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AR064476A1 - Derivados de 1h-pirrolo[2, 3-b]piridina sustituidos, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por a-raf, b-raf y/o por c-raf-1. - Google Patents

Derivados de 1h-pirrolo[2, 3-b]piridina sustituidos, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por a-raf, b-raf y/o por c-raf-1.

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Publication number
AR064476A1
AR064476A1 ARP070105759A ARP070105759A AR064476A1 AR 064476 A1 AR064476 A1 AR 064476A1 AR P070105759 A ARP070105759 A AR P070105759A AR P070105759 A ARP070105759 A AR P070105759A AR 064476 A1 AR064476 A1 AR 064476A1
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AR
Argentina
Prior art keywords
lower alkyl
nr8c
fluorine
nr8r7
group
Prior art date
Application number
ARP070105759A
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English (en)
Inventor
Hanna Cho
Prabha N Ibrahim
Shenghua Shi
Shumeye Mamo
Samuel J Gillette
Hongyao Zhu
Wayne Spevak
Original Assignee
Plexxikon Inc
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Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of AR064476A1 publication Critical patent/AR064476A1/es

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Abstract

Se describen compuestos activos en proteína quinasa, así como el uso de dichos compuestos para tratar enfermedades y condiciones asociadas con actividad aberrante de proteínas quinasas. Reivindicacion 1: Un compuesto que tiene la estructura química de formula 1, todas las sales, pro-drogas, tautomeros e isomeros de la misma, en donde: R1 se selecciona del grupo que consiste de hidrogeno, halogeno, alquilo inferior, alquenilo inferior, alquinilo inferior, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, -OH, -NH2, -CN, -NO2, -C(O)OH, -S(O)2NH2, -C(O)NH2, -C(S)NH2, -NHC(O)NH2, -NHC(S)NH2, -NHS(O)2NH2, -OR7, -SR7, -NR8R7, -C(O)R7, -C(S)R7, -C(O)OR7, -C(O)NR8R7, -C(S)NR8R7, -S(O)2NR8R7, -NR8C(O)R7, -NR8C(S)R7, - NR8S(O)2R7, -NR8C(O)NH2, -NR8C(O)NR8R7, -NR8C(S)NH2, -NR8C(S)NR8R7, -NR8S(O)2NH2, -NR8S(O)2NR8R7, -S(O)R7, y -S(O)2R7, en donde el alquilo inferior, alquenilo inferior o alquinilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados de fluor, -OH, -NH2, C(O)OH, -C(O)NH2, -OR7, -NR8R7, -C(O)OR7, -C(O)NR8R7, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el cicloalquilo, heterocicloalquilo, arilo y heteroarilo como R1 o como sustituyentes de alquilo inferior, alquenilo inferior o alquinilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR9, -SR9, -NHR9, -NR8R9, -NR8C(O)R9, -NR8S(O)2R9, - S(O)2R9, -S(O)2NR8R9, -C(O)R9, -C(O)NR8R9, halogeno, alquilo inferior, alquilo inferior sustituido con fluor y cicloalquilamino; R2 se selecciona del grupo que consiste de halogeno, alquilo inferior, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, -OH, -NH2, -CN, -NO2, -C(O)OH, -S(O)2NH2, -C(O)NH2, -C(S)NH2, -NHC(O)NH2, -NHC(S)NH2, -NHS(O)2NH2, -OR7, -SR7, -NR8R7, -C(O)R7, -C(S)R7, -C(O)OR7, -C(O)NR8R7, -C(S)NR8R7, -S(O)2NR8R7, -NR8C(O)R7, -NR8C(S)R7, -NR8S(O)2R7, -NR8C(O)NH2, - NR8C(O)NR8R7, -NR8C(S)NH2, -NR8C(S)NR8R7, -NR8S(O)2NH2, -NR8S(O)2NR8R7, -S(O)R7, y -S(O)2R7, en donde el alquilo inferior es opcionalmente sustituido con uno o más sustituyentes seleccionados de fluor, -OR7, -NR8R7, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el cicloalquilo, heterocicloalquilo, arilo y heteroarilo como R2 o como sustituyentes de alquilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR9, -SR9, -NHR9, -NR8R9, -NR8C(O)R9, -NR8S(O)2R9, -S(O)2R9, -S(O)2NR8R9, -C(O)R9, -C(O)NR8R9, halogeno, alquilo inferior, alquilo inferior sustituido con fluor y cicloalquilamino; R3 se selecciona del grupo que consiste de hidrogeno, fluor y cloro; R7 se selecciona del grupo que consiste de alquilo inferior, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el alquilo inferior es opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de fluor, alcoxi inferior, alcoxi inferior sustituido con fluor, alquiltio inferior, alquiltio inferior sustituido con fluor, mono-alquilamino, di-alquilamino, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el cicloalquilo, heterocicloalquilo, arilo y heteroarilo como R7 o como sustituyentes de alquilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR9, -SR9, -NHR9, -NR8R9, -NR8C(O)R9, -NR8S(O)2R9, -S(O)2R9, -S(O)2NR8R9, -C(O)R9, -C(O)NR8R9, halogeno, alquilo inferior, alquilo inferior sustituido con fluor y cicloalquilamino; R8 en cada ocurrencia es independientemente hidrogeno o alquilo inferior y R9 en cada ocurrencia es independientemente seleccionado del grupo que consiste de alquilo inferior, heterocicloalquilo y heteroarilo, en donde el alquilo inferior es opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de fluor, alcoxi inferior, alcoxi inferior sustituido con fluor, alquiltio inferior, alquiltio inferior sustituido con fluor, monoalquilamino, di-alquilamino y cicloalquilamino y en donde el heterocicloalquilo y heteroarilo son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de halogeno, -CN, alquilo inferior, alquilo inferior sustituido con fluor, alcoxi inferior y alcoxi inferior sustituido con fluor, siempre que, sin embargo, el compuesto no sea ninguno de los del grupo de formulas (2).
ARP070105759A 2006-12-21 2007-12-20 Derivados de 1h-pirrolo[2, 3-b]piridina sustituidos, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por a-raf, b-raf y/o por c-raf-1. AR064476A1 (es)

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CO6190519A2 (es) 2010-08-19
US20110092538A1 (en) 2011-04-21
MA31153B1 (fr) 2010-02-01
RU2009122436A (ru) 2011-01-27
WO2008079906A1 (en) 2008-07-03
US7863289B2 (en) 2011-01-04
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US20080167338A1 (en) 2008-07-10
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EP2097414A1 (en) 2009-09-09
AU2007336906A1 (en) 2008-07-03
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