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EA200802203A1 - Дикетопиперазиновые и пиперидиновые производные в качестве противовирусных агентов - Google Patents

Дикетопиперазиновые и пиперидиновые производные в качестве противовирусных агентов

Info

Publication number
EA200802203A1
EA200802203A1 EA200802203A EA200802203A EA200802203A1 EA 200802203 A1 EA200802203 A1 EA 200802203A1 EA 200802203 A EA200802203 A EA 200802203A EA 200802203 A EA200802203 A EA 200802203A EA 200802203 A1 EA200802203 A1 EA 200802203A1
Authority
EA
Eurasian Patent Office
Prior art keywords
piperidine derivatives
diquetopyperson
antiviral agents
relates
present
Prior art date
Application number
EA200802203A
Other languages
English (en)
Other versions
EA014957B1 (ru
Inventor
Тао Ванг
Джон Ф. Кэдоу
Жонгксинг Жанг
Живей Йин
Николас А. Минвелл
Алисия Регуэйро-Рен
Джейкоб Свидорски
Йинг Хан
Дэвид Дж. Карини
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA200802203A1 publication Critical patent/EA200802203A1/ru
Publication of EA014957B1 publication Critical patent/EA014957B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение обеспечивает соединения, обладающие фармакологическими и биологически активными свойствами, их фармацевтические композиции и способ их применения. В частности, изобретение относится к дикетопиперазиновым и пиперидиновым производным, которые обладают уникальной противовирусной активностью. В особенности, настоящее изобретение касается соединений, применимых для лечения ВИЧ-инфекции и СПИДа.
EA200802203A 2006-04-25 2007-04-16 Дикетопиперазиновые и пиперидиновые производные в качестве противовирусных агентов EA014957B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79470006P 2006-04-25 2006-04-25
US79470306P 2006-04-25 2006-04-25
US11/733,283 US7807671B2 (en) 2006-04-25 2007-04-10 Diketo-piperazine and piperidine derivatives as antiviral agents
PCT/US2007/066700 WO2007127635A2 (en) 2006-04-25 2007-04-16 Diketo-piperazine and piperidine derivatives as antiviral agents

Publications (2)

Publication Number Publication Date
EA200802203A1 true EA200802203A1 (ru) 2009-04-28
EA014957B1 EA014957B1 (ru) 2011-04-29

Family

ID=38335673

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802203A EA014957B1 (ru) 2006-04-25 2007-04-16 Дикетопиперазиновые и пиперидиновые производные в качестве противовирусных агентов

Country Status (17)

Country Link
US (2) US7807671B2 (ru)
EP (1) EP2010525B1 (ru)
JP (1) JP5214590B2 (ru)
KR (1) KR101450349B1 (ru)
AR (1) AR060658A1 (ru)
AU (1) AU2007242989B2 (ru)
BR (1) BRPI0710919A2 (ru)
CA (1) CA2650382C (ru)
EA (1) EA014957B1 (ru)
ES (1) ES2432758T3 (ru)
IL (1) IL194540A (ru)
MX (1) MX2008013265A (ru)
NO (1) NO341412B1 (ru)
NZ (1) NZ571995A (ru)
PE (1) PE20080318A1 (ru)
TW (1) TWI394754B (ru)
WO (1) WO2007127635A2 (ru)

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CA2650382A1 (en) 2007-11-08
EP2010525A2 (en) 2009-01-07
JP5214590B2 (ja) 2013-06-19
TWI394754B (zh) 2013-05-01
US20080139572A1 (en) 2008-06-12
ES2432758T3 (es) 2013-12-05
MX2008013265A (es) 2008-10-27
CA2650382C (en) 2014-05-27
AR060658A1 (es) 2008-07-02
IL194540A0 (en) 2009-08-03
AU2007242989A1 (en) 2007-11-08
US7807671B2 (en) 2010-10-05
JP2009535352A (ja) 2009-10-01
BRPI0710919A2 (pt) 2012-06-26
WO2007127635A3 (en) 2008-03-13
NZ571995A (en) 2011-11-25
TW200811174A (en) 2008-03-01
US20070249579A1 (en) 2007-10-25
AU2007242989B2 (en) 2012-06-28
PE20080318A1 (es) 2008-04-10
EP2010525B1 (en) 2013-08-28
US7807676B2 (en) 2010-10-05
NO341412B1 (no) 2017-10-30
KR101450349B1 (ko) 2014-10-14
KR20090005393A (ko) 2009-01-13
NO20084257L (no) 2008-11-19
IL194540A (en) 2015-03-31
EA014957B1 (ru) 2011-04-29

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