PE20091572A1 - Derivados de amida espirociclica de formula i, sales farmaceuticamente aceptables, composiciones farmaceuticas conteniendolas y procesos de preparacion - Google Patents
Derivados de amida espirociclica de formula i, sales farmaceuticamente aceptables, composiciones farmaceuticas conteniendolas y procesos de preparacionInfo
- Publication number
- PE20091572A1 PE20091572A1 PE2009000179A PE2009000179A PE20091572A1 PE 20091572 A1 PE20091572 A1 PE 20091572A1 PE 2009000179 A PE2009000179 A PE 2009000179A PE 2009000179 A PE2009000179 A PE 2009000179A PE 20091572 A1 PE20091572 A1 PE 20091572A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- hydroxy
- formula
- thiazol
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 abstract 2
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical compound C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 abstract 1
- PVXFCOPBOYHONF-UHFFFAOYSA-N 3-ethyl-1,3-benzothiazol-2-one Chemical compound C1=CC=C2SC(=O)N(CC)C2=C1 PVXFCOPBOYHONF-UHFFFAOYSA-N 0.000 abstract 1
- 241000670727 Amida Species 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- -1 THIAZOL-4-CARBONYL Chemical class 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940117803 phenethylamine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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Abstract
REFERIDA A UN DERIVADO DE AMIDA ESPIROCICLICA DE FORMULA (I), DONDE Ar ES UN GRUPO (a), (b), (c), ENTRE OTROS; L ES UNA CADENA HIDROCARBILO DE ENLACE DE HASTA 15 ATOMOS DE CARBONO OPCIONALMENTE SUSTITUIDA CON ALQUILO C1-C6, HALOGENO, ENTRE OTROS; L1 Y L2 SON H, ALQUILO C1-C6 O CICLOALQUILO C3-C6; L3 Y L4 SON ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R1 ES FENILO, UN ANILLO HETEROALIFATICO DE 4 A 8 MIEMBROS, ENTRE OTROS; X ES O, S, S(O) O CR25R26; m ES 0 O UN ENTERO DE 1 A 3; n ES UN ENTERO DE 1 A 4; W ES CR27R28CR29R30 O CR31R32CR33R34CR35R36; V Y Z SON UN ENLACE, CR37R38, CR39R40CR41R42, ENTRE OTROS; Y ES CO, CONR43, SO2 O SO2NR44; R25 A R42 SON H, F, ALQUILO C1-C6, CICLOALQUILO C3-C6; R43 Y R44 SON H, ALQUILO C1-C6 O CICLOALQUILO C3-C6; A3 ES CH2OH, NHCHO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: DITRIFLUOROACETATO DE (R)-4-HIDROXI-7-(1-HIDROXI-2-(2-(5-((4-(5-ISOPROPILTIOFENA-3-CARBONIL)-1-OXA-4,9-DIAZASPIRO[5,5]UNDECAN-9-IL)METIL)TIOFEN-3-IL)ETILAMINO)ETILBENZO[d]TIAZOL-2(3H)-ONA, DITRIFLUOROACETATO DE (R)-4-HIDROXI-7-(1-HIDROXI-2-(3-((4-(2-(PENTAN-3-IL)TIAZOL-4-CARBONIL)-1-OXA-4,9-DIAZASPIRO[5,5]UNDECAN-9-IL)METIL)FENETILAMINO)ETIL)BENZO[d]TIAZOL-2(3H)-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LOS RECEPTORES MUSCARINICOS Y ADRENORECEPTORES BETA 2 Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS PULMONARES
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Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| PT2242759E (pt) | 2008-02-06 | 2012-12-17 | Astrazeneca Ab | Compostos |
| WO2009138707A1 (en) | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic m3 receptor antagonists |
| WO2010067102A1 (en) * | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| JP5379224B2 (ja) | 2009-04-30 | 2013-12-25 | 帝人ファーマ株式会社 | 四級アンモニウム塩化合物 |
| GB0913342D0 (en) * | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
| GB0913345D0 (en) * | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| US8680098B2 (en) | 2010-03-05 | 2014-03-25 | Janssen Pharmaceutica, Nv | Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| GB201107985D0 (en) * | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| EP2592077A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| CA2865525C (en) | 2012-03-02 | 2019-05-21 | Genentech, Inc. | Amido spirocyclic amide and sulfonamide derivatives |
| JP6041643B2 (ja) * | 2012-11-30 | 2016-12-14 | 関東電化工業株式会社 | ３，３，３−トリフルオロプロピオニル化合物の製造方法 |
| MA38260B1 (fr) | 2012-12-18 | 2018-04-30 | Almirall Sa | Nouveaux dérivés de cyclohexyl et quinuclidinyl carbamate ayant une activité d'agoniste adrénergique beta2 et une activité d'antagoniste muscarinique m3 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TWI685497B (zh) | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| TW201615643A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物 |
| TW201615642A (zh) * | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| MX2018004777A (es) | 2015-10-23 | 2018-06-19 | Esteve Labor Dr | Compuestos oxa-diazaspiro que tienen actividad contra el dolor. |
| SG11201803153RA (en) | 2015-11-16 | 2018-06-28 | Esteve Labor Dr | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
| CN109195975B (zh) * | 2016-09-30 | 2022-01-04 | 四川海思科制药有限公司 | 一种二氮杂螺[5.5]十一碳烷衍生物及其用途 |
| EP3556435B1 (en) | 2016-12-14 | 2020-10-28 | Beijing Showby Pharmaceutical Co., Ltd. | Class of bifunctional compounds with quaternary ammonium salt structure |
| CN108264456A (zh) * | 2016-12-30 | 2018-07-10 | 湖北尚赛光电材料有限公司 | 2,8-二溴屈的合成方法及其合成中间体 |
| BR112020007359A2 (pt) | 2017-10-17 | 2020-09-29 | Esteve Pharmaceuticals, S.A. | sais de (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oxa-4,9-diazaespiro[5.5]undecan-3-ona |
| CN111349003B (zh) * | 2018-12-20 | 2023-10-03 | 四川科瑞德制药股份有限公司 | 一种丙戊酸钠的制备方法 |
| EP4129402A4 (en) | 2020-03-31 | 2024-06-12 | Mitsubishi Tanabe Pharma Corporation | HYDROXYPYRROLIDINE DERIVATIVE AND MEDICAL USE THEREOF |
| EP4373805B1 (en) * | 2022-05-04 | 2025-04-09 | Symrise AG | Precursors for the controlled release of alpha, beta-unsaturated aldehydes or ketones and other high impact fragrance substances |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2707186A (en) | 1954-05-06 | 1955-04-26 | Hoffmann La Roche | Imidazolone derivatives |
| GB9604578D0 (en) | 1996-03-04 | 1996-05-01 | Sericol Ltd | Photocurable compositions |
| SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AU6539400A (en) | 1999-08-13 | 2001-03-13 | Gore Enterprise Holdings, Inc. | Fibrous polymeric material and its composites |
| TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
| IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| KR20030022264A (ko) | 2000-07-07 | 2003-03-15 | 앤지오젠 파마슈티칼스 리미티드 | 신생 혈관 형성 억제제인 콜치놀 유도체 |
| WO2002004434A1 (en) | 2000-07-07 | 2002-01-17 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| JP4767842B2 (ja) * | 2003-04-01 | 2011-09-07 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物 |
| ES2329133T3 (es) * | 2003-05-28 | 2009-11-23 | Theravance, Inc. | Compuestos azabicicloalcanicos como antagonistas de receptores de muscarinicos. |
| EP1751131B1 (en) | 2004-03-10 | 2008-11-19 | Janssen Pharmaceutica N.V. | Mtp inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles |
| CN1934104A (zh) * | 2004-03-23 | 2007-03-21 | 辉瑞大药厂 | 用于治疗疾病的化合物 |
| WO2006023460A2 (en) * | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| EP1852434B1 (en) | 2005-02-21 | 2011-07-13 | Shionogi Co., Ltd. | Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity |
| TW200738659A (en) | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200734342A (en) | 2005-12-15 | 2007-09-16 | Astrazeneca Ab | New compounds for the treatment of cardiac arrhythmias |
| US7858635B2 (en) * | 2005-12-22 | 2010-12-28 | Vertex Pharmaceuticals Incorporated | Spiro compounds as modulators of muscarinic receptors |
| TW200745084A (en) | 2006-03-08 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| GB0613154D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| JP2010513439A (ja) | 2006-12-20 | 2010-04-30 | アストラゼネカ・アクチエボラーグ | アミン誘導体およびｂ２アドレナリン受容体活性の調節におけるその使用 |
| GB0702413D0 (en) | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New chemical compounds |
| WO2008096129A1 (en) | 2007-02-07 | 2008-08-14 | Argenta Discovery Ltd | Nitrogen containing hetrocyclic compounds useful as bifunctional modulators of m3 receptors and beta- 2 receptors |
| PT2242759E (pt) | 2008-02-06 | 2012-12-17 | Astrazeneca Ab | Compostos |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
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