[go: up one dir, main page]

PE20110409A1 - Compuestos heterociclicos antiviricos - Google Patents

Compuestos heterociclicos antiviricos

Info

Publication number
PE20110409A1
PE20110409A1 PE2011000046A PE2011000046A PE20110409A1 PE 20110409 A1 PE20110409 A1 PE 20110409A1 PE 2011000046 A PE2011000046 A PE 2011000046A PE 2011000046 A PE2011000046 A PE 2011000046A PE 20110409 A1 PE20110409 A1 PE 20110409A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
hydroxy
halogen
antiviric
Prior art date
Application number
PE2011000046A
Other languages
English (en)
Inventor
Kenneth Albert Brameld
David Scott Carter
Elbert Chin
Vicente Fidalgo Javier De
Jim Li
Ryan Craig Schoenfeld
Eric Brian Sjogren
Francisco Xavier Talamas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20110409A1 publication Critical patent/PE20110409A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C6, HALOALQUILO C1-C6, HALOGENO, HIDROXI, ENTRE OTROS; R2 ES ALQUILO C1-C6, HIDROXIALQUILO C1-C6, ALCOXI C1-C6, HIDROXI, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, HALOALCOXI C1-C6, HALOGENO, ENTRE OTROS; R4a, R4b, R4c SON CADA UNO ALQUILO C1-C3, ALCOXI C1-C2, HIDROXIALQUILO C1-C3, CO2H, ENTRE OTROS; R5 ES H, HALOGENO, ALQUILO C1-C6, HIDROXI, ENTRE OTROS; R6 ES HALOGENO, ALQUILO C1-C6, HALOALQUILO C1-C3, ALCOXI C1-C3, ENTRE OTROS; n ES 0-2. SON COMPUESTOS PREFERIDOS: 3-(3-TERT-BUTIL-FENIL)-1H-PIRIDIN-2-ONA; 3-(3-TERT-BUTIL-4-DIFLUORMETOXI-FENIL)-1h-PIRIDIN-2-ONA; 3-(5-TERT-BUTIL-3-ETIL-2-HIDROXI-FENIL)-1H-PIRIDIN-2-ONA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE UNA ENFERMEDAD CAUSADA POR EL VIRUS DE LA HEPATITIS C
PE2011000046A 2008-07-23 2009-07-15 Compuestos heterociclicos antiviricos PE20110409A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8284708P 2008-07-23 2008-07-23
US20792509P 2009-02-17 2009-02-17
US17983709P 2009-05-20 2009-05-20

Publications (1)

Publication Number Publication Date
PE20110409A1 true PE20110409A1 (es) 2011-06-22

Family

ID=41057595

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000046A PE20110409A1 (es) 2008-07-23 2009-07-15 Compuestos heterociclicos antiviricos

Country Status (18)

Country Link
US (1) US8273773B2 (es)
EP (1) EP2307372B1 (es)
JP (1) JP2011528686A (es)
KR (1) KR20110033291A (es)
CN (1) CN102099335A (es)
AR (1) AR072824A1 (es)
AT (1) ATE555096T1 (es)
AU (1) AU2009273327A1 (es)
BR (1) BRPI0916233A2 (es)
CA (1) CA2730517A1 (es)
CL (1) CL2011000136A1 (es)
ES (1) ES2383273T3 (es)
IL (1) IL209696A0 (es)
MX (1) MX2011000656A (es)
PE (1) PE20110409A1 (es)
TW (1) TW201008922A (es)
WO (1) WO2010010017A1 (es)
ZA (1) ZA201009183B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2542099C2 (ru) 2007-09-17 2015-02-20 Эббви Бахамаз Лтд. N-фенил-диоксо-гидропиримидины, используемые в качестве ингибитора вируса гепатита с (hcv)
EP2725015A1 (en) 2007-09-17 2014-04-30 AbbVie Bahamas Ltd. Uracil or thymine derivative for treating hepatitis c
ES2523864T3 (es) 2007-09-17 2014-12-02 Abbvie Bahamas Ltd. Pirimidinas antiinfecciosas y usos de las mismas
EP2334662A1 (en) * 2008-09-26 2011-06-22 F. Hoffmann-La Roche AG Pyrine or pyrazine derivatives for treating hcv
AU2009309813A1 (en) * 2008-10-30 2010-05-06 F. Hoffmann-La Roche Ag Heterocyclic antiviral arylpyridone derivatives
AU2010220374A1 (en) * 2009-03-06 2011-09-01 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
ES2488821T3 (es) * 2009-03-24 2014-08-29 Abbvie Bahamas Ltd. Proceso de preparación de un compuesto antiviral
SG10201400957UA (en) * 2009-03-25 2014-09-26 Abbott Lab Antiviral Compounds And Uses Thereof
KR20120011880A (ko) * 2009-04-25 2012-02-08 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스성 화합물
MX2011012240A (es) * 2009-05-20 2011-12-08 Hoffmann La Roche Compuestos heterociclicos antivirales.
AR084370A1 (es) * 2009-08-07 2013-05-15 Chugai Pharmaceutical Co Ltd Derivados de aminopirazol
WO2011033045A1 (en) * 2009-09-21 2011-03-24 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
JP2013511489A (ja) 2009-11-21 2013-04-04 エフ．ホフマン−ラ ロシュ アーゲー 複素環式抗ウイルス化合物
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
EP2593439B1 (en) 2010-07-16 2016-08-17 AbbVie Bahamas Ltd. Process for preparing antiviral compounds
EP2593226B1 (en) 2010-07-16 2018-11-14 AbbVie Ireland Unlimited Company Phosphine ligands for catalytic reactions
JP5620417B2 (ja) * 2011-02-07 2014-11-05 中外製薬株式会社 アミノピラゾール誘導体を含む医薬
NO2686520T3 (es) 2011-06-06 2018-03-17
TW201329025A (zh) 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
WO2014022461A1 (en) 2012-07-31 2014-02-06 Dow Global Technologies Llc Method of making an olefin polymerization catalyst activator
WO2014095555A1 (en) 2012-12-19 2014-06-26 Basf Se New substituted triazoles and imidazoles and their use as fungicides
SI3007695T1 (sl) 2013-06-13 2024-04-30 Akebia Therapeutics, Inc. Sestavki in metode za zdravljenje anemije
MX362994B (es) 2013-07-31 2019-03-01 Chugai Pharmaceutical Co Ltd Preparacion farmaceutica que comprende un derivado de aminopirazol.
SG11201604477SA (en) * 2013-12-13 2016-07-28 Vertex Pharma Prodrugs of pyridone amides useful as modulators of sodium channels
EP3087986B1 (en) 2013-12-27 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Fgfr gatekeeper mutant gene and drug targeting same
JP2018502882A (ja) 2015-01-23 2018-02-01 アケビア セラピューティクス インコーポレイテッドＡｋｅｂｉａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． ２−（５−（３−フルオロフェニル）−３−ヒドロキシピコリンアミド）酢酸の固体形態、その組成物及び使用
HRP20211862T1 (hr) 2015-04-01 2022-03-04 Akebia Therapeutics, Inc. Pripravci za i postupci liječenja anemije
US10479780B2 (en) 2015-06-17 2019-11-19 Chugai Seiyaku Kabushiki Kaisha Aminopyrazole derivatives
TWI822776B (zh) 2018-05-09 2023-11-21 美商阿克比治療有限公司 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法
CN110724091B (zh) * 2019-12-04 2022-03-11 阿里生物新材料（常州）有限公司 一种6-（二氟甲基）-2-羟基吡啶-3-磺酰氯的合成方法
CN112898200A (zh) * 2021-01-20 2021-06-04 都创(上海)医药科技股份有限公司 5-溴-6-甲氧基吡啶-2-羧酸酯的合成方法
CN112876409A (zh) * 2021-01-20 2021-06-01 都创(上海)医药科技股份有限公司 一种2-(5-溴-6-甲氧基吡啶-2-基)乙腈及其衍生物的合成方法
CN117285510A (zh) * 2023-09-21 2023-12-26 西南大学 苯并吡啶酮乙烯嘧啶类化合物及其制备方法和医药应用
CN117285509A (zh) * 2023-09-21 2023-12-26 西南大学 氰乙烯桥联的喹诺酮咪唑类及其类似物的制备方法和医药应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
EP1292310A1 (en) 2000-05-10 2003-03-19 SmithKline Beecham Corporation Novel anti-infectives
KR20050065670A (ko) * 2002-11-01 2005-06-29 아보트 러보러터리즈 항감염제
US20040097492A1 (en) 2002-11-01 2004-05-20 Pratt John K Anti-infective agents
JP2008510748A (ja) * 2004-08-23 2008-04-10 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス４’−アジド−ヌクレオシド
WO2008082488A1 (en) * 2006-12-22 2008-07-10 Schering Corporation 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections
BRPI0816116A2 (pt) 2007-08-29 2015-03-03 Schering Corp Derivados de indol 2,3-substituídos para o tratamento de infecções virais.
TW200918536A (en) 2007-08-29 2009-05-01 Schering Corp Tetracyclic indole derivatives and methods of use thereof
TW200911807A (en) 2007-08-29 2009-03-16 Schering Corp 2,3-substituted azaindole derivatives and methods of use thereof
RU2542099C2 (ru) 2007-09-17 2015-02-20 Эббви Бахамаз Лтд. N-фенил-диоксо-гидропиримидины, используемые в качестве ингибитора вируса гепатита с (hcv)
EP2725015A1 (en) 2007-09-17 2014-04-30 AbbVie Bahamas Ltd. Uracil or thymine derivative for treating hepatitis c
ES2523864T3 (es) 2007-09-17 2014-12-02 Abbvie Bahamas Ltd. Pirimidinas antiinfecciosas y usos de las mismas
CN102317285A (zh) 2007-11-16 2012-01-11 先灵公司 3-氨基磺酰基取代的吲哚衍生物及其使用方法
MX2010005356A (es) 2007-11-16 2010-05-27 Schering Corp Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
JP5571167B2 (ja) 2009-03-25 2014-08-13 アッヴィ・インコーポレイテッド 抗ウイルス組成物およびこの使用
SG10201400957UA (en) 2009-03-25 2014-09-26 Abbott Lab Antiviral Compounds And Uses Thereof

Also Published As

Publication number Publication date
IL209696A0 (en) 2011-02-28
TW201008922A (en) 2010-03-01
JP2011528686A (ja) 2011-11-24
ZA201009183B (en) 2013-05-29
CA2730517A1 (en) 2010-01-28
CL2011000136A1 (es) 2011-07-08
KR20110033291A (ko) 2011-03-30
EP2307372A1 (en) 2011-04-13
US8273773B2 (en) 2012-09-25
MX2011000656A (es) 2011-02-23
WO2010010017A1 (en) 2010-01-28
BRPI0916233A2 (pt) 2018-03-13
AU2009273327A1 (en) 2010-01-28
AR072824A1 (es) 2010-09-22
ES2383273T3 (es) 2012-06-19
ATE555096T1 (de) 2012-05-15
US20100021423A1 (en) 2010-01-28
CN102099335A (zh) 2011-06-15
EP2307372B1 (en) 2012-04-25

Similar Documents

Publication Publication Date Title
PE20110409A1 (es) Compuestos heterociclicos antiviricos
PE20080772A1 (es) Nuevos derivados de bipiridina sustituidos y su uso
PE20141598A1 (es) Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina
PE20141203A1 (es) Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas
PE20140245A1 (es) Compuesto de furo[3,2-d]pirimidina
PE20121506A1 (es) Compuestos triazolopiridinas como inhibidores de c-met
PE20120659A1 (es) Inhibidores de la replicacion del virus de la inmunodeficiencia humana
PE20120690A1 (es) Derivados de 5-fluoropirimidinona
PE20141682A1 (es) Derivados de (4-fenilimidazol-2-il) etilamina utiles como moduladores de canal de sodio
AR078944A1 (es) Inhibidores de n1-pirazoloespirocetona acetil-coa carboxilasa
PE20130155A1 (es) Derivados de ariletinilo
PE20120632A1 (es) Inhibidores de bace
AR077977A1 (es) Compuestos y composiciones como inhibidores de cinasa de proteina
PE20140161A1 (es) Compuesto biciclico
AR072952A1 (es) Compuestos de 2-imino-3-metilpirrolopirimidinona fenilo-sustituida como inhibidores de bace-1, composiciones y su uso
PE20081836A1 (es) Derivados de piperidina como inhibidores de la sintasa de acido graso
PE20142148A1 (es) Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio
PE20131153A1 (es) Inhibidores de la tirosina-quinasa de bruton
PE20120693A1 (es) Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)
PE20090813A1 (es) Inhibidores de la 11b-hidroxiesteroide-deshidrogenasa
PE20091450A1 (es) INHIBIDORES DE LA ESTEAROIL-CoA-DESATURASA
PE20091096A1 (es) Compuestos organicos
PE20130281A1 (es) Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae
PE20121158A1 (es) Derivados de feniletinilo como moduladores alostericos positivos (map)
PE20080056A1 (es) Derivados de cromencarboxamida como antagonistas del receptor s1p1

Legal Events

Date Code Title Description
FC Refusal