PE20050145A1 - Dihidroquinazolinas sustituidas como agentes antivirales - Google Patents
Dihidroquinazolinas sustituidas como agentes antiviralesInfo
- Publication number
- PE20050145A1 PE20050145A1 PE2004000432A PE2004000432A PE20050145A1 PE 20050145 A1 PE20050145 A1 PE 20050145A1 PE 2004000432 A PE2004000432 A PE 2004000432A PE 2004000432 A PE2004000432 A PE 2004000432A PE 20050145 A1 PE20050145 A1 PE 20050145A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- alkyltio
- trifluormethyl
- quinazolinyl
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- -1 CARBOXYL Chemical class 0.000 abstract 7
- CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 150000003973 alkyl amines Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
- FYNOXMZUVCBYQL-UHFFFAOYSA-N 2-[8-fluoro-2-[4-(3-methylphenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetic acid Chemical compound CC1=CC=CC(N2CCN(CC2)C=2N(C(CC(O)=O)C3=CC=CC(F)=C3N=2)C=2C=C(C=CC=2)C(F)(F)F)=C1 FYNOXMZUVCBYQL-UHFFFAOYSA-N 0.000 abstract 1
- RXJZLEMNUURVBP-UHFFFAOYSA-N 2-[8-fluoro-2-[4-(4-fluorophenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetic acid Chemical compound N=1C2=C(F)C=CC=C2C(CC(=O)O)N(C=2C=C(C=CC=2)C(F)(F)F)C=1N(CC1)CCN1C1=CC=C(F)C=C1 RXJZLEMNUURVBP-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical group C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical group C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical class C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DIHIDROQUINAZOLINAS SUSTITUIDAS DE FORMULA I DONDE Ar ES ARILO CON 1 A 3 SUSTITUYENTES SELECCIONADOS DE ALQUILO, ALCOXI, FORMILO, CARBOXILO, ENTRE OTROS; R1 ES H, AMINO, ALQUILO, ALCOXI, ALQUILAMINO, ALQUILTIO, ENTRE OTROS; R2 ES H, ALQUILO, ALCOXI, CIANO, ENTRE OTROS; R3 ES AMINO, ALQUILO, ALCOXI, ALQUILAMINO, ALQUILTIO, ENTRE OTROS; O BIEN UNO DE LOS RESTOS R1, R2 Y R3 ES H, ALQUILO, ALCOXI, CIANO, ENTRE OTROS Y LOS OTROS DOS JUNTO CON EL CARBONO AL QUE ESTAN UNIDOS FORMAN UN 1,3-DIOXOLANO, UN ANILLO CICLOPENTANO O UN ANILLO CICLOHEXANO; R4 Y R5 SON H o ALQUILO; O BIEN R4 Y R5 EN EL ANILLO DE PIPERAZINA ESTAN UNIDOS A ATOMOS DE CARBONO EXACTAMENTE OPUESTOS Y FORMAN UN PUENTE METILENO SUSTITUIDO O NO CON 1 A 2 GRUPOS METILO; R6 ES ALQUILO, ALCOXI, ALQUILTIO, FORMILO, CARBOXILO, AMINOCARBONILO, ENTRE OTROS; R7 ES H, ALQUILO, ALCOXI, ALQUILTIO, FORMILO, CARBOXILO, ALQUILCARBONILO, ENTRE OTROS; R8 ES H, ALQUILO, ALCOXI, ALQUILTIO, FORMILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO {8-FLUORO-2-[4-(4-FLUOROFENIL)-1-PIPERAZINIL]-3-[3-(TRIFLUORMETIL)FENIL]-3,4-DIHIDRO-4-QUINAZOLINIL}ACETICO; ACIDO {8-FLUORO-2-[4-(3-METILFENIL)-1-PIPERAZINIL]-3-[3-(TRIFLUORMETIL)FENIL]-3,4-DIHIDRO-4-QUINAZOLINIL}ACETICO; ACIDO {8-FLUORO-2-[4-(3-METOXIFENIL)-1-PIPERAZINIL]-3-[3-(TRIFLUORMETIL)FENIL]-3,4-DIHIDRO-4-QUINAZOLINIL}ACETICO; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON UTILES COMO AGENTE ANTIVIRAL CONTRA CITOMEGALOVIRUS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10319612A DE10319612A1 (de) | 2003-05-02 | 2003-05-02 | Substituierte Dihydrochinazoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050145A1 true PE20050145A1 (es) | 2005-05-22 |
Family
ID=33305099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000432A PE20050145A1 (es) | 2003-05-02 | 2004-04-30 | Dihidroquinazolinas sustituidas como agentes antivirales |
Country Status (38)
| Country | Link |
|---|---|
| US (4) | US7196086B2 (es) |
| EP (1) | EP1622880B3 (es) |
| JP (1) | JP4733631B2 (es) |
| KR (1) | KR100927063B1 (es) |
| CN (1) | CN100393706C (es) |
| AR (1) | AR044078A1 (es) |
| AT (1) | ATE355280T1 (es) |
| AU (1) | AU2004233978B2 (es) |
| BR (1) | BRPI0410029B8 (es) |
| CA (1) | CA2524069C (es) |
| CL (1) | CL2004000930A1 (es) |
| CO (1) | CO5700764A2 (es) |
| CY (2) | CY1106476T1 (es) |
| DE (2) | DE10319612A1 (es) |
| DK (1) | DK1622880T6 (es) |
| EC (1) | ECSP056138A (es) |
| EG (1) | EG25273A (es) |
| ES (1) | ES2284007T7 (es) |
| FR (1) | FR18C1029I2 (es) |
| HN (1) | HN2004000146A (es) |
| HU (2) | HUS1800018I1 (es) |
| IL (1) | IL171513A (es) |
| MA (1) | MA27794A1 (es) |
| MX (1) | MXPA05011707A (es) |
| MY (1) | MY144616A (es) |
| NL (1) | NL300933I2 (es) |
| NO (2) | NO333265B3 (es) |
| NZ (1) | NZ543317A (es) |
| PE (1) | PE20050145A1 (es) |
| PL (1) | PL1622880T6 (es) |
| PT (1) | PT1622880E (es) |
| RU (1) | RU2360912C2 (es) |
| SI (1) | SI1622880T1 (es) |
| TW (1) | TWI335912B (es) |
| UA (1) | UA82519C2 (es) |
| UY (1) | UY28294A1 (es) |
| WO (1) | WO2004096778A1 (es) |
| ZA (1) | ZA200508710B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10319612A1 (de) | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE10305785A1 (de) * | 2003-02-12 | 2004-08-26 | Bayer Healthcare Ag | Dihydrochinazoline |
| DE10320780A1 (de) | 2003-05-09 | 2005-01-20 | Bayer Healthcare Ag | Heterocyclyl-substituierte Dihydrochinazoline |
| DE10352499A1 (de) * | 2003-11-11 | 2005-06-09 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline II |
| DE102004022672A1 (de) | 2004-05-07 | 2005-11-24 | Bayer Healthcare Ag | Substituierte Azachinazoline |
| DE102005027517A1 (de) | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| DE102011101446A1 (de) | 2011-05-10 | 2012-11-15 | Aicuris Gmbh & Co. Kg | Herstellung von "Dense Bodies" (DB) |
| DE102012101680A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat |
| DE102012101673A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| DE102012101659A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| NZ715387A (en) * | 2013-06-19 | 2018-02-23 | Aicuris Anti Infective Cures Gmbh | Amorphous letermovir and solid pharmaceutical formulations thereof for oral administration |
| US9890128B2 (en) | 2013-12-12 | 2018-02-13 | Merck Sharp & Dohme Corp. | Process for making substituted quinazoline compounds |
| US10392353B2 (en) * | 2015-11-24 | 2019-08-27 | Merck Sharp & Dohme Corp. | Processes for making substituted quinazoline compounds using hydrogen bonding catalysts |
| JP6951418B2 (ja) * | 2016-08-08 | 2021-10-20 | メッドシャイン ディスカバリー インコーポレイテッド | 抗ｈｃｍｖウイルス化合物 |
| AU2019218150B2 (en) * | 2018-02-08 | 2021-05-13 | Phaeno Therapeutics Co., Ltd. | Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor |
| EP3527209A1 (en) * | 2018-02-16 | 2019-08-21 | UCB Biopharma SPRL | Pharmaceutical 6,5 heterobicyclic ring derivatives |
| KR102672512B1 (ko) | 2018-09-12 | 2024-06-10 | 노파르티스 아게 | 항바이러스 피리도피라진디온 화합물 |
| US11667613B2 (en) | 2019-09-26 | 2023-06-06 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
| UY39095A (es) | 2020-02-27 | 2021-09-30 | Aic246 Gmbh & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2- [(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio |
| AR121439A1 (es) | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato |
| UY39099A (es) | 2020-02-27 | 2021-08-31 | Aic246 Gmbh & Co Kg | 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo |
| AR121437A1 (es) * | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético |
| AR121440A1 (es) | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales |
| EP3906929A1 (en) | 2020-05-08 | 2021-11-10 | AiCuris GmbH & Co. KG | Letermovir for use in the prevention and the treatment of coronavirus infections |
| US20230312485A1 (en) | 2020-08-17 | 2023-10-05 | Lupin Limited | A precipitation process for amorphous letermovir |
| CN115403528B (zh) * | 2021-05-27 | 2025-01-07 | 南京正大天晴制药有限公司 | 无定形3,4-二氢喹唑啉衍生物的制备方法 |
| CN114031560B (zh) * | 2021-11-16 | 2022-10-04 | 山东诚创蓝海医药科技有限公司 | 一种来特莫韦钠盐的制备方法 |
| UY40078A (es) | 2021-12-21 | 2023-06-30 | Aic246 Ag & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin |
| CN118974026A (zh) * | 2022-04-01 | 2024-11-15 | 上海迪赛诺化学制药有限公司 | 莱特莫韦中间体及其制备方法 |
| CN115322157B (zh) * | 2022-06-02 | 2023-12-05 | 浙江车头制药股份有限公司 | 来特莫韦中间体化合物及其制备方法和应用 |
| CN117229223A (zh) * | 2022-06-08 | 2023-12-15 | 苏州远智医药科技有限公司 | 一种杂环衍生物及其药物组合物、应用 |
| WO2025133248A1 (en) | 2023-12-21 | 2025-06-26 | Aic246 Ag & Co. Kg | Diastereomeric aminoalcohol and aminoether salts of 2-[(4r,s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl]acetic acid and their use for enantiomeric separation |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4320347A1 (de) | 1993-06-19 | 1994-12-22 | Boehringer Mannheim Gmbh | Quinazolin-Derivate und diese enthaltende Arzneimittel |
| US5854245A (en) * | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| DE19802437A1 (de) | 1998-01-23 | 1999-07-29 | Bayer Ag | Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe |
| US6200977B1 (en) | 1998-02-17 | 2001-03-13 | Tularik Inc. | Pyrimidine derivatives |
| KR20010113820A (ko) | 1999-04-19 | 2001-12-28 | 시오노 요시히코 | 옥사디아졸 고리를 갖는 술폰아미드 유도체 |
| DE19930075A1 (de) | 1999-06-30 | 2001-01-04 | Bayer Ag | Neue Amino- und Amidosulfonamide als antivirale Mittel |
| US6730682B2 (en) * | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| DK1325008T3 (da) * | 2000-07-31 | 2006-02-13 | Hoffmann La Roche | Piperazinderivater |
| EP1201765A3 (en) * | 2000-10-16 | 2003-08-27 | Axxima Pharmaceuticals Aktiengesellschaft | Cellular kinases involved in cytomegalovirus infection and their inhibition |
| ES2252455T3 (es) | 2001-04-19 | 2006-05-16 | Bayer Healthcare Ag | Arilsulfonamidas como agentes antivirales. |
| DE10138578A1 (de) | 2001-08-06 | 2003-02-27 | Bayer Ag | Heterocyclylarylsulfonamide |
| DE10251914A1 (de) * | 2002-11-08 | 2004-05-19 | Bayer Ag | Substituierte Chinazoline |
| DE10319612A1 (de) * | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE10305785A1 (de) * | 2003-02-12 | 2004-08-26 | Bayer Healthcare Ag | Dihydrochinazoline |
| DE10320780A1 (de) | 2003-05-09 | 2005-01-20 | Bayer Healthcare Ag | Heterocyclyl-substituierte Dihydrochinazoline |
| DE10352499A1 (de) * | 2003-11-11 | 2005-06-09 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline II |
| KR100610731B1 (ko) * | 2004-02-24 | 2006-08-09 | 한국과학기술연구원 | Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법 |
| DE102004022672A1 (de) | 2004-05-07 | 2005-11-24 | Bayer Healthcare Ag | Substituierte Azachinazoline |
| JP5139083B2 (ja) * | 2005-01-25 | 2013-02-06 | プロレキシーズ ファーマシューティカルズ インコーポレイテッド | 抗腫瘍剤としてのキノキサリン誘導体 |
| DE102005027517A1 (de) * | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| JP4880684B2 (ja) * | 2005-07-21 | 2012-02-22 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐｔｐ１ｂ阻害剤としてのピリド［２，３−ｄ］ピリミジン−２，４−ジアミン化合物 |
| DE102006009928A1 (de) | 2006-03-03 | 2007-09-06 | Aicuris Gmbh & Co. Kg | Substituierte Arylsulfonamide |
| DE102012101659A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| DE102012101680A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat |
| DE102012101673A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| NZ715387A (en) * | 2013-06-19 | 2018-02-23 | Aicuris Anti Infective Cures Gmbh | Amorphous letermovir and solid pharmaceutical formulations thereof for oral administration |
-
2003
- 2003-05-02 DE DE10319612A patent/DE10319612A1/de not_active Withdrawn
-
2004
- 2004-04-17 AU AU2004233978A patent/AU2004233978B2/en active Active
- 2004-04-17 KR KR1020057020720A patent/KR100927063B1/ko not_active Expired - Lifetime
- 2004-04-17 CA CA2524069A patent/CA2524069C/en not_active Expired - Lifetime
- 2004-04-17 ES ES04728119.1T patent/ES2284007T7/es active Active
- 2004-04-17 DE DE502004003052T patent/DE502004003052D1/de not_active Expired - Lifetime
- 2004-04-17 AT AT04728119T patent/ATE355280T1/de active
- 2004-04-17 SI SI200430301T patent/SI1622880T1/sl unknown
- 2004-04-17 EP EP04728119.1A patent/EP1622880B3/de not_active Expired - Lifetime
- 2004-04-17 BR BRPI0410029A patent/BRPI0410029B8/pt not_active IP Right Cessation
- 2004-04-17 DK DK04728119.1T patent/DK1622880T6/da active
- 2004-04-17 NZ NZ543317A patent/NZ543317A/en not_active IP Right Cessation
- 2004-04-17 PL PL04728119T patent/PL1622880T6/pl unknown
- 2004-04-17 CN CNB2004800119284A patent/CN100393706C/zh not_active Expired - Lifetime
- 2004-04-17 MX MXPA05011707A patent/MXPA05011707A/es active IP Right Grant
- 2004-04-17 PT PT04728119T patent/PT1622880E/pt unknown
- 2004-04-17 UA UAA200511418A patent/UA82519C2/uk unknown
- 2004-04-17 WO PCT/EP2004/004103 patent/WO2004096778A1/de not_active Ceased
- 2004-04-17 RU RU2005137276/04A patent/RU2360912C2/ru active
- 2004-04-17 JP JP2006505178A patent/JP4733631B2/ja not_active Expired - Lifetime
- 2004-04-23 AR ARP040101391A patent/AR044078A1/es active IP Right Grant
- 2004-04-26 US US10/832,109 patent/US7196086B2/en not_active Ceased
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