[go: up one dir, main page]

PE20080175A1 - Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolincarboxilico - Google Patents

Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolincarboxilico

Info

Publication number
PE20080175A1
PE20080175A1 PE2007000348A PE2007000348A PE20080175A1 PE 20080175 A1 PE20080175 A1 PE 20080175A1 PE 2007000348 A PE2007000348 A PE 2007000348A PE 2007000348 A PE2007000348 A PE 2007000348A PE 20080175 A1 PE20080175 A1 PE 20080175A1
Authority
PE
Peru
Prior art keywords
malate
quinolincarboxyl
metoxy
piperidinyl
cyclopropyl
Prior art date
Application number
PE2007000348A
Other languages
English (en)
Inventor
Nancy Lee Redman-Furey
Jane Ellen Godlewski
Michael Lloyd Dieks
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38441484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080175(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20080175A1 publication Critical patent/PE20080175A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A SALES POLIMORFICAS DE MALATO DE (3S,5S)-7-[3-AMINO-5-METIL-PIPERIDINIL]-1-CICLOPROPIL-1,4-DIHIDRO-8-METOXI-4-OXO-3-QUINOLINCARBOXILICO QUE COMPRENDE DE 0% A 5% DE AGUA EN PESO, Y PRESENTA PICOS CARACTERISTICOS DE DIFRACCION DE RAYOS X A APROXIMADAMENTE 9,3; 12,1 Y 22,6 GRADOS 2 THETA, SIENDO SELECCIONADAS LAS SALES POLIMORFAS: D,L-MALATO SEMIHIDRATADO, D-MALATO HIDARATADO, L-MALATO HIDRATADO, D-MALATO ANHIDRO Y L-MALATO ANHIDRO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LO COMPRENDE PARA TRATAR O PREVENIR UN TRASTORNO INFECCIOSO
PE2007000348A 2006-03-28 2007-03-28 Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolincarboxilico PE20080175A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78648306P 2006-03-28 2006-03-28

Publications (1)

Publication Number Publication Date
PE20080175A1 true PE20080175A1 (es) 2008-03-14

Family

ID=38441484

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000348A PE20080175A1 (es) 2006-03-28 2007-03-28 Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolincarboxilico

Country Status (27)

Country Link
US (1) US8039485B2 (es)
EP (1) EP2001862B1 (es)
JP (1) JP5097967B2 (es)
KR (1) KR101102288B1 (es)
AR (2) AR060189A1 (es)
AT (1) ATE507219T1 (es)
AU (1) AU2007230630B2 (es)
BR (1) BRPI0709772B8 (es)
CA (1) CA2647346C (es)
CY (1) CY1111683T1 (es)
DE (1) DE602007014191D1 (es)
DK (1) DK2001862T3 (es)
ES (1) ES2366150T3 (es)
HR (1) HRP20110558T1 (es)
IL (1) IL193990A (es)
MA (1) MA30554B1 (es)
MX (1) MX2008012328A (es)
MY (1) MY148393A (es)
NZ (1) NZ570494A (es)
PE (1) PE20080175A1 (es)
PL (1) PL2001862T3 (es)
PT (1) PT2001862E (es)
SI (1) SI2001862T1 (es)
SM (1) SMP200800058B (es)
TW (1) TWI364419B (es)
WO (1) WO2007110834A2 (es)
ZA (1) ZA200807158B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101084521B1 (ko) * 2006-03-28 2011-11-18 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
US8658183B2 (en) * 2007-08-09 2014-02-25 Taigen Biotechnology Company, Ltd. Antimicrobial parenteral formulation
KR20110044168A (ko) * 2008-07-01 2011-04-28 타이젠 바이오테크놀러지 컴퍼니 리미티드 항생제 내성 세균 감염의 치료
CN101618039B (zh) * 2008-07-02 2012-04-11 太景生物科技股份有限公司 肺炎的治疗药物
US8553466B2 (en) 2010-03-04 2013-10-08 Samsung Electronics Co., Ltd. Non-volatile memory device, erasing method thereof, and memory system including the same
CZ304984B6 (cs) 2012-10-12 2015-03-11 Zentiva, K.S. Zlepšený způsob výroby a nové intermediáty syntézy elvitegraviru
CZ304983B6 (cs) * 2012-10-12 2015-03-11 Zentiva, K.S. Způsob výroby a nové intermediáty syntézy elvitegraviru
CN103145615B (zh) * 2013-03-20 2015-07-29 浙江医药股份有限公司 一种奈诺沙星螯合物的后处理方法
CN114437026A (zh) * 2021-10-26 2022-05-06 浙江医药股份有限公司新昌制药厂 一种低组合物杂质的苹果酸奈诺沙星原料药及其制备方法
CN116332831B (zh) * 2023-03-15 2025-10-28 浙江医药股份有限公司新昌制药厂 氨基被Boc保护的3-氨基-5-甲基哌啶的提纯方法

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017622A (en) 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
JPS5186476A (en) 1975-01-17 1976-07-29 Yoshitomi Pharmaceutical Shinkina kinoronkarubonsanjudotaino seiho
JPS5845426B2 (ja) 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS604820B2 (ja) 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS5649382A (en) 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
US5281612A (en) 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
IE55898B1 (en) 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4665079A (en) 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
DE3248506A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4994599A (en) 1987-11-20 1991-02-19 Abbott Laboratories Intermediates for producing quinolone-3-carboxylic acids
JPS60221484A (ja) 1984-04-17 1985-11-06 Fuji Photo Film Co Ltd 放射線像変換方法およびその方法に用いられる放射線像変換パネル
DE3420798A1 (de) 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
US4822801A (en) 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4771054A (en) 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61225181A (ja) 1986-02-04 1986-10-06 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
AU5427286A (en) 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
JPS61205258A (ja) 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
IL79189A (en) 1985-06-26 1990-07-12 Daiichi Seiyaku Co Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them
JPS6236377A (ja) 1985-07-03 1987-02-17 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPH089597B2 (ja) 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPH0717608B2 (ja) 1986-04-25 1995-03-01 杏林製薬株式会社 ６−アルコキシキノロンカルボン酸誘導体
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
US4780468A (en) 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4997946A (en) 1987-08-18 1991-03-05 Eastman Kodak Company Process for the iodination of hydroxyaromatic and aminoaromatic compounds
JPH0676400B2 (ja) 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
US4921857A (en) 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
CA1340285C (en) 1988-05-19 1998-12-22 Hiroyuki Nagano Novel quinolonecarboxylic acid derivatives having at 7-position a piperidin-1-yl substituent
JP2844079B2 (ja) 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
DE3906365A1 (de) 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
FI95130C (fi) 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
US5328908A (en) 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
CA2001203C (en) 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0997466A1 (en) 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
WO1991002526A1 (en) 1989-08-16 1991-03-07 Pfizer Inc. Azabicyclo quinolone carboxylic acids
EP0443498A1 (en) 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Isoindoline derivatives
US5116834A (en) 1990-04-12 1992-05-26 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents
US5599816A (en) 1990-05-02 1997-02-04 Abbott Laboratories Quinolizinone type compounds
JP2514136B2 (ja) 1990-05-02 1996-07-10 アボツト・ラボラトリーズ キノリジノン型化合物
US5580872A (en) 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
JPH0778065B2 (ja) 1990-07-06 1995-08-23 杏林製薬株式会社 （６，７―置換―８―アルコキシ―１―シクロプロピル―１，４―ジヒドロ―４―オキソ―３―キノリンカルボン酸―ｏ▲上３▼，ｏ▲上４▼）ビス（アシルオキシ―ｏ）ホウ素化合物及びその塩並びにその製造方法
US5072001A (en) 1990-11-30 1991-12-10 Warner-Lambert Company Certain optically active substituted 3-pyrraidine acetic acid derivatives useful as intermediates
US5364861A (en) 1990-11-30 1994-11-15 Warner-Lambert Company Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
US5258528A (en) 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
DE4120646A1 (de) 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4123918A1 (de) 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
US5412098A (en) 1991-12-27 1995-05-02 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivative or salt thereof and antibacterial containing the same
EP0550016A1 (en) 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
DE4230804A1 (de) 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4234078A1 (de) 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
KR0148277B1 (ko) 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
DE4301246A1 (de) 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
DE4301245A1 (de) 1993-01-19 1994-07-21 Bayer Ag Fluor-trifluormethylbenzoesäure-Derivate
CA2152828A1 (en) 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
TW252107B (es) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
AU689809B2 (en) 1993-10-14 1998-04-09 Abbott Laboratories Quinolizinone type compounds
DE69531350T2 (de) 1994-08-12 2004-05-27 Toyama Chemical Co. Ltd. Neue chinolon- oder naphthyridoncarbonsäurederivate oder deren salze
CA2212007C (en) 1995-02-02 2004-09-14 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives substitued by a bicyclic amino group
JP3745433B2 (ja) 1995-02-02 2006-02-15 第一製薬株式会社 複素環式化合物
CA2212226A1 (en) 1995-02-02 1995-08-10 Katsumi Chiba Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
WO1996039407A1 (en) 1995-06-06 1996-12-12 Abbott Laboratories Quinolizinone type compounds
IT1279532B1 (it) 1995-07-24 1997-12-16 Mediolanum Farmaceutici Spa Derivati chinolonici non fluorurati e loro impiego come agenti antibatterici
CA2238765A1 (en) 1995-11-22 1997-05-29 Satoru Miyauchi Substituted aminocycloalkylpyrrolidine derivatives
EP0947513B1 (en) 1996-10-25 2004-05-19 Daiichi Pharmaceutical Co., Ltd. Tricyclic amine derivatives
US6274592B1 (en) 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
DE69829682T2 (de) 1997-05-21 2006-03-09 Daiichi Pharmaceutical Co., Ltd. Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
MY119816A (en) 1997-05-30 2005-07-29 Daiichi Seiyaku Co Substituted cyclobutylamine derivatives
KR100241673B1 (ko) 1997-08-09 2000-03-02 김충섭 퀴놀리진 카르복실산 유도체
CO4970702A1 (es) * 1997-09-15 2000-11-07 Procter & Gamble Quinolonas antimicrobianas, sus composiciones y sus usos
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
WO2001053273A1 (en) 2000-01-24 2001-07-26 Warner-Lambert Company 3-aminoquinazolin-2,4-dione antibacterial agents
WO2002048138A1 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones
JP4250353B2 (ja) 2001-06-22 2009-04-08 エドワーズ株式会社 真空ポンプ
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
US6803469B2 (en) 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
SI1675852T1 (sl) * 2003-09-22 2009-06-30 Janssen Pharmaceutica Nv 7-amino alkilidenil-heterociklični kinoloni in naftiridoni
US7732612B2 (en) 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
KR101084521B1 (ko) 2006-03-28 2011-11-18 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
KR101030202B1 (ko) * 2006-03-28 2011-04-22 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체의 제조를 위한 수소화물 환원 방법

Also Published As

Publication number Publication date
KR101102288B1 (ko) 2012-01-03
US8039485B2 (en) 2011-10-18
MA30554B1 (fr) 2009-07-01
DK2001862T3 (da) 2011-08-08
EP2001862A2 (en) 2008-12-17
DE602007014191D1 (en) 2011-06-09
JP2009531417A (ja) 2009-09-03
NZ570494A (en) 2011-09-30
MY148393A (en) 2013-04-15
ZA200807158B (en) 2009-09-30
CA2647346C (en) 2011-07-19
AR060189A1 (es) 2008-05-28
PT2001862E (pt) 2011-07-20
BRPI0709772B8 (pt) 2021-05-25
SMP200800058B (it) 2009-09-07
SMAP200800058A (it) 2008-10-29
BRPI0709772A2 (pt) 2011-07-26
HRP20110558T1 (hr) 2011-09-30
ES2366150T3 (es) 2011-10-17
JP5097967B2 (ja) 2012-12-12
TW200808759A (en) 2008-02-16
RU2008134544A (ru) 2010-05-10
SI2001862T1 (sl) 2011-10-28
WO2007110834A2 (en) 2007-10-04
TWI364419B (en) 2012-05-21
RU2417222C2 (ru) 2011-04-27
US20070232650A1 (en) 2007-10-04
WO2007110834A3 (en) 2007-12-06
KR20090004887A (ko) 2009-01-12
AU2007230630A1 (en) 2007-10-04
EP2001862B1 (en) 2011-04-27
ATE507219T1 (de) 2011-05-15
AR060377A1 (es) 2008-06-11
MX2008012328A (es) 2008-10-09
CA2647346A1 (en) 2007-10-04
BRPI0709772B1 (pt) 2019-10-15
CY1111683T1 (el) 2015-10-07
AU2007230630B2 (en) 2012-12-20
IL193990A (en) 2014-12-31
PL2001862T3 (pl) 2011-09-30

Similar Documents

Publication Publication Date Title
PE20080175A1 (es) Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolincarboxilico
EA201270216A1 (ru) Фармацевтический состав
EA201101672A1 (ru) Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
BR112015002821A8 (pt) compostos inibidores de neprilisina, composição farmacêutica e uso dos compostos
PE20121337A1 (es) Forma cristalina y amorfa de hemitartrato de genz 112638 como inhibidor de glucosilceramida sintasa
ECSP12012290A (es) Formulaciones farmacéuticas
BR112013016595A2 (pt) inibidores de neprilisina
UY31084A1 (es) Compuestos de azaindol para la inhibicion de b-secretasa
PE20120083A1 (es) Sal monotosilato del compuesto 2-metil-2-[4-(3-metil-2-oxo-8-quinolin-3-il-2, 3-dihidro-imidazo-[4,5-c]-quinolin-1-il)-fenil]-propionitrilo en su forma cristalina a
BR112012018384A2 (pt) composição farmacêutica sólida com intensificadores e métodos de preparação da mesma.
ATE554084T1 (de) N-hydroxyacrylamidverbindungen
EA201070588A1 (ru) Производные 1,2,3-триазола для применения в качестве ингибиторов стеароил-соа десатуразы
UA109290C2 (uk) Спільні кристали і солі інгібіторів ccr3
EA201690072A1 (ru) Состав, содержащий гиполипидемическое средство
BR112013029730A2 (pt) composição farmacêutica de rosuvastatina cálcica
BR112013018938A2 (pt) agente antifúngico tópico
CL2011001829A1 (es) 3'-n-desmetil-4''-o-(2-dietilaminoetanoil)-6-o-metil-9a-aza-9a-homoeritromicina a, sus sales y formas cristalinas 1, 2 y 3; proceso de preparacion; uso para tratar enfermedades inflamatorias; composicion farmaceutica; y composicion que ademas comprende otro compuesto activo.
EP2152292A4 (en) ANGIOGENESIS HEMMER WITH METEORIN AS AN ACTIVE SUBSTANCE
UY34916A (es) "preparación sólida que contiene ácido[(3s)-6-){2´,6´-dimetil-4´-[3-(metilsulfonil)propoxi]bifenil-3-il}metoxi)-2,3-dihidro-1-benzofuran-3-il]acético"
BR112014016450A2 (pt) composto antagonista de leucotrieno b4
BRPI0713523A8 (pt) derivados de ácido fenilacético
AR065070A1 (es) Sal de estronico de atorvastatina y una composicion farmaceutica que la comprende
DK2293791T3 (da) Farmaceutiske præparater med entacapon co-mikroniseret med sukkeralkoholer
AR091849A1 (es) Compuestos inhibidores selectivos de la cyp26a1, utiles en el tratamiento de patologias
EP2637654A4 (en) TOPICAL ORGANIC ACID SALT COMPOSITIONS FOR THE TREATMENT OF INFECTIONS

Legal Events

Date Code Title Description
FG Grant, registration