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MX2018005315A - Composiciones y metodos para el tratamiento del cancer. - Google Patents

Composiciones y metodos para el tratamiento del cancer.

Info

Publication number
MX2018005315A
MX2018005315A MX2018005315A MX2018005315A MX2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A MX 2018005315 A MX2018005315 A MX 2018005315A
Authority
MX
Mexico
Prior art keywords
compositions
methods
cancer
treatment
therapeutic agents
Prior art date
Application number
MX2018005315A
Other languages
English (en)
Inventor
Paul Rennert
Lobb Roy
Original Assignee
Aleta Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aleta Biotherapeutics Inc filed Critical Aleta Biotherapeutics Inc
Publication of MX2018005315A publication Critical patent/MX2018005315A/es

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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

Se describen composiciones, p. ej., composiciones que comprenden agentes terapéuticos celulares y/o agentes terapéuticos proteicos, y métodos de utilizar estas composiciones para tratar el cáncer.
MX2018005315A 2015-10-30 2016-10-28 Composiciones y metodos para el tratamiento del cancer. MX2018005315A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562249144P 2015-10-30 2015-10-30
US201662331010P 2016-05-03 2016-05-03
US201662396783P 2016-09-19 2016-09-19
PCT/US2016/059582 WO2017075537A1 (en) 2015-10-30 2016-10-28 Compositions and methods for treatment of cancer

Publications (1)

Publication Number Publication Date
MX2018005315A true MX2018005315A (es) 2018-08-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005315A MX2018005315A (es) 2015-10-30 2016-10-28 Composiciones y metodos para el tratamiento del cancer.

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US (3) US10508143B1 (es)
EP (1) EP3368559A4 (es)
JP (1) JP7115982B2 (es)
KR (1) KR102868293B1 (es)
CN (1) CN108602872A (es)
AU (1) AU2016343809B2 (es)
BR (1) BR112018008326A2 (es)
CA (1) CA3002674A1 (es)
CL (1) CL2018001152A1 (es)
IL (1) IL258955B1 (es)
MA (1) MA43135A (es)
MX (1) MX2018005315A (es)
WO (1) WO2017075537A1 (es)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017013176A2 (en) * 2014-12-19 2018-05-15 Dana-Farber Cancer Institute Inc. chimeric antigen receptors and methods for using them
MX2018005315A (es) 2015-10-30 2018-08-14 Aleta Biotherapeutics Inc Composiciones y metodos para el tratamiento del cancer.
BR112018008390A2 (pt) 2015-10-30 2018-11-27 Aleta Biotherapeutics Inc composições e métodos para transdução tumoral
US11020429B2 (en) * 2015-11-05 2021-06-01 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
US11896615B2 (en) 2016-10-13 2024-02-13 Juno Therapeutics, Inc. Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators
CN108395482B (zh) * 2017-02-08 2021-02-05 西比曼生物科技(香港)有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
CN110637033A (zh) * 2017-02-22 2019-12-31 艾丽塔生物治疗剂公司 用于治疗癌症的组合物和方法
KR20240059648A (ko) 2017-04-19 2024-05-07 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 조작된 항원 수용체를 발현하는 면역 세포
CA3062506A1 (en) 2017-05-12 2019-05-23 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
US12331103B2 (en) 2017-06-16 2025-06-17 Protelica, Inc. Fibronectin binding domain chimeric antigen receptors and methods of use thereof
CN109096401B (zh) * 2017-06-20 2021-07-27 和迈生物科技有限公司 抗Her2纳米抗体及其编码序列和用途
CA3069522A1 (en) * 2017-07-12 2019-01-17 Refuge Biotechnologies, Inc. Methods and systems for conditionally regulating gene expression
EP3662055A1 (en) * 2017-08-02 2020-06-10 Autolus Limited Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed
WO2019094955A1 (en) * 2017-11-13 2019-05-16 The Broad Institute, Inc. Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
CA3082570A1 (en) * 2017-11-14 2019-05-23 Memorial Sloan-Kettering Cancer Center Il-36 secreting immunoresponsive cells and uses thereof
KR102847676B1 (ko) * 2017-12-15 2025-08-21 알레타 바이오쎄라퓨틱스, 인크. Cd19 변이체
CN109988242A (zh) * 2018-01-02 2019-07-09 武汉波睿达生物科技有限公司 联合嵌合抗原受体、表达载体、慢病毒及t细胞
US11851475B2 (en) 2018-01-03 2023-12-26 Xi'an Jiaotong-Liverpool University Membrane-type metalloprotease inhibitory protein and pharmaceutical and pharmaceutical composition containing same, and respective uses thereof
US12491153B2 (en) 2018-01-03 2025-12-09 Qu Biologics Inc. Innate targeting of adoptive cellular therapies
JP7534215B2 (ja) 2018-01-24 2024-08-14 ベイジン パーカンズ オンコロジー カンパニー リミテッド サイトカイン融合タンパク質
WO2020113403A1 (en) * 2018-12-04 2020-06-11 Beijing Percans Oncology Co. Ltd. Cytokine fusion proteins
CN110157675B (zh) * 2018-02-12 2022-05-27 深圳宾德生物技术有限公司 一种靶向性t淋巴细胞及其制备方法和应用
WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
JP7474702B2 (ja) 2018-03-28 2024-04-25 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム エキソソームから単離されたdnaにおけるエピジェネティック変化の同定法
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
EP3561053A1 (en) * 2018-04-26 2019-10-30 Baylor College of Medicine Immune effector cells and molecular adaptors with an antigen cytokine complex for effective cancer immunotherapy
US20210094994A1 (en) * 2018-04-27 2021-04-01 Baylor College Of Medicine Car t cells with one or more interleukins
AU2019257789A1 (en) * 2018-04-27 2020-11-12 Crispr Therapeutics Ag Anti-BCMA CAR-T-cells for plasma cell depletion
AU2019266398A1 (en) 2018-05-11 2020-11-19 Crispr Therapeutics Ag Methods and compositions for treating cancer
CN110623977A (zh) * 2018-06-25 2019-12-31 深圳宾德生物技术有限公司 靶向bcma的嵌合抗原受体t细胞在自身免疫性疾病中的应用
AU2019321540B2 (en) 2018-08-14 2025-08-21 Sotio, LLC Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating Krebs cycle and therapeutic uses thereof
CN110856751B (zh) * 2018-08-24 2024-12-03 杭州康万达医药科技有限公司 包含核酸及tcr修饰的免疫细胞的治疗剂及其应用
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
CN113416251B (zh) * 2018-09-26 2022-05-17 重庆精准生物技术有限公司 抗cd123人源化单链抗体及其应用
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2020077341A1 (en) 2018-10-13 2020-04-16 Memorial Sloan-Kettering Center Center Methods and compositions for identifying and treating subjects at risk for poor car t cell therapy response
AU2019384145A1 (en) * 2018-11-20 2021-06-10 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expressing therapeutic agent and uses thereof
US20220047634A1 (en) * 2018-11-30 2022-02-17 Dana-Farber Cancer Institute, Inc. Chimeric antigen receptor factories and methods of use thereof
CN109468283A (zh) * 2018-11-30 2019-03-15 北京美康基免生物科技有限公司 一种基于cd19和bcma的双重嵌合抗原受体基因修饰的免疫细胞及其应用
CN109536444B (zh) * 2018-12-11 2022-06-28 吉林省拓华生物科技有限公司 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法
WO2020127376A2 (en) * 2018-12-17 2020-06-25 Alligator Bioscience Ab Novel polypeptides
CN111378046B (zh) * 2018-12-27 2024-03-15 上海细胞治疗集团有限公司 一种免疫效应细胞转换受体
CN111378623B (zh) * 2018-12-29 2023-10-20 深圳市第三人民医院 一种靶向性抗肿瘤t细胞及其制备方法和应用
WO2020172641A1 (en) * 2019-02-21 2020-08-27 Arbele Limited Artificial immunosurveillance chimeric antigen receptor and cells expressing the same
AU2020224160A1 (en) * 2019-02-21 2021-08-26 John M. LUK Artificial immunosurveillance chimeric antigen receptor (AI-CAR) and cells expressing the same
WO2020177992A1 (en) 2019-03-01 2020-09-10 Universität Für Bodenkultur Wien Stabilized extracellular domain of cd19
CN113853388B (zh) * 2019-03-27 2024-07-19 加拿大国家研究委员会 抗-egfrviii抗体及其抗原结合片段
AU2020262956A1 (en) * 2019-04-26 2021-12-16 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
SG11202112032WA (en) 2019-04-30 2021-11-29 Crispr Therapeutics Ag Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
CA3144071A1 (en) * 2019-06-21 2020-12-24 Shattuck Labs, Inc. Chimeric protein expressing t-cells
US20230139944A1 (en) * 2019-06-21 2023-05-04 Board Of Regents, The University Of Texas System Targeting alpha3beta1 integrin for treatment of cancer and other diseases
BR112022003735A2 (pt) * 2019-08-29 2022-06-21 Nat Institute For Biotechnology In The Negev Ltd Anticorpo de domínio único para alvejar antígeno de membrana específico da próstata (psma)
US20220389076A1 (en) * 2019-09-26 2022-12-08 Oricell Therapeutics Co., Ltd. Modified immune cell and use thereof
WO2021096275A1 (ko) * 2019-11-15 2021-05-20 주식회사 제넥신 변형된 인터루킨-7 및 tgf 베타 수용체 ii를 포함하는 융합단백질 및 이의 용도
WO2021147886A1 (zh) * 2020-01-21 2021-07-29 张晋宇 一种药物组合物及其用途
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
CN113402612A (zh) 2020-03-17 2021-09-17 西比曼生物科技(香港)有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
CN116323647A (zh) * 2020-05-13 2023-06-23 博纳姆治疗公司 蛋白质复合物的组合物及其使用方法
EP3915578A1 (en) * 2020-05-28 2021-12-01 Miltenyi Biotec B.V. & Co. KG Chimeric antigen receptor with a spacer comprising c2-set ig-like domains
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
US20230338422A1 (en) * 2020-07-09 2023-10-26 Nanjing Legend Biotech Co., Ltd. Engineering gamma delta t cells with interleukin-36 for immunotherapy
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
US20230272341A1 (en) * 2020-08-10 2023-08-31 Crage Medical Co., Limited Multifunctional immune effector cell and use thereof
CN111944063A (zh) * 2020-08-20 2020-11-17 深圳市因诺转化医学研究院 特异性识别人cd19嵌合抗原受体的融合蛋白、核酸分子及其应用
CN116033919A (zh) 2020-09-04 2023-04-28 美天施生物科技有限两合公司 用于免疫细胞中衔接子的诱导型表达的系统
JP2023541455A (ja) 2020-09-14 2023-10-02 ブイオーアール バイオファーマ インコーポレーテッド Cd33に対する単一ドメイン抗体
EP4232052A4 (en) * 2020-10-22 2025-08-20 Actinium Pharmaceuticals Inc COMBINATION OF RADIOMUNOTHERAPY AND CD47 BLOCKADE IN THE TREATMENT OF CANCER
CN112225822B (zh) * 2020-12-14 2021-03-23 北京基因启明生物科技有限公司 高扩增、存续能力和杀瘤作用的CAR-iNKT及应用
CN114163513B (zh) * 2021-03-24 2025-02-25 深圳市新靶向生物科技有限公司 一种与肝癌驱动基因突变相关的抗原肽组合及其应用
WO2022246041A2 (en) * 2021-05-20 2022-11-24 Achelois Biopharma, Inc. Compositions and methods for multivalent surface display on enveloped particles
CN113238061B (zh) * 2021-07-09 2021-10-01 中南大学湘雅医院 以cd180阴性b细胞指示重症肌无力病情的试剂盒及应用
US12077607B2 (en) 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G
CN116338196A (zh) * 2021-12-15 2023-06-27 上海佳文英莉生物技术有限公司 老年痴呆症诊断及治疗的新靶点及其应用
KR102732911B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 유방암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732912B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732910B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 대장암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732909B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 유두상 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732913B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 흑색종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
CA3248167A1 (en) 2022-04-11 2023-10-19 Vor Biopharma Inc. LIAISON AGENTS AND THEIR METHODS OF USE
EP4626447A1 (en) 2023-03-31 2025-10-08 AbelZeta Inc. Bispecific chimeric antigen receptors targeting cd20 and bcma
WO2024238565A1 (en) 2023-05-15 2024-11-21 Vor Biopharma Inc. Egf-like module containing mucin-like hormone-like 2 (erm2) binding agents and methods of use thereof
EP4470555A1 (en) 2023-05-31 2024-12-04 Miltenyi Biotec B.V. & Co. KG Anti-tag chimeric antigen receptors with specificity for mutated peptides derived from human fgfr2

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
US5614191A (en) 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
ATE312178T1 (de) 1996-07-17 2005-12-15 Us Health Infektiöse pseudovirale papillomavirus partikel
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
ES2332435T3 (es) 1997-06-04 2010-02-04 Oxford Biomedica (Uk) Limited Vector dirigido a tumores.
DE69835294T2 (de) 1997-09-05 2007-07-26 Medimmune, Inc. Methode zur in vitro auseinander- und wiederzusammensetzung von papillomavirus virusähnlichen teilchen (vlps)
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
JP2003516124A (ja) 1999-10-15 2003-05-13 ユニバーシティー オブ マサチューセッツ 標的とした遺伝的干渉の手段としてのrna干渉経路遺伝子
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
CA2412901A1 (en) 2000-06-22 2001-12-27 Idec Pharmaceutical Corporation Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
CA2425862C (en) * 2000-11-07 2013-01-22 City Of Hope Cd19-specific redirected immune cells
CN1114690C (zh) 2001-05-15 2003-07-16 乔良 乳头瘤假病毒及其制备方法
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
CN103751780A (zh) 2005-03-02 2014-04-30 比奥根艾迪克Ma公司 用于治疗th2介导的疾病的kim-1抗体
JP2009500346A (ja) * 2005-06-29 2009-01-08 ユニバーシティー・オブ・マイアミ 癌処置用の抗体−免疫細胞リガンド融合タンパク質
US20070274908A1 (en) 2006-04-07 2007-11-29 The Board Of Regents Of The University Of Texas System Methods and compositions related to adenoassociated virus-phage particles
SI2145189T1 (sl) 2007-05-08 2016-08-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Papilomavirusni psevdovirusi za detekcijo in terapijo tumorjev
TR201000668T1 (tr) * 2007-07-31 2010-06-21 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Neoplasti̇k veya enfeksi̇yoz bozukluklara yöneli̇k i̇mmunoprofi̇laksi̇ veya i̇mmünoterapi̇ i̇çi̇n poli̇pepti̇d-nüklei̇k asi̇t konjugati
US20090304719A1 (en) 2007-08-22 2009-12-10 Patrick Daugherty Activatable binding polypeptides and methods of identification and use thereof
US20110070191A1 (en) * 2008-03-19 2011-03-24 Wong Hing C T cell receptor fusions and conjugates and methods of use there of
US20110159023A1 (en) 2008-08-25 2011-06-30 Solomon Langermann Pd-1 antagonists and methods for treating infectious disease
US20120034223A1 (en) * 2008-11-06 2012-02-09 Hall Christopher J Methods of improving the therapeutic efficacy and utility of antibody fragments
EP2385955B1 (en) 2009-01-12 2020-08-12 CytomX Therapeutics, Inc. Modified antibody compositions, methods of making and using thereof
BRPI1011384A2 (pt) 2009-02-23 2016-03-15 Cytomx Therapeutics Inc pro-proteinas e seus metodos de uso
US20130209514A1 (en) * 2009-06-09 2013-08-15 Eli Gilboa Aptamer-targeted costimulatory ligand aptamer
ES2638521T5 (es) * 2010-03-05 2021-03-02 Univ Johns Hopkins Composiciones y métodos para anticuerpos y proteínas de fusión inmunomoduladores dirigidos contra dianas
NZ706016A (en) * 2010-10-27 2016-10-28 Baylor College Medicine Chimeric cd27 receptors for redirecting t cells to cd70-positive malignancies
RU2628089C2 (ru) 2011-09-26 2017-08-14 Филоген С.П.А. Комбинированная терапия иммуноцитокинами
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
BR112014026354A2 (pt) * 2012-04-27 2017-06-27 Cytomx Therapeutics Inc anticorpos ativáveis que ligam o receptor de fator de crescimento epidermal e métodos de uso do mesmo
PE20150643A1 (es) 2012-06-22 2015-05-29 Cytomx Therapeutics Inc Anticuerpos de reaccion cruzada anti-jagged 1/jagged 2 anticuerpos anti-jagged activables y metodos de uso de los mismos
WO2014052462A2 (en) 2012-09-25 2014-04-03 Cytomx Therapeutics, Inc. Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
SG10201708896WA (en) * 2013-05-13 2017-11-29 Cellectis Cd19 specific chimeric antigen receptor and uses thereof
CN105612180B (zh) 2013-07-19 2019-11-12 弗拉芒区生物技术研究所 经靶向修饰的il-1家族成员
AU2014337367B2 (en) 2013-10-15 2020-04-30 The Scripps Research Institute Peptidic chimeric antigen receptor T cell switches and uses thereof
HRP20201906T1 (hr) * 2013-12-20 2021-04-02 Fred Hutchinson Cancer Research Center Označene kimerne efektorske molekule i njihovi receptori
WO2015142675A2 (en) * 2014-03-15 2015-09-24 Novartis Ag Treatment of cancer using chimeric antigen receptor
EP3811970A1 (en) 2014-03-15 2021-04-28 Novartis AG Regulatable chimeric antigen receptor
JP6779909B2 (ja) * 2015-01-26 2020-11-04 セレクティスCellectis がん免疫治療のための抗CLL1特異的単鎖キメラ抗原受容体(scCAR)
US11091546B2 (en) 2015-04-15 2021-08-17 The Scripps Research Institute Optimized PNE-based chimeric receptor T cell switches and uses thereof
JP2018522907A (ja) * 2015-08-11 2018-08-16 セレクティスCellectis Cd38抗原を標的とするためおよびcd38遺伝子を不活化するために操作された、免疫療法用の細胞
MX2018005315A (es) 2015-10-30 2018-08-14 Aleta Biotherapeutics Inc Composiciones y metodos para el tratamiento del cancer.
BR112018008390A2 (pt) 2015-10-30 2018-11-27 Aleta Biotherapeutics Inc composições e métodos para transdução tumoral
EA201891641A1 (ru) * 2016-01-21 2019-01-31 Пфайзер Инк. Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста
EP3426684B1 (en) * 2016-03-08 2024-10-09 Ventana Medical Systems, Inc. Multiplexed immunohistochemistry using recombinant antibodies with epitope tags
CA3029197A1 (en) * 2016-06-24 2017-12-28 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof

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