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JO3118B1 - تراكيب وطرق لبروتين c5 المتمم يستهدف الأجسام المضادة - Google Patents

تراكيب وطرق لبروتين c5 المتمم يستهدف الأجسام المضادة

Info

Publication number
JO3118B1
JO3118B1 JOP/2009/0292A JOP20090292A JO3118B1 JO 3118 B1 JO3118 B1 JO 3118B1 JO P20090292 A JOP20090292 A JO P20090292A JO 3118 B1 JO3118 B1 JO 3118B1
Authority
JO
Jordan
Prior art keywords
compositions
methods
complement protein
antibodies targeting
targeting complement
Prior art date
Application number
JOP/2009/0292A
Other languages
English (en)
Inventor
Eberth Adina
Splawski Igor
Charles Guild Braydon
Diefenbach-Streiber Beate
Roguska Michael
Kim Yong-In
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3118B1 publication Critical patent/JO3118B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

يتعلق الإختراع الحالي ببروتين C5 المتمم يستهدف الأجسام المضادة وتراكيب وطرق الإستعمال من ذلك.
JOP/2009/0292A 2008-08-05 2009-08-05 تراكيب وطرق لبروتين c5 المتمم يستهدف الأجسام المضادة JO3118B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8635508P 2008-08-05 2008-08-05

Publications (1)

Publication Number Publication Date
JO3118B1 true JO3118B1 (ar) 2017-09-20

Family

ID=41227252

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2009/0292A JO3118B1 (ar) 2008-08-05 2009-08-05 تراكيب وطرق لبروتين c5 المتمم يستهدف الأجسام المضادة

Country Status (38)

Country Link
US (5) US8241628B2 (ar)
EP (3) EP2815766B1 (ar)
JP (2) JP5815403B2 (ar)
KR (1) KR101463296B1 (ar)
CN (2) CN102170906B (ar)
AR (1) AR072897A1 (ar)
AU (1) AU2009279197B2 (ar)
BR (1) BRPI0916668B1 (ar)
CA (1) CA2732782C (ar)
CL (1) CL2011000233A1 (ar)
CO (1) CO6351750A2 (ar)
CR (2) CR20110035A (ar)
CU (1) CU23978B1 (ar)
DK (1) DK2328616T3 (ar)
EA (1) EA027575B1 (ar)
EC (1) ECSP11010805A (ar)
ES (2) ES2541142T3 (ar)
HK (1) HK1203156A1 (ar)
HN (1) HN2011000357A (ar)
HR (1) HRP20150799T1 (ar)
HU (1) HUE026179T2 (ar)
IL (1) IL210768B (ar)
JO (1) JO3118B1 (ar)
MA (1) MA32535B1 (ar)
MX (2) MX2011001371A (ar)
MY (1) MY159396A (ar)
NZ (2) NZ590634A (ar)
PE (1) PE20110225A1 (ar)
PL (1) PL2328616T3 (ar)
PT (1) PT2328616E (ar)
RS (1) RS54113B1 (ar)
SG (1) SG10201405377XA (ar)
SI (1) SI2328616T1 (ar)
SV (1) SV2011003834A (ar)
TW (2) TW201350130A (ar)
UA (1) UA105009C2 (ar)
WO (1) WO2010015608A1 (ar)
ZA (1) ZA201100375B (ar)

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