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PE20040207A1 - Anticuerpos humanizados que reconocen el peptido amiloide beta - Google Patents

Anticuerpos humanizados que reconocen el peptido amiloide beta

Info

Publication number
PE20040207A1
PE20040207A1 PE2003000251A PE2003000251A PE20040207A1 PE 20040207 A1 PE20040207 A1 PE 20040207A1 PE 2003000251 A PE2003000251 A PE 2003000251A PE 2003000251 A PE2003000251 A PE 2003000251A PE 20040207 A1 PE20040207 A1 PE 20040207A1
Authority
PE
Peru
Prior art keywords
waste
light
sequence
variable region
immunoglobulin
Prior art date
Application number
PE2003000251A
Other languages
English (en)
Inventor
Guriq Basi
Jose Saldanha
Original Assignee
Wyeth Corp
Elan Pharma Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Elan Pharma Int Ltd filed Critical Wyeth Corp
Publication of PE20040207A1 publication Critical patent/PE20040207A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA CADENA LIGERA O PESADA DE INMUNOGLOBULINA HUMANIZADA COMPRENDIENDO REGIONES COMPLEMENTARIAS DETERMINANTES DE LA DE REGION VARIABLE (CDRs) A PARTIR DE LA SECUENCIA DE REGION VARIABLE DE LA CADENA LIGERA O PESADA DE LA INMUNOGLOBULINA 12B4 ESTABLECIDA COMO SEQ ID N°2 Y QUE COMPRENDE REGIONES DE MARCO VARIABLE DE UNA SECUENCIA DE CADENA LIGERA DE INMUNOGLOBULINA DE RECEPTOR HUMANO, SIEMPRE Y CUANDO AL MENOS UN RESIDUO MARCO SEA SUSTITUIDO CON EL CORRESPONDIENTE AMINOACIDO DE LA SECUENCIA DE LA REGION VARIABLE DE LA CADENA LIGERA O PESADA 12B4 DONDE EL RESIDUO MARCO SE SELECCIONA DE: a) UN RESIDUO QUE NO SE UNE COVALENTEMENTE AL ANTIGENO DE MANERA DIRECTA; b) UN RESIDUO ADYACENTE A UNA CDR; c) UN RESIDUO QUE INTERACTUA CON LA CDR Y d) UN RESIDUO QUE PARTICIPA EN LA INTERFASE VL-VH.SE REFIERE TAMBIEN A AGENTES MEJORADOS QUE INCLUYEN ANTICUERPOS HUMANIZADOS PARA EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS A LOS DEPOSITOS AMILOIDEOS DE AB EN EL CEREBRO COMO LA ENFERMEDADA DE ALZHEIMER.
PE2003000251A 2002-03-12 2003-03-12 Anticuerpos humanizados que reconocen el peptido amiloide beta PE20040207A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36375102P 2002-03-12 2002-03-12

Publications (1)

Publication Number Publication Date
PE20040207A1 true PE20040207A1 (es) 2004-04-13

Family

ID=28041806

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000251A PE20040207A1 (es) 2002-03-12 2003-03-12 Anticuerpos humanizados que reconocen el peptido amiloide beta

Country Status (29)

Country Link
US (2) US7256273B2 (es)
EP (1) EP1554311B1 (es)
JP (1) JP2006503549A (es)
KR (2) KR20110027846A (es)
CN (1) CN1703426B (es)
AR (1) AR038953A1 (es)
AU (1) AU2003214152B2 (es)
BR (1) BR0308143A (es)
CA (1) CA2478049C (es)
CO (1) CO5611164A2 (es)
EA (1) EA010902B1 (es)
EC (1) ECSP045314A (es)
ES (1) ES2389541T3 (es)
GE (1) GEP20084474B (es)
HR (1) HRP20040950A2 (es)
IL (2) IL163626A0 (es)
IS (1) IS7499A (es)
MX (1) MXPA04008740A (es)
MY (1) MY139983A (es)
NO (1) NO20043992L (es)
NZ (1) NZ535769A (es)
PE (1) PE20040207A1 (es)
PL (1) PL215258B1 (es)
SG (1) SG180018A1 (es)
TW (1) TWI328116B (es)
UA (1) UA89469C2 (es)
UY (1) UY27721A1 (es)
WO (1) WO2003077858A2 (es)
ZA (1) ZA200406616B (es)

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US8128928B2 (en) 2012-03-06
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CN1703426A (zh) 2005-11-30
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