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MX2012013081A - Compuestos utiles como inhibidores de cinasa atr. - Google Patents

Compuestos utiles como inhibidores de cinasa atr.

Info

Publication number
MX2012013081A
MX2012013081A MX2012013081A MX2012013081A MX2012013081A MX 2012013081 A MX2012013081 A MX 2012013081A MX 2012013081 A MX2012013081 A MX 2012013081A MX 2012013081 A MX2012013081 A MX 2012013081A MX 2012013081 A MX2012013081 A MX 2012013081A
Authority
MX
Mexico
Prior art keywords
compounds
inhibitors
compounds useful
kinases
study
Prior art date
Application number
MX2012013081A
Other languages
English (en)
Inventor
Jean-Damien Charrier
David Kay
Pramod Joshi
Stephen Clinton Young
Michael O'donnell
Joanne Pinder
Anisa Nizarali Virani
Philip Michael Reaper
Hayley Marie Binch
Thomas Cleveland
Steven John Durrant
Ronald Marcellus Alphonsus Knegtel
Lev Tyler Dewey Fanning
Dennis James Hurley
Pierre-Henri Storck
Matthew Paul Grote
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2012013081A publication Critical patent/MX2012013081A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a compuestos de pirazina y piridina útiles como inhibidores de la proteína cinasa ATR. La invención también se refiere a composiciones farmacéuticamente aceptables que comprenden los compuestos de esta invención; métodos para tratar diversas enfermedades, trastornos y afecciones usando los compuestos de esta invención; procesos para preparar los compuestos de esta invención; intermedios para la preparación de los compuestos de esta invención; y métodos para usar los compuestos en aplicaciones in vitro, tales como el estudio de cinasas en fenómenos biológicos y patológicos; el estudio de vías de transducción de señales intracelulares mediadas por tales cinasas y la evaluación comparativa de nuevos inhibidores de cinasas. Los compuestos de la presente invención tienen la fórmula I donde las variables son tal como se describen en la presente.
MX2012013081A 2010-05-12 2011-05-12 Compuestos utiles como inhibidores de cinasa atr. MX2012013081A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33386710P 2010-05-12 2010-05-12
US201161470585P 2011-04-01 2011-04-01
PCT/US2011/036246 WO2011143426A1 (en) 2010-05-12 2011-05-12 Compounds useful as inhibitors of atr kinase

Publications (1)

Publication Number Publication Date
MX2012013081A true MX2012013081A (es) 2013-05-09

Family

ID=44227860

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013081A MX2012013081A (es) 2010-05-12 2011-05-12 Compuestos utiles como inhibidores de cinasa atr.

Country Status (14)

Country Link
US (1) US9630956B2 (es)
EP (1) EP2569313A1 (es)
JP (1) JP5836367B2 (es)
KR (1) KR20130066633A (es)
CN (1) CN103228651A (es)
AU (1) AU2011253025A1 (es)
CA (1) CA2798763A1 (es)
IL (1) IL222968A0 (es)
MX (1) MX2012013081A (es)
NZ (1) NZ603477A (es)
RU (1) RU2012153675A (es)
SG (1) SG185524A1 (es)
WO (1) WO2011143426A1 (es)
ZA (1) ZA201208373B (es)

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