CL2004000930A1 - Compuesto derivado de dihidroquinazolina de formula definida, util para el tratamiento y/o profilaxis de infecciones virales; composicion farmaceutica que comprende al compuesto y uso del compuesto en la preparacion de medicamentos. - Google Patents

Compuesto derivado de dihidroquinazolina de formula definida, util para el tratamiento y/o profilaxis de infecciones virales; composicion farmaceutica que comprende al compuesto y uso del compuesto en la preparacion de medicamentos.

Info

Publication number: CL2004000930A1
Authority: CL; Chile
Prior art keywords: compound; profilaxis; dihydroquinazoline; medicines; useful
Prior art date: 2003-05-02

Application number

CL200400930A

Other languages

English (en)

Inventor

Holger Zimmermann

Kerstin Henninger

Rolf Grosser

Guy Hewlett

Ulrich Betz

Mario Jeske

Thomas Lampe

Judith Baumeister

Dieter Lang

Joerg Keldenich

Tobias Wunberg

Frank Suessmeier

Peter Nell

Susanne Nikolic

Juergen Reefschlaeger

Rudolf Schohe-Loop

Original Assignee

Aicuris Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-02

Filing date

2004-04-30

Publication date

2005-03-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33305099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2004000930(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-04-30 Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg

2005-03-18 Publication of CL2004000930A1 publication Critical patent/CL2004000930A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CL200400930A 2003-05-02 2004-04-30 Compuesto derivado de dihidroquinazolina de formula definida, util para el tratamiento y/o profilaxis de infecciones virales; composicion farmaceutica que comprende al compuesto y uso del compuesto en la preparacion de medicamentos. CL2004000930A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10319612A DE10319612A1 (de)	2003-05-02	2003-05-02	Substituierte Dihydrochinazoline

Publications (1)

Publication Number	Publication Date
CL2004000930A1 true CL2004000930A1 (es)	2005-03-18

Family

ID=33305099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200400930A CL2004000930A1 (es)	2003-05-02	2004-04-30	Compuesto derivado de dihidroquinazolina de formula definida, util para el tratamiento y/o profilaxis de infecciones virales; composicion farmaceutica que comprende al compuesto y uso del compuesto en la preparacion de medicamentos.

Country Status (38)

Country	Link
US (4)	US7196086B2 (es)
EP (1)	EP1622880B3 (es)
JP (1)	JP4733631B2 (es)
KR (1)	KR100927063B1 (es)
CN (1)	CN100393706C (es)
AR (1)	AR044078A1 (es)
AT (1)	ATE355280T1 (es)
AU (1)	AU2004233978B2 (es)
BR (1)	BRPI0410029B8 (es)
CA (1)	CA2524069C (es)
CL (1)	CL2004000930A1 (es)
CO (1)	CO5700764A2 (es)
CY (2)	CY1106476T1 (es)
DE (2)	DE10319612A1 (es)
DK (1)	DK1622880T6 (es)
EC (1)	ECSP056138A (es)
EG (1)	EG25273A (es)
ES (1)	ES2284007T7 (es)
FR (1)	FR18C1029I2 (es)
HN (1)	HN2004000146A (es)
HU (2)	HUS1800018I1 (es)
IL (1)	IL171513A (es)
MA (1)	MA27794A1 (es)
MX (1)	MXPA05011707A (es)
MY (1)	MY144616A (es)
NL (1)	NL300933I2 (es)
NO (2)	NO333265B3 (es)
NZ (1)	NZ543317A (es)
PE (1)	PE20050145A1 (es)
PL (1)	PL1622880T6 (es)
PT (1)	PT1622880E (es)
RU (1)	RU2360912C2 (es)
SI (1)	SI1622880T1 (es)
TW (1)	TWI335912B (es)
UA (1)	UA82519C2 (es)
UY (1)	UY28294A1 (es)
WO (1)	WO2004096778A1 (es)
ZA (1)	ZA200508710B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10319612A1 (de)	2003-05-02	2004-11-18	Bayer Healthcare Ag	Substituierte Dihydrochinazoline
DE10305785A1 (de) *	2003-02-12	2004-08-26	Bayer Healthcare Ag	Dihydrochinazoline
DE10320780A1 (de)	2003-05-09	2005-01-20	Bayer Healthcare Ag	Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) *	2003-11-11	2005-06-09	Bayer Healthcare Ag	Substituierte Dihydrochinazoline II
DE102004022672A1 (de)	2004-05-07	2005-11-24	Bayer Healthcare Ag	Substituierte Azachinazoline
DE102005027517A1 (de)	2005-06-15	2006-12-21	Bayer Healthcare Ag	Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de)	2011-05-10	2012-11-15	Aicuris Gmbh & Co. Kg	Herstellung von "Dense Bodies" (DB)
DE102012101680A1 (de)	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de)	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) *	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Salze eines Dihydrochinazolinderivats
NZ715387A (en) *	2013-06-19	2018-02-23	Aicuris Anti Infective Cures Gmbh	Amorphous letermovir and solid pharmaceutical formulations thereof for oral administration
US9890128B2 (en)	2013-12-12	2018-02-13	Merck Sharp & Dohme Corp.	Process for making substituted quinazoline compounds
US10392353B2 (en) *	2015-11-24	2019-08-27	Merck Sharp & Dohme Corp.	Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
JP6951418B2 (ja) *	2016-08-08	2021-10-20	メッドシャインディスカバリーインコーポレイテッド	抗ｈｃｍｖウイルス化合物
AU2019218150B2 (en) *	2018-02-08	2021-05-13	Phaeno Therapeutics Co., Ltd.	Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor
EP3527209A1 (en) *	2018-02-16	2019-08-21	UCB Biopharma SPRL	Pharmaceutical 6,5 heterobicyclic ring derivatives
KR102672512B1 (ko)	2018-09-12	2024-06-10	노파르티스 아게	항바이러스 피리도피라진디온 화합물
US11667613B2 (en)	2019-09-26	2023-06-06	Novartis Ag	Antiviral pyrazolopyridinone compounds
UY39095A (es)	2020-02-27	2021-09-30	Aic246 Gmbh & Co Kg	Composiciones farmacéuticas que comprenden acetato de 2- [(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
AR121439A1 (es)	2020-02-27	2022-06-08	Aic246 Gmbh & Co Kg	Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
UY39099A (es)	2020-02-27	2021-08-31	Aic246 Gmbh & Co Kg	2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
AR121437A1 (es) *	2020-02-27	2022-06-08	Aic246 Gmbh & Co Kg	Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR121440A1 (es)	2020-02-27	2022-06-08	Aic246 Gmbh & Co Kg	Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales
EP3906929A1 (en)	2020-05-08	2021-11-10	AiCuris GmbH & Co. KG	Letermovir for use in the prevention and the treatment of coronavirus infections
US20230312485A1 (en)	2020-08-17	2023-10-05	Lupin Limited	A precipitation process for amorphous letermovir
CN115403528B (zh) *	2021-05-27	2025-01-07	南京正大天晴制药有限公司	无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) *	2021-11-16	2022-10-04	山东诚创蓝海医药科技有限公司	一种来特莫韦钠盐的制备方法
UY40078A (es)	2021-12-21	2023-06-30	Aic246 Ag & Co Kg	Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin
CN118974026A (zh) *	2022-04-01	2024-11-15	上海迪赛诺化学制药有限公司	莱特莫韦中间体及其制备方法
CN115322157B (zh) *	2022-06-02	2023-12-05	浙江车头制药股份有限公司	来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) *	2022-06-08	2023-12-15	苏州远智医药科技有限公司	一种杂环衍生物及其药物组合物、应用
WO2025133248A1 (en)	2023-12-21	2025-06-26	Aic246 Ag & Co. Kg	Diastereomeric aminoalcohol and aminoether salts of 2-[(4r,s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl]acetic acid and their use for enantiomeric separation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4320347A1 (de)	1993-06-19	1994-12-22	Boehringer Mannheim Gmbh	Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) *	1996-06-28	1998-12-29	Merck & Co., Inc.	Fibrinogen receptor antagonists
GB9718972D0 (en) *	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
DE19802437A1 (de)	1998-01-23	1999-07-29	Bayer Ag	Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
US6200977B1 (en)	1998-02-17	2001-03-13	Tularik Inc.	Pyrimidine derivatives
KR20010113820A (ko)	1999-04-19	2001-12-28	시오노 요시히코	옥사디아졸 고리를 갖는 술폰아미드 유도체
DE19930075A1 (de)	1999-06-30	2001-01-04	Bayer Ag	Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) *	2000-07-12	2004-05-04	Pharmacia & Upjohn Company	Heterocycle carboxamides as antiviral agents
DK1325008T3 (da) *	2000-07-31	2006-02-13	Hoffmann La Roche	Piperazinderivater
EP1201765A3 (en) *	2000-10-16	2003-08-27	Axxima Pharmaceuticals Aktiengesellschaft	Cellular kinases involved in cytomegalovirus infection and their inhibition
ES2252455T3 (es)	2001-04-19	2006-05-16	Bayer Healthcare Ag	Arilsulfonamidas como agentes antivirales.
DE10138578A1 (de)	2001-08-06	2003-02-27	Bayer Ag	Heterocyclylarylsulfonamide
DE10251914A1 (de) *	2002-11-08	2004-05-19	Bayer Ag	Substituierte Chinazoline
DE10319612A1 (de) *	2003-05-02	2004-11-18	Bayer Healthcare Ag	Substituierte Dihydrochinazoline
DE10305785A1 (de) *	2003-02-12	2004-08-26	Bayer Healthcare Ag	Dihydrochinazoline
DE10320780A1 (de)	2003-05-09	2005-01-20	Bayer Healthcare Ag	Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) *	2003-11-11	2005-06-09	Bayer Healthcare Ag	Substituierte Dihydrochinazoline II
KR100610731B1 (ko) *	2004-02-24	2006-08-09	한국과학기술연구원	Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de)	2004-05-07	2005-11-24	Bayer Healthcare Ag	Substituierte Azachinazoline
JP5139083B2 (ja) *	2005-01-25	2013-02-06	プロレキシーズファーマシューティカルズインコーポレイテッド	抗腫瘍剤としてのキノキサリン誘導体
DE102005027517A1 (de) *	2005-06-15	2006-12-21	Bayer Healthcare Ag	Verfahren zur Herstellung von Dihydrochinazolinen
JP4880684B2 (ja) *	2005-07-21	2012-02-22	エフ．ホフマン−ラロシュアーゲー	Ｐｔｐ１ｂ阻害剤としてのピリド［２，３−ｄ］ピリミジン−２，４−ジアミン化合物
DE102006009928A1 (de)	2006-03-03	2007-09-06	Aicuris Gmbh & Co. Kg	Substituierte Arylsulfonamide
DE102012101659A1 (de) *	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) *	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de)	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Salze eines Dihydrochinazolinderivats
NZ715387A (en) *	2013-06-19	2018-02-23	Aicuris Anti Infective Cures Gmbh	Amorphous letermovir and solid pharmaceutical formulations thereof for oral administration

2003
- 2003-05-02 DE DE10319612A patent/DE10319612A1/de not_active Withdrawn
2004
- 2004-04-17 AU AU2004233978A patent/AU2004233978B2/en active Active
- 2004-04-17 KR KR1020057020720A patent/KR100927063B1/ko not_active Expired - Lifetime
- 2004-04-17 CA CA2524069A patent/CA2524069C/en not_active Expired - Lifetime
- 2004-04-17 ES ES04728119.1T patent/ES2284007T7/es active Active
- 2004-04-17 DE DE502004003052T patent/DE502004003052D1/de not_active Expired - Lifetime
- 2004-04-17 AT AT04728119T patent/ATE355280T1/de active
- 2004-04-17 SI SI200430301T patent/SI1622880T1/sl unknown
- 2004-04-17 EP EP04728119.1A patent/EP1622880B3/de not_active Expired - Lifetime
- 2004-04-17 BR BRPI0410029A patent/BRPI0410029B8/pt not_active IP Right Cessation
- 2004-04-17 DK DK04728119.1T patent/DK1622880T6/da active
- 2004-04-17 NZ NZ543317A patent/NZ543317A/en not_active IP Right Cessation
- 2004-04-17 PL PL04728119T patent/PL1622880T6/pl unknown
- 2004-04-17 CN CNB2004800119284A patent/CN100393706C/zh not_active Expired - Lifetime
- 2004-04-17 MX MXPA05011707A patent/MXPA05011707A/es active IP Right Grant
- 2004-04-17 PT PT04728119T patent/PT1622880E/pt unknown
- 2004-04-17 UA UAA200511418A patent/UA82519C2/uk unknown
- 2004-04-17 WO PCT/EP2004/004103 patent/WO2004096778A1/de not_active Ceased
- 2004-04-17 RU RU2005137276/04A patent/RU2360912C2/ru active
- 2004-04-17 JP JP2006505178A patent/JP4733631B2/ja not_active Expired - Lifetime
- 2004-04-23 AR ARP040101391A patent/AR044078A1/es active IP Right Grant
- 2004-04-26 US US10/832,109 patent/US7196086B2/en not_active Ceased
- 2004-04-28 UY UY28294A patent/UY28294A1/es not_active IP Right Cessation
- 2004-04-29 HN HN2004000146A patent/HN2004000146A/es unknown
- 2004-04-29 MY MYPI20041603A patent/MY144616A/en unknown
- 2004-04-30 PE PE2004000432A patent/PE20050145A1/es active IP Right Grant
- 2004-04-30 CL CL200400930A patent/CL2004000930A1/es unknown
- 2004-04-30 TW TW093112100A patent/TWI335912B/zh active
2005
- 2005-10-20 IL IL171513A patent/IL171513A/en active IP Right Grant
- 2005-10-27 ZA ZA2005/08710A patent/ZA200508710B/en unknown
- 2005-10-29 EG EGNA2005000688 patent/EG25273A/xx active
- 2005-11-01 EC EC2005006138A patent/ECSP056138A/es unknown
- 2005-11-02 CO CO05111848A patent/CO5700764A2/es active IP Right Grant
- 2005-11-08 MA MA28581A patent/MA27794A1/fr unknown
- 2005-11-30 NO NO20055649A patent/NO333265B3/no active Protection Beyond IP Right Term
2007
- 2007-03-26 US US11/728,896 patent/US8513255B2/en active Active
- 2007-05-25 CY CY20071100709T patent/CY1106476T1/el unknown
2015
- 2015-04-09 US US14/682,512 patent/USRE46791E1/en active Active
2018
- 2018-04-17 NL NL300933C patent/NL300933I2/nl unknown
- 2018-04-21 HU HUS1800018C patent/HUS1800018I1/hu unknown
- 2018-06-15 HU HUS1800028C patent/HUS1800028I1/hu unknown
- 2018-06-29 CY CY2018019C patent/CY2018019I1/el unknown
- 2018-07-04 NO NO2018022C patent/NO2018022I1/no unknown
- 2018-07-06 FR FR18C1029C patent/FR18C1029I2/fr active Active
2020
- 2020-07-21 US US16/934,363 patent/USRE49698E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO20055649L (no)	2006-01-31
US20070191387A1 (en)	2007-08-16
BRPI0410029B1 (pt)	2019-12-31
CO5700764A2 (es)	2006-11-30
CY1106476T1 (el)	2012-01-25
MA27794A1 (fr)	2006-03-01
NO333265B3 (no)	2019-06-03
CY2018019I2 (el)	2018-12-12
USRE49698E1 (en)	2023-10-17
CN1784390A (zh)	2006-06-07
MXPA05011707A (es)	2006-02-13
BRPI0410029A (pt)	2006-04-25
TW200510343A (en)	2005-03-16
KR20060009883A (ko)	2006-02-01
CN100393706C (zh)	2008-06-11
BRPI0410029B8 (pt)	2021-06-15
ECSP056138A (es)	2006-04-19
JP4733631B2 (ja)	2011-07-27
NL300933I2 (nl)	2018-04-26
DK1622880T3 (da)	2007-06-25
KR100927063B1 (ko)	2009-11-13
HUS1800028I1 (hu)	2018-07-30
ATE355280T1 (de)	2006-03-15
JP2006525249A (ja)	2006-11-09
HK1092463A1 (zh)	2007-02-09
USRE46791E1 (en)	2018-04-17
RU2360912C2 (ru)	2009-07-10
DE10319612A1 (de)	2004-11-18
UA82519C2 (uk)	2008-04-25
AU2004233978B2 (en)	2010-02-11
NO2018022I1 (no)	2018-07-04
UY28294A1 (es)	2004-11-30
ES2284007T7 (es)	2018-06-20
EP1622880B3 (de)	2018-05-23
WO2004096778A1 (de)	2004-11-11
FR18C1029I1 (es)	2018-08-17
US20050065160A1 (en)	2005-03-24
DE502004003052D1 (de)	2007-04-12
DK1622880T6 (da)	2018-06-18
EP1622880B1 (de)	2007-02-28
US7196086B2 (en)	2007-03-27
AR044078A1 (es)	2005-08-24
TWI335912B (en)	2011-01-11
FR18C1029I2 (fr)	2020-07-17
EG25273A (en)	2011-12-04
PT1622880E (pt)	2007-06-04
CY2018019I1 (el)	2018-12-12
PL1622880T6 (pl)	2018-08-31
AU2004233978A1 (en)	2004-11-11
CA2524069A1 (en)	2004-11-11
EP1622880A1 (de)	2006-02-08
PL1622880T3 (pl)	2007-08-31
NZ543317A (en)	2008-05-30
HN2004000146A (es)	2008-06-24
ES2284007T3 (es)	2007-11-01
MY144616A (en)	2011-10-14
ZA200508710B (en)	2006-12-27
RU2005137276A (ru)	2006-07-27
NO333265B1 (no)	2013-04-22
US8513255B2 (en)	2013-08-20
IL171513A (en)	2011-11-30
SI1622880T1 (sl)	2007-08-31
PE20050145A1 (es)	2005-05-22
NO20055649D0 (no)	2005-11-30
CA2524069C (en)	2011-11-08
HUS1800018I1 (hu)	2018-05-28

Publication	Publication Date	Title
CL2004000930A1 (es)	2005-03-18	Compuesto derivado de dihidroquinazolina de formula definida, util para el tratamiento y/o profilaxis de infecciones virales; composicion farmaceutica que comprende al compuesto y uso del compuesto en la preparacion de medicamentos.
CL2004001069A1 (es)	2005-04-01	Compuestos derivados de 1-benzoil-isoquinolinas sustituidos; procedimiento de preparacion, composicion farmaceutica; y uso para el tratamiento o profilaxis de diabetes tipo ii.
CL2004000306A1 (es)	2005-04-08	Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa.
CL2007002649A1 (es)	2008-04-11	Composicion farmaceutica que comprende 2-[6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo-3,4-dihidro-2h-pirimidin-1-ilmetil]-4-fluoro-benzonitrilo; y uso para el tratamiento de la diabetes.
CL2007003635A1 (es)	2008-08-22	Compuestos derivados de 6-amino-purin-8-ona; proceso de preparacion; composicion farmaceutica; proceso para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades alergicas, virales o cancer.
CL2007003244A1 (es)	2008-04-04	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
CL2007003495A1 (es)	2008-05-30	Compuestos derivados de heterociclos condensados sustituidos, inhibidores de la actividad de la akt; composicion farmaceutica; y uso para el tratamiento o prevencion del cancer.
BR0312573A (pt)	2005-04-26	Derivados de fenil-[4-(3-fenil-1h-pirazol-4-il)-pirimidin-2-il]-amina
CL2007002578A1 (es)	2008-07-04	Compuestos derivados de n-(1-ftalazin-1-il-piperidin-4-il)-amidas; composicion farmaceutica; y uso para el tratamiento y prevencion de trastornos de la fertilidad, osteoporosis y cancer.
BRPI0806531A2 (pt)	2014-04-22	Composto, composição farmacêutica, agente terapêutico, e, uso do composto.
CL2007001847A1 (es)	2008-02-08	Composicion farmaceutica intramuscular o subcutanea que comprende tmc278 (rilpivirina); proceso para preparar la composicion; y uso para el tratamiento o prevencion de infeccion por vih.
BRPI0814593A2 (pt)	2015-01-20	Composto, composição farmacêutica que o contém e uso do composto.
BRPI0312649A2 (pt)	2017-05-16	compostos, composições farmacêuticas contendo os mesmos, e processos de uso para os mesmos.
CL2007003332A1 (es)	2008-06-20	Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
CL2007001630A1 (es)	2008-02-08	Compuestos derivados de pirrolidinamida; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.
SE0301653D0 (sv)	2003-06-05	Novel compounds
BRPI0717369A2 (pt)	2014-10-07	Composto, medicamento, composição farmacêutica que o contém e uso do composto.
CL2007002757A1 (es)	2008-06-20	Compuestos derivados de 1,2,4-triazina sustituida; composicion farmaceutica; y uso en el tratamiento o prevencion del reflujo gastroesofagico y ansiedad.
CL2008000409A1 (es)	2008-08-29	Compuestos derivados de 2-(4 amino-pirrolo-piridin) furan-3,4 diol; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento y/o prevencion de infecciones virales.
CL2008000254A1 (es)	2008-08-08	Compuestos derivados de 6-oxo-6,7-dihidro-5h-dibenzo-[b,d]azepin-7-ilo; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de la enfermedad de alzheimer o cancer.
CL2007002671A1 (es)	2008-04-18	Compuestos derivados de octahidro-pirrolo[3,4-c]pirrol; composicion farmaceutica que la comprende; y uso del compuesto en el tratamiento del vih, sida o arc.
CL2007002619A1 (es)	2008-04-18	Compuestos derivados de 3-aza-biciclo[4.1.0]heptano; composicion farmaceutica; y uso en el tratamiento de la depresion.
EE200300064A (et)	2004-12-15	Farmatseutiline kompositsioon C. pneumoniae pooltpõhjustatud infektsioonide raviks ja/või ennetamiseks, mahekompositsioon ja nende kasutamine
CL2007001542A1 (es)	2008-03-14	Compuestos derivados de aminotiazoles, composicion farmaceutica; y uso para el tratamiento de infecciones bacterianas.
BRPI0415123A (pt)	2006-11-28	uso de l-butilftalida e respectiva composição farmacêutica