PE20091649A1 - Derivados de pirrolidinilo - Google Patents
Derivados de pirrolidiniloInfo
- Publication number
- PE20091649A1 PE20091649A1 PE2009000424A PE2009000424A PE20091649A1 PE 20091649 A1 PE20091649 A1 PE 20091649A1 PE 2009000424 A PE2009000424 A PE 2009000424A PE 2009000424 A PE2009000424 A PE 2009000424A PE 20091649 A1 PE20091649 A1 PE 20091649A1
- Authority
- PE
- Peru
- Prior art keywords
- lower alkyl
- indol
- pyrrolidin
- hydroxy
- benzyl
- Prior art date
Links
- -1 PYRROLIDINYL Chemical class 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000032841 Bulimia Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009103 reabsorption Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRROLIDINILO DE FORMULA (I) DONDE UNO DE Z1 Y Z2 ES N(Ra) Y EL OTRO ES CH2, DONDE Ra ES H, ALQUILO INFERIOR O BENCILO; X E Y SON CADA UNO CH O N; m ES 0 O 1; R ES HIDROXI, HALOGENO, ALQUILO INFERIOR, ENTRE OTROS; Q ES CH, C(Rb) O N, DONDE Rb ES Rb' O Rb''; Rb' ES HIDROXI, HALOGENO, CN, ENTRE OTROS; Rb'' ES ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR, ENTRE OTROS; Ra' ES H, ALQUILO INFERIOR, CICLOALQUIL-ALQUILO, ENTRE OTROS; n ES 0 O 1; R2a Y R2b SON CADA UNO H, HIDROXI, ALQUILO INFERIOR, ENTRE OTROS; R3 ES HALOGENO, HIDROXI, ALQUILO INFERIOR; ENTRE OTROS; r ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: 5-(3-BENCIL-PIRROLIDIN-3-IL)-1H-INDOL, 5-(3-PIRIDIN-2-ILMETIL-PIRROLIDIN-3-IL)-1H-INDOL, 5-(1,3-DIBENCIL-PIRROLIDIN-3-IL)-1H-INDOL, 5-(3-BENCIL-PIRROLIDIN-3-IL)-1H-INDOL-3-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE REABSORCION DE MONOAMINAS SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, ENFERMEDAD DE ALZHEIMER, ANOREXIA, BULIMIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3816008P | 2008-03-20 | 2008-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091649A1 true PE20091649A1 (es) | 2009-11-04 |
Family
ID=40651460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000424A PE20091649A1 (es) | 2008-03-20 | 2009-03-20 | Derivados de pirrolidinilo |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110021556A1 (es) |
| EP (1) | EP2257545B1 (es) |
| JP (1) | JP2011515355A (es) |
| KR (1) | KR101209373B1 (es) |
| CN (1) | CN101977907A (es) |
| AR (1) | AR070930A1 (es) |
| AT (1) | ATE522519T1 (es) |
| AU (1) | AU2009226868A1 (es) |
| BR (1) | BRPI0909737A2 (es) |
| CA (1) | CA2718736A1 (es) |
| CL (1) | CL2009000665A1 (es) |
| ES (1) | ES2370593T3 (es) |
| IL (1) | IL207223A0 (es) |
| MX (1) | MX2010009147A (es) |
| PE (1) | PE20091649A1 (es) |
| TW (1) | TW200942529A (es) |
| WO (1) | WO2009115427A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013538800A (ja) * | 2010-08-10 | 2013-10-17 | アッヴィ・インコーポレイテッド | 新規ｔｒｐｖ３モジュレーター |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| CN110662541B (zh) * | 2017-03-12 | 2023-02-10 | 王晓冬 | 多环胺作为阿片受体调节剂 |
| US11584765B2 (en) | 2017-03-12 | 2023-02-21 | Ecstasy LLC | Polycyclic amines as sigma receptor modulators |
| US11787780B2 (en) * | 2020-06-22 | 2023-10-17 | Corcept Therapeutics Incorporated | Quaternary indazole glucocorticoid receptor antagonists |
| CN116897043A (zh) * | 2020-07-01 | 2023-10-17 | 艾斯特希有限责任公司 | 用于阿片受体调节的多环胺 |
| MX2024007590A (es) | 2021-12-21 | 2024-08-20 | Corcept Therapeutics Inc | Antagonistas piperazino indazólicos del receptor de glucocorticoides. |
| AU2022421212A1 (en) | 2021-12-21 | 2024-07-04 | Corcept Therapeutics Incorporated | Bicyclic indazole glucocorticoid receptor antagonists |
| CN117285452A (zh) * | 2023-09-19 | 2023-12-26 | 苏州雄鹰笔墨新材料有限公司 | 一种取代琥珀酰亚胺及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5079202B2 (ja) * | 2000-07-18 | 2012-11-21 | 大日本住友製薬株式会社 | セロトニン再取り込み阻害剤 |
| TWI439452B (zh) * | 2005-05-13 | 2014-06-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物（二） |
| ES2401129T3 (es) * | 2006-12-19 | 2013-04-17 | F. Hoffmann-La Roche Ag | Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona |
-
2009
- 2009-03-10 EP EP09722963A patent/EP2257545B1/en not_active Not-in-force
- 2009-03-10 CA CA2718736A patent/CA2718736A1/en not_active Abandoned
- 2009-03-10 ES ES09722963T patent/ES2370593T3/es active Active
- 2009-03-10 US US12/922,656 patent/US20110021556A1/en not_active Abandoned
- 2009-03-10 AT AT09722963T patent/ATE522519T1/de active
- 2009-03-10 WO PCT/EP2009/052748 patent/WO2009115427A1/en not_active Ceased
- 2009-03-10 CN CN2009801100150A patent/CN101977907A/zh active Pending
- 2009-03-10 MX MX2010009147A patent/MX2010009147A/es active IP Right Grant
- 2009-03-10 KR KR1020107020629A patent/KR101209373B1/ko not_active Expired - Fee Related
- 2009-03-10 AU AU2009226868A patent/AU2009226868A1/en not_active Abandoned
- 2009-03-10 BR BRPI0909737-6A patent/BRPI0909737A2/pt not_active IP Right Cessation
- 2009-03-10 JP JP2011500151A patent/JP2011515355A/ja active Pending
- 2009-03-17 TW TW098108642A patent/TW200942529A/zh unknown
- 2009-03-18 AR ARP090100963A patent/AR070930A1/es unknown
- 2009-03-19 CL CL2009000665A patent/CL2009000665A1/es unknown
- 2009-03-20 PE PE2009000424A patent/PE20091649A1/es not_active Application Discontinuation
-
2010
- 2010-07-26 IL IL207223A patent/IL207223A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009226868A1 (en) | 2009-09-24 |
| EP2257545B1 (en) | 2011-08-31 |
| US20110021556A1 (en) | 2011-01-27 |
| KR20100118601A (ko) | 2010-11-05 |
| ES2370593T3 (es) | 2011-12-20 |
| CL2009000665A1 (es) | 2010-04-09 |
| BRPI0909737A2 (pt) | 2019-03-06 |
| EP2257545A1 (en) | 2010-12-08 |
| AR070930A1 (es) | 2010-05-12 |
| MX2010009147A (es) | 2010-09-07 |
| KR101209373B1 (ko) | 2012-12-06 |
| CA2718736A1 (en) | 2009-09-24 |
| WO2009115427A1 (en) | 2009-09-24 |
| TW200942529A (en) | 2009-10-16 |
| ATE522519T1 (de) | 2011-09-15 |
| IL207223A0 (en) | 2010-12-30 |
| CN101977907A (zh) | 2011-02-16 |
| JP2011515355A (ja) | 2011-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |