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PE20060259A1 - Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico - Google Patents

Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico

Info

Publication number
PE20060259A1
PE20060259A1 PE2005000457A PE2005000457A PE20060259A1 PE 20060259 A1 PE20060259 A1 PE 20060259A1 PE 2005000457 A PE2005000457 A PE 2005000457A PE 2005000457 A PE2005000457 A PE 2005000457A PE 20060259 A1 PE20060259 A1 PE 20060259A1
Authority
PE
Peru
Prior art keywords
bromide
octane
hydroxy
alkyl
optionally substituted
Prior art date
Application number
PE2005000457A
Other languages
English (en)
Inventor
Dramane Ibrahim Laine
Michael R Palovich
Brent W Mccleland
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35242158&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060259(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20060259A1 publication Critical patent/PE20060259A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE QUINUCLIDINA DE FORMULA (I), EN DONDE R1 ES ALQUILO(C1-C15) OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C10)-ARILO O CICLOARILO, ALQUENILO(C2-C10), (CR7R7)qORc, O ES a), b), c), ENTRE OTROS. R2 Y R3 SON INDEPENDIENTEMENTE FENIL, 2-TIENIL, 3-TIENIL, OPCIONALMENTE SUSTITUIDOS POR H, HALOGENO, ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO O ALCOXI(C1-C4); X- ES UN ANION COMO CLORURO, BROMURO, YODURO, HIDROXIDO, SULFATO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BROMURO DE 4-[HIDROXI(DIFENIL)METIL]-1-{2-[(FENILMETIL)OXI]ETIL}-1-AZONIABICICLO[2,2,2] OCTANO, BROMURO DE 1-[2-(1-BENZOFURAN-2-UIL)-2-OXOETIL]-4-[HIDROXI(DIFENIL)METIL]-1-AZONIABICICLO[2.2.2] OCTANO, BROMURO DE 4-[HIDROXI(DI-3-TIENIL)METIL]-1-[2-FENILOXI)PROPIL]-1-AZONIABICICLO[2,2,2] OCTANO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE RECEPTORES DE ACETILCOLINA MUSCARINICO (mAChR), ESPECFICAMENTE M3, POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDAD PULMONAR OBSTRUCTICVA CRONICA, BRONQUITIS CRONICA, ASMA, FIBROSIS PULMONAR, EFISMA PULMONAR Y RINITIS ALERGICA
PE2005000457A 2004-04-27 2005-04-25 Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico PE20060259A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56562304P 2004-04-27 2004-04-27

Publications (1)

Publication Number Publication Date
PE20060259A1 true PE20060259A1 (es) 2006-03-25

Family

ID=35242158

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000457A PE20060259A1 (es) 2004-04-27 2005-04-25 Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico

Country Status (38)

Country Link
US (9) US7498440B2 (es)
EP (3) EP3111936A1 (es)
JP (2) JP5014121B2 (es)
KR (2) KR101037026B1 (es)
CN (2) CN1976701A (es)
AP (1) AP2213A (es)
AR (1) AR050902A1 (es)
AU (1) AU2005237576B2 (es)
BE (1) BE2014C063I2 (es)
BR (1) BRPI0510170B8 (es)
CA (2) CA2755954C (es)
CY (3) CY1113196T1 (es)
DK (2) DK1740177T3 (es)
EA (2) EA021994B1 (es)
EC (1) ECSP066940A (es)
ES (2) ES2392848T4 (es)
FR (1) FR14C0075I2 (es)
HR (2) HRP20120832T1 (es)
HU (2) HUE031304T2 (es)
IL (1) IL178152A (es)
LT (1) LT2570128T (es)
LU (1) LU92565I2 (es)
MA (1) MA28631B1 (es)
MX (1) MXPA06012405A (es)
MY (1) MY144753A (es)
NL (1) NL300694I2 (es)
NO (3) NO338959B1 (es)
NZ (1) NZ549997A (es)
PE (1) PE20060259A1 (es)
PL (2) PL2570128T3 (es)
PT (2) PT2570128T (es)
SG (1) SG186597A1 (es)
SI (2) SI1740177T1 (es)
TW (1) TWI363759B (es)
UA (1) UA95768C2 (es)
UY (1) UY28871A1 (es)
WO (1) WO2005104745A2 (es)
ZA (1) ZA200608565B (es)

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