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CU22545A1 - Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico - Google Patents

Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico

Info

Publication number
CU22545A1
CU22545A1 CU1994128A CU1994128A CU22545A1 CU 22545 A1 CU22545 A1 CU 22545A1 CU 1994128 A CU1994128 A CU 1994128A CU 1994128 A CU1994128 A CU 1994128A CU 22545 A1 CU22545 A1 CU 22545A1
Authority
CU
Cuba
Prior art keywords
diagnostic
receptor
obtaining
chemical
growth factor
Prior art date
Application number
CU1994128A
Other languages
English (en)
Inventor
De Acosta Del Rio Cristina Maria Mateo
Frias Ernesto Moreno
Rodriguez Rolando Perez
Original Assignee
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Priority to CU1994128A priority Critical patent/CU22545A1/es
Priority to PT95203126T priority patent/PT712863E/pt
Priority to ES95203126T priority patent/ES2173149T3/es
Priority to EP95203126A priority patent/EP0712863B1/en
Priority to DE69525593T priority patent/DE69525593T2/de
Priority to AT95203126T priority patent/ATE213744T1/de
Priority to DK95203126T priority patent/DK0712863T3/da
Priority to CN95118826A priority patent/CN1054609C/zh
Priority to CA002163151A priority patent/CA2163151C/en
Priority to US08/560,558 priority patent/US5891996A/en
Priority to CA002332183A priority patent/CA2332183C/en
Priority to JP33764495A priority patent/JP3585303B2/ja
Priority to US09/217,268 priority patent/US6506883B2/en
Publication of CU22545A1 publication Critical patent/CU22545A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se relaciona con la rama de la inmunología y en particular con dos productos novedosos que son, un anticuerpo quimérico y la versión humanizada, ambos reconocen el receptor del Factor de Crecimiento Epidérmico (EGF-R). El anticuerpo humanizado comprende la secuencia de los FRs de la región variable de una inmunoglobulina humana. Las regiones hipervariables (CDRs) de ambos anticuerpos tienen las siguientes secuencias: Cadena Ligera: CDR1:- arg-ser-ser-gln-asn-ile-val-his-ser-asn-gly-asn-thr-tyr-leu-asp CDR2:- lys-val-ser-asn-arg-phe-ser CDR3:- phe-gln-tyr-ser-his-val-pro-trp-thr Cadena Pesada: CDR1:- asn-tyr-tyr-ile-tyr CDR2:- gly-ile-asn-pro-thr-ser-gly-gly-ser-asn-phe-asn-glu-lys-phe-lys-thr CDR3:- gln-gly-leu-trp-phe-asp-ser-asp-gly-arg-gly-phe-asp-phe Estos anticuerpos pueden ser usados tanto con fines diagnóstico como terapéutico. El objeto de la invención es proporcionar un producto menos inmunogénico y con funciones efectoras mejoradas para la terapéutica de enfermedades malignas asociadas al Factor de Crecimiento Epidérmico (EGF), así como para el diagnóstico de estas enfermedades. La invención también se relaciona con las composiciones que contengan estos anticuerpos y que pudieran tener uso diagnóstico o terapéutico.
CU1994128A 1972-09-17 1994-11-18 Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico CU22545A1 (es)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CU1994128A CU22545A1 (es) 1994-11-18 1994-11-18 Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
PT95203126T PT712863E (pt) 1994-11-18 1995-11-15 Anticorpos monoclonais humanizados e quimericos que reconhecem o receptor do factor de crescimento epidermico (egf-r); utilizacao diagnostica e terapetica
ES95203126T ES2173149T3 (es) 1994-11-18 1995-11-15 Anticuerpos monoclonales humanizados y quimericos que reconocen el receptor del factor del crecimiento epidermico (egf-r); uso de diagnostico y terapeutico.
EP95203126A EP0712863B1 (en) 1994-11-18 1995-11-15 Humanized and chimeric monoclonal antibodies that recognize epidermal growth factor receptor (EGF-R); diagnostic and therapeutic use
DE69525593T DE69525593T2 (de) 1994-11-18 1995-11-15 Humanisierte und chimäre monoklonale Antikörper die den Rezeptor für epidermalen Wachstumfaktor (EGF-R) erkennen; diagnostische und therapeutische Verwendung
AT95203126T ATE213744T1 (de) 1994-11-18 1995-11-15 Humanisierte und chimäre monoklonale antikörper die den rezeptor für epidermalen wachstumfaktor (egf-r) erkennen; diagnostische und therapeutische verwendung
DK95203126T DK0712863T3 (da) 1994-11-18 1995-11-15 Humaniserede og kimæriske monoklonale antistoffer, som genkender epidermisvækstfaktor-receptor (EFG-R), diagnostiske og terapeutiske anvendelser
CN95118826A CN1054609C (zh) 1994-11-18 1995-11-17 识别表皮生长因子受体的人源化和嵌合体单克隆抗体
CA002163151A CA2163151C (en) 1994-11-18 1995-11-17 Humanized and chimeric monoclonal antibodies that recognized epidermal growth factor receptor (egf-r). use diagnostic and therapeutic
US08/560,558 US5891996A (en) 1972-09-17 1995-11-17 Humanized and chimeric monoclonal antibodies that recognize epidermal growth factor receptor (EGF-R); diagnostic and therapeutic use
CA002332183A CA2332183C (en) 1994-11-18 1995-11-17 Humanized and chimeric monoclonal antibodies that recognize epidermal growth factor receptor (egf-r); diagnostic and therapeutic use
JP33764495A JP3585303B2 (ja) 1994-11-18 1995-11-20 表皮成長因子レセプター（ｅｇｆ−ｒ）を認識するヒト化キメラモノクローナル抗体及びその診断並びに治療用途
US09/217,268 US6506883B2 (en) 1994-11-18 1998-12-21 Humanized and chimeric monoclonal antibodies that recognize epidermal growth factor receptor (EGF-R); diagnostic and therapeutic use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU1994128A CU22545A1 (es) 1994-11-18 1994-11-18 Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico

Publications (1)

Publication Number Publication Date
CU22545A1 true CU22545A1 (es) 1999-03-31

Family

ID=5459426

Family Applications (1)

Application Number Title Priority Date Filing Date
CU1994128A CU22545A1 (es) 1972-09-17 1994-11-18 Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico

Country Status (11)

Country Link
US (2) US5891996A (es)
EP (1) EP0712863B1 (es)
JP (1) JP3585303B2 (es)
CN (1) CN1054609C (es)
AT (1) ATE213744T1 (es)
CA (2) CA2332183C (es)
CU (1) CU22545A1 (es)
DE (1) DE69525593T2 (es)
DK (1) DK0712863T3 (es)
ES (1) ES2173149T3 (es)
PT (1) PT712863E (es)

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CA2163151A1 (en) 1996-05-19
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PT712863E (pt) 2002-08-30
CA2332183A1 (en) 1996-05-19
CN1054609C (zh) 2000-07-19
JPH08291200A (ja) 1996-11-05
DE69525593T2 (de) 2002-10-31
US6506883B2 (en) 2003-01-14
EP0712863A1 (en) 1996-05-22
CA2163151C (en) 2001-04-10
DE69525593D1 (de) 2002-04-04
EP0712863B1 (en) 2002-02-27
JP3585303B2 (ja) 2004-11-04
US20020065398A1 (en) 2002-05-30
CA2332183C (en) 2006-10-31
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CN1130193A (zh) 1996-09-04

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