AR045805A1 - Quinolonas y naftridonas 7- amino alquidenil - heterociclicas - Google Patents
Quinolonas y naftridonas 7- amino alquidenil - heterociclicasInfo
- Publication number
- AR045805A1 AR045805A1 ARP040103422A ARP040103422A AR045805A1 AR 045805 A1 AR045805 A1 AR 045805A1 AR P040103422 A ARP040103422 A AR P040103422A AR P040103422 A ARP040103422 A AR P040103422A AR 045805 A1 AR045805 A1 AR 045805A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- hydroxy
- alkylthio
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 150000002431 hydrogen Chemical group 0.000 abstract 6
- 125000004414 alkyl thio group Chemical group 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- -1 amino, hydroxy Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000676 alkoxyimino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente se refiere a compuestos antimiciosiano. Reivindicación 1: Un compuesto que tiene una estructura de acuerdo con la fórmula (1), en la cual: n es un número entero de 1 a 3; m es un número entero de 1 a 3; z es un número entero de 0 a 3; R se selecciona de hidrógeno, hidroxi y alcoxi; R2 es hidrógeno; R3 y R4 se seleccionan independientemente de hidrógeno, halógeno, amino, hidroxi, alcoxi, alquiltio, alquilo, alquenilo y alquinilo; R5 se seleccionan de hidrógeno, hidroxi, halógeno, alquilo, arilo, alcoxi y alquiltio; R6 se selecciona independientemente de alquilo, hidroxi, alcoxi, alquiltio, alquenilo, alquinilo, arilo, alcoxiimino, y halógeno; o R5 y R6 se unen para formar un anillo carbocíclico de 4 a 7 miembros en donde cada átomo de carbono del anillo puede ser opcionalmente sustituido con R12, en donde R12 se selecciona del grupo que consiste en halógeno, amino, hidroxi, alcoxi, alquiltio, alquilo, alquenilo, alquinilo, oxo, alcoxiimino e hidroxiimino; E se selecciona del grupo que consiste en: a) la fórmula (2) en donde: q es un número entero de 1 a 3; R7 y R8 son cada uno independientemente seleccionado de hidrógeno y alquilo, o R7 y R8 se unen para formar un anillo carbocíclico de 3 a 6 miembros, o cualquiera de R7 o R8 puede estar unido independientemente de cualquiera de R9 o R10 para formar un anillo heterocíclico que contiene el átomo de nitrógeno al cual R9 o R10 están unidos, en donde R9 y R10 son cada uno independientemente seleccionado de hidrógeno, alquilo, acilo, alcoxicarbonilo, o sulfonilo, o alternativamente R9 y R10 se unen para formar un anillo heterocíclico que contiene el átomo de nitrógeno al cual están unidos; b) la fórmula (2) en donde: q es según lo definido anteriormente; R7 y R8 son cada uno independientemente seleccionado de hidrógeno y alquilo, o R7 y R8 se unen para formar un anillo carbocíclico de 3 a 6 miembros, y R9 se selecciona de hidrógeno, alquilo, acilo, alcoxicarbonilo o sulfonilo; y c) alquenilo; A se selecciona de N y C(R11), en donde R11 se selecciona de hidrógeno, alquilo, halógeno, hidroxi, alcoxi, alquiltio, y ciano; X se selecciona de C y N, donde si X es C, a es un enlace doble y b es un enlace único, y si X es N, a es un enlace único y b es un enlace doble; e Y se selecciona de N(R1), y C(R1), con la condición de que cuando Y es N(R1), X es C y cuando Y es C(R1), X es N, donde R1 se selecciona de cicloalquilo C3-6, heterocicloalquilo C4-6, alquilo, alqueno, un arilo de 6 miembros y un heteroarilo de 6 miembros, siempre que si A es C(R11), X es C e Y es N(R1), entonces R11 y R1 pueden unirse para formar un anillo heterocíclico de 6 miembros, o si A es C(R11), X es C e Y N(R1), entonces R2 y R1 pueden unirse para formar un anillo heterocíclico monocíclico o bicíclico, o si A es C(R11), X es C e Y es N(R1), entonces R2 y R pueden unirse para formar un anillo heterocíclico de 5 miembros; o un isómero, diastereómero o enantiómero óptico del mismo; su sal, hidrato o profármaco farmacéuticamente aceptable.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50492403P | 2003-09-22 | 2003-09-22 | |
| US10/937,238 US7179805B2 (en) | 2003-09-22 | 2004-09-09 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045805A1 true AR045805A1 (es) | 2005-11-16 |
Family
ID=34421521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103422A AR045805A1 (es) | 2003-09-22 | 2004-09-22 | Quinolonas y naftridonas 7- amino alquidenil - heterociclicas |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7179805B2 (es) |
| EP (1) | EP1675852B1 (es) |
| JP (2) | JP2007522093A (es) |
| KR (1) | KR101137311B1 (es) |
| CN (1) | CN1997642B (es) |
| AR (1) | AR045805A1 (es) |
| AT (1) | ATE423117T1 (es) |
| AU (1) | AU2004278320B2 (es) |
| BR (1) | BRPI0414573A (es) |
| CA (1) | CA2539349C (es) |
| CY (1) | CY1109424T1 (es) |
| DE (1) | DE602004019555D1 (es) |
| DK (1) | DK1675852T3 (es) |
| ES (1) | ES2321722T3 (es) |
| IL (1) | IL174397A (es) |
| MY (1) | MY176860A (es) |
| NZ (1) | NZ545970A (es) |
| PL (1) | PL1675852T3 (es) |
| PT (1) | PT1675852E (es) |
| RU (1) | RU2350615C2 (es) |
| SI (1) | SI1675852T1 (es) |
| TW (1) | TWI359150B (es) |
| WO (1) | WO2005033108A1 (es) |
| ZA (1) | ZA200603223B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004066824A2 (en) * | 2003-01-24 | 2004-08-12 | The General Hospital Corporation | System and method for identifying tissue using low-coherence interferometry |
| US7732612B2 (en) * | 2004-09-09 | 2010-06-08 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| US20090156577A1 (en) * | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| AU2012244358B2 (en) * | 2005-03-21 | 2015-05-28 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| EP1891037A1 (en) * | 2005-06-15 | 2008-02-27 | Hetero Drugs Limited | Gemifloxacin process and polymorphs |
| JO2752B1 (en) | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| CA2617557A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Benzimidazole derivatives as sirtuin modulators |
| AU2006287157A1 (en) * | 2005-09-02 | 2007-03-08 | Pfizer Inc. | Hydroxy substituted 1H-imidazopyridines and methods |
| CA2626641A1 (en) * | 2005-10-21 | 2007-07-19 | Glaxo Group Limited | Compounds |
| US20070185153A1 (en) | 2005-12-22 | 2007-08-09 | Nathalie Cailleau | Compounds |
| MX2008012327A (es) | 2006-03-28 | 2008-10-09 | Procter & Gamble | Un proceso de reduccion con hidruro para preparar intermedios de quinolona. |
| MY148393A (en) * | 2006-03-28 | 2013-04-15 | Taigen Biotechnology Co Ltd | Malate salts, and polymorphs of (3s, 5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
| MX2008012488A (es) | 2006-03-28 | 2008-10-10 | Procter & Gamble | Un proceso de acoplamiento para preparar intermedios de quinolona. |
| US20080009628A1 (en) * | 2006-07-05 | 2008-01-10 | Michael Reuman | One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols |
| PT2214491T (pt) * | 2007-10-05 | 2016-10-25 | Senhwa Biosciences Inc | Análogos de quinolona e métodos com eles relacionados |
| NZ596492A (en) | 2009-05-15 | 2013-08-30 | Redx Pharma Ltd | Redox drug derivatives |
| EP2523948A1 (en) * | 2010-01-11 | 2012-11-21 | Janssen Pharmaceutica, N.V. | Pro-drugs of (e) -7- (3- (2-amino-1-fluoroethylidene) piperidin-1-yl) -1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| CN104098588B (zh) * | 2013-04-02 | 2016-05-25 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一类三环喹诺酮衍生物及其制备方法和用途 |
| US10787424B2 (en) | 2014-05-21 | 2020-09-29 | New York University | Oxopiperazine helix mimetics for control of Hypoxia-Inducible gene expression |
| EP3377068B1 (en) | 2015-11-20 | 2025-03-26 | Senhwa Biosciences, Inc. | Combination therapy of tetracyclic quinolone analogs for treating cancer |
| US9957282B2 (en) | 2015-12-14 | 2018-05-01 | Senhwa Biosciences, Inc. | Crystalline forms of quinolone analogs and their salts |
| RU2020130050A (ru) | 2018-02-15 | 2022-03-15 | Сэньхва Байосайенсиз, Инк. | Аналоги хинолонов и их соли, композиции и способ их применения |
| RU2671573C1 (ru) * | 2018-09-03 | 2018-11-02 | Алина Викторовна Шумадалова | 2-[6-метил-4-(тиетан-3-илокси)пиримидин-2-илтио]ацетогидразид малеиновой кислоты, проявляющий противомикробную активность |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS605539B2 (ja) * | 1980-03-17 | 1985-02-12 | 日東紡績株式会社 | 耐アルカリ性、耐熱性無機質繊維 |
| DK164287A (da) * | 1986-03-31 | 1987-10-01 | Sankyo Co | Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse |
| JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
| CA1332605C (en) * | 1988-10-03 | 1994-10-18 | Yasuhiro Nishitani | Pyridonecarboxylic acids |
| US5580872A (en) * | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| FR2681865B1 (fr) * | 1991-10-01 | 1993-11-19 | Bel Laboratoire Roger | Nouveaux derives de la benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent. |
| FR2692577B1 (fr) * | 1992-05-26 | 1996-02-02 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
| JPH06263754A (ja) * | 1993-03-12 | 1994-09-20 | Hokuriku Seiyaku Co Ltd | ７−アミノピロリジニルキノリン−３−カルボン酸誘導体 |
| ZA944369B (en) * | 1993-08-27 | 1995-02-13 | Hokuriku Seuyaku Co Ltd | 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative |
| BR9407806A (pt) * | 1993-10-14 | 1997-08-19 | Abbott Lab | Composto processo de tratamento de uma infecção bacteriana em um paciente humano ou veterinário e intermediário sintético |
| US5392154A (en) * | 1994-03-30 | 1995-02-21 | Bell Communications Research, Inc. | Self-regulating multiwavelength optical amplifier module for scalable lightwave communications systems |
| KR0131999B1 (ko) * | 1994-06-16 | 1998-04-17 | 성재갑 | 7-(4-아미노메틸-3-옥심)피롤리딘 치환제를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법 |
| JPH11510478A (ja) * | 1995-06-06 | 1999-09-14 | アボツト・ラボラトリーズ | キノリジノン型化合物 |
| WO1997031001A1 (de) * | 1996-02-23 | 1997-08-28 | Bayer Aktiengesellschaft | Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre derivate |
| IL135036A0 (en) | 1997-09-15 | 2001-05-20 | Procter & Gamble | Antimicrobial quinolones, their compositions and uses |
| KR100330409B1 (ko) * | 1998-07-23 | 2002-08-27 | 한국과학기술원 | 파장분할다중 방식 다중화/역다중화 장치와 이를 이용한 파장분할다중 방식 수동형 광 가입자망 |
| US6964966B2 (en) * | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
-
2004
- 2004-09-09 JP JP2006526944A patent/JP2007522093A/ja active Pending
- 2004-09-09 RU RU2006109004/04A patent/RU2350615C2/ru active
- 2004-09-09 CA CA2539349A patent/CA2539349C/en not_active Expired - Fee Related
- 2004-09-09 PL PL04783671T patent/PL1675852T3/pl unknown
- 2004-09-09 AU AU2004278320A patent/AU2004278320B2/en not_active Ceased
- 2004-09-09 NZ NZ545970A patent/NZ545970A/en not_active IP Right Cessation
- 2004-09-09 CN CN2004800337880A patent/CN1997642B/zh not_active Expired - Fee Related
- 2004-09-09 AT AT04783671T patent/ATE423117T1/de active
- 2004-09-09 DK DK04783671T patent/DK1675852T3/da active
- 2004-09-09 SI SI200431076T patent/SI1675852T1/sl unknown
- 2004-09-09 ES ES04783671T patent/ES2321722T3/es not_active Expired - Lifetime
- 2004-09-09 US US10/937,238 patent/US7179805B2/en not_active Expired - Lifetime
- 2004-09-09 WO PCT/US2004/029523 patent/WO2005033108A1/en not_active Ceased
- 2004-09-09 BR BRPI0414573-9A patent/BRPI0414573A/pt not_active Application Discontinuation
- 2004-09-09 EP EP04783671A patent/EP1675852B1/en not_active Expired - Lifetime
- 2004-09-09 KR KR1020067007817A patent/KR101137311B1/ko not_active Expired - Fee Related
- 2004-09-09 DE DE602004019555T patent/DE602004019555D1/de not_active Expired - Lifetime
- 2004-09-09 PT PT04783671T patent/PT1675852E/pt unknown
- 2004-09-21 MY MYPI20043865A patent/MY176860A/en unknown
- 2004-09-21 TW TW093128488A patent/TWI359150B/zh not_active IP Right Cessation
- 2004-09-22 AR ARP040103422A patent/AR045805A1/es not_active Application Discontinuation
-
2006
- 2006-03-19 IL IL174397A patent/IL174397A/en active IP Right Grant
- 2006-04-21 ZA ZA2006/03223A patent/ZA200603223B/en unknown
-
2009
- 2009-04-29 CY CY20091100474T patent/CY1109424T1/el unknown
-
2012
- 2012-03-07 JP JP2012050624A patent/JP5431515B2/ja not_active Expired - Fee Related
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