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PE20110834A1 - DERIVADOS DE PIRROL[3,4-d]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1) - Google Patents

DERIVADOS DE PIRROL[3,4-d]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1)

Info

Publication number
PE20110834A1
PE20110834A1 PE2011001168A PE2011001168A PE20110834A1 PE 20110834 A1 PE20110834 A1 PE 20110834A1 PE 2011001168 A PE2011001168 A PE 2011001168A PE 2011001168 A PE2011001168 A PE 2011001168A PE 20110834 A1 PE20110834 A1 PE 20110834A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrrol
pde1
phosphodiesterase
inhibitors
Prior art date
Application number
PE2011001168A
Other languages
English (en)
Inventor
Peng Li
Lawrence P Wennogle
Jun Zhao
Hailin Zeng
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42233531&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110834(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of PE20110834A1 publication Critical patent/PE20110834A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Birds (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE (5- O 7-AMINO)-3,4-DIHIDRO-(OPCIONALMENTE 4-OXO, 4-TIOXO O 4-IMINO)-1H-PIRROL[3,4-d]PIRIMIDIN-2(6H)-ONA DE FORMULA (II-A) O (II-B) DONDE Q ES -C(=S)-, -C(=O)-, ENTRE OTROS; R1 ES H O ALQUILO(C1-C6); R2 ES H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALO O HIDROXI, ARILALQUILO(C0-C6), ENTRE OTROS; R3 ES HETEROALQUILO, -D-E-F, ENTRE OTROS, EN DONDE D ES UN ENLACE SIMPLE, ALQUILENO(C1-C6) O ARILALQUILENO; E ES UN ENLACE SIMPLE, ALQUILENO(C1-C4), ALQUINILENO(C2-C6), ENTRE OTROS; F ES H, HALO, ALQUILO(C1-C6), ENTRE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ENTRE OTROS; R6 ES H, ALQUILO(C1-C6), ALCOXI(C1-C6), ARILOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-(4-(6-FLUOROPIRIDIN-2-IL)BENCIL)-1-ISOBUTIL-3-METIL-7-(FENILAMINO)-1H-PIRROL[3,4-d]PIRIMIDINA-2,4(3H,6H)-DIONA; 6-(4-(6-FLUOROPIRIDIN-2-IL)BENCIL)-3-METIL-1-NEOPENTIL-7-(FENILAMINO)-1H-PIRROL[3,4-d]PIRIMIDINA-2,4(3H,6H)-DIONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFODIESTERASA 1 (PDE1) SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, DEPRESION, NARCOLEPSIA, ESQUIZOFRENIA
PE2011001168A 2008-12-06 2009-12-07 DERIVADOS DE PIRROL[3,4-d]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1) PE20110834A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12044308P 2008-12-06 2008-12-06
US23588809P 2009-08-21 2009-08-21

Publications (1)

Publication Number Publication Date
PE20110834A1 true PE20110834A1 (es) 2011-12-14

Family

ID=42233531

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001168A PE20110834A1 (es) 2008-12-06 2009-12-07 DERIVADOS DE PIRROL[3,4-d]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1)

Country Status (21)

Country Link
US (2) US8927556B2 (es)
EP (1) EP2367428B1 (es)
JP (1) JP5710492B2 (es)
KR (1) KR20110098730A (es)
CN (1) CN102238873A (es)
AU (1) AU2009322899A1 (es)
BR (1) BRPI0922809A2 (es)
CA (1) CA2740385A1 (es)
CO (1) CO6390080A2 (es)
CR (1) CR20110311A (es)
DO (1) DOP2011000171A (es)
EA (1) EA201170768A1 (es)
EC (1) ECSP11011185A (es)
ES (1) ES2580759T3 (es)
IL (1) IL213316A0 (es)
MA (1) MA32939B1 (es)
MX (1) MX2011005935A (es)
PE (1) PE20110834A1 (es)
TN (1) TN2011000244A1 (es)
WO (1) WO2010065147A1 (es)
ZA (1) ZA201103630B (es)

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EP1888534B1 (en) 2005-06-06 2017-07-26 Intra-Cellular Therapies, Inc. Organic compounds
CA2651519A1 (en) 2006-06-06 2007-12-13 Intra-Cellular Therapies, Inc. Organic compounds
EP2081431B1 (en) * 2006-11-13 2013-01-16 Intra-Cellular Therapies, Inc. Organic compounds
JP5837278B2 (ja) 2006-12-05 2015-12-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
JP5701608B2 (ja) * 2007-12-06 2015-04-15 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2009075784A1 (en) 2007-12-06 2009-06-18 Intra-Cellular Therapies, Inc. Organic compounds
GEP20146046B (en) 2008-12-06 2014-02-25 Intracellular Therapies Inc Organic compounds
US8536159B2 (en) 2008-12-06 2013-09-17 Intra-Cellular Therapies, Inc. Organic compounds
EP2358723B1 (en) 2008-12-06 2015-05-13 Intra-Cellular Therapies, Inc. 4,5,7,8-tetrahydro-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors
AU2009322900A1 (en) * 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
BRPI0922700A2 (pt) 2008-12-06 2015-08-11 Intracellular Therapies Inc Compostos orgânicos
JP2012518685A (ja) * 2009-02-25 2012-08-16 イントラ−セルラー・セラピーズ・インコーポレイテッド 眼障害のためのｐｄｅ１阻害剤
WO2010132127A1 (en) 2009-05-13 2010-11-18 Intra-Cellular Therapies, Inc. Organic compounds
US8858911B2 (en) 2009-10-08 2014-10-14 Intra-Cellular Therapies, Inc. Phosphodiesterase 1-targeting tracers and methods
EP2576551A4 (en) 2010-05-31 2014-04-16 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
EP2590657A4 (en) 2010-05-31 2014-02-12 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
EP2575817A4 (en) 2010-05-31 2014-01-08 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
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