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PE20090593A1 - Compuestos heterociclos como antagonistas del receptor de bradiquinina b1 - Google Patents

Compuestos heterociclos como antagonistas del receptor de bradiquinina b1

Info

Publication number
PE20090593A1
PE20090593A1 PE2008001366A PE2008001366A PE20090593A1 PE 20090593 A1 PE20090593 A1 PE 20090593A1 PE 2008001366 A PE2008001366 A PE 2008001366A PE 2008001366 A PE2008001366 A PE 2008001366A PE 20090593 A1 PE20090593 A1 PE 20090593A1
Authority
PE
Peru
Prior art keywords
compounds
bradiquinin
antagonists
receptor
alkyl
Prior art date
Application number
PE2008001366A
Other languages
English (en)
Inventor
Norbert Hauel
Angelo Ceci
Henri Doods
Iris Kauffmann-Hefner
Ingo Konetzki
Annette Schuler-Metz
Rainer Walter
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2007/058408 external-priority patent/WO2008022945A1/de
Priority claimed from PCT/EP2008/052157 external-priority patent/WO2009021758A1/de
Priority claimed from EP08102043A external-priority patent/EP2025673A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20090593A1 publication Critical patent/PE20090593A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A COMPUESTOS HETEROCICLOS DE FORMULA (I) DONDE A ES UN ENLACE; B ES UN ENLACE; D-Y SON JUNTOS UN GRUPO SELECCIONADO DE (i), (ii) O (iii); R1 ES (z); R2 ES H O ALQUILO(C1-C3) OPCIONALMENTE SUSTITUIDO CON F O H3C-C(O)-; R3 ES CICLOALQUILENO(C4-C6) OPCIONALMENTE SUSTITUIDO CON R3,1, DONDE R3,1 ES -CH3, -C2H5, ISOPROPILO, TERCBUTILO, ENTRE OTROS; R4 ES UN DIAZA-HETEROCICLO SATURADO DE 6 O 7 MIEMBROS; R5 ES ALQUILO(C1-C3) O CICLOALQUILO(C3-C5). SON COMPUESTOS PREFERIDOS LOS DE FORMULA (a), (b), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE BRADIQUININA B1 SIENDO UTILES EN EL TRATAMIENTO DE DOLORES AGUDOS, VISCERALES, NEUROPATICOS, TUMORALES
PE2008001366A 2007-08-14 2008-08-12 Compuestos heterociclos como antagonistas del receptor de bradiquinina b1 PE20090593A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2007/058408 WO2008022945A1 (de) 2006-08-19 2007-08-14 Arylsulfonamide mit analgetischer wirkung
PCT/EP2008/052157 WO2009021758A1 (de) 2007-08-14 2008-02-21 Arylsulfonamide mit analgetischer wirkung
EP08102043A EP2025673A1 (de) 2007-08-14 2008-02-26 Arylsulfonamide mit analgetischer Wirkung

Publications (1)

Publication Number Publication Date
PE20090593A1 true PE20090593A1 (es) 2009-06-03

Family

ID=40589564

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001366A PE20090593A1 (es) 2007-08-14 2008-08-12 Compuestos heterociclos como antagonistas del receptor de bradiquinina b1

Country Status (21)

Country Link
US (1) US8394805B2 (es)
EP (1) EP2188269B1 (es)
JP (1) JP5250627B2 (es)
KR (1) KR20100055469A (es)
CN (1) CN101821245B (es)
AR (1) AR068341A1 (es)
AU (2) AU2008288431A1 (es)
BR (1) BRPI0815181A2 (es)
CA (1) CA2696261A1 (es)
CO (1) CO6331335A2 (es)
EA (1) EA201000296A1 (es)
EC (1) ECSP109978A (es)
MA (1) MA31613B1 (es)
MX (1) MX2010001664A (es)
NZ (1) NZ583815A (es)
PE (1) PE20090593A1 (es)
TN (1) TN2010000072A1 (es)
TW (1) TW200911744A (es)
UY (1) UY31287A1 (es)
WO (1) WO2009021944A1 (es)
ZA (1) ZA201008350B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006039003A1 (de) * 2006-08-19 2008-02-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Verbindungen
EP2025675A1 (de) 2007-08-14 2009-02-18 Boehringer Ingelheim International GmbH Arylsulfonamide mit analgetischer Wirkung
CN101821245B (zh) 2007-08-14 2012-10-10 贝林格尔·英格海姆国际有限公司 化合物
EP2240458B1 (de) * 2008-02-06 2011-08-03 Boehringer Ingelheim International GmbH Arylsulfonamide wirksam als schmerzmittel
CA2735560A1 (en) * 2008-08-12 2010-02-18 Boehringer Ingelheim International Gmbh Process for preparing cycloalkyl-substituted piperazine compounds
US8207335B2 (en) * 2009-02-13 2012-06-26 Boehringer Ingelheim International Gmbh Process for making certain compounds having B1 antagonistic activity
US20130289049A1 (en) * 2010-08-05 2013-10-31 Boehringer Ingelheim International Gmbh Acid addition salts of the 2-[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-(methyl)amino]ethoxy]-n-methyl-n-[3-(4-methylpiperazin-1-yl)cyclohexyl] acetamide and the use thereof as bradykinin b1 receptorantagonists
WO2012022796A2 (de) 2010-08-20 2012-02-23 Boehringer Ingelheim International Gmbh Neue kombinationen
AR082890A1 (es) 2010-09-03 2013-01-16 Gruenenthal Gmbh Derivados sustituidos de tetrahidropirrolopirazina
AU2020333225A1 (en) * 2019-08-16 2022-02-24 Cyclacel Limited Process for the preparation of a pyrimidino-diazepine derivative

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EP0173552B1 (en) 1984-08-24 1991-10-09 The Upjohn Company Recombinant dna compounds and the expression of polypeptides such as tpa
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
DK1249233T3 (da) 1999-11-26 2008-11-17 Shionogi & Co NPYY5-antagonister
FR2819254B1 (fr) * 2001-01-08 2003-04-18 Fournier Lab Sa Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
FR2840897B1 (fr) * 2002-06-14 2004-09-10 Fournier Lab Sa Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
CA2509881A1 (en) 2002-12-19 2004-07-08 Elan Pharmaceuticals, Inc. Substituted n-phenyl sulfonamide bradykinin antagonists
CN1756551A (zh) * 2003-01-31 2006-04-05 普雷迪克医药品控股公司 新型芳基哌嗪基化合物
WO2004087700A1 (fr) * 2003-03-25 2004-10-14 Laboratoires Fournier S.A. Derives du benzenesulfonamide, leur procede de preparation et leur utilisation de la douleur
US7521457B2 (en) 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
EP1799637A1 (en) 2004-09-23 2007-06-27 Amgen, Inc Substituted sulfonamidopropionamides and methods of use
US20080090863A1 (en) 2004-09-30 2008-04-17 Taisho Pharmaceutical Co., Ltd. Pyridine Derivatives and Their Use as Medicaments for Treating Diseases Related to Mch Receptor
DE102005013967A1 (de) * 2004-11-05 2006-10-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2006071775A2 (en) 2004-12-29 2006-07-06 Elan Pharmaceuticals, Inc. Novel compounds useful for bradykinin b1 receptor antagonism
JP5603770B2 (ja) 2007-05-31 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体拮抗薬およびその使用
DE102007034620A1 (de) * 2007-07-25 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue B1-Antagonisten
ATE502918T1 (de) * 2007-08-14 2011-04-15 Boehringer Ingelheim Int Arylsulfonamide mit analgetischer wirkung
CN101821245B (zh) 2007-08-14 2012-10-10 贝林格尔·英格海姆国际有限公司 化合物
DE102007046887A1 (de) * 2007-09-28 2009-04-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von (1R,5S)-Anhydroecgoninestersalzen

Also Published As

Publication number Publication date
KR20100055469A (ko) 2010-05-26
ZA201008350B (en) 2011-08-31
CN101821245B (zh) 2012-10-10
AU2008288431A1 (en) 2009-02-19
JP2010535839A (ja) 2010-11-25
US20110098282A1 (en) 2011-04-28
WO2009021944A1 (de) 2009-02-19
CA2696261A1 (en) 2009-02-19
UY31287A1 (es) 2009-04-30
US8394805B2 (en) 2013-03-12
NZ583815A (en) 2012-03-30
AR068341A1 (es) 2009-11-11
AU2009281472A1 (en) 2010-02-18
TN2010000072A1 (en) 2011-09-26
MX2010001664A (es) 2010-03-10
EP2188269B1 (de) 2014-05-07
ECSP109978A (es) 2010-03-31
EA201000296A1 (ru) 2010-08-30
CO6331335A2 (es) 2011-10-20
BRPI0815181A2 (pt) 2015-03-31
TW200911744A (en) 2009-03-16
JP5250627B2 (ja) 2013-07-31
CN101821245A (zh) 2010-09-01
MA31613B1 (fr) 2010-08-02
EP2188269A1 (de) 2010-05-26

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