AR092971A1 - Inhibidores de agrecanasa - Google Patents
Inhibidores de agrecanasaInfo
- Publication number
- AR092971A1 AR092971A1 ARP130103679A ARP130103679A AR092971A1 AR 092971 A1 AR092971 A1 AR 092971A1 AR P130103679 A ARP130103679 A AR P130103679A AR P130103679 A ARP130103679 A AR P130103679A AR 092971 A1 AR092971 A1 AR 092971A1
- Authority
- AR
- Argentina
- Prior art keywords
- agrecanasa
- inhibitors
- cyclopropyl
- intermediates
- propyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a compuestos que tienen la fórmula (1) en donde R¹ se selecciona a partir de metilo, etilo, propilo, ciclopropilo, y dimetilo, o una sal de los mismos farmacéuticamente aceptable, junto con métodos e intermediarios para su preparación, y usos de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718965P | 2012-10-26 | 2012-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092971A1 true AR092971A1 (es) | 2015-05-06 |
Family
ID=49515523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103679A AR092971A1 (es) | 2012-10-26 | 2013-10-10 | Inhibidores de agrecanasa |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9206139B2 (es) |
| EP (1) | EP2912021B1 (es) |
| JP (1) | JP6251279B2 (es) |
| KR (1) | KR101689983B1 (es) |
| CN (1) | CN104755464B (es) |
| AR (1) | AR092971A1 (es) |
| AU (1) | AU2013334989B2 (es) |
| BR (1) | BR112015009032B1 (es) |
| CA (1) | CA2886526C (es) |
| DK (1) | DK2912021T3 (es) |
| EA (1) | EA026037B1 (es) |
| ES (1) | ES2645970T3 (es) |
| HU (1) | HUE034616T2 (es) |
| MX (1) | MX364207B (es) |
| NZ (1) | NZ706772A (es) |
| PL (1) | PL2912021T3 (es) |
| PT (1) | PT2912021T (es) |
| TW (1) | TWI620738B (es) |
| WO (1) | WO2014066151A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX380621B (es) | 2014-10-16 | 2025-03-12 | Monsato Tech Llc | Proteinas de variantes de secuencias de aminoacidos de cry1da1 activas para lepidopteros. |
| JO3501B1 (ar) | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
| GB201610055D0 (en) | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
| GB201610056D0 (en) * | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
| WO2021011723A1 (en) * | 2019-07-18 | 2021-01-21 | Avidence Therapeutics, Inc. | Anti-osteoarthritis hydantoin compounds and related compositions and methods |
| EP3822268A1 (en) | 2019-11-15 | 2021-05-19 | Bayer Aktiengesellschaft | Substituted hydantoinamides as adamts7 antagonists |
| EP3822265A1 (en) | 2019-11-15 | 2021-05-19 | Bayer AG | Substituted hydantoinamides as adamts7 antagonists |
| US20230201208A1 (en) * | 2020-04-20 | 2023-06-29 | St. Jude Children's Research Hospital | Composition and methods for treating respiratory diseases |
| WO2022007866A1 (zh) * | 2020-07-09 | 2022-01-13 | 深圳信立泰药业股份有限公司 | 并三环类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004535411A (ja) * | 2001-05-25 | 2004-11-25 | ブリストルーマイヤーズ スクイブ カンパニー | マトリックスメタロプロテナーゼ及び／またはＴＮＦ−α転換酵素（ＴＡＣＥ）の阻害剤としてのヒダントイン及び関連複素環化合物 |
| SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| US7799795B2 (en) * | 2005-06-27 | 2010-09-21 | Amgen Inc. | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders |
| BRPI0613030A2 (pt) * | 2005-07-11 | 2012-01-03 | Wyeth Corp | composto de fàrmula i; composto ou sal farmaceuticamente aceitÁvel do composto; mÉtodo para modular a atividade de uma metaloproteinase em animal que dele necessite; composiÇço; mÉtodo para tratamento de um distérbio relacionado a metaloproteinase em animal que dele necessite; mÉtodo de sintetizar um composto; composto de fàrmula ii |
| AR059036A1 (es) * | 2006-01-17 | 2008-03-12 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
-
2013
- 2013-10-10 AR ARP130103679A patent/AR092971A1/es active IP Right Grant
- 2013-10-15 TW TW102137198A patent/TWI620738B/zh active
- 2013-10-18 BR BR112015009032-0A patent/BR112015009032B1/pt active IP Right Grant
- 2013-10-18 PL PL13785745T patent/PL2912021T3/pl unknown
- 2013-10-18 DK DK13785745.4T patent/DK2912021T3/en active
- 2013-10-18 EA EA201590621A patent/EA026037B1/ru not_active IP Right Cessation
- 2013-10-18 HU HUE13785745A patent/HUE034616T2/en unknown
- 2013-10-18 PT PT137857454T patent/PT2912021T/pt unknown
- 2013-10-18 MX MX2015005297A patent/MX364207B/es active IP Right Grant
- 2013-10-18 CA CA2886526A patent/CA2886526C/en active Active
- 2013-10-18 JP JP2015539672A patent/JP6251279B2/ja active Active
- 2013-10-18 KR KR1020157010390A patent/KR101689983B1/ko active Active
- 2013-10-18 CN CN201380055719.9A patent/CN104755464B/zh active Active
- 2013-10-18 EP EP13785745.4A patent/EP2912021B1/en active Active
- 2013-10-18 ES ES13785745.4T patent/ES2645970T3/es active Active
- 2013-10-18 US US14/422,018 patent/US9206139B2/en active Active
- 2013-10-18 NZ NZ706772A patent/NZ706772A/en unknown
- 2013-10-18 WO PCT/US2013/065591 patent/WO2014066151A1/en not_active Ceased
- 2013-10-18 AU AU2013334989A patent/AU2013334989B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015005297A (es) | 2015-07-17 |
| BR112015009032A2 (pt) | 2017-07-04 |
| BR112015009032B1 (pt) | 2022-06-28 |
| PT2912021T (pt) | 2017-11-14 |
| CN104755464A (zh) | 2015-07-01 |
| US20150218107A1 (en) | 2015-08-06 |
| KR101689983B1 (ko) | 2016-12-26 |
| ES2645970T3 (es) | 2017-12-11 |
| MX364207B (es) | 2019-04-16 |
| CA2886526C (en) | 2018-03-27 |
| DK2912021T3 (en) | 2017-10-02 |
| TW201427955A (zh) | 2014-07-16 |
| EA201590621A1 (ru) | 2015-07-30 |
| KR20150058480A (ko) | 2015-05-28 |
| JP2015535248A (ja) | 2015-12-10 |
| EP2912021A1 (en) | 2015-09-02 |
| TWI620738B (zh) | 2018-04-11 |
| JP6251279B2 (ja) | 2017-12-20 |
| AU2013334989A1 (en) | 2015-04-23 |
| CN104755464B (zh) | 2017-03-29 |
| US9206139B2 (en) | 2015-12-08 |
| AU2013334989B2 (en) | 2016-02-18 |
| EP2912021B1 (en) | 2017-08-16 |
| PL2912021T3 (pl) | 2018-01-31 |
| NZ706772A (en) | 2018-05-25 |
| WO2014066151A1 (en) | 2014-05-01 |
| EA026037B1 (ru) | 2017-02-28 |
| CA2886526A1 (en) | 2014-05-01 |
| HUE034616T2 (en) | 2018-02-28 |
| HK1211927A1 (en) | 2016-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR092971A1 (es) | Inhibidores de agrecanasa | |
| EP2704573A4 (en) | AMINOMETHYL biaryl BENZOTRIAZOL DERIVATIVES | |
| CR20140259A (es) | Compuestos novedosos de benzopirano, composiciones y usos de los mismos | |
| CU20180059A7 (es) | Compuestos inhibidores de la quinasa de unión a tank | |
| EP2753701A4 (en) | Acyl-ACP WACHSESTERSYNTHASEN | |
| IL245314A0 (en) | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor | |
| DK2812431T3 (da) | Peptidblandinger til generering af multivirale ctl'er med bred specificitet | |
| UY35683A (es) | Polimorfo de inhibidores de tirosina quinasa de bazo (syk) | |
| EP2931891A4 (en) | RNA-CONTROLLED ENGINEERING OF A HUMAN GENOME | |
| CR20140134A (es) | Composiciones farmacéuticas | |
| EP2796126A4 (en) | OIL-IN-WATER EMULSION COMPOUND | |
| DK2755481T3 (da) | Anvendelse af alginatoligomerer til at forøge virkningerne af svampemidler | |
| BR112013018875A2 (pt) | métodos e composições para a preparação de noribogaína a partir de voacangina | |
| CL2013002123A1 (es) | Composicion herbicida que comprende topramezona y pinoxaden; uso de dicha composicion para controlar vegetación indeseable; formulación indeseable. | |
| BR112015022077A2 (pt) | composto de pirazol-amida e usos medicinais do mesmo | |
| EP2869817A4 (en) | STABLE AQUEOUS FORMULATIONS OF ETANERCEPT | |
| EP2721029A4 (en) | Imidazopyridine-2-ON DERIVATIVES | |
| BR112012031861A2 (pt) | uso de 5a-androstano (alquil)-3b, 5, 6b-triol | |
| BR112012018086A2 (pt) | método para gerar vapor d'água | |
| CO7010828A2 (es) | Preparación farmacéutica que comprende ßciclodextrina sustituida | |
| CR20130375A (es) | Preparaciones que contienen antraquinona/formulaciones de lignina | |
| HK1205095A1 (en) | Methods and intermediates for preparing pharmaceutical agents | |
| EP2931042A4 (en) | ANTHRACYCLINFORMULIERUNGEN | |
| EP2951144A4 (en) | PREPARATION OF HYDROXYALDEHYDE | |
| EP2750849A4 (en) | PREPARATION OF INORGANIC SAMPLES BY MELTING |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |