AR106184A1 - Proteínas de unión a pd-1 y sus métodos de uso - Google Patents
Proteínas de unión a pd-1 y sus métodos de usoInfo
- Publication number
- AR106184A1 AR106184A1 ARP160102967A ARP160102967A AR106184A1 AR 106184 A1 AR106184 A1 AR 106184A1 AR P160102967 A ARP160102967 A AR P160102967A AR P160102967 A ARP160102967 A AR P160102967A AR 106184 A1 AR106184 A1 AR 106184A1
- Authority
- AR
- Argentina
- Prior art keywords
- pd1ab
- antibody
- chain variable
- binding fragment
- variable region
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 abstract 6
- 102000036639 antigens Human genes 0.000 abstract 6
- 108091007433 antigens Proteins 0.000 abstract 6
- 239000012634 fragment Substances 0.000 abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 abstract 3
- 102000048362 human PDCD1 Human genes 0.000 abstract 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 abstract 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Un anticuerpo o su fragmento de unión con el antígeno que (a) se une con un epítope de PD-1 humana reconocido por un anticuerpo que comprende una región variable de cadena liviana que tiene una secuencia de aminoácidos de la SEQ ID Nº 8 y una región variable de cadena pesada que tiene una secuencia de aminoácidos de la SEQ ID Nº 13; o (b) compite por la unión con PD-1 humana con un anticuerpo que comprende una región variable de cadena liviana que tiene una secuencia de aminoácidos de la SEQ ID Nº 8 y una región variable de cadena pesada que tiene una secuencia de aminoácidos de la SEQ ID Nº 13. Reivindicación 2: Un anticuerpo o su fragmento de unión con el antígeno que se une con PD-1, en donde el anticuerpo o su fragmento de unión con el antígeno comprende: (a) una región variable de cadena liviana (VL) que comprende la región determinante de complementariedad 1 de VL (CDR1), VL CDR2 y VL CDR3 de cualquiera de los anticuerpos PD1AB-1, PD1AB-2, PD1AB-3, PD1AB-4, PD1AB-5 o PD1AB-6 como se establece en la tabla 1; y/o (b) una región variable de cadena pesada (VH) que comprende la región determinante de complementariedad 1 de VH (CDR1), VH CDR2 y VH CDR3 de cualquiera de los anticuerpos PD1AB-1, PD1AB-2, PD1AB-3, PD1AB-4, PD1AB-5 o PD1AB-6 como se establece en la tabla 2. Reivindicación 69: Una composición que comprende el anticuerpo o su fragmento de unión con el antígeno de acuerdo con cualquiera de las reivindicaciones 1 - 68 y un portador farmacéuticamente aceptable. Reivindicación 70: Un polinucleótido que comprende secuencias de nucleótidos que codifican VH, VL o tanto VH como VL del anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 - 68. Reivindicación 79: Un método de preparación de un anticuerpo o su fragmento de unión con el antígeno que se une específicamente con un epítope de PD-1 humana, que comprende expresar el polinucleótido de acuerdo con cualquiera de las reivindicaciones 70 a 72. Reivindicación 80: Un método de atenuación de la actividad de una célula T, que comprende poner en contacto la célula T con una cantidad efectiva de un anticuerpo o su fragmento de unión a antígeno de acuerdo con cualquiera de, las reivindicaciones 1 a 68.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562234535P | 2015-09-29 | 2015-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106184A1 true AR106184A1 (es) | 2017-12-20 |
Family
ID=58409303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102967A AR106184A1 (es) | 2015-09-29 | 2016-09-28 | Proteínas de unión a pd-1 y sus métodos de uso |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10428145B2 (es) |
| EP (1) | EP3355920A4 (es) |
| JP (2) | JP6843868B2 (es) |
| KR (1) | KR20180054824A (es) |
| CN (1) | CN108289953B (es) |
| AR (1) | AR106184A1 (es) |
| AU (1) | AU2016332725A1 (es) |
| BR (1) | BR112018006237A2 (es) |
| CA (1) | CA2997963A1 (es) |
| CL (1) | CL2018000778A1 (es) |
| CO (1) | CO2018003973A2 (es) |
| EA (1) | EA201890790A1 (es) |
| EC (1) | ECSP18030970A (es) |
| HK (1) | HK1251158A1 (es) |
| IL (1) | IL258273A (es) |
| MX (1) | MX2018003689A (es) |
| TW (1) | TWI702232B (es) |
| WO (1) | WO2017058859A1 (es) |
Families Citing this family (50)
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| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| SG11201704283PA (en) | 2014-11-26 | 2017-06-29 | Xencor Inc | Heterodimeric antibodies that bind cd3 and tumor antigens |
| MX383464B (es) | 2015-07-13 | 2025-03-14 | Cytomx Therapeutics Inc | Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos. |
| CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
| EA201890790A1 (ru) * | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | Связывающие pd-1 белки и способы их применения |
| CN108697791B (zh) | 2015-11-03 | 2022-08-23 | 詹森生物科技公司 | 特异性结合pd-1的抗体及其用途 |
| KR102317574B1 (ko) | 2015-11-18 | 2021-10-26 | 머크 샤프 앤드 돔 코포레이션 | Pd1 및/또는 lag3 결합제 |
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| US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
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| CN108285493B (zh) * | 2018-02-02 | 2020-09-15 | 上海科医联创生物科技有限公司 | 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用 |
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| KR102740444B1 (ko) | 2015-04-17 | 2024-12-10 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물 |
| CN105061597B (zh) | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
| CA3006224A1 (en) | 2015-06-23 | 2016-12-29 | Memorial Sloan-Kettering Cancer Center | Novel pd-1 immune modulating agents |
| MX383464B (es) | 2015-07-13 | 2025-03-14 | Cytomx Therapeutics Inc | Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos. |
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| PT3456346T (pt) | 2015-07-30 | 2021-09-28 | Macrogenics Inc | Moléculas de ligação pd-1 e lag-3 e respetivos métodos de utilização |
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| WO2017024465A1 (en) | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
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| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
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| US11207393B2 (en) | 2015-10-16 | 2021-12-28 | President And Fellows Of Harvard College | Regulatory T cell PD-1 modulation for regulating T cell effector immune responses |
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| CN107137712A (zh) | 2017-05-09 | 2017-09-08 | 中山大学 | Pd‑1h激动剂或拮抗剂的应用 |
-
2016
- 2016-09-28 EA EA201890790A patent/EA201890790A1/ru unknown
- 2016-09-28 US US15/278,425 patent/US10428145B2/en active Active
- 2016-09-28 AR ARP160102967A patent/AR106184A1/es not_active Application Discontinuation
- 2016-09-28 JP JP2018536085A patent/JP6843868B2/ja active Active
- 2016-09-28 CN CN201680068507.8A patent/CN108289953B/zh active Active
- 2016-09-28 BR BR112018006237A patent/BR112018006237A2/pt not_active IP Right Cessation
- 2016-09-28 MX MX2018003689A patent/MX2018003689A/es unknown
- 2016-09-28 CA CA2997963A patent/CA2997963A1/en not_active Abandoned
- 2016-09-28 HK HK18110609.2A patent/HK1251158A1/zh unknown
- 2016-09-28 AU AU2016332725A patent/AU2016332725A1/en not_active Abandoned
- 2016-09-28 WO PCT/US2016/054089 patent/WO2017058859A1/en not_active Ceased
- 2016-09-28 KR KR1020187011467A patent/KR20180054824A/ko not_active Ceased
- 2016-09-28 EP EP16852445.2A patent/EP3355920A4/en active Pending
- 2016-09-29 TW TW105131416A patent/TWI702232B/zh not_active IP Right Cessation
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2018
- 2018-03-21 IL IL258273A patent/IL258273A/en unknown
- 2018-03-26 CL CL2018000778A patent/CL2018000778A1/es unknown
- 2018-04-13 CO CONC2018/0003973A patent/CO2018003973A2/es unknown
- 2018-04-20 EC ECIEPI201830970A patent/ECSP18030970A/es unknown
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2019
- 2019-09-17 US US16/573,322 patent/US20200255525A1/en not_active Abandoned
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2021
- 2021-02-24 JP JP2021027687A patent/JP2021087448A/ja not_active Withdrawn
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- 2022-08-01 US US17/878,667 patent/US20230272076A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN108289953B (zh) | 2022-03-11 |
| JP6843868B2 (ja) | 2021-03-17 |
| JP2018533973A (ja) | 2018-11-22 |
| IL258273A (en) | 2018-05-31 |
| MX2018003689A (es) | 2018-04-30 |
| HK1251158A1 (zh) | 2019-01-25 |
| EA201890790A1 (ru) | 2018-10-31 |
| TW201718653A (zh) | 2017-06-01 |
| WO2017058859A1 (en) | 2017-04-06 |
| EP3355920A1 (en) | 2018-08-08 |
| US20230272076A1 (en) | 2023-08-31 |
| US20170088618A1 (en) | 2017-03-30 |
| CO2018003973A2 (es) | 2018-07-19 |
| BR112018006237A2 (pt) | 2018-10-09 |
| US20200255525A1 (en) | 2020-08-13 |
| JP2021087448A (ja) | 2021-06-10 |
| KR20180054824A (ko) | 2018-05-24 |
| CA2997963A1 (en) | 2017-04-06 |
| CN108289953A (zh) | 2018-07-17 |
| AU2016332725A1 (en) | 2018-03-22 |
| US10428145B2 (en) | 2019-10-01 |
| ECSP18030970A (es) | 2018-05-31 |
| CL2018000778A1 (es) | 2019-03-22 |
| TWI702232B (zh) | 2020-08-21 |
| EP3355920A4 (en) | 2019-05-15 |
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