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PE20131413A1 - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents

Inmunoglobulinas con dominio variable dual y usos de las mismas

Info

Publication number
PE20131413A1
PE20131413A1 PE2013000031A PE2013000031A PE20131413A1 PE 20131413 A1 PE20131413 A1 PE 20131413A1 PE 2013000031 A PE2013000031 A PE 2013000031A PE 2013000031 A PE2013000031 A PE 2013000031A PE 20131413 A1 PE20131413 A1 PE 20131413A1
Authority
PE
Peru
Prior art keywords
seq
variable domain
immunoglobulins
sequence selected
dual variable
Prior art date
Application number
PE2013000031A
Other languages
English (en)
Inventor
Tariq Ghayur
Junjian Liu
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20131413A1 publication Critical patent/PE20131413A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/46—Hybrid immunoglobulins
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

REFERIDO A INMUNOGLOBULINAS CON DOMINIO VARIABLE DUAL QUE COMPRENDE UNA PRIMERA Y UNA SEGUNDA CADENA DE POLIPEPTIDOS, CADA UNA DE LAS CUALES COMPRENDE DE MANERA INDEPENDIENTE VD1-(X1)n-VD2-C-(X2)n, EN DONDE: VD1 ES UN PRIMER DOMINIO VARIABLE QUE FORMA EN AMBAS CADENAS UN PRIMER SITIO DE UNION BLANCO FUNCIONAL; VD2 ES UN SEGUNDO DOMINIO VARIABLE QUE FORMA EN AMBAS CADENAS UN SEGUNDO SITIO DE UNION BLANCO FUNCIONAL; C ES UN DOMINIO CONSTANTE; X1 ES UN CONECTOR CON LA CONDICION QUE NO SEA CH1; X2 ES UNA REGION Fc; n ES 0 -1. ADEMAS DICHA PROTEINA TIENE CAPACIDAD DE UNIR NGF QUE COMPRENDE UNA SECUENCIA SELECCIONADA ENTRE LAS SEQ ID N� 60-61 Y LAS SEQ ID N� 86-87, IGF1,2 QUE COMPRENDE UNA SECUENCIA SELECCIONADA ENTRE LAS SEQ ID N� 46-47, RON QUE COMPRENDE UNA SECUENCIA SELECCIONADA ENTRE LAS SEQ ID N� 36-37 Y LAS SEQ ID N� 64-65 ENTRE OTRAS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHA PROTEINA ES UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, OSTEOARTRITIS ENTRE OTRAS.
PE2013000031A 2010-07-09 2011-07-08 Inmunoglobulinas con dominio variable dual y usos de las mismas PE20131413A1 (es)

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KR20130105601A (ko) 2013-09-25
EP2590671A4 (en) 2013-12-18

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