PE20110225A1 - Composiciones y metodos para anticuerpos que se dirigen a la proteina de complemento c5 - Google Patents
Composiciones y metodos para anticuerpos que se dirigen a la proteina de complemento c5Info
- Publication number
- PE20110225A1 PE20110225A1 PE2011000122A PE2011000122A PE20110225A1 PE 20110225 A1 PE20110225 A1 PE 20110225A1 PE 2011000122 A PE2011000122 A PE 2011000122A PE 2011000122 A PE2011000122 A PE 2011000122A PE 20110225 A1 PE20110225 A1 PE 20110225A1
- Authority
- PE
- Peru
- Prior art keywords
- antibody
- human
- chain
- iggst
- encodes
- Prior art date
Links
- 102000000989 Complement System Proteins Human genes 0.000 title 1
- 108010069112 Complement System Proteins Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
REFERIDA A UN ANTICUERPO AISLADO O UN FRAGMENTO DE ENLACE DE ANTIGENO DEL MISMO QUE SE ENLAZA ESPECIFICAMENTE A UNA PROTEINA C5 DE COMPLEMENTO EL CUAL ES UN ANTICUERPO MONOCLONAL QUIMERICO HUMANO O HUMANIZADO ISOTIPO DE IgG DE UNA SOLA CADENA QUE POSEE UNA REGION CONSTANTE DE CADENA PESADA HUMANA Y QUE PUEDE SER UN FRAGMENTO Fab O scFv. EL ANTICUERPO COMPRENDE UNA ESTRUCTURA EN DONDE LOS AMINOACIDOS HAN SIDO SUSTITUIDOS EN LA ESTRUCTURA DEL ANTICUERPO A PARTIR DE LAS SECUENCIAS DE LA LINEA GERMINAL VH O VL HUMANAS RESPECTIVAMENTE; Y COMPRENDE ADEMAS, UNA SECUENCIA DE CDR CON UNA IDENTIDAD DE AL MENOS 95% CON LAS SEQ ID NOs: 1,2,3,4, 5,6,17,18, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA, UN VECTOR QUE CODIFICA LOS POLIPEPTIDOS DEL ANTICUERPO Y A UNA CELULA HUESPED AISLADA QUE CONSTA DE UN ADN RECOMBINANTE QUE CODIFICA LAS CADENAS DEL ANTICUERPO. DICHOS ANTICUERPOS SON UTILES EN EL TRATAMIENTO DE ASMA, ARTRITIS, ESCLEROSIS MULTIPLE, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8635508P | 2008-08-05 | 2008-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110225A1 true PE20110225A1 (es) | 2011-04-05 |
Family
ID=41227252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000122A PE20110225A1 (es) | 2008-08-05 | 2009-08-03 | Composiciones y metodos para anticuerpos que se dirigen a la proteina de complemento c5 |
Country Status (38)
| Country | Link |
|---|---|
| US (5) | US8241628B2 (es) |
| EP (3) | EP2837388A1 (es) |
| JP (2) | JP5815403B2 (es) |
| KR (1) | KR101463296B1 (es) |
| CN (2) | CN104177495B (es) |
| AR (1) | AR072897A1 (es) |
| AU (1) | AU2009279197B2 (es) |
| BR (1) | BRPI0916668B1 (es) |
| CA (1) | CA2732782C (es) |
| CL (1) | CL2011000233A1 (es) |
| CO (1) | CO6351750A2 (es) |
| CR (2) | CR20110035A (es) |
| CU (1) | CU23978B1 (es) |
| DK (1) | DK2328616T3 (es) |
| EA (1) | EA027575B1 (es) |
| EC (1) | ECSP11010805A (es) |
| ES (2) | ES2541142T3 (es) |
| HK (1) | HK1203156A1 (es) |
| HN (1) | HN2011000357A (es) |
| HR (1) | HRP20150799T1 (es) |
| HU (1) | HUE026179T2 (es) |
| IL (1) | IL210768B (es) |
| JO (1) | JO3118B1 (es) |
| MA (1) | MA32535B1 (es) |
| MX (2) | MX2011001371A (es) |
| MY (1) | MY159396A (es) |
| NZ (2) | NZ590634A (es) |
| PE (1) | PE20110225A1 (es) |
| PL (1) | PL2328616T3 (es) |
| PT (1) | PT2328616E (es) |
| RS (1) | RS54113B1 (es) |
| SG (1) | SG10201405377XA (es) |
| SI (1) | SI2328616T1 (es) |
| SV (1) | SV2011003834A (es) |
| TW (2) | TWI417107B (es) |
| UA (1) | UA105009C2 (es) |
| WO (1) | WO2010015608A1 (es) |
| ZA (1) | ZA201100375B (es) |
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| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
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| CA2822288A1 (en) * | 2010-12-22 | 2012-06-28 | Medimmune, Llc | Anti-c5/c5a/c5adesr antibodies and fragments |
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| EP2731970B1 (en) | 2011-07-15 | 2018-11-28 | MorphoSys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt) |
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| SG10201609301QA (en) | 2011-11-30 | 2016-12-29 | Chugai Pharmaceutical Co Ltd | Drug containing carrier into cell for forming immune complex |
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| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
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