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PE20050627A1 - Anticuerpos humanizados que reconocen el peptido beta amiloideo - Google Patents

Anticuerpos humanizados que reconocen el peptido beta amiloideo

Info

Publication number
PE20050627A1
PE20050627A1 PE2004000544A PE2004000544A PE20050627A1 PE 20050627 A1 PE20050627 A1 PE 20050627A1 PE 2004000544 A PE2004000544 A PE 2004000544A PE 2004000544 A PE2004000544 A PE 2004000544A PE 20050627 A1 PE20050627 A1 PE 20050627A1
Authority
PE
Peru
Prior art keywords
heavy chain
sequence
light
residue
region
Prior art date
Application number
PE2004000544A
Other languages
English (en)
Inventor
Guriq Basi
Jose Saldanha
Frederique Bard
Original Assignee
Wyeth Corp
Elan Pharma Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Elan Pharma Int Ltd filed Critical Wyeth Corp
Publication of PE20050627A1 publication Critical patent/PE20050627A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE REFIERE A LA IDENTIFICACION Y CARACTERIZACION DE UN ANTICUERPO QUE PRESENTA UNA CADENA LIGERA O PESADA DE INMUNOGLOBULINA HUMANIZADA QUE COMPRENDE: (i) REGIONES DE DETERMINACION DE COMPLEMENTARIEDAD DE REGION VARIABLE (CDRs) A PARTIR DE LA SECUENCIA DE REGION VARIABLE DE LA CADENA LIGERA O PESADA DE LA INMUNOGLOBULINA 12A11 COMO SE PRESENTA EN SEQ ID NO:2 Y SEQ ID NO:4 RESPECTIVAMENTE, Y (ii) REGION DE MARCO VARABLE DE UNA SECUENCIA DE CADENA LIGERA O PESADA DE INMUNOGLOBULINA DE RECEPTOR HUMANO, SIEMPRE Y CUANDO AL MENOS UN RESIDUO DEL MARCO SEA SUSTITUIDO CON EL CORRESPONDIENTE RESIDUO AMINOACIDO DE LA SECUENCIA DE LA REGION VARIABLE DE LA CADENA LIGERA O PESADA DE 12A11, DONDE EL RESIDUO SE SELECCIONA DE: UNO QUE DE MANERA NO COVALENTE SE UNA AL ANTIGENO DIRECTAMENTE; UNO ADYACENTE A UNA CDR; UNO QUE INTERACTUA CON LA CDR O UNO QUE PARTICIPE EN LA INTERFASE VL-VH. TAMBIEN SE REFIERE A METODOS PARA TRATAR O PREVENIR LAS ENFERMEDADES O DESORDENES ASOCIADAS A LOS DEPOSITOS AMILOIDEOS DE AB EN EL CEREBRO (COMO LA ENFERMEDAD DE ALZHEIMER) Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN
PE2004000544A 2003-05-30 2004-05-28 Anticuerpos humanizados que reconocen el peptido beta amiloideo PE20050627A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47465403P 2003-05-30 2003-05-30

Publications (1)

Publication Number Publication Date
PE20050627A1 true PE20050627A1 (es) 2005-08-10

Family

ID=33511618

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000544A PE20050627A1 (es) 2003-05-30 2004-05-28 Anticuerpos humanizados que reconocen el peptido beta amiloideo

Country Status (30)

Country Link
US (1) US7871615B2 (es)
EP (1) EP1636268B8 (es)
JP (1) JP4908203B2 (es)
KR (2) KR101152583B1 (es)
CN (1) CN1798766B (es)
AR (1) AR044580A1 (es)
AT (1) ATE545656T1 (es)
AU (1) AU2004245989B2 (es)
BR (1) BRPI0410860A (es)
CA (1) CA2525975C (es)
CO (1) CO5660296A2 (es)
CR (1) CR8095A (es)
DK (1) DK1636268T3 (es)
EA (1) EA012407B1 (es)
EC (1) ECSP056263A (es)
ES (1) ES2382547T3 (es)
IL (1) IL171877A (es)
MX (1) MXPA05012718A (es)
MY (1) MY176959A (es)
NO (1) NO20055415L (es)
NZ (1) NZ544324A (es)
PE (1) PE20050627A1 (es)
PL (1) PL1636268T3 (es)
PT (1) PT1636268E (es)
SI (1) SI1636268T1 (es)
TW (2) TWI374893B (es)
UA (1) UA90846C2 (es)
UY (1) UY28337A1 (es)
WO (1) WO2004108895A2 (es)
ZA (1) ZA200509585B (es)

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