[go: up one dir, main page]

NO20084674L - 1- [ (4-(benzoyl (metyl) amino] -3- (fenyl) butyl] azetidinderivater for behandling av gastrointestinale lidelser - Google Patents

1- [ (4-(benzoyl (metyl) amino] -3- (fenyl) butyl] azetidinderivater for behandling av gastrointestinale lidelser

Info

Publication number
NO20084674L
NO20084674L NO20084674A NO20084674A NO20084674L NO 20084674 L NO20084674 L NO 20084674L NO 20084674 A NO20084674 A NO 20084674A NO 20084674 A NO20084674 A NO 20084674A NO 20084674 L NO20084674 L NO 20084674L
Authority
NO
Norway
Prior art keywords
treatment
gastrointestinal disorders
benzoyl
phenyl
butyl
Prior art date
Application number
NO20084674A
Other languages
English (en)
Inventor
Carl-Gustaf Sigfridsson
Anders Johansson
Johan Johansson
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38723558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20084674(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Albireo Ab filed Critical Albireo Ab
Publication of NO20084674L publication Critical patent/NO20084674L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

(I) Foreliggende oppfinnelse angår nye forbindelser med formel (I), hvor R1, R2 og X er som definert i beskrivelsen, så vel som salter og enantiomerer derav. Oppfinnelsen angår også farmasøytiske preparater omfattende nevnte forbindelser og anvendelse av nevnte forbindelser i terapi, for eksempel for behandling av gastrointestinale lidelser. Oppfinnelsen angår videre fremgangsmåter for fremstilling av forbindelsene. Forbindelsene er neurokinin- (NK) reseptor-antagonister.
NO20084674A 2006-05-18 2008-11-06 1- [ (4-(benzoyl (metyl) amino] -3- (fenyl) butyl] azetidinderivater for behandling av gastrointestinale lidelser NO20084674L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80157706P 2006-05-18 2006-05-18
PCT/SE2007/000482 WO2007136324A1 (en) 2006-05-18 2007-05-16 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 1

Publications (1)

Publication Number Publication Date
NO20084674L true NO20084674L (no) 2009-01-29

Family

ID=38723558

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084674A NO20084674L (no) 2006-05-18 2008-11-06 1- [ (4-(benzoyl (metyl) amino] -3- (fenyl) butyl] azetidinderivater for behandling av gastrointestinale lidelser

Country Status (23)

Country Link
US (1) US8106208B2 (no)
EP (1) EP2024354B1 (no)
JP (1) JP5196381B2 (no)
KR (1) KR101429779B1 (no)
CN (1) CN101472910B (no)
AR (1) AR060956A1 (no)
AT (1) ATE525355T1 (no)
AU (1) AU2007253666B2 (no)
BR (1) BRPI0712405A2 (no)
CA (1) CA2652443C (no)
DK (1) DK2024354T3 (no)
ES (1) ES2373335T3 (no)
IL (1) IL195197A (no)
MX (1) MX2008014686A (no)
MY (1) MY147474A (no)
NO (1) NO20084674L (no)
PL (1) PL2024354T3 (no)
PT (1) PT2024354E (no)
RU (1) RU2439067C2 (no)
TW (1) TW200813006A (no)
UY (1) UY30356A1 (no)
WO (1) WO2007136324A1 (no)
ZA (1) ZA200809909B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057828A1 (es) * 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
WO2008031227A1 (en) * 2006-09-14 2008-03-20 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
ES2445049T3 (es) * 2007-03-08 2014-02-27 Albireo Ab Derivados del ácido 3-fenilpropiónico y su uso en el tratamiento de la enfermedad inflamatoria intestinal
CA2721303C (en) * 2008-05-08 2016-06-28 Evotec Ag Azetidines and cyclobutanes as histamine h3 receptor antagonists
CA2815350A1 (en) * 2010-10-22 2012-04-26 Janssen Pharmaceutica Nv Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors
KR20140072897A (ko) * 2011-09-30 2014-06-13 얀센 파마슈티카 엔.브이. （１－（４－플루오로페닐）－１ｈ－인돌－５－일）－（３－（４－（티아졸－2－카르보닐）피페라진－１－일）아제티딘－１－일）메탄온의 결정성 하이드로클로라이드 염，및 통증 및 대사 장애의 치료에 있어서의 이의 용도
CN104529833B (zh) * 2014-12-10 2016-04-20 广东东阳光药业有限公司 取代的环丁烷羧酸类化合物及其用途
KR102476938B1 (ko) 2017-12-07 2022-12-13 기초과학연구원 핫전자 기반의 산화물-금속 하이브리드 역촉매

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310066D0 (en) 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
GB9317104D0 (en) 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
TW432061B (en) * 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
GB9502644D0 (en) 1995-02-10 1995-03-29 Zeneca Ltd Heterocyclic derivatives
GB9600235D0 (en) 1996-01-05 1996-03-06 Pfizer Ltd Therapeutic agents
GB9601202D0 (en) 1996-01-22 1996-03-20 Pfizer Ltd Piperidones
GB9601697D0 (en) 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
GB9601680D0 (en) 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
GB9714129D0 (en) 1997-07-04 1997-09-10 Pfizer Ltd Azetidines
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
CN1309638A (zh) * 1998-07-10 2001-08-22 阿斯特拉曾尼卡有限公司 作为神经激肽受体拮抗剂的n－取代的萘甲酰胺
GB9922521D0 (en) 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9922519D0 (en) 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9924141D0 (en) 1998-10-30 1999-12-15 Zeneca Ltd Treatment of gastric asthma
GB9826941D0 (en) 1998-12-09 1999-02-03 Zeneca Pharmaceuticals Compounds
SE0004827D0 (sv) 2000-12-22 2000-12-22 Astrazeneca Ab Therapeutic compounds
SE0103795D0 (sv) 2001-11-02 2001-11-02 Astrazeneca Ab Compounds and method for the treatment of överactive bladder
TW200508221A (en) 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds
MX2007015606A (es) * 2005-06-23 2008-02-25 Astrazeneca Ab Nuevos derivados de azetidina como antagonistas del receptor de neuroquinina para el tratamiento de enfermedades gastrointestinales.
JP2008546768A (ja) * 2005-06-23 2008-12-25 アストラゼネカ・アクチエボラーグ 胃腸疾患を治療するためのニューロキニン受容体アンタゴニストとしての新規なアゼチジン誘導体
AR057828A1 (es) * 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
AR056087A1 (es) * 2005-09-29 2007-09-19 Astrazeneca Ab Derivados de azetidina como antagonistas de receptores de neuroquina nk

Also Published As

Publication number Publication date
JP5196381B2 (ja) 2013-05-15
AR060956A1 (es) 2008-07-23
KR101429779B1 (ko) 2014-08-19
EP2024354B1 (en) 2011-09-21
AU2007253666B2 (en) 2012-03-15
AU2007253666A1 (en) 2007-11-29
DK2024354T3 (da) 2012-01-16
ZA200809909B (en) 2009-08-26
MX2008014686A (es) 2009-02-10
HK1121758A1 (en) 2009-04-30
IL195197A0 (en) 2009-08-03
JP2009537516A (ja) 2009-10-29
CN101472910A (zh) 2009-07-01
CN101472910B (zh) 2014-03-26
ES2373335T3 (es) 2012-02-02
CA2652443A1 (en) 2007-11-29
CA2652443C (en) 2014-01-14
BRPI0712405A2 (pt) 2012-10-16
EP2024354A1 (en) 2009-02-18
PL2024354T3 (pl) 2012-02-29
EP2024354A4 (en) 2009-11-11
MY147474A (en) 2012-12-14
US20070270398A1 (en) 2007-11-22
WO2007136324A1 (en) 2007-11-29
RU2008149927A (ru) 2010-06-27
KR20090018926A (ko) 2009-02-24
TW200813006A (en) 2008-03-16
US8106208B2 (en) 2012-01-31
IL195197A (en) 2013-10-31
RU2439067C2 (ru) 2012-01-10
UY30356A1 (es) 2008-01-02
ATE525355T1 (de) 2011-10-15
PT2024354E (pt) 2011-12-19

Similar Documents

Publication Publication Date Title
NO20063470L (no) Tetrazolforbindelser og deres anvendelse av metabotrofe glutamatreseptorantagonister
NO20063599L (no) Ytterligere heterosykliske forbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister
NO20084674L (no) 1- [ (4-(benzoyl (metyl) amino] -3- (fenyl) butyl] azetidinderivater for behandling av gastrointestinale lidelser
NO20063468L (no) Triazolforbindelser og deres anvendelse som metabotrofe glutamatreseptorantagonister
NO341591B1 (no) 3-Z-[1-(4-(N-((4-metyl-piperazin-1-yl)-metylkarbonyl)-N-metyl-amino)-anilino)-1-fenyl-metylen]-6-metoksykarbonyl-2-indolinon, tautomerene, diastereomerene, enantiomerene, blandinger derav og saltene derav, og i kombinasjon med en ytterligere farmakologisk aktiv substans, for anvendelse i forebygging eller behandling av fibrose ved revmatoid artritt
NO20073663L (no) Tiazol-4-karboksamid-derivater som mGluR5 antagonister
NO20071140L (no) Nye piperidinderivater som histamin H3 reseptorligander for behandling av depresjon
NO20091590L (no) Heterocykliske amidforbindelser anvendbare som kinaseinhibitorer
PE20060748A1 (es) Derivados de indolcarboxamida como inhibidores de quinasa ikk2
NO20062677L (no) Benzyleteraminforbindelser anvendbare som CCR-5-antagonister
NO20076060L (no) Piperidin-4-yl-amidderivater og deres anvendelse som SST-reseptor subtype 5-antagonister
NO20070445L (no) Pyrimidinderivater.
NO20063469L (no) Polyeheterosykliske forbindelser og deres anvendelse som metabotrofe glutamat reseptorantagonister
NO20071593L (no) Pyrimidinderivater
NO20083514L (no) Heterobicykliske sulfonamidderivater for behandling av diabetes
NZ594597A (en) Substituted piperidines as ccr3 antagonists
NO20080670L (no) Substituerte piperaziner som metabotrofiske glutamatreseptorantagonister
NO20084418L (no) Azolopyridin-3-on derivater som inhibitorer av endoteliallipase
NO20085068L (no) Fenylamino-benzoksazolsubstituerte karboksylsyrer, fremgangsmate for deres fremstilling og anvendelse derav som medikamenter
NO20076424L (no) N-koblete heterocykliske antagonister av P2Y1 reseptoren nyttige for behandling av tromboseforstyrrelser
NO20082388L (no) Heteroaryl substituerte piperidinderivater som L-CPT1 inhibitorer
NO20080445L (no) Nye azetidinderivater som neurokininreseptorantagonister for behandling av gastrointestinale sykdommer
NO20084318L (no) Inhibitorer av II-beta-hydroksystereoid dehydrogenase I
NO20070336L (no) Indolderivater som histamin-reseptorantagonister
NO20070213L (no) Glucagon reseptorantagonister, fremstilling og terapeutiske anvendelser

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application