AR057032A1 - Tigeciclina y metodos de preparacion - Google Patents
Tigeciclina y metodos de preparacionInfo
- Publication number
- AR057032A1 AR057032A1 ARP060102154A ARP060102154A AR057032A1 AR 057032 A1 AR057032 A1 AR 057032A1 AR P060102154 A ARP060102154 A AR P060102154A AR P060102154 A ARP060102154 A AR P060102154A AR 057032 A1 AR057032 A1 AR 057032A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- methods
- branched
- alkyl
- preparing
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- SOVUOXKZCCAWOJ-HJYUBDRYSA-N (4s,4as,5ar,12ar)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O SOVUOXKZCCAWOJ-HJYUBDRYSA-N 0.000 abstract 2
- 239000004098 Tetracycline Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 235000019364 tetracycline Nutrition 0.000 abstract 2
- 150000003522 tetracyclines Chemical class 0.000 abstract 2
- 229960004089 tigecycline Drugs 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
- -1 tigecycline Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se revelan en la presente métodos para preparar y purificar tetraciclinas, tales como tigeciclina. También se revelan composiciones de tetraciclina, tales como composiciones de tigeciclina, preparadas mediante estos métodos. Reivindicacion 1: Un método para preparar al menos un compuesto de formula (1) o una sal aceptable para uso farmacéutico del mismo, donde R1 y R2 se seleccionan cada uno en forma independiente de H, alquilo C1-6 de cadena recta y ramificada, y cicloalquilo, o R1 y R2, junto con N, forman un heterociclo; R es -NR3R4, donde R3 y R4 se seleccionan cada uno en forma independiente de H, alquilo C1-4 de cadena recta o ramificada; y n oscila entre 1-4, que comprende hacer reaccionar al menos un compuesto de formula (4) o una sal del mismo, con al menos un compuesto con grupo aminoacilo en un medio de reaccion seleccionado de un medio acuoso, y al menos un solvente básico en ausencia de una base reactiva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68528505P | 2005-05-27 | 2005-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057032A1 true AR057032A1 (es) | 2007-11-14 |
Family
ID=37023025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102154A AR057032A1 (es) | 2005-05-27 | 2006-05-24 | Tigeciclina y metodos de preparacion |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20070049562A1 (es) |
| EP (1) | EP1888507A1 (es) |
| JP (1) | JP2008545701A (es) |
| KR (1) | KR20080015470A (es) |
| CN (1) | CN101228112A (es) |
| AR (1) | AR057032A1 (es) |
| AU (1) | AU2006252783A1 (es) |
| BR (1) | BRPI0610648A2 (es) |
| CA (1) | CA2609306A1 (es) |
| CR (1) | CR9541A (es) |
| EC (1) | ECSP078059A (es) |
| GT (1) | GT200600221A (es) |
| IL (1) | IL187360A0 (es) |
| MX (1) | MX2007014731A (es) |
| NI (1) | NI200700301A (es) |
| NO (1) | NO20076001L (es) |
| PE (1) | PE20070009A1 (es) |
| RU (1) | RU2007143157A (es) |
| TW (1) | TW200718676A (es) |
| WO (1) | WO2006130418A1 (es) |
| ZA (1) | ZA200710153B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR057649A1 (es) * | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
| US20070244335A1 (en) * | 2006-04-17 | 2007-10-18 | Teva Pharmaceutical Industries Ltd. | Isolation of tetracycline derivatives |
| DE202007019460U1 (de) * | 2006-04-24 | 2012-10-24 | Teva Pharmaceutical Industries Ltd. | Kristalline Tigecyclin-Formen |
| US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
| US8198469B2 (en) * | 2006-11-29 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of tigecycline and processes for preparation thereof |
| BRPI0706517A2 (pt) * | 2006-11-30 | 2011-03-29 | Teva Pharma | processos para preparação de f 9-haloacetamidominociclinas |
| WO2008106234A1 (en) * | 2007-03-01 | 2008-09-04 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
| US20090099376A1 (en) * | 2007-10-16 | 2009-04-16 | Wyeth | Tigecycline and methods of preparing intermediates |
| ES2532880T3 (es) | 2007-11-14 | 2015-04-01 | Sandoz Ag | Formas cristalinas del Clorhidrato de Tigeciclina |
| US20110124893A1 (en) * | 2008-01-23 | 2011-05-26 | Sandoz Ag | Antibiotic compounds |
| WO2010032219A1 (en) * | 2008-09-18 | 2010-03-25 | Ranbaxy Laboratories Limited | Process for the preparation of tigecycline |
| CA2746585C (en) | 2008-12-18 | 2017-08-29 | Sandoz Ag | Crystalline form c of tigecycline dihydrochloride and methods for its preparation |
| CA2751238A1 (en) | 2009-03-12 | 2010-10-07 | Wyeth Llc | Nitration of tetracyclines |
| ES2469829T3 (es) * | 2009-11-26 | 2014-06-20 | Sandoz Ag | Reacción de compuestos orgánicos con bajas cantidades de hidrógeno |
| CN102821769A (zh) * | 2010-03-10 | 2012-12-12 | 大学健康网络 | 替加环素用于治疗癌症的用途 |
| CN102276497A (zh) * | 2010-06-10 | 2011-12-14 | 武汉启瑞药业有限公司 | 替加环素的合成方法 |
| CN102746183B (zh) * | 2011-04-20 | 2014-12-17 | 胡梨芳 | 替加环素结晶水合物及其制备方法和用途 |
| DK2900634T3 (en) | 2012-09-27 | 2017-05-22 | Bayer Cropscience Ag | PROCEDURE FOR PREPARING SUBSTITUTED SUBSTITUTED PHENYL AND PYRIDYLPYRROLIDINES |
| CN102911077B (zh) * | 2012-11-12 | 2015-01-07 | 成都百裕科技制药有限公司 | 4r-替加环素的制备方法 |
| CN103044281A (zh) * | 2013-01-02 | 2013-04-17 | 湖南赛隆药业有限公司 | 高纯度替加环素的制法 |
| CN104230744B (zh) * | 2014-09-01 | 2016-06-08 | 湖南尔康制药股份有限公司 | 一种替加环素原料药的生产方法 |
| CN107365359B (zh) * | 2017-07-17 | 2021-06-04 | 昆明理工大学 | 一种万古霉素手性功能单体合成方法 |
| WO2019160037A1 (ja) * | 2018-02-14 | 2019-08-22 | 国立大学法人 東京大学 | 酸ハロゲン化物による化合物の製造方法 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
| US3026248A (en) * | 1959-09-11 | 1962-03-20 | Pfizer & Co C | Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents |
| US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
| FR1430859A (es) * | 1960-05-23 | 1966-05-25 | ||
| US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| US3239499A (en) * | 1961-05-19 | 1966-03-08 | Pfizer & Co C | Tetracycline derivative |
| US3502696A (en) * | 1961-08-18 | 1970-03-24 | Pfizer & Co C | Antibacterial agents |
| US3148212A (en) * | 1961-12-22 | 1964-09-08 | American Cyanamid Co | Reductive alkylation process |
| US3145228A (en) * | 1962-09-06 | 1964-08-18 | Pfizer & Co C | 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof |
| US3250810A (en) * | 1962-09-06 | 1966-05-10 | Pfizer & Co C | 6-hydroxy-6-halomethyl tetracyclines |
| US3250809A (en) * | 1962-09-06 | 1966-05-10 | Pfizer & Co C | 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives |
| US3219529A (en) * | 1962-10-04 | 1965-11-23 | American Cyanamid Co | Stable tetracycline solutions |
| USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| US3397230A (en) * | 1966-03-14 | 1968-08-13 | American Cyanamid Co | Nitration of tetracyclines |
| US3433834A (en) * | 1966-03-14 | 1969-03-18 | American Cyanamid Co | Nitration of 11a-chloro tetracyclines |
| US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
| US3849493A (en) * | 1966-08-01 | 1974-11-19 | Pfizer | D-ring substituted 6-deoxytetracyclines |
| US3345410A (en) * | 1966-12-01 | 1967-10-03 | American Cyanamid Co | Substituted 7- and/or 9-amino tetracyclines |
| US3373196A (en) * | 1967-03-21 | 1968-03-12 | American Cyanamid Co | 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines |
| US3373197A (en) * | 1967-04-27 | 1968-03-12 | American Cyanamid Co | Substituted 6-epitetracyclines and 5a-epi-6-epitetracyclines |
| US3373198A (en) * | 1967-04-27 | 1968-03-12 | American Cyanamid Co | Substituted 5a, 11a-dehydro-6-epitetracyclines |
| US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
| US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
| US3579579A (en) * | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
| US4038315A (en) * | 1972-05-11 | 1977-07-26 | American Cyanamid Company | Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride |
| US5202449A (en) * | 1987-07-28 | 1993-04-13 | Nippon Kayaku Kabushiki Kaisha | Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline |
| US5141960A (en) * | 1991-06-25 | 1992-08-25 | G. D. Searle & Co. | Tricyclic glycinamide derivatives as anti-convulsants |
| US5281628A (en) * | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
| US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
| US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
| US5248797A (en) * | 1992-08-13 | 1993-09-28 | American Cyanamid Company | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
| WO1995022529A1 (en) * | 1994-02-17 | 1995-08-24 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5672030A (en) * | 1996-01-02 | 1997-09-30 | Berryville Graphics | Method of making books |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6946453B2 (en) * | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
| WO2001052858A1 (en) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| US6818634B2 (en) * | 2000-03-31 | 2004-11-16 | Paratek Pharmaceuticals, Inc. | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds |
| CZ2003343A3 (cs) * | 2000-07-07 | 2003-05-14 | Trustees Of Tufts College | 7-Substituované tetracyklinové sloučeniny |
| ATE504562T1 (de) * | 2000-07-07 | 2011-04-15 | Tufts College | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
| EA013908B1 (ru) * | 2000-07-07 | 2010-08-30 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| AU2002341970B2 (en) * | 2001-10-05 | 2008-02-14 | Tetragenex Pharmaceuticals, Inc. | Tetracycline derivatives and methods of use thereof |
| EP2311798A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| UA83266C2 (en) * | 2003-12-08 | 2008-06-25 | Уайет | Oxazole derivatives of tetracyclines |
-
2006
- 2006-05-24 AR ARP060102154A patent/AR057032A1/es unknown
- 2006-05-25 US US11/440,035 patent/US20070049562A1/en not_active Abandoned
- 2006-05-25 CN CNA2006800267637A patent/CN101228112A/zh active Pending
- 2006-05-25 MX MX2007014731A patent/MX2007014731A/es not_active Application Discontinuation
- 2006-05-25 AU AU2006252783A patent/AU2006252783A1/en not_active Abandoned
- 2006-05-25 RU RU2007143157/04A patent/RU2007143157A/ru not_active Application Discontinuation
- 2006-05-25 PE PE2006000553A patent/PE20070009A1/es not_active Application Discontinuation
- 2006-05-25 TW TW095118580A patent/TW200718676A/zh unknown
- 2006-05-25 GT GT200600221A patent/GT200600221A/es unknown
- 2006-05-25 WO PCT/US2006/020229 patent/WO2006130418A1/en not_active Ceased
- 2006-05-25 EP EP06771160A patent/EP1888507A1/en not_active Withdrawn
- 2006-05-25 CA CA002609306A patent/CA2609306A1/en not_active Abandoned
- 2006-05-25 KR KR1020077030631A patent/KR20080015470A/ko not_active Withdrawn
- 2006-05-25 JP JP2008513704A patent/JP2008545701A/ja not_active Withdrawn
- 2006-05-25 BR BRPI0610648-0A patent/BRPI0610648A2/pt not_active IP Right Cessation
-
2007
- 2007-11-14 IL IL187360A patent/IL187360A0/en unknown
- 2007-11-22 CR CR9541A patent/CR9541A/es not_active Application Discontinuation
- 2007-11-22 NI NI200700301A patent/NI200700301A/es unknown
- 2007-11-23 NO NO20076001A patent/NO20076001L/no not_active Application Discontinuation
- 2007-11-26 ZA ZA200710153A patent/ZA200710153B/xx unknown
- 2007-12-27 EC EC2007008059A patent/ECSP078059A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NI200700301A (es) | 2008-07-24 |
| BRPI0610648A2 (pt) | 2010-07-13 |
| WO2006130418A1 (en) | 2006-12-07 |
| PE20070009A1 (es) | 2007-01-29 |
| US20070049562A1 (en) | 2007-03-01 |
| RU2007143157A (ru) | 2009-07-10 |
| CR9541A (es) | 2008-02-20 |
| ECSP078059A (es) | 2008-01-23 |
| TW200718676A (en) | 2007-05-16 |
| AU2006252783A1 (en) | 2006-12-07 |
| IL187360A0 (en) | 2008-04-13 |
| KR20080015470A (ko) | 2008-02-19 |
| MX2007014731A (es) | 2008-02-15 |
| CA2609306A1 (en) | 2006-12-07 |
| ZA200710153B (en) | 2009-08-26 |
| EP1888507A1 (en) | 2008-02-20 |
| CN101228112A (zh) | 2008-07-23 |
| GT200600221A (es) | 2009-08-28 |
| NO20076001L (no) | 2008-02-19 |
| JP2008545701A (ja) | 2008-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR057032A1 (es) | Tigeciclina y metodos de preparacion | |
| AR057034A1 (es) | Metodos para purificar tigeciclina | |
| AR057033A1 (es) | Tigeciclina y metodos para preparar 9-nitrominociclina | |
| AR082029A1 (es) | Derivados de heterociclos nitrogenados, composiciones y metodos para modular la via de señalizacion de wnt | |
| AR086319A1 (es) | Compuestos heterociclicos fusionados como moduladores de canal ionico | |
| AR062677A1 (es) | Derivados de biaril-sulfonamida, procesos de produccion y composiciones farmaceuticas que los comprenden | |
| AR058065A1 (es) | Compuestos de carboxiamina y uso de los mismos.composiciones farmaceuticas. | |
| AR064027A1 (es) | Proceso quimico para preparar rosuvastatina y su sal de sodio y/o calcio | |
| EA201000413A1 (ru) | Способ получения производных лактамида, новые производные лактамида и препараты, содержащие производные лактамида | |
| NI201200051A (es) | Nuevos maitansinoides y el uso de dichos maitansonoides para preparar conjugados con un anticuerpo. | |
| CO6241101A2 (es) | Derivados de quinolina como inhibidores de la p13 quinasa | |
| AR066562A1 (es) | Derivados de pirrol condensados; una formulacion farmaceutica en base al compuesto y su uso para preparar medicamentos | |
| BRPI0516911A (pt) | método para a preparação de um composto e composto de anilina | |
| ES2623023T3 (es) | Nuevos adhesivos de dispersión, un procedimiento para su preparación y su uso | |
| AR054881A1 (es) | Inhibidores macrociclicos de la replicacion del virus de la hepatitis c, un proceso para su preparacion, una composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento para el tratamiento de la hepatitis c | |
| AR087909A1 (es) | Composiciones farmaceuticas | |
| AR079205A1 (es) | Morfolinotiazoles como moduladores alostericos positivos alfa 7 | |
| CO5580815A2 (es) | Derivados de adamantana, procesos para su preparacion y composiciones farmaceuticas que los contienen | |
| AR049401A1 (es) | Aza-biciclononanos | |
| CU20080165A7 (es) | Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparación y las composiciones farmacéuticas que las contienen | |
| AR057324A1 (es) | Tigeciclina y metodos para preparar 9-aminominociclina | |
| AR081064A1 (es) | Compuestos de tetraciclina policiclica | |
| AR045999A1 (es) | Compuesto de eter de piperidina, su uso para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para prepararlo | |
| AR040968A1 (es) | Bifenilcarboxamidas sustituidas con n- aril piperidina, un metodo para su preparacion, composicion farmaceutica y proceso de preparacion | |
| AR054484A1 (es) | Derivados de 2-azetidinonas como inhibidores de la absorcion de colesterol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |