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PE20070024A1 - Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas - Google Patents

Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas

Info

Publication number
PE20070024A1
PE20070024A1 PE2006000551A PE2006000551A PE20070024A1 PE 20070024 A1 PE20070024 A1 PE 20070024A1 PE 2006000551 A PE2006000551 A PE 2006000551A PE 2006000551 A PE2006000551 A PE 2006000551A PE 20070024 A1 PE20070024 A1 PE 20070024A1
Authority
PE
Peru
Prior art keywords
tigecycline
preparing
methods
crystalline forms
solid crystalline
Prior art date
Application number
PE2006000551A
Other languages
English (en)
Inventor
Lalitha Krishnan
Subodh S Deshmukh
W James Huang
Mannching Sherry Ku
Anthony Hadfield
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37026996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070024(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070024A1 publication Critical patent/PE20070024A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

SE REFIERE A FORMAS CRISTALINAS DE TIGECICLINA TAL COMO LA FORMA I, ENTRE OTRAS; DICHA FORMA I TIENE PICOS DE DIFRACCION DE POLVOS POR RAYOS X EXPRESADOS EN 2q DE 5,2; 8,3; 11,1; 24,8, ENTRE OTROS. LA FORMA CRISTALINA I PRESENTA UNA TEMPERATURA DE INICIO DE PUNTO DE FUSION DE PLATINA CALIENTE DE 170ºC A 172ºC; DICHA FORMA I SE PREPARA CRISTALIZANDO TIGECICLINA FUERA DE UNA SOLUCION TAL COMO CLORURO DE METILENO. SE REFIERE TAMBIEN A PROCEDIMIENTOS DE PREPARACION DE LAS FORMAS II, III, IV, V Y A UNA COMPOSICION FARMACEUTICA. LA TIGECICLINA ES UN ANTIBIOTICO UTIL CONTRA STAPHYLOCOCCUS AUREUS, STREPTOCOCCUS PNEUMONIAE
PE2006000551A 2005-05-27 2006-05-25 Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas PE20070024A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68495505P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
PE20070024A1 true PE20070024A1 (es) 2007-02-06

Family

ID=37026996

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000551A PE20070024A1 (es) 2005-05-27 2006-05-25 Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas

Country Status (27)

Country Link
US (1) US8372995B2 (es)
EP (1) EP1890996B1 (es)
JP (2) JP2008545717A (es)
KR (1) KR20080016890A (es)
CN (1) CN101248038B (es)
AR (1) AR057649A1 (es)
AU (1) AU2006251954A1 (es)
BR (1) BRPI0610653A2 (es)
CA (1) CA2609875C (es)
CL (1) CL2006001266A1 (es)
CR (1) CR9540A (es)
DK (1) DK1890996T3 (es)
EC (1) ECSP078055A (es)
ES (1) ES2415518T3 (es)
GT (1) GT200600227A (es)
IL (1) IL187359A (es)
MX (1) MX2007014735A (es)
NO (1) NO20076005L (es)
PE (1) PE20070024A1 (es)
PL (1) PL1890996T3 (es)
PT (1) PT1890996E (es)
RU (1) RU2478612C2 (es)
SI (1) SI1890996T1 (es)
SV (1) SV2008002542A (es)
TW (1) TWI421232B (es)
WO (1) WO2006128150A2 (es)
ZA (1) ZA200710151B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
DE202007019460U1 (de) * 2006-04-24 2012-10-24 Teva Pharmaceutical Industries Ltd. Kristalline Tigecyclin-Formen
US8198469B2 (en) * 2006-11-29 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
PT103661B (pt) * 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
AT13157U1 (de) * 2007-04-24 2013-07-15 Teva Pharma Tigecyclin, kristalline Formen und Herstellungsverfahren dafür
EP2178827A1 (en) 2007-06-21 2010-04-28 Sandoz AG Crystalline solid forms
US20100256402A1 (en) * 2007-11-14 2010-10-07 Sandoz Ag Novel solvate
ES2532880T3 (es) * 2007-11-14 2015-04-01 Sandoz Ag Formas cristalinas del Clorhidrato de Tigeciclina
WO2009070799A1 (en) * 2007-11-29 2009-06-04 Teva Pharmaceutical Industries Ltd. Processes for preparation of crystalline tigecycline form ii
US20110124893A1 (en) * 2008-01-23 2011-05-26 Sandoz Ag Antibiotic compounds
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202332671A (zh) * 2008-05-19 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
CA2746585C (en) 2008-12-18 2017-08-29 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
PT104350A (pt) 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
CN102746183B (zh) * 2011-04-20 2014-12-17 胡梨芳 替加环素结晶水合物及其制备方法和用途
CN102295576A (zh) * 2011-06-29 2011-12-28 赵军旭 替加环素的晶型及其制备方法
CN102898325B (zh) * 2011-07-29 2015-07-08 江苏奥赛康药业股份有限公司 替加环素晶体及其制备方法
CN102924322B (zh) * 2012-11-05 2014-09-17 赵军旭 一种替加环素的新晶型及其制备方法
CN103833590A (zh) * 2012-11-26 2014-06-04 石药集团中奇制药技术（石家庄）有限公司 替加环素晶型及其制备方法
TWI656116B (zh) * 2016-06-22 2019-04-11 山東亨利醫藥科技有限責任公司 Crystal form of 9-aminomethyl substituted tetracycline compound and preparation method thereof
CA3196954A1 (en) 2020-11-03 2022-05-12 Josep Bassaganya-Riera Crystalline forms of piperazine-1,4-diylbis((6-(1h-benzoi[d]imidazo-2-yl)pyridin-2yl)methanone) as lancl2 modulators
TWI843989B (zh) 2021-02-19 2024-06-01 美商美威高能離子醫療系統公司 用於粒子治療系統之支架

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT536515E (pt) 1991-10-04 2002-05-31 American Cyanamid Co Novas 7-substituido-9-(amino substitido)-6-desmetil-6-desoxitetraciclinas
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
NZ519984A (en) * 2000-01-07 2004-03-26 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
CN102512429A (zh) * 2005-03-14 2012-06-27 惠氏公司 替加环素组合物及制备方法
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion

Also Published As

Publication number Publication date
AU2006251954A1 (en) 2006-11-30
JP2013100354A (ja) 2013-05-23
CL2006001266A1 (es) 2008-05-16
HK1113786A1 (en) 2008-10-17
ES2415518T3 (es) 2013-07-25
JP2008545717A (ja) 2008-12-18
CN101248038A (zh) 2008-08-20
SI1890996T1 (sl) 2013-06-28
MX2007014735A (es) 2008-02-15
BRPI0610653A2 (pt) 2010-07-13
CR9540A (es) 2008-02-21
NO20076005L (no) 2008-02-22
US20070123497A1 (en) 2007-05-31
RU2007143160A (ru) 2009-07-10
SV2008002542A (es) 2008-02-22
IL187359A (en) 2013-04-30
EP1890996B1 (en) 2013-04-24
ZA200710151B (en) 2010-05-26
IL187359A0 (en) 2008-04-13
DK1890996T3 (da) 2013-05-13
WO2006128150A3 (en) 2007-03-08
TW200720232A (en) 2007-06-01
CA2609875C (en) 2014-01-07
PL1890996T3 (pl) 2013-08-30
TWI421232B (zh) 2014-01-01
GT200600227A (es) 2007-01-12
PT1890996E (pt) 2013-06-24
CN101248038B (zh) 2014-03-05
US8372995B2 (en) 2013-02-12
ECSP078055A (es) 2008-01-23
AR057649A1 (es) 2007-12-12
WO2006128150A2 (en) 2006-11-30
EP1890996A2 (en) 2008-02-27
KR20080016890A (ko) 2008-02-22
RU2478612C2 (ru) 2013-04-10
CA2609875A1 (en) 2006-11-30

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