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CY2018019I1 - Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες - Google Patents

Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες

Info

Publication number
CY2018019I1
CY2018019I1 CY2018019C CY2018019C CY2018019I1 CY 2018019 I1 CY2018019 I1 CY 2018019I1 CY 2018019 C CY2018019 C CY 2018019C CY 2018019 C CY2018019 C CY 2018019C CY 2018019 I1 CY2018019 I1 CY 2018019I1
Authority
CY
Cyprus
Prior art keywords
antiviral properties
dihydroquinazolines
substituted
substituted dihydroquinazolines
antiviral
Prior art date
Application number
CY2018019C
Other languages
English (en)
Other versions
CY2018019I2 (el
Original Assignee
Aicuris Anti-Infective Cures Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33305099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2018019(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Anti-Infective Cures Gmbh filed Critical Aicuris Anti-Infective Cures Gmbh
Publication of CY2018019I2 publication Critical patent/CY2018019I2/el
Publication of CY2018019I1 publication Critical patent/CY2018019I1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CY2018019C 2003-05-02 2018-06-29 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες CY2018019I1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (de) 2003-05-02 2004-04-17 Substituierte dihydrochinazoline mit antiviralen eigenschaften

Publications (2)

Publication Number Publication Date
CY2018019I2 CY2018019I2 (el) 2018-12-12
CY2018019I1 true CY2018019I1 (el) 2018-12-12

Family

ID=33305099

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071100709T CY1106476T1 (el) 2003-05-02 2007-05-25 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες
CY2018019C CY2018019I1 (el) 2003-05-02 2018-06-29 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20071100709T CY1106476T1 (el) 2003-05-02 2007-05-25 Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες

Country Status (38)

Country Link
US (4) US7196086B2 (el)
EP (1) EP1622880B3 (el)
JP (1) JP4733631B2 (el)
KR (1) KR100927063B1 (el)
CN (1) CN100393706C (el)
AR (1) AR044078A1 (el)
AT (1) ATE355280T1 (el)
AU (1) AU2004233978B2 (el)
BR (1) BRPI0410029B8 (el)
CA (1) CA2524069C (el)
CL (1) CL2004000930A1 (el)
CO (1) CO5700764A2 (el)
CY (2) CY1106476T1 (el)
DE (2) DE10319612A1 (el)
DK (1) DK1622880T6 (el)
EC (1) ECSP056138A (el)
EG (1) EG25273A (el)
ES (1) ES2284007T7 (el)
FR (1) FR18C1029I2 (el)
HN (1) HN2004000146A (el)
HU (2) HUS1800018I1 (el)
IL (1) IL171513A (el)
MA (1) MA27794A1 (el)
MX (1) MXPA05011707A (el)
MY (1) MY144616A (el)
NL (1) NL300933I2 (el)
NO (2) NO333265B3 (el)
NZ (1) NZ543317A (el)
PE (1) PE20050145A1 (el)
PL (1) PL1622880T6 (el)
PT (1) PT1622880E (el)
RU (1) RU2360912C2 (el)
SI (1) SI1622880T1 (el)
TW (1) TWI335912B (el)
UA (1) UA82519C2 (el)
UY (1) UY28294A1 (el)
WO (1) WO2004096778A1 (el)
ZA (1) ZA200508710B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101680A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
NZ715387A (en) * 2013-06-19 2018-02-23 Aicuris Anti Infective Cures Gmbh Amorphous letermovir and solid pharmaceutical formulations thereof for oral administration
US9890128B2 (en) 2013-12-12 2018-02-13 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
US10392353B2 (en) * 2015-11-24 2019-08-27 Merck Sharp & Dohme Corp. Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
JP6951418B2 (ja) * 2016-08-08 2021-10-20 メッドシャイン ディスカバリー インコーポレイテッド 抗ｈｃｍｖウイルス化合物
AU2019218150B2 (en) * 2018-02-08 2021-05-13 Phaeno Therapeutics Co., Ltd. Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
KR102672512B1 (ko) 2018-09-12 2024-06-10 노파르티스 아게 항바이러스 피리도피라진디온 화합물
US11667613B2 (en) 2019-09-26 2023-06-06 Novartis Ag Antiviral pyrazolopyridinone compounds
UY39095A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2- [(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
AR121439A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
AR121437A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR121440A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
US20230312485A1 (en) 2020-08-17 2023-10-05 Lupin Limited A precipitation process for amorphous letermovir
CN115403528B (zh) * 2021-05-27 2025-01-07 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
UY40078A (es) 2021-12-21 2023-06-30 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin
CN118974026A (zh) * 2022-04-01 2024-11-15 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用
WO2025133248A1 (en) 2023-12-21 2025-06-26 Aic246 Ag & Co. Kg Diastereomeric aminoalcohol and aminoether salts of 2-[(4r,s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl]acetic acid and their use for enantiomeric separation

Family Cites Families (27)

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DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
US6200977B1 (en) 1998-02-17 2001-03-13 Tularik Inc. Pyrimidine derivatives
KR20010113820A (ko) 1999-04-19 2001-12-28 시오노 요시히코 옥사디아졸 고리를 갖는 술폰아미드 유도체
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) * 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
DK1325008T3 (da) * 2000-07-31 2006-02-13 Hoffmann La Roche Piperazinderivater
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
ES2252455T3 (es) 2001-04-19 2006-05-16 Bayer Healthcare Ag Arilsulfonamidas como agentes antivirales.
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) * 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) * 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) * 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
JP5139083B2 (ja) * 2005-01-25 2013-02-06 プロレキシーズ ファーマシューティカルズ インコーポレイテッド 抗腫瘍剤としてのキノキサリン誘導体
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
JP4880684B2 (ja) * 2005-07-21 2012-02-22 エフ．ホフマン−ラ ロシュ アーゲー Ｐｔｐ１ｂ阻害剤としてのピリド［２，３−ｄ］ピリミジン−２，４−ジアミン化合物
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
NZ715387A (en) * 2013-06-19 2018-02-23 Aicuris Anti Infective Cures Gmbh Amorphous letermovir and solid pharmaceutical formulations thereof for oral administration

Also Published As

Publication number Publication date
NO20055649L (no) 2006-01-31
US20070191387A1 (en) 2007-08-16
BRPI0410029B1 (pt) 2019-12-31
CO5700764A2 (es) 2006-11-30
CY1106476T1 (el) 2012-01-25
CL2004000930A1 (es) 2005-03-18
MA27794A1 (fr) 2006-03-01
NO333265B3 (no) 2019-06-03
CY2018019I2 (el) 2018-12-12
USRE49698E1 (en) 2023-10-17
CN1784390A (zh) 2006-06-07
MXPA05011707A (es) 2006-02-13
BRPI0410029A (pt) 2006-04-25
TW200510343A (en) 2005-03-16
KR20060009883A (ko) 2006-02-01
CN100393706C (zh) 2008-06-11
BRPI0410029B8 (pt) 2021-06-15
ECSP056138A (es) 2006-04-19
JP4733631B2 (ja) 2011-07-27
NL300933I2 (nl) 2018-04-26
DK1622880T3 (da) 2007-06-25
KR100927063B1 (ko) 2009-11-13
HUS1800028I1 (hu) 2018-07-30
ATE355280T1 (de) 2006-03-15
JP2006525249A (ja) 2006-11-09
HK1092463A1 (zh) 2007-02-09
USRE46791E1 (en) 2018-04-17
RU2360912C2 (ru) 2009-07-10
DE10319612A1 (de) 2004-11-18
UA82519C2 (uk) 2008-04-25
AU2004233978B2 (en) 2010-02-11
NO2018022I1 (no) 2018-07-04
UY28294A1 (es) 2004-11-30
ES2284007T7 (es) 2018-06-20
EP1622880B3 (de) 2018-05-23
WO2004096778A1 (de) 2004-11-11
FR18C1029I1 (el) 2018-08-17
US20050065160A1 (en) 2005-03-24
DE502004003052D1 (de) 2007-04-12
DK1622880T6 (da) 2018-06-18
EP1622880B1 (de) 2007-02-28
US7196086B2 (en) 2007-03-27
AR044078A1 (es) 2005-08-24
TWI335912B (en) 2011-01-11
FR18C1029I2 (fr) 2020-07-17
EG25273A (en) 2011-12-04
PT1622880E (pt) 2007-06-04
PL1622880T6 (pl) 2018-08-31
AU2004233978A1 (en) 2004-11-11
CA2524069A1 (en) 2004-11-11
EP1622880A1 (de) 2006-02-08
PL1622880T3 (pl) 2007-08-31
NZ543317A (en) 2008-05-30
HN2004000146A (es) 2008-06-24
ES2284007T3 (es) 2007-11-01
MY144616A (en) 2011-10-14
ZA200508710B (en) 2006-12-27
RU2005137276A (ru) 2006-07-27
NO333265B1 (no) 2013-04-22
US8513255B2 (en) 2013-08-20
IL171513A (en) 2011-11-30
SI1622880T1 (sl) 2007-08-31
PE20050145A1 (es) 2005-05-22
NO20055649D0 (no) 2005-11-30
CA2524069C (en) 2011-11-08
HUS1800018I1 (hu) 2018-05-28

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