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MX2008013728A - Inductor de neurogenesis o agente terapeutico de neuropatia que abarca el derivado del eter alkilico o sal del mismo. - Google Patents

Inductor de neurogenesis o agente terapeutico de neuropatia que abarca el derivado del eter alkilico o sal del mismo.

Info

Publication number
MX2008013728A
MX2008013728A MX2008013728A MX2008013728A MX2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A
Authority
MX
Mexico
Prior art keywords
group
salt
therapeutic agent
amino
alkyl ether
Prior art date
Application number
MX2008013728A
Other languages
English (en)
Inventor
Noboru Iwakami
Shigeki Marubuchi
Tomohiro Okuda
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of MX2008013728A publication Critical patent/MX2008013728A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se divulga un agente que consta de un derivado de éter de alquil-benzotiofeno representado por la fórmula general que se describe abajo o una sal del mismo: (ver fórmula I) en donde R1 y R2 representan de manera independiente por lo menos uno de los grupos seleccionados de un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo, un grupo arilo, un grupo aralquilo, un grupo alcoxi, un grupo ariloxi, un grupo alquiltio, un grupo ariltio, un grupo alquenilo, un grupo alqueniloxi, un grupo alquilsulfonilo, un grupo carbamoilo, un grupo heterocíclico, un grupo amino, grupo hidroxilo, un grupo carboxilo, un grupo nitro, un grupo oxo y similares; R3 representa un grupo alquilamino que puede ser sustituido o un grupo amino o un grupo hidroxilo que se puede proteger; y m y n representan de manera independiente un número entero de 1 a 6. El agente es útil como inductor de neurogénesis o un agente terapéutico para neuropatía.
MX2008013728A 2006-04-26 2007-04-24 Inductor de neurogenesis o agente terapeutico de neuropatia que abarca el derivado del eter alkilico o sal del mismo. MX2008013728A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006122080 2006-04-26
PCT/JP2007/058841 WO2007125913A1 (ja) 2006-04-26 2007-04-24 アルキルエーテル誘導体またはその塩を含有する神経細胞新生誘導剤および精神障害治療剤

Publications (1)

Publication Number Publication Date
MX2008013728A true MX2008013728A (es) 2009-01-07

Family

ID=38655439

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008013728A MX2008013728A (es) 2006-04-26 2007-04-24 Inductor de neurogenesis o agente terapeutico de neuropatia que abarca el derivado del eter alkilico o sal del mismo.

Country Status (20)

Country Link
US (1) US20090093453A1 (es)
EP (1) EP2011796B1 (es)
JP (2) JP5695293B2 (es)
KR (1) KR101374593B1 (es)
CN (1) CN101432280B (es)
AU (1) AU2007244409B2 (es)
BR (1) BRPI0710239A2 (es)
CA (1) CA2648898C (es)
CY (1) CY1115643T1 (es)
DK (1) DK2011796T3 (es)
ES (1) ES2518371T3 (es)
IL (1) IL194569A (es)
MX (1) MX2008013728A (es)
NO (1) NO342153B1 (es)
NZ (1) NZ571975A (es)
PL (1) PL2011796T3 (es)
PT (1) PT2011796E (es)
SI (1) SI2011796T1 (es)
WO (1) WO2007125913A1 (es)
ZA (1) ZA200808728B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43676E1 (en) 2001-10-19 2012-09-18 Toyama Chemical Co., Ltd. Alkyl ether derivatives or salts thereof
TR201816386T4 (tr) 2002-06-14 2018-11-21 Toyama Chemical Co Ltd Beyin fonksiyonunu arttırmak için tıbbi bileşim.
CA2799659C (en) * 2005-03-28 2014-12-02 Toyama Chemical Co., Ltd. Process for production of 1-(3-(2-(1-benzothiophen-5-yl) ethoxy)propyl) azetidin-3-ol or salts thereof
ES2355768T3 (es) * 2006-08-04 2011-03-30 Toyama Chemical Co., Ltd. Potenciador de la actividad de la proteína quinasa c que contiene un derivado de éter de alquilo o una sal del mismo.
PT2287160E (pt) * 2008-05-28 2014-06-24 Toyama Chemical Co Ltd Derivado de óxido de benzotiofeno e os seus sais
WO2015036412A1 (en) * 2013-09-12 2015-03-19 F. Hoffmann-La Roche Ag Indol-carboxamide derivatives
LT3100725T (lt) * 2014-01-31 2020-08-10 Fujifilm Toyama Chemical Co., Ltd. Reabilitacijos poveikį po nervo pažeidimo sustiprinanti priemonė, apimanti alkileterio darinį arba jo druską
US10238632B2 (en) 2015-06-11 2019-03-26 Fujifilm Toyama Chemical Co., Ltd. Sigma receptor-binding agent
DK3395342T3 (da) 2015-12-25 2020-10-12 Fujifilm Toyama Chemical Co Ltd Tablet omfattende 1-(3-(2-(1-benzothiophen-5-YL)ethoxy)propyl)azetidin-3-ol eller salt deraf
EP3563843A4 (en) * 2016-12-28 2019-12-11 FUJIFILM Toyama Chemical Co., Ltd. TOPICAL COMPOSITION
WO2018221730A1 (ja) * 2017-06-02 2018-12-06 富山化学工業株式会社 脊髄小脳変性症予防または治療剤
SG11201911519UA (en) 2017-06-02 2020-01-30 Fujifilm Toyama Chemical Co Ltd AGENT FOR REDUCING AMOUNT OF AMYLOID ß PROTEIN
CN116473962A (zh) 2017-06-02 2023-07-25 富士胶片富山化学株式会社 脑萎缩预防或治疗剂
EP3636262A4 (en) 2017-06-02 2020-06-10 FUJIFILM Toyama Chemical Co., Ltd. AGENT FOR PREVENTING OR TREATING ALZHEIMER-LIKE DEMENTIA
JP7227914B2 (ja) 2017-10-30 2023-02-22 富士フイルム富山化学株式会社 エモパミル結合タンパク質結合剤およびその利用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294346B1 (en) * 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
JPH05284992A (ja) * 1992-04-14 1993-11-02 Sagami Chem Res Center 神経成長因子産生促進剤及びその製造法
GB9309749D0 (en) * 1993-05-12 1993-06-23 Boots Co Plc Therapeutic agents
JPH07285912A (ja) * 1994-04-19 1995-10-31 Asahi Chem Ind Co Ltd 新規化合物ａｍ５２２１
JP2733207B2 (ja) * 1995-05-18 1998-03-30 工業技術院長 繊維芽細胞成長因子キメラ蛋白質を含有する医薬組成物
AU1506499A (en) * 1997-12-12 1999-07-05 Toyama Chemical Co. Ltd. Alkyl ether derivatives or salts thereof and calcium antagonists containing the same
IL129178A0 (en) * 1999-03-25 2000-02-17 Yeda Res & Dev Induction of nerve generation
DE60042686D1 (de) * 1999-06-11 2009-09-17 Toyama Chemical Co Ltd N-alkoxyalkyl-n,n-dialkylamin-derivate oder ihre salze und heilmittel zur behandlung degenerativer erkrankungen der nerven die diese enthalten
US20040030131A1 (en) * 2000-10-04 2004-02-12 Martine Keenan Pharmaceutical compounds
GB2367554A (en) * 2000-10-04 2002-04-10 Lilly Co Eli Pharmacologically active amines
JP4303435B2 (ja) * 2001-02-26 2009-07-29 富山化学工業株式会社 ミトコンドリア機能賦活剤
EP1411052B1 (en) * 2001-07-05 2011-10-05 Takeda Pharmaceutical Company Limited Benzo-fused 5-membered hetrocycle compounds,process for preparation of the same, and use thereof
JP4357802B2 (ja) * 2001-07-05 2009-11-04 武田薬品工業株式会社 ベンゼン環縮合５員複素環式化合物、その製造法および用途
JP4905752B2 (ja) * 2001-07-24 2012-03-28 エスティー・ラボ株式会社 揮発性有機塩素化合物センサ
USRE43676E1 (en) * 2001-10-19 2012-09-18 Toyama Chemical Co., Ltd. Alkyl ether derivatives or salts thereof
JP4537011B2 (ja) * 2002-03-01 2010-09-01 武田薬品工業株式会社 抗うつ剤
TR201816386T4 (tr) * 2002-06-14 2018-11-21 Toyama Chemical Co Ltd Beyin fonksiyonunu arttırmak için tıbbi bileşim.
JP2004256428A (ja) * 2003-02-25 2004-09-16 Science Univ Of Tokyo 神経栄養因子様プリン系化合物含有作用剤
US20060205709A1 (en) * 2003-04-17 2006-09-14 Toyama Chemical Co., Ltd. Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof
DE602004032165D1 (de) * 2003-10-03 2011-05-19 Ono Pharmaceutical Co Nervenregenerationsförderer

Also Published As

Publication number Publication date
CN101432280A (zh) 2009-05-13
DK2011796T3 (da) 2014-10-27
US20090093453A1 (en) 2009-04-09
CA2648898A1 (en) 2007-11-08
EP2011796B1 (en) 2014-10-08
PT2011796E (pt) 2014-11-26
NZ571975A (en) 2011-04-29
AU2007244409B2 (en) 2011-12-01
CY1115643T1 (el) 2017-01-04
EP2011796A4 (en) 2010-07-07
KR20080111131A (ko) 2008-12-22
JP5695293B2 (ja) 2015-04-01
EP2011796A1 (en) 2009-01-07
JPWO2007125913A1 (ja) 2009-09-10
JP2013177410A (ja) 2013-09-09
NO20084338L (no) 2008-11-19
PL2011796T3 (pl) 2015-03-31
NO342153B1 (no) 2018-04-03
KR101374593B1 (ko) 2014-03-17
ES2518371T3 (es) 2014-11-05
ZA200808728B (en) 2010-01-27
SI2011796T1 (sl) 2015-02-27
CN101432280B (zh) 2012-11-21
IL194569A0 (en) 2009-08-03
BRPI0710239A2 (pt) 2011-08-09
WO2007125913A1 (ja) 2007-11-08
AU2007244409A1 (en) 2007-11-08
CA2648898C (en) 2015-01-20
IL194569A (en) 2014-09-30

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