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MA29113B1 - Derives de carboxamide bicycliques condenses destines a une utilisation en tant qu'inhibiteurs de cxcr2 pour le traitement de l'inflammation - Google Patents

Derives de carboxamide bicycliques condenses destines a une utilisation en tant qu'inhibiteurs de cxcr2 pour le traitement de l'inflammation

Info

Publication number
MA29113B1
MA29113B1 MA30032A MA30032A MA29113B1 MA 29113 B1 MA29113 B1 MA 29113B1 MA 30032 A MA30032 A MA 30032A MA 30032 A MA30032 A MA 30032A MA 29113 B1 MA29113 B1 MA 29113B1
Authority
MA
Morocco
Prior art keywords
inflammation
treatment
carboxamide derivatives
condensed bicyclic
cxcr2 inhibitors
Prior art date
Application number
MA30032A
Other languages
English (en)
Inventor
Stephanie Knieps
Juergen Dedio
Holger Heitsch
Werngard Czechtizky
Sven Grueneberg
Stephen Shimshock
Raymond W Kosley
Carolina Lanter
Hui Li
Rosy Sher
Aleksandra Weichsel
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of MA29113B1 publication Critical patent/MA29113B1/fr

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005115384A2 (fr) * 2004-05-25 2005-12-08 Metabolex, Inc. Triazoles substitués bicyliques comme modulateurs de ppar et méthodes de préparation
EP1676834A1 (fr) 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Dérivés de carboxamide bicycliqués et fusionnés utiles comme des inhibiteurs de CXCR2 pour traiter l'inflammation
BRPI0707302B8 (pt) 2006-01-27 2021-05-25 Fibrogen Inc compostos de cianoisoquinolina que atuam no dano tecidual associado com isquemia, hipóxia e anemia, bem como composição farmacêutica que os compreende
BRPI0710527B8 (pt) 2006-04-04 2021-05-25 Fibrogen Inc compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende
EP2040690B1 (fr) 2006-06-28 2014-08-06 Sanofi Inhibiteurs cxcr2
EP2041072B1 (fr) 2006-06-28 2013-09-11 Sanofi Antagonistes de cxcr2
CA2656150A1 (fr) 2006-06-28 2008-01-03 Sanofi-Aventis Nouveaux inhibiteurs de cxcr2
WO2008000410A1 (fr) * 2006-06-30 2008-01-03 Sanofi-Aventis Inhibiteurs de cxcr2
MX2009005358A (es) * 2006-11-23 2009-06-05 Novartis Ag Derivados de 5-sulfanilmetil-pirazolo[1,5-a]pirimidin-7-ol como antagonistas de cxcr2.
EP2094696B1 (fr) * 2006-11-23 2010-10-13 Novartis AG Dérivés de 5-sulfanylméthyl-[1,2,4] triazol[1, 5-a] pyrimidin-7-ol utilisés comme antagonistes de cxcr2
EP2364971B1 (fr) * 2006-11-30 2014-04-30 Dow AgroSciences LLC Pyridines disubstitués en 2,5 comme intermédiaires pour la préparation des 5-(1-alkylthio)-alkylpyridines substitués en 2
CN101679346B (zh) * 2007-06-05 2014-10-22 塞诺菲-安万特股份有限公司 取代的苯甲酰氨基茚满-2-羧酸及相关化合物
AU2009314155B2 (en) 2008-11-14 2015-10-08 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
WO2012079154A1 (fr) * 2010-12-14 2012-06-21 Dalhousie University Modulateurs sélectifs des récepteurs des oestrogènes
ES2577306T3 (es) * 2012-06-19 2016-07-14 F. Hoffmann-La Roche Ag Nuevos compuestos de tiofenilamida bicíclicos
BR112015004008A8 (pt) * 2012-09-12 2018-01-23 Hoffmann La Roche novas tiofenilamidas não anuladas
JP6437456B2 (ja) 2013-01-24 2018-12-12 フィブロジェン インコーポレイテッド ｛［１−シアノ−５−（４−クロロフェノキシ）−４−ヒドロキシ−イソキノリン−３−カルボニル］−アミノ｝−酢酸の結晶形態
WO2014114603A1 (fr) * 2013-01-24 2014-07-31 F. Hoffmann-La Roche Ag Composés thiazole substitués
CN106471004A (zh) * 2014-02-28 2017-03-01 麦吉尔大学学术发展皇家学院 作为用于免疫疗法的apc活化剂的tc‑ptp抑制剂
HUE039062T2 (hu) * 2014-04-15 2018-12-28 Vertex Pharma Gyógyszerészeti készítmények cisztás fibrózis transzmembrán konduktancia regulátor által mediált betegségek kezelésére
BR112017002060A2 (pt) * 2014-07-31 2017-12-26 Glaxosmithkline Ip Dev Ltd novo uso
CN105906608B (zh) * 2016-05-03 2018-10-19 中山大学 8-氨基喹啉-松果体素杂联体及其药物组合物
CN106187974B (zh) * 2016-07-01 2018-01-12 广州军区广州总医院 具有抗肿瘤作用的鱼藤素断环结构与氨基酸衍生物的合成方法
KR20240161203A (ko) 2017-12-01 2024-11-12 더 텍사스 에이 & 엠 유니버시티 시스템 엔젤만 증후군 안티센스 치료
MX2020008188A (es) 2018-02-02 2020-11-18 Maverix Oncology Inc Conjugados de fármacos de molécula pequeña de monofosfato de gemcitabina.
GB201807924D0 (en) * 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
KR20250044476A (ko) 2018-07-09 2025-03-31 베링거잉겔하임베트메디카게엠베하 구충성 헤테로시클릭 화합물
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
WO2021113808A1 (fr) * 2019-12-05 2021-06-10 Genzyme Corporation Arylamides modulant cftr
WO2021113806A1 (fr) * 2019-12-05 2021-06-10 Genzyme Corporation Arylamides et leurs procédés d'utilisation
JP7662644B2 (ja) 2019-12-18 2025-04-15 シーティーエックスティー・ピーティーワイ・リミテッド 化合物
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
CN111559991B (zh) * 2020-06-01 2022-01-25 河南省锐达医药科技有限公司 一种萘胺类化合物及其盐的制备方法和应用
CN118339164A (zh) 2021-11-01 2024-07-12 勃林格殷格翰动物保健有限公司 驱虫吡咯并哒嗪化合物
CN115385865B (zh) * 2022-06-29 2023-06-16 深圳大学 一种具有cxcr2抑制活性的小分子抑制剂及其制备方法与应用
CN116041300B (zh) * 2023-02-20 2024-04-26 沈阳药科大学 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962224A (en) * 1987-12-23 1990-10-09 American Home Products Corporation N-naphthoylglycines as aldose reductase inhibitors
US4994477A (en) * 1988-03-24 1991-02-19 Abbott Laboratories Heterocyclic renin inhibitors
US6531467B2 (en) * 1996-09-12 2003-03-11 Idun Pharmaceuticals, Inc. Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
DE10006139A1 (de) * 2000-02-11 2001-08-16 Merck Patent Gmbh Indol-3-yl-Derivate
IT1317826B1 (it) 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
FR2825706B1 (fr) * 2001-06-06 2003-12-12 Pf Medicament Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase
US6673791B2 (en) * 2001-07-30 2004-01-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
GB2389580A (en) * 2002-06-12 2003-12-17 Bayer Ag 2-Naphthamide PGI2 antagonists
EP1644336B1 (fr) * 2003-06-06 2011-01-19 Fibrogen, Inc. Composes heteroaryliques contenant de l'azote et leur utilisation dans l'augmentation de l'erythropoietine endogene
CA2531796A1 (fr) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Composes aryle et heteroaryle, compositions et procedes d'utilisation
EP1670804A2 (fr) 2003-09-10 2006-06-21 GPC Biotech AG Composés heterobicycliques ayant une activité pharmaceutique
US20050085531A1 (en) 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
DE602004008505T2 (de) 2003-11-20 2008-05-21 Eli Lilly And Co., Indianapolis Modulatoren des vitamin-d-rezeptors
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
WO2006040646A1 (fr) 2004-10-14 2006-04-20 Pfizer, Inc. Amides de benzimidazole ou d'indole en tant qu'inhibiteurs de pin1
BRPI0517567A (pt) 2004-11-09 2008-06-17 Smithkline Beecham Corp composto ou um sal, solvato, ou derivado fisiologicamente funcional farmaceuticamente aceitável do mesmo, composição farmacêutica, usos de um composto ou um sal, solvato, ou derivado fisiologicamente funcional farmaceuticamente aceitável do mesmo e de uma composição farmacêutica, e, processo para preparar um composto
EP1676834A1 (fr) * 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Dérivés de carboxamide bicycliqués et fusionnés utiles comme des inhibiteurs de CXCR2 pour traiter l'inflammation
AR055319A1 (es) 2005-03-17 2007-08-15 Wyeth Corp Derivados de isoquinoleina, composiciones farmaceuticas y usos

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RU2007128949A (ru) 2009-02-10
PE20060855A1 (es) 2006-10-10
NO20073932L (no) 2007-08-09
US8283479B2 (en) 2012-10-09
BRPI0519452A2 (pt) 2009-01-27
US20080090854A1 (en) 2008-04-17
MX2007007068A (es) 2007-08-08
CA2592430A1 (fr) 2006-07-06
UY29322A1 (es) 2006-07-31
AU2005321609A1 (en) 2006-07-06
IL184173A (en) 2011-10-31
AU2005321609B2 (en) 2011-02-17
JP2008526695A (ja) 2008-07-24
WO2006069656A1 (fr) 2006-07-06
EP1676834A1 (fr) 2006-07-05
RU2404962C2 (ru) 2010-11-27
ATE543795T1 (de) 2012-02-15
ZA200704089B (en) 2008-09-25
AR055830A1 (es) 2007-09-12
KR20070091634A (ko) 2007-09-11
NZ556192A (en) 2010-06-25
US20110184177A1 (en) 2011-07-28
TW200639141A (en) 2006-11-16
EP1836158A1 (fr) 2007-09-26
US7919628B2 (en) 2011-04-05
EP1836158B1 (fr) 2012-02-01
JP5123667B2 (ja) 2013-01-23
CN101094830A (zh) 2007-12-26
IL184173A0 (en) 2007-10-31

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