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PE20060855A1 - Derivados de carboxamida biciclicos fusionados como inhibidores de cxcr2 - Google Patents

Derivados de carboxamida biciclicos fusionados como inhibidores de cxcr2

Info

Publication number
PE20060855A1
PE20060855A1 PE2006000027A PE2006000027A PE20060855A1 PE 20060855 A1 PE20060855 A1 PE 20060855A1 PE 2006000027 A PE2006000027 A PE 2006000027A PE 2006000027 A PE2006000027 A PE 2006000027A PE 20060855 A1 PE20060855 A1 PE 20060855A1
Authority
PE
Peru
Prior art keywords
cxcr2
bicycle
inhibitors
independently
triathione
Prior art date
Application number
PE2006000027A
Other languages
English (en)
Inventor
Stephanie Knieps
Juergen Dedio
Werngard Czechtizky
Stephen Shimshock
Carolina Lanter
Rosy Sher
Aleksandra Weichsel
Hui Li
Raymond W Kosley
Sven Grueneberg
Holger Heitsch
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20060855A1 publication Critical patent/PE20060855A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CARBOXAMIDA BICICLICOS FUSIONADOS DE FORMULA (I), EN DONDE X ES -CR3=CR4-, -S-, -CR5=N-, ENTRE OTROS, DONDE R3, R4, R5 SON INDEPENDIENTEMENTE H, F, Cl, Br, ENTRE OTROS; Y1, Y2, Y3 E Y4 SON INDEPENDIENTEMENTE -CR8-, DONDE R8 ES H, F, Cl; A ES CICLOALQUILO(C3-C8), HETEROCICLO O ARILO, OPCIONALMENTE CONDENSADOS AL ARILO TAL COMO CICLOHEXILO, FENILO, PIPERIDILO, NAFTILO, BENZO[1,4]DIOXANILO, TIENILO, ISOXAZOLILO, TRIAZOLILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; B ES -OC(R11R12)-, NR17-C(R18R19)-, ENTRE OTROS; D ES C(O)OH, C(O)NHR21, C(N-OH)NHR22, ENTRE OTROS; R1 Y R2 SON INDEPENDIENTEMENTE ALQUILO(C1-C3) O JUNTOS FORMAN UN ANILLO(C3-C5). SON PREFERIDOS: ACIDO 2-[(1-CICLOHEXILMETOXI-NAFTALENO-2-CARBONIL-AMINO]-PROPIONICO, ACIDO 2-{[1-(4-BROMO-BENCILOXI)NAFTALENO-2-CARBONIL]-AMINO}-2-METIL-PROPIONICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE RECEPTORES DE QUIMIOQUINAS CXC, Y PARTICULARMENTE DE CXCR2, POR LO QUE SON UTILES EN EL TRATAMIENTO Y PROFILAXIS DE ENFERMEDADES INFLAMATORIAS AGUDAS Y CRONICAS
PE2006000027A 2004-12-30 2006-01-03 Derivados de carboxamida biciclicos fusionados como inhibidores de cxcr2 PE20060855A1 (es)

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AU2005321609A1 (en) 2006-07-06
AR055830A1 (es) 2007-09-12
CA2592430A1 (en) 2006-07-06
RU2404962C2 (ru) 2010-11-27
IL184173A0 (en) 2007-10-31
MA29113B1 (fr) 2007-12-03
EP1836158B1 (en) 2012-02-01
AU2005321609B2 (en) 2011-02-17
MX2007007068A (es) 2007-08-08
US7919628B2 (en) 2011-04-05
RU2007128949A (ru) 2009-02-10
US20080090854A1 (en) 2008-04-17
UY29322A1 (es) 2006-07-31
KR20070091634A (ko) 2007-09-11
BRPI0519452A2 (pt) 2009-01-27
JP2008526695A (ja) 2008-07-24
US20110184177A1 (en) 2011-07-28
NZ556192A (en) 2010-06-25
US8283479B2 (en) 2012-10-09
JP5123667B2 (ja) 2013-01-23
WO2006069656A1 (en) 2006-07-06
EP1836158A1 (en) 2007-09-26
ATE543795T1 (de) 2012-02-15
TW200639141A (en) 2006-11-16
IL184173A (en) 2011-10-31
EP1676834A1 (en) 2006-07-05
ZA200704089B (en) 2008-09-25
NO20073932L (no) 2007-08-09

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