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PE20070505A1 - Inhibidores de glutamato de metaloproteinasas de matriz y agrecanasas - Google Patents

Inhibidores de glutamato de metaloproteinasas de matriz y agrecanasas

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Publication number
PE20070505A1
PE20070505A1 PE2006000825A PE2006000825A PE20070505A1 PE 20070505 A1 PE20070505 A1 PE 20070505A1 PE 2006000825 A PE2006000825 A PE 2006000825A PE 2006000825 A PE2006000825 A PE 2006000825A PE 20070505 A1 PE20070505 A1 PE 20070505A1
Authority
PE
Peru
Prior art keywords
alkyl
glutamine
biphenyl
agrecanases
ilcarbonyl
Prior art date
Application number
PE2006000825A
Other languages
English (en)
Inventor
Phaik-Eng Sum
David Brian How
Jason Shaoyun Xiang
Eric Feyfant
Joshua James Sabatini
Jerauld Stanley Skotnicki
Tarek Suhayl Mansour
Steve Yik-Kai Tam
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070505A1 publication Critical patent/PE20070505A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE W ES -C(O)-, -OC(O)-, -NHC(O)-, ENTRE OTROS; R1 ES FENILO, BIFENILO, ARILO BICICLICO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON R5 O R6, DONDE R5 ES NHSO2-ALQUILO(C1-C6), ALQUILO(C1-C6), O-CICLOALQUILO(C3-C6), ENTRE OTROS; R6 ES H, HALOGENO, CN, OCF3, CF3, ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), ALQUENILO(C2-C6), OH, ENTRE OTROS; R3 ES CO2H, CONH2, TETRAZOL, ENTRE OTROS; R4 ES CO2H, CONH2, (CH2)nOR7, ENTRE OTROS, DONDE R7 ES H, ALQUILO(C1-C6), ALQUINILO(C2-C6), ENTRE OTROS; n ES DE 0 A 4; m ES DE 0 A 4; p ES DE 0 A 2. N2-(1,1'-BIFENIL-4-ILCARBONIL)-N1-BUTIL-L-?-GLUTAMINA, N2-(1,1'-BIFENIL-4-ILCARBONIL)-N1-CICLOHEXIL-L-?-GLUTAMINA, N1-BENCIL-N2-(4-TIEN-2-ILBENZOIL)-L- ?-GLUTAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE METALOPROTEINASAS TAL COMO METALOPROTEINASA DE MATRIZ Y AGRECANASA SIENDO UTILES EN EL TRATAMIENTO DE OSTEOARTRITIS, ARTRITIS REUMATOIDE, ASMA, ATEROSCLEROSIS
PE2006000825A 2005-07-11 2006-07-11 Inhibidores de glutamato de metaloproteinasas de matriz y agrecanasas PE20070505A1 (es)

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Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2473521C (en) * 2002-01-22 2014-04-15 Biomatera Inc. Method of drying biodegradable polymers
WO2007001448A2 (en) * 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
JP2009505962A (ja) * 2005-07-29 2009-02-12 バイエル・ヘルスケア・エルエルシー 肥満を治療するためのビフェニルアミノ酸誘導体の製造および使用
WO2007044100A1 (en) 2005-10-13 2007-04-19 Wyeth Methods for preparing glutamic acid derivatives
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
EP1998612A4 (en) 2006-01-25 2010-11-24 Synta Pharmaceuticals Corp SUBSTITUTED BIARYL COMPOUNDS FOR USE AGAINST INFLAMMATION AND IMMUNE DISORDERS
ES2776100T3 (es) * 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
US20110052697A1 (en) * 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
PE20080312A1 (es) * 2006-06-02 2008-05-14 Wyeth Corp Metodos para preparar derivados de acido glutamico e intermediarios del mismo
US9381477B2 (en) * 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
EP2089012A2 (en) * 2006-11-09 2009-08-19 Wyeth Polymorphs of n²-(1,1'- biphenyl- 4-ylcarbonyl)-n¹-[2-(4-fluorophenyl)-1,1-dimethylethyl]-l-alpha -glutamine
US20100216886A1 (en) * 2006-11-09 2010-08-26 Wyeth Polymorphs of n2-(1,1'-biphenyl-4-ylcarbonyl)-n1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-l-alpha-glutamine
WO2008147456A2 (en) * 2006-11-20 2008-12-04 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
JP2010523595A (ja) * 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー ポリ（アミノ酸）ターゲッティング部分
EP2644192B1 (en) 2007-09-28 2017-05-10 Pfizer Inc Cancer Cell Targeting Using Nanoparticles
JP2011500569A (ja) * 2007-10-12 2011-01-06 マサチューセッツ インスティテュート オブ テクノロジー ワクチンナノテクノロジー
EP2309990B2 (en) 2008-06-16 2017-03-15 Pfizer Inc. Drug loaded polymeric nanoparticles and methods of making and using same
JP2012501966A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド ビンカアルカロイド含有治療用ポリマーナノ粒子並びにその製造方法及び使用方法
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
JP5584696B2 (ja) * 2008-11-17 2014-09-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｍｍｐ−１３阻害剤として有用なヘテロアリールジアミド化合物
WO2010068866A2 (en) 2008-12-12 2010-06-17 Bind Biosciences Therapeutic particles suitable for parenteral administration and methods of making and using same
EP2379064B1 (en) * 2008-12-15 2020-02-26 Pfizer Inc. Long circulating nanoparticles for sustained release of therapeutic agents
DK2509634T3 (en) 2009-12-11 2019-04-23 Pfizer Stable formulations for lyophilization of therapeutic particles
US9295649B2 (en) 2009-12-15 2016-03-29 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
EP2576536B1 (en) * 2010-06-01 2016-09-14 The University of Queensland Haematopoietic-prostaglandin d2 synthase inhibitors
HUE043998T2 (hu) 2012-09-17 2019-09-30 Pfizer Eljárás terápiás nanorészecskék elõállítására
AR092971A1 (es) * 2012-10-26 2015-05-06 Lilly Co Eli Inhibidores de agrecanasa
EP2953932B1 (en) * 2013-02-06 2017-03-01 Merck Patent GmbH Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis
GB201312311D0 (en) 2013-07-09 2013-08-21 Uni I Oslo Uses of enzyme inhibitors
WO2015075699A1 (en) 2013-11-25 2015-05-28 Sanofi Dotam derivatives for therapeutic use
SI3116547T1 (sl) 2014-03-14 2019-08-30 Pfizer, Inc. Terapevtski nanodelci, ki obsegajo terapevtsko stredstvo, in postopek izdelave ter uporabe le-teh
CA3072735A1 (en) 2017-08-21 2019-02-28 Celgene Corporation Processes for the preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate
CN109516925B (zh) * 2018-10-31 2021-07-16 陕西慧康生物科技有限责任公司 一种谷氨酸-1-甲酯-5-叔丁酯的合成方法
CN109824582B (zh) * 2019-01-18 2020-06-19 西安交通大学 一种丙氨酸衍生物及其制备方法和应用
CN109824584B (zh) * 2019-01-18 2020-08-18 西安交通大学 一种含有叔亮氨酸的类肽类化合物及其制备方法和应用
CN109734660B (zh) * 2019-01-18 2020-07-28 西安交通大学 一种含有叔丁基取代的丝氨酸的类肽类化合物及其制备方法和应用
CN109824581B (zh) * 2019-01-18 2020-08-18 西安交通大学 一种含有丙氨酸的类肽类化合物以及其制备方法和应用
AU2020242053C1 (en) 2019-03-20 2025-11-13 Emory University Prostaglandin receptor EP2 antagonists, derivatives, and uses related thereto
AU2021408790B2 (en) * 2020-12-25 2025-12-18 Amtixbio Co., Ltd. Novel derivative compound having biphenyl group introduced into amino-alkanoic acid and anti-inflammatory composition comprising same

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2440649A (en) * 1948-04-27 Quinazoline
GB1108819A (en) 1964-07-31 1968-04-03 Rotta Research Lab Derivatives of 2-acylaminobicarboxylic acids and method for preparing same
DE3332633A1 (de) 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel
IT1215169B (it) * 1985-12-17 1990-01-31 Rotta Research Lab Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione
IT1217123B (it) * 1987-02-05 1990-03-14 Rotta Research Lab Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU675689B2 (en) * 1992-12-01 1997-02-13 Merck & Co., Inc. Fibrinogen receptor antagonists
JPH06192199A (ja) 1992-12-25 1994-07-12 Mitsubishi Kasei Corp ケトン誘導体
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
ATE239680T1 (de) * 1994-03-11 2003-05-15 Pharmacopeia Inc Sulfonamid derivate und deren verwendung
GB2292149A (en) 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
EA199800155A1 (ru) 1995-07-24 1999-02-25 Фудзисава, Фармасьютикал Ко., Лтд Новое соединение
ES2293651T3 (es) * 1995-11-28 2008-03-16 Cephalon, Inc. Inhibidores de cisteina y serina proteasas derivados de aminoacidos d.
DE19648793A1 (de) * 1996-11-26 1998-05-28 Basf Ag Neue Benzamide und deren Anwendung
DE69833858T2 (de) 1997-07-08 2007-02-22 Ono Pharmaceutical Co. Ltd. Aminosäurederivate
JP4129069B2 (ja) 1997-09-16 2008-07-30 株式会社Ａｄｅｋａ アシル化ペプチド類の製造方法
JP4090541B2 (ja) 1997-10-15 2008-05-28 株式会社Ａｄｅｋａ アシル化ペプチド類の製造方法
WO1999048371A1 (en) 1998-03-27 1999-09-30 The Regents Of The University Of California Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors
TWI245035B (en) * 1998-06-26 2005-12-11 Ono Pharmaceutical Co Amino acid derivatives and a pharmaceutical composition comprising the derivatives
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en) * 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
DE19851184A1 (de) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-Arylsulfonyl-aminosäure-omega-amide
AU4180900A (en) * 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
IL146312A0 (en) 1999-05-07 2002-07-25 Texas Biotechnology Corp Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
EP1081137A1 (en) * 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
JP2003146905A (ja) * 1999-11-11 2003-05-21 Yamanouchi Pharmaceut Co Ltd アグリカナーゼ活性を有する新規な金属プロテアーゼ
EP1189882A1 (en) * 2000-04-25 2002-03-27 SAMSUNG ELECTRONICS Co. Ltd. Biphenyl butyric acid derivative as a matrix metalloproteinase inhibitor
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
JP2002145849A (ja) 2000-11-10 2002-05-22 Kyorin Pharmaceut Co Ltd アルキニルアミノ酸誘導体及びその製造法
US20050049242A1 (en) * 2000-12-21 2005-03-03 W. Edward Robinson Novel HIV integrase inhibitors and HIV therapy based on drug combinations including integrase inhibitors
WO2003093498A1 (en) 2002-04-29 2003-11-13 The Ohio State University Inhibition of protein tyrosine phosphatases and sh2 domains by a neutral phosphotyrosine mimetic
JP2006502980A (ja) * 2002-06-25 2006-01-26 ファルマシア・コーポレーション アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用
EA011808B1 (ru) * 2003-01-08 2009-06-30 Новартис Вэксинес Энд Дайэгностикс, Инк. Антибактериальные агенты
JP2007502287A (ja) 2003-08-13 2007-02-08 アムジェン インコーポレイテッド メラニン凝集ホルモン受容体アンタゴニスト
AU2004283313A1 (en) 2003-10-24 2005-05-06 Exelixis, Inc. TAO kinase modulators and methods of use
WO2005061459A1 (en) 2003-12-04 2005-07-07 Wyeth Biaryl sulfonamides and methods for using same
EP1694638A1 (en) * 2003-12-15 2006-08-30 Japan Tobacco, Inc. N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof

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AU2006268183B2 (en) 2012-08-09
AR054631A1 (es) 2007-07-04
JP5181118B2 (ja) 2013-04-10
ZA200800379B (en) 2011-06-29
JP2009500456A (ja) 2009-01-08
US7998965B2 (en) 2011-08-16
BRPI0613030A2 (pt) 2012-01-03
MY144590A (en) 2011-10-14
US20070043066A1 (en) 2007-02-22
TW200800209A (en) 2008-01-01
WO2007008994A2 (en) 2007-01-18
KR20080031379A (ko) 2008-04-08
WO2007008994A3 (en) 2007-07-12
CN101223130A (zh) 2008-07-16
US20100010012A1 (en) 2010-01-14
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CA2614930A1 (en) 2007-01-18
AU2006268183A1 (en) 2007-01-18
UA94412C2 (en) 2011-05-10
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PE20100809A1 (es) 2011-01-07
US7553873B2 (en) 2009-06-30
RU2007149182A (ru) 2009-08-20
EP1902014A2 (en) 2008-03-26

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