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AR057034A1 - Metodos para purificar tigeciclina - Google Patents

Metodos para purificar tigeciclina

Info

Publication number
AR057034A1
AR057034A1 ARP060102156A ARP060102156A AR057034A1 AR 057034 A1 AR057034 A1 AR 057034A1 AR P060102156 A ARP060102156 A AR P060102156A AR P060102156 A ARP060102156 A AR P060102156A AR 057034 A1 AR057034 A1 AR 057034A1
Authority
AR
Argentina
Prior art keywords
methods
compound
formula
branched
alkyl
Prior art date
Application number
ARP060102156A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36997702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR057034(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR057034A1 publication Critical patent/AR057034A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se revelan métodos para preparar y purificar tetraciclinas, tales como tigeciclina. También se revelan composiciones de tetraciclina, tales como composiciones de tigeciclina, preparadas por estos métodos. Reivindicacion 1: Un método para purificar al menos un compuesto de formula (1) o una sal aceptable para uso farmacéutico del mismo, donde R1 y R2 se selecciona cada uno en forma independiente de H, alquilo C1-6 de cadena recta y ramificada, y cicloalquilo, o R1 y R2, junto con N, forman un heterociclo; R es -NR3R4, donde R3 y R4 se selecciona cada uno en forma independiente de H, y alquilo C1-4 recto y ramificado; y n oscila de 1-4, que comprende: A combinar el al menos un compuesto de formula (1) con al menos un solvente aprotico polar y al menos un solvente polar protico; B) mezclar durante al menos un período de tiempo que oscila entre 15 minutos y 2 horas a una temperatura que oscila entre 0°C y 40°C para dar una primera mezcla; y C) obtener el al menos un compuesto de formula (1).
ARP060102156A 2005-05-27 2006-05-24 Metodos para purificar tigeciclina AR057034A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68562605P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
AR057034A1 true AR057034A1 (es) 2007-11-14

Family

ID=36997702

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102156A AR057034A1 (es) 2005-05-27 2006-05-24 Metodos para purificar tigeciclina

Country Status (22)

Country Link
US (1) US20070049561A1 (es)
EP (1) EP1890997A1 (es)
JP (1) JP2008545702A (es)
KR (1) KR20080016892A (es)
CN (1) CN101228114A (es)
AR (1) AR057034A1 (es)
AU (1) AU2006252796A1 (es)
BR (1) BRPI0610057A2 (es)
CA (1) CA2609307A1 (es)
CR (1) CR9542A (es)
EC (1) ECSP078050A (es)
GT (1) GT200600224A (es)
IL (1) IL187361A0 (es)
MX (1) MX2007014717A (es)
NI (1) NI200700302A (es)
NO (1) NO20075997L (es)
PA (1) PA8676401A1 (es)
PE (1) PE20070318A1 (es)
RU (1) RU2007143158A (es)
TW (1) TW200716516A (es)
WO (1) WO2006130431A1 (es)
ZA (1) ZA200710174B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102512429A (zh) 2005-03-14 2012-06-27 惠氏公司 替加环素组合物及制备方法
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR055336A1 (es) 2005-06-16 2007-08-22 Wyeth Corp Proeso de elaboracion para la produccion de tigeciclina como un polvo reconstituible, polvo de tigeciclina liofilizado y producto hecho mediante el proceso
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
DE202007019460U1 (de) * 2006-04-24 2012-10-24 Teva Pharmaceutical Industries Ltd. Kristalline Tigecyclin-Formen
US8198469B2 (en) 2006-11-29 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
AU2008246119A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2178827A1 (en) * 2007-06-21 2010-04-28 Sandoz AG Crystalline solid forms
US20090099376A1 (en) * 2007-10-16 2009-04-16 Wyeth Tigecycline and methods of preparing intermediates
ES2532880T3 (es) 2007-11-14 2015-04-01 Sandoz Ag Formas cristalinas del Clorhidrato de Tigeciclina
CN101450916B (zh) * 2007-11-30 2012-11-21 上海来益生物药物研究开发中心有限责任公司 替加环素的合成方法
US20110124893A1 (en) * 2008-01-23 2011-05-26 Sandoz Ag Antibiotic compounds
CA2746585C (en) 2008-12-18 2017-08-29 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
CA2751238A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
ES2469829T3 (es) * 2009-11-26 2014-06-20 Sandoz Ag Reacción de compuestos orgánicos con bajas cantidades de hidrógeno
CN102898325B (zh) * 2011-07-29 2015-07-08 江苏奥赛康药业股份有限公司 替加环素晶体及其制备方法
CN102952035A (zh) * 2011-09-15 2013-03-06 北京海步国际医药科技发展有限公司 替加环素新晶型及其制备方法
CN103091424B (zh) * 2013-01-31 2014-11-19 成都百裕科技制药有限公司 替加环素中杂质的检测方法
CN104515820B (zh) * 2013-10-06 2018-08-14 山东新时代药业有限公司 一种替加环素中间体的分析检测方法
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
PT108223B (pt) * 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
CN105085311A (zh) * 2015-08-13 2015-11-25 江苏豪森药业股份有限公司 替加环素或其盐的高效纯化方法
CN107304173A (zh) * 2016-04-25 2017-10-31 浙江医药股份有限公司新昌制药厂 一种替加环素的晶型及其制备方法
CN111978196A (zh) * 2020-08-03 2020-11-24 河北圣雪大成制药有限责任公司 一种替加环素的纯化方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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USRE26271E (en) * 1967-09-26 Reductive alkylation process
US3502696A (en) * 1961-08-18 1970-03-24 Pfizer & Co C Antibacterial agents
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3433834A (en) * 1966-03-14 1969-03-18 American Cyanamid Co Nitration of 11a-chloro tetracyclines
US3849493A (en) * 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5843925A (en) * 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
CZ2003343A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny

Also Published As

Publication number Publication date
GT200600224A (es) 2007-01-12
NO20075997L (no) 2008-02-19
RU2007143158A (ru) 2009-07-10
ZA200710174B (en) 2009-08-26
EP1890997A1 (en) 2008-02-27
TW200716516A (en) 2007-05-01
KR20080016892A (ko) 2008-02-22
AU2006252796A1 (en) 2006-12-07
CA2609307A1 (en) 2006-12-07
PA8676401A1 (es) 2009-03-31
WO2006130431A1 (en) 2006-12-07
JP2008545702A (ja) 2008-12-18
PE20070318A1 (es) 2007-04-11
BRPI0610057A2 (pt) 2010-05-25
MX2007014717A (es) 2008-02-15
CN101228114A (zh) 2008-07-23
ECSP078050A (es) 2008-01-23
IL187361A0 (en) 2008-04-13
US20070049561A1 (en) 2007-03-01
CR9542A (es) 2008-02-20
NI200700302A (es) 2008-07-24

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