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MX2013000366A - Inmonoglubulinas de dominio variable doble y usos de las mismas. - Google Patents

Inmonoglubulinas de dominio variable doble y usos de las mismas.

Info

Publication number
MX2013000366A
MX2013000366A MX2013000366A MX2013000366A MX2013000366A MX 2013000366 A MX2013000366 A MX 2013000366A MX 2013000366 A MX2013000366 A MX 2013000366A MX 2013000366 A MX2013000366 A MX 2013000366A MX 2013000366 A MX2013000366 A MX 2013000366A
Authority
MX
Mexico
Prior art keywords
binding proteins
immonoglubulines
same
variable domain
multivalent
Prior art date
Application number
MX2013000366A
Other languages
English (en)
Inventor
Tariq Ghayur
Junjian Liu
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2013000366A publication Critical patent/MX2013000366A/es

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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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Abstract

Se proporcionan métodos para hacer proteínas de unión multivalentes y multiespecíficas diseñadas por ingeniería, y usar las proteínas de unión en la prevención, diagnóstico, yio tratamiento de enfermedad. Las proteínas de unión multivalentes pueden contener más de una región variable de cadena pesada y/o cadena ligera enlazada unida a través de una región constante a una región Fc. Las proteínas de unión multivalentes pueden unirse a un número de citocinas, hormonas, factores de crecimiento, moléculas pequeñas o receptores de superficie de célula, incluyendo NGF y cualquiera de un número de moléculas pequeñas, factores de crecimiento, citocinas, hormonas o receptores de superficie de célula.
MX2013000366A 2010-07-09 2011-07-08 Inmonoglubulinas de dominio variable doble y usos de las mismas. MX2013000366A (es)

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