0二医院 肠道微生物作为胆管细胞癌诊断标志物的用途
US11851663B2 (en) 2018-10-14 2023-12-26 Snipr Biome Aps Single-vector type I vectors
KR102069622B1 (ko) * 2019-06-25 2020-01-23 한국식품연구원 락토바실러스 퍼멘텀 WiKim0102를 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물
KR102136772B1 (ko) * 2018-12-10 2020-07-23 한국식품연구원 락토바실러스 사케아이 wikim30을 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물
WO2020122476A1 (ko) * 2018-12-10 2020-06-18 한국식품연구원 락토바실러스 사케아이 wikim30을 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물
CN110106104B (zh) * 2019-03-19 2021-12-17 江南大学 假小链双歧杆菌ccfm1048、其组合物、发酵食品、用途、菌剂及其菌剂制备方法
IL265735A (en) 2019-03-31 2019-05-30 Biomica A microbial consortium and its uses
CN111773377B (zh) * 2019-04-04 2023-03-14 中南大学 阿尼芬净在制备抗肿瘤药物中的应用及抗肿瘤药物
CN110063970B (zh) * 2019-04-30 2024-09-03 上海心脉途医疗科技有限公司 与irAE相关的肠道菌群及irAE的治疗和预防方法
CN111991427A (zh) * 2019-05-07 2020-11-27 瑞微（深圳）生物科技有限公司 肠道细菌在制备用于促进TCR γδ+T细胞增殖的药物中的应用
CN110734888B (zh) * 2019-09-17 2021-08-03 广州维生君生物科技有限公司 Tim3人源单链抗体融合基因转化乳酸菌及其应用
WO2021081676A1 (en) * 2019-11-01 2021-05-06 Uti Limited Partnership Harnessing the power of microbiota and metabolites for the treatment of cancer
US20220378855A1 (en) * 2019-12-20 2022-12-01 Persephone Biosciences, Inc. Compositions for modulating gut microflora populations, enhancing drug potency and treating cancer, and methods for making and using same
WO2021146647A1 (en) * 2020-01-17 2021-07-22 Second Genome, Inc. Methods and compositions for treating cancer
CN111228315A (zh) * 2020-02-27 2020-06-05 上海上药信谊药厂有限公司 抗肿瘤组合物
CN117159594A (zh) * 2020-02-27 2023-12-05 上海上药信谊药厂有限公司 抗肿瘤组合物
US11744866B2 (en) 2020-03-18 2023-09-05 Sabine Hazan Methods of preventing and treating COVID-19 infection with probiotics
US20220120746A1 (en) * 2020-03-18 2022-04-21 Sabine Hazan Methods of Determining Susceptibility to COVID-19 Infection
GB202007452D0 (en) 2020-05-19 2020-07-01 Microbiotica Ltd Threrapeutic bacterial composition
NL2025863B1 (en) * 2020-06-19 2022-02-17 Acad Medisch Ct Fecal matter for treatment of cachexia
KR20220028425A (ko) 2020-08-28 2022-03-08 주식회사 리비옴 항종양 세균 균주, 및 이를 이용한 조성물 및 방법
WO2022045637A1 (ko) 2020-08-28 2022-03-03 주식회사 리비옴 항종양 세균 균주, 및 이를 이용한 조성물 및 방법
KR102489493B1 (ko) * 2020-08-31 2023-01-18 주식회사 리비옴 항암 활성을 갖는 락토바실러스 플란타룸 미생물, 그를 포함하는 조성물 및 그를 이용한 암 예방 또는 치료 방법
US20240016787A1 (en) 2020-11-03 2024-01-18 Rdiscovery, LLC Methods for treatment of cancer and phagocytosis-deficiency related diseases
KR102307603B1 (ko) * 2020-11-13 2021-10-05 주식회사 비피도 비피도박테리움 롱검 rapo (kctc13773bp)를 포함하는 암 예방 또는 치료용 조성물
US20240277778A1 (en) * 2021-06-09 2024-08-22 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compositions and methods for determining responsiveness to immune checkpoint inhibitors (ici), increasing effectiveness of ici, and treating cancer
CN115786156A (zh) * 2021-09-10 2023-03-14 香港中文大学 用于结直肠肿瘤的预防、治疗或风险控制的组合物
WO2023118868A1 (en) * 2021-12-21 2023-06-29 Quadram Institute Bioscience Bifidobacterium and compositions thereof for breast cancer treatment
CN114344342B (zh) * 2021-12-29 2023-06-30 广东南芯医疗科技有限公司 副干酪乳杆菌Lp. R3在制备预防或治疗肿瘤药物中的应用
US20250064871A1 (en) * 2022-01-18 2025-02-27 The Regents Of The University Of California Bacterial compositions and methods for treating cancer and immune diseases
GB202209518D0 (en) 2022-06-29 2022-08-10 Snipr Biome Aps Treating & preventing E coli infections
WO2024035638A1 (en) * 2022-08-08 2024-02-15 Cornell University Methods for classifying and treating gastrointestinal tumors based on mycobiome analysis
IT202200022401A1 (it) * 2022-10-31 2024-05-01 Probionova Sa Ceppi di batteri per il trattamento di disturbi urologici, loro composizioni e usi relativi
CN117089490B (zh) * 2023-08-11 2024-06-07 浙江大学 青春双歧杆菌basj001及应用
WO2025176152A1 (en) * 2024-02-19 2025-08-28 The University Of Hong Kong Probiotics mixtures and methods of use thereof for treating cancers
CN118001305B (zh) * 2024-04-09 2024-06-11 山东中科嘉亿生物工程有限公司 长双歧杆菌jblc-141在制备改善副肿瘤性血小板增多症药物中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0281604B1 (en) 1986-09-02 1993-03-31 Enzon Labs Inc. Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ID29150A (id) 1999-01-15 2001-08-02 Entpr Ireland Cs Penggunaan lactobacillus salivarius
JP2005089388A (ja) * 2003-09-18 2005-04-07 Biofuerumin Seiyaku Kk 免疫賦活作用増強剤
GB0323039D0 (en) 2003-10-01 2003-11-05 Danisco Method
EP2439273B1 (en) 2005-05-09 2019-02-27 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
TW200819540A (en) * 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
US8444967B2 (en) 2010-07-09 2013-05-21 Master Supplements, Inc. Treatment including prebiotic composition for use with probiotics
DE102008045815A1 (de) * 2008-09-05 2010-03-11 Universität Rostock Kombination aus mindestens einem Antikörper und einem Bakterium, welches Fc-Rezeptoren oder die leichte Kette eines Antikörpers bindendende Proteine exprimiert
WO2011058535A1 (en) * 2009-11-11 2011-05-19 Alimentary Health Limited Probiotic bifidobacterium strain
JP2013512251A (ja) * 2009-11-24 2013-04-11 アンプリミューン、インコーポレーテッド Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害
EP3318248B1 (en) * 2009-12-01 2019-04-10 Translate Bio, Inc. Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
HK1220326A1 (zh) * 2013-03-15 2017-05-05 Seres Therapeutics, Inc. 基於网络微生物组成和方法
CN104415060A (zh) * 2013-08-30 2015-03-18 深圳华大基因科技有限公司 可食用组合物及其制备方法和用途
WO2015061372A1 (en) * 2013-10-21 2015-04-30 Hemoshear, Llc In vitro model for a tumor microenvironment
IL292510A (en) * 2013-11-05 2022-06-01 Cognate Bioservices Inc Combinations of checkpoint inhibitors and therapeutics to treat cancer
EP2876167A1 (en) * 2013-11-21 2015-05-27 Institut Gustave Roussy Microbiota composition, as a marker of responsiveness to chemotherapy, and use of microbial modulators (pre-,pro- or synbiotics) for improving the efficacy of a cancer treatment
WO2015176033A1 (en) * 2014-05-15 2015-11-19 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
US20190282632A1 (en) 2014-10-23 2019-09-19 Institut Gustave Roussy Methods and products for modulating microbiota composition for improving the efficacy of a cancer treatment with an immune checkpoint blocker
BR112019028301A2 (pt) * 2017-07-05 2020-07-14 Evelo Biosciences, Inc. composições e métodos para tratar câncer com o uso de bifidobacterium animalis ssp. lactis

Also Published As

Publication number Publication date
ZA201907641B (en) 2021-05-26
KR102661603B1 (ko) 2024-04-29
IL255940A (en) 2018-01-31
MX2017015473A (es) 2018-08-15
EP3303401C0 (en) 2024-10-16
KR20240059639A (ko) 2024-05-07
UY36701A (es) 2016-12-30
KR20180011262A (ko) 2018-01-31
HK1253064A1 (zh) 2019-06-06
WO2016196605A1 (en) 2016-12-08
EP3303401A1 (en) 2018-04-11
US20180015131A1 (en) 2018-01-18
AU2016270750B2 (en) 2022-06-16
EP3303401B1 (en) 2024-10-16
EP4541361A2 (en) 2025-04-23
US20160354416A1 (en) 2016-12-08
TW201717975A (zh) 2017-06-01
AU2016270750A1 (en) 2017-12-14
EP4541361A3 (en) 2025-07-30
CN107847530A (zh) 2018-03-27
EP3303401A4 (en) 2018-12-26
CL2017003024A1 (es) 2018-07-06
JP2022000447A (ja) 2022-01-04
BR112017025813A2 (pt) 2018-08-14
CA2987129A1 (en) 2016-12-08
US20220296656A1 (en) 2022-09-22
ZA201707986B (en) 2020-01-29
US9855302B2 (en) 2018-01-02
US20190183942A1 (en) 2019-06-20
RU2017141448A3 (es) 2019-11-19
JP2018521013A (ja) 2018-08-02
RU2017141448A (ru) 2019-07-15

Similar Documents

Publication Publication Date Title
PE20180673A1 (es) Tratamiento contra el cancer por manipulacion de la microflora comensal
JOP20200192A1 (ar) أجسام مضادة لـ tigit
MX2024008096A (es) Mavacamten para su uso en el tratamiento de la cardiomiopatia hipertrofica.
MX2018005315A (es) Composiciones y metodos para el tratamiento del cancer.
EA201990296A1 (ru) Антитела против siglec-7 для лечения рака
BR112017018954A2 (pt) uso de forma mutante de proteína ras e método para tratar câncer
EA201691866A1 (ru) Проникающие в опухоль лимфоциты для адоптивной клеточной терапии
TR201808169T3 (tr) Rekombinant probiyotik bakteriler .
MX387283B (es) Tratamiento del cancer con tg02.
EA201690206A1 (ru) Терапевтически активные соединения и способы их применения
CL2023003217A1 (es) Vacunación con el dominio alfa 3 de mica/b para el tratamiento del cáncer
BR112018003526A2 (pt) métodos de tratamento de doenças inflamatórias
MX388834B (es) Metodos y composiciones para tratar la obesidad, prevenir el aumento de peso, promover la perdida de peso, promover el adelgazamiento o tratar o prevenir el desarrollo de la diabetes.
MX2016015378A (es) Uso de eribulina en el tratamiento de cancer.
JO3541B1 (ar) علاجات طبية قائمة على اناموريلين
EA201891664A1 (ru) Составы/композиции, содержащие ингибитор btk
EA201890868A1 (ru) Бактерии с ослабленной вирулентностью для лечения злокачественных солидных опухолей
MX2018014938A (es) Combinaciones farmaceuticas para el tratamiento del cancer.
DK3383872T3 (da) 1,3,4-thiadiazolforbindelser og anvendelse deraf i cancerbehandling
MX2017000306A (es) Metodos para tratar hipotension.
MX2017007000A (es) Composiciones que comprenden acido 15-hidroxieicosapentaenoico (15-hepe) y metodos para tratar o prevenir la fibrosis usando las mismas.
BR112014026813A2 (pt) espaçadores de implante mamário para o tratamento de infecções de implante mamário periprostético
AR112531A1 (es) Tratamiento de cáncer usando una cepa de blautia
MX381429B (es) Tricostatina a (tsa) para usarse en el tratamiento del cáncer.
CY1125266T1 (el) To rad1901 για χρηση στη θεραπεια του καρκινου των ωοθηκων