PE20040673A1 - Derivados de la ciclohexilurea - Google Patents
Derivados de la ciclohexilureaInfo
- Publication number
- PE20040673A1 PE20040673A1 PE2003001137A PE2003001137A PE20040673A1 PE 20040673 A1 PE20040673 A1 PE 20040673A1 PE 2003001137 A PE2003001137 A PE 2003001137A PE 2003001137 A PE2003001137 A PE 2003001137A PE 20040673 A1 PE20040673 A1 PE 20040673A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- substituted
- cycloalkyl
- heteroaryl
- Prior art date
Links
- WUESWDIHTKHGQA-UHFFFAOYSA-N cyclohexylurea Chemical class NC(=O)NC1CCCCC1 WUESWDIHTKHGQA-UHFFFAOYSA-N 0.000 title abstract 2
- 208000002193 Pain Diseases 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 3- (PHENYLPROPYL) -UREA HYDROCHLORIDE Chemical compound 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 102100021469 Equilibrative nucleoside transporter 1 Human genes 0.000 abstract 1
- 101000822020 Homo sapiens Equilibrative nucleoside transporter 1 Proteins 0.000 abstract 1
- 102000048266 Nociceptin Human genes 0.000 abstract 1
- 108090000622 Nociceptin Proteins 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000009278 visceral effect Effects 0.000 abstract 1
- 208000009935 visceral pain Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/14—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A DERIVADOS DE LA CICLOHEXILUREA DE FORMULA I, DONDE n ES 0 A 3; m ES 0 A 2; X ES O o S (CUANDO m=0); R1 Y R2 SON H, ALQUILO(C1-C8) O CICLOALQUILO(C3-C8), OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS, ARILO O HETEROARILO, SUSTITUIDOS O NO, O ARILO, CICLOALQUILO(C3-C8) O HETEROARILO, ENLAZADO A ALQUILENO(C1-C3), O R1 Y R2 JUNTOS FORMAN UN ANILLO Y REPRESENTAN CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 O (CH2)3-6; R3 ES ALQUILO(C1-C8) O CICLOALQUILO(C3-C8), OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS; ARILO O HETEROARILO, SUSTITUIDOS NO, ARILO, CICLOALQUILO(C3-C8) O HETEROARILO, ENLAZADO POR ALQUILO(C1-C4); R4 ES H, ALQUILO(C1-C8) OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS, O ES (CH2)o-W-(CH2)p-H; R5 CUANDO m ES DIFERENTE DE 0, ES (CH2)qR12, C(Y)ZR12, C(Y)OZR12; O BIEN R5, CUANDO m ES 0, ES CICLOALQUILO(C3-C8), ARILO O HETEROARILO, SUSTITUIDOS O NO; O ES (CH2)qR12. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE 1-(4-DIMETILAMINO-4-FENILCICLOHEXIL)3-(FENILPROPIL)-UREA; CLOHIDRATO DE 1-(4-DIMETILAMINO-4-FENILCICLOHEXIL)3-[2-(1H-INDOL-3-ILO)-ETIL]-UREA; CLORHIDRATO DE N-[(4-DIMETILAMINO-4-FENILCICLOHEXIL-CARBAMOIL)-METIL]-3-(1H-INDOL-3-ILO)-BUTIRAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA OBTENCION DE ESTOS DERIVADOS. ESTOS COMPUESTOS INFLUYEN SOBRE EL SISTEMA NOCICEPTINA/RECEPTOR ORL1 Y SON UTILES PARA EL TRATAMIENTO DEL DOLOR, DOLOR AGUDO, VISCERAL O CRONICO, Y TAMBIEN PARA ESTADOS DE ANGUSTIA, ESTRES Y DE SINDROMES RELACIONADOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10252650A DE10252650A1 (de) | 2002-11-11 | 2002-11-11 | Cyclohexyl-Harnstoff-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040673A1 true PE20040673A1 (es) | 2004-09-25 |
Family
ID=32185549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001137A PE20040673A1 (es) | 2002-11-11 | 2003-11-11 | Derivados de la ciclohexilurea |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7348354B2 (es) |
| EP (1) | EP1560809B1 (es) |
| AR (1) | AR041931A1 (es) |
| AT (1) | ATE370929T1 (es) |
| AU (1) | AU2003287992A1 (es) |
| DE (2) | DE10252650A1 (es) |
| ES (1) | ES2293053T3 (es) |
| PE (1) | PE20040673A1 (es) |
| WO (1) | WO2004043909A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2860514A1 (fr) | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
| DE102004023501A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023522A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023632A1 (de) * | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
| DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023507A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
| DE102004023508A1 (de) * | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
| DE102004023506A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| AR070398A1 (es) | 2008-02-22 | 2010-03-31 | Gruenenthal Chemie | Derivados sustituidos de indol |
| RU2514192C2 (ru) | 2008-03-27 | 2014-04-27 | Грюненталь Гмбх | Гидроксиметилциклогексиламины |
| JP5650637B2 (ja) | 2008-03-27 | 2015-01-07 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | （ヘテロ−）アリール−シクロヘキサン誘導体 |
| ES2375543T3 (es) | 2008-03-27 | 2012-03-01 | Grünenthal GmbH | Derivados de espiro(5.5)undecano. |
| AU2009228647B2 (en) | 2008-03-27 | 2013-07-04 | Grunenthal Gmbh | Substituted spirocyclic cyclohexane derivatives |
| CN102046596B (zh) | 2008-03-27 | 2013-12-25 | 格吕伦塔尔有限公司 | 取代的环己二胺 |
| AU2009228642B2 (en) | 2008-03-27 | 2013-11-07 | Grunenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| BRPI1004176A2 (pt) * | 2010-10-25 | 2015-08-11 | Univ Rio De Janeiro | Compostos aril e/ou hetero aril uréias funcionalizados; processo de síntese desses composto; composição farmacêutica contendo tais compostos e usos |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1179200B (de) * | 1960-01-26 | 1964-10-08 | Hoechst Ag | Verfahren zur Herstellung von N-Benzolsulfonyl-N'-methyl-cyclohexylharnstoffen |
| US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
| CA2180021A1 (en) * | 1994-11-04 | 1996-05-17 | Yoichi Kawashima | Novel 1,3-dialkylurea derivatives having a hydroxyl group |
| DE19756036A1 (de) * | 1997-12-17 | 1999-06-24 | Merck Patent Gmbh | Amid- und Harnstoffderivate |
| AU2001252575A1 (en) * | 2000-04-28 | 2001-11-12 | Asahi Kasei Kabushiki Kaisha | Novel tricyclic compounds |
| GB0012240D0 (en) * | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB0100623D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds IV |
| DE10123163A1 (de) * | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
-
2002
- 2002-11-11 DE DE10252650A patent/DE10252650A1/de not_active Withdrawn
-
2003
- 2003-11-05 AU AU2003287992A patent/AU2003287992A1/en not_active Abandoned
- 2003-11-05 EP EP03779844A patent/EP1560809B1/de not_active Expired - Lifetime
- 2003-11-05 WO PCT/EP2003/012304 patent/WO2004043909A1/de not_active Ceased
- 2003-11-05 AT AT03779844T patent/ATE370929T1/de active
- 2003-11-05 ES ES03779844T patent/ES2293053T3/es not_active Expired - Lifetime
- 2003-11-05 DE DE50308027T patent/DE50308027D1/de not_active Expired - Lifetime
- 2003-11-11 AR ARP030104134A patent/AR041931A1/es unknown
- 2003-11-11 PE PE2003001137A patent/PE20040673A1/es not_active Application Discontinuation
-
2005
- 2005-05-11 US US11/126,161 patent/US7348354B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE370929T1 (de) | 2007-09-15 |
| ES2293053T3 (es) | 2008-03-16 |
| DE10252650A1 (de) | 2004-05-27 |
| DE50308027D1 (en) | 2007-10-04 |
| AR041931A1 (es) | 2005-06-01 |
| US7348354B2 (en) | 2008-03-25 |
| US20050261358A1 (en) | 2005-11-24 |
| WO2004043909A1 (de) | 2004-05-27 |
| EP1560809A1 (de) | 2005-08-10 |
| AU2003287992A1 (en) | 2004-06-03 |
| EP1560809B1 (de) | 2007-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |