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MX2015008971A - Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor. - Google Patents

Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor.

Info

Publication number
MX2015008971A
MX2015008971A MX2015008971A MX2015008971A MX2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A
Authority
MX
Mexico
Prior art keywords
pyrido
pyrrolo
pyrimidine derivatives
treating pain
autotaxin inhibitors
Prior art date
Application number
MX2015008971A
Other languages
English (en)
Inventor
Bryan Hurst Norman
Lance Allen Pfeifer
Yen Dao
Spencer Brian Jones
Thomas James Beauchamp
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2015008971A publication Critical patent/MX2015008971A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

La presente invención proporciona compuestos de la Fórmula I: donde X es un enlace o CH2; R se selecciona del grupo que consiste enR1 y R2 se selecciona cada uno independientemente del grupo que consiste en CH y N; R3 es H o CH3; R4 es H o CH3; L se selecciona del grupo que consiste en -O(CH2)3-, -C(O)NH(CH2)2-, -CH2C(O)NH(NH(CH2)2-, -(CH2)3N(C(O)CH3)CH2-, -(CH2)2N(C(O)CH3)CH2- , (CH2)2OCH2-, -(CH2)4-, -(CH2)2NHCH2-, -(CH2)3O -, and -CH2O(CH2)2-; una sal farmacéuticamente aceptable de este. Los compuestos de invención son inhibidores de autotaxina. (ver Formulas).
MX2015008971A 2013-01-11 2014-01-07 Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor. MX2015008971A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361751363P 2013-01-11 2013-01-11
US201361777201P 2013-03-12 2013-03-12
PCT/US2014/010400 WO2014110000A1 (en) 2013-01-11 2014-01-07 Pyrido- or pyrrolo-fused pyrimidine derivatives as autotaxin inhibitors for treating pain

Publications (1)

Publication Number Publication Date
MX2015008971A true MX2015008971A (es) 2015-09-28

Family

ID=50031555

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008971A MX2015008971A (es) 2013-01-11 2014-01-07 Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor.

Country Status (13)

Country Link
US (1) US8969555B2 (es)
EP (1) EP2943494B1 (es)
JP (1) JP6285461B2 (es)
KR (1) KR101757997B1 (es)
CN (1) CN104903327B (es)
AU (1) AU2014205642B2 (es)
BR (1) BR112015015812A2 (es)
CA (1) CA2893253C (es)
EA (1) EA025106B1 (es)
ES (1) ES2636248T3 (es)
MX (1) MX2015008971A (es)
TW (1) TWI499591B (es)
WO (1) WO2014110000A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物
MX375706B (es) 2013-11-22 2025-03-06 Sabre Therapeutics Llc Compuestos de inhibidor de autotaxina.
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
MX2017015225A (es) 2015-05-27 2018-02-19 Pharmakea Inc Inhibidores de la autotaxina y sus usos.
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
CN110526929A (zh) * 2018-05-24 2019-12-03 广州市恒诺康医药科技有限公司 芳杂环化合物、其药物组合物及其应用
AU2019308231B2 (en) * 2018-07-16 2022-12-22 The Scripps Research Institute Opioid haptens, conjugates, vaccines, and methods of generating antibodies
IL284994B2 (en) * 2019-02-01 2024-10-01 Wuhan Humanwell Innovative Drug Res And Development Center Limited Company Pyrrolopyrimidine derivative and use thereof
AU2020342202B2 (en) 2019-09-06 2023-07-06 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Pyrimidine compound and preparation method therefor
AU2020349516A1 (en) * 2019-09-17 2022-03-17 Bial-R&D Investments, S.A. Substituted imidazole carboxamides and their use in the treatment of medical disorders
WO2021088957A1 (zh) * 2019-11-07 2021-05-14 广州市恒诺康医药科技有限公司 芳杂环化合物、其药物组合物及其应用
KR20220113731A (ko) * 2019-12-11 2022-08-16 스촨 하이스코 파마수티컬 씨오., 엘티디 질소-함유 헤테로사이클릭 오토택신 억제제, 및 이를 함유하는 조성물 및 이의 용도
CN113943295B (zh) * 2020-07-16 2025-08-12 武汉人福创新药物研发中心有限公司 吡咯并嘧啶类化合物及其用途
CN113943296B (zh) * 2020-07-16 2025-07-04 武汉人福创新药物研发中心有限公司 吡咯并嘧啶衍生物及其应用
TW202214644A (zh) * 2020-07-28 2022-04-16 大陸商武漢人福創新藥物研發中心有限公司 含氮雜環化合物的固體形式及其藥物組合物和用途
TWI894325B (zh) * 2020-07-28 2025-08-21 大陸商武漢人福創新藥物研發中心有限公司 含氮雜環化合物的鹽及其鹽的固體形式、藥物組合物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1071301A (en) 1999-11-01 2001-05-14 Eli Lilly And Company Pharmaceutical compounds
US7524852B2 (en) 2002-06-07 2009-04-28 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
DE102004020908A1 (de) 2004-04-28 2005-11-17 Grünenthal GmbH Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
ES2552804T3 (es) * 2005-05-04 2015-12-02 Evotec Ag Compuestos heterocíclicos condensados, y sus composiciones y usos
ES2407852T3 (es) * 2008-12-01 2013-06-14 Merck Patent Gmbh Pirido[4,3-d]pirimidinas 2,5-diamino sustituidas como inhibidores de autotaxina frente al cáncer
WO2012009258A2 (en) * 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
US9000025B2 (en) * 2010-08-20 2015-04-07 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
WO2012085167A1 (en) * 2010-12-22 2012-06-28 Merz Pharma Gmbh & Co. Kgaa Metabotropic glutamate receptor modulators
WO2013054185A1 (en) * 2011-10-13 2013-04-18 Pfizer, Inc. Pyrimidine and pyridine derivatives useful in therapy
JP6158817B2 (ja) * 2011-10-28 2017-07-05 インヒビタクシン リミテッド 治療に有用なピリダジン誘導体
TW201520219A (zh) * 2013-03-12 2015-06-01 Lilly Co Eli 咪唑並吡啶化合物
TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物

Also Published As

Publication number Publication date
TW201437209A (zh) 2014-10-01
JP6285461B2 (ja) 2018-02-28
KR20150092761A (ko) 2015-08-13
EP2943494A1 (en) 2015-11-18
EA025106B1 (ru) 2016-11-30
BR112015015812A2 (pt) 2017-07-11
EA201591098A1 (ru) 2015-11-30
AU2014205642A1 (en) 2015-07-02
TWI499591B (zh) 2015-09-11
KR101757997B1 (ko) 2017-07-13
CN104903327B (zh) 2016-09-07
CN104903327A (zh) 2015-09-09
US20140200231A1 (en) 2014-07-17
CA2893253C (en) 2017-11-28
JP2016505010A (ja) 2016-02-18
US8969555B2 (en) 2015-03-03
ES2636248T3 (es) 2017-10-05
CA2893253A1 (en) 2014-07-17
EP2943494B1 (en) 2017-02-22
WO2014110000A1 (en) 2014-07-17
AU2014205642B2 (en) 2016-02-25

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