PE20040671A1 - Derivados de la 4-hidroximetil-1-aril-ciclohexilamina - Google Patents
Derivados de la 4-hidroximetil-1-aril-ciclohexilaminaInfo
- Publication number
- PE20040671A1 PE20040671A1 PE2003001133A PE2003001133A PE20040671A1 PE 20040671 A1 PE20040671 A1 PE 20040671A1 PE 2003001133 A PE2003001133 A PE 2003001133A PE 2003001133 A PE2003001133 A PE 2003001133A PE 20040671 A1 PE20040671 A1 PE 20040671A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- cycloalkyl
- heteroaryl
- substituted
- branched
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 102100021469 Equilibrative nucleoside transporter 1 Human genes 0.000 abstract 1
- 101000822020 Homo sapiens Equilibrative nucleoside transporter 1 Proteins 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009278 visceral effect Effects 0.000 abstract 1
- 208000009935 visceral pain Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A DERIVADOS DE 4-HIDROXIMETIL-1-ARIL-CICLOHEXILAMINA DE FORMULA I, EN DONDE R1 Y R2 SON H, ALQUILO(C1-C8) O CICLOALQUILO(C3-C8), OPCIONALMENTE SATURADOS, RAMIFICADOS, Y SUSTITUIDOS UNO O MAS VECES, ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS O ARILO, CICLOALQUILO(C3-C8) O HETEROARILO OPCIONALMENTE SUSTITUIDO, ENLAZADO A TRAVES DE ALQUILO(C1-C3); O R1 Y R2 FORMAN JUNTOS UN ANILLO Y REPRESENTAN CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 O (CH2)3-6); R3 ES ALQUILO(C1-C8) O CICLOALQUILO(C3-C8) OPCIONALMENTE SATURADOS, RAMIFICADOS, Y UNA O MAS VECES SUSTITUIDOS, ARILO O HETEROARILO, OPCIONALMENTE SUSTITUIDOS, ARILO, CICLOALQUILO(C3-C8) O HETEROARILO SUSTITUIDOS O NO Y ENLAZADOS A TRAVES DE UN GRUPO ALQUILO(C1-C4) OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS; R5 ES CICLOALQUILO(C3-C8), ARILO O HETEROARILO SUSTITUIDOS O NO, POR -CH2R12, -CH2CH2R12, -CH2CH2CH2R12. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE (4-BENCILOXIMETIL-1-FENILCICLOHEXIL)-DIMETILAMINA, CLORHIDRATO DE [4-(4-FLUOROBENCIL-OXIMETIL)-1-FENILCICLOHEXIL]-DIMETILAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA PREPARAR DICHOS COMPUESTOS Y FORMULACIONES FARMACEUTICAS QUE LOS CONTENGAN. ESTOS COMPUESTOS TIENE INFLUENCIA SOBRE EL SISTEMA NOCICEPTINA /RECEPTOR ORL1 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR, EN ESPECIAL DOLOR AGUDO, VISCERAL, NEUROPATICO O CRONICO
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10252872A DE10252872A1 (de) | 2002-11-12 | 2002-11-12 | 4-Hydroxymethyl-1-Aryl-Cyclohexylamin-Derivate |
| DE10253323A DE10253323A1 (de) | 2002-11-14 | 2002-11-14 | 4-Oxymethyl-1-Aryl-Cyclohexylamin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040671A1 true PE20040671A1 (es) | 2004-09-25 |
Family
ID=32313558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001133A PE20040671A1 (es) | 2002-11-12 | 2003-11-10 | Derivados de la 4-hidroximetil-1-aril-ciclohexilamina |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7232847B2 (es) |
| EP (1) | EP1560807B1 (es) |
| AR (1) | AR041933A1 (es) |
| AT (1) | ATE457299T1 (es) |
| AU (1) | AU2003296564A1 (es) |
| DE (1) | DE50312412D1 (es) |
| ES (1) | ES2340766T3 (es) |
| PE (1) | PE20040671A1 (es) |
| WO (1) | WO2004043902A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| CN104840416A (zh) * | 2005-09-28 | 2015-08-19 | 奥里斯医学股份有限公司 | 治疗内耳疾病的药用组合物 |
| EP2792347A1 (en) * | 2005-09-28 | 2014-10-22 | Auris Medical AG | Pharmaceutical compositions for the treatment of inner ear disorders |
| US20090215725A1 (en) * | 2008-02-26 | 2009-08-27 | Grunenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| JP5650637B2 (ja) | 2008-03-27 | 2015-01-07 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | （ヘテロ−）アリール−シクロヘキサン誘導体 |
| ES2375543T3 (es) | 2008-03-27 | 2012-03-01 | Grünenthal GmbH | Derivados de espiro(5.5)undecano. |
| CN102046596B (zh) | 2008-03-27 | 2013-12-25 | 格吕伦塔尔有限公司 | 取代的环己二胺 |
| AU2009228647B2 (en) | 2008-03-27 | 2013-07-04 | Grunenthal Gmbh | Substituted spirocyclic cyclohexane derivatives |
| AU2009228642B2 (en) | 2008-03-27 | 2013-11-07 | Grunenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| RU2514192C2 (ru) * | 2008-03-27 | 2014-04-27 | Грюненталь Гмбх | Гидроксиметилциклогексиламины |
| US20150044200A1 (en) | 2011-12-12 | 2015-02-12 | Otolanum Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115589A (en) * | 1977-05-17 | 1978-09-19 | The Upjohn Company | Compounds, compositions and method of use |
| US5968737A (en) * | 1996-11-12 | 1999-10-19 | The University Of Mississippi | Method of identifying inhibitors of glutathione S-transferase (GST) gene expression |
| US6423725B1 (en) * | 1998-01-19 | 2002-07-23 | Pfizer Inc | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as ORL1-receptor agonists |
| DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
-
2003
- 2003-11-05 EP EP03810964A patent/EP1560807B1/de not_active Expired - Lifetime
- 2003-11-05 ES ES03810964T patent/ES2340766T3/es not_active Expired - Lifetime
- 2003-11-05 AU AU2003296564A patent/AU2003296564A1/en not_active Abandoned
- 2003-11-05 AT AT03810964T patent/ATE457299T1/de active
- 2003-11-05 DE DE50312412T patent/DE50312412D1/de not_active Expired - Lifetime
- 2003-11-05 WO PCT/EP2003/012312 patent/WO2004043902A1/de not_active Ceased
- 2003-11-10 PE PE2003001133A patent/PE20040671A1/es not_active Application Discontinuation
- 2003-11-11 AR ARP030104136A patent/AR041933A1/es unknown
-
2005
- 2005-05-11 US US11/126,306 patent/US7232847B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7232847B2 (en) | 2007-06-19 |
| WO2004043902A1 (de) | 2004-05-27 |
| EP1560807B1 (de) | 2010-02-10 |
| DE50312412D1 (en) | 2010-03-25 |
| AR041933A1 (es) | 2005-06-01 |
| AU2003296564A1 (en) | 2004-06-03 |
| US20050267218A1 (en) | 2005-12-01 |
| ATE457299T1 (de) | 2010-02-15 |
| EP1560807A1 (de) | 2005-08-10 |
| ES2340766T3 (es) | 2010-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |