PE20030906A1 - INHIBIDORES DE LA MICROGLIA PARA INTERRUMPIR REACCIONES INMUNES ASOCIADAS CON INTERLEUCINA 12 Y IFNy - Google Patents
INHIBIDORES DE LA MICROGLIA PARA INTERRUMPIR REACCIONES INMUNES ASOCIADAS CON INTERLEUCINA 12 Y IFNyInfo
- Publication number
- PE20030906A1 PE20030906A1 PE2003000119A PE2003000119A PE20030906A1 PE 20030906 A1 PE20030906 A1 PE 20030906A1 PE 2003000119 A PE2003000119 A PE 2003000119A PE 2003000119 A PE2003000119 A PE 2003000119A PE 20030906 A1 PE20030906 A1 PE 20030906A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- microgly
- interleukin
- cells
- immune reactions
- Prior art date
Links
- 238000006243 chemical reaction Methods 0.000 title abstract 4
- 102000013462 Interleukin-12 Human genes 0.000 title abstract 2
- 108010065805 Interleukin-12 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229940117681 interleukin-12 Drugs 0.000 title abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- -1 COOR5 Chemical group 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- JSHDAORXSNJOBA-UHFFFAOYSA-N Isopropyl hexanoate Chemical compound CCCCCC(=O)OC(C)C JSHDAORXSNJOBA-UHFFFAOYSA-N 0.000 abstract 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 208000028774 intestinal disease Diseases 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 230000003959 neuroinflammation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10207843A DE10207843A1 (de) | 2002-02-15 | 2002-02-15 | Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030906A1 true PE20030906A1 (es) | 2004-01-17 |
Family
ID=27674912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000119A PE20030906A1 (es) | 2002-02-15 | 2003-02-03 | INHIBIDORES DE LA MICROGLIA PARA INTERRUMPIR REACCIONES INMUNES ASOCIADAS CON INTERLEUCINA 12 Y IFNy |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1474138A1 (de) |
| JP (1) | JP2005522447A (de) |
| KR (1) | KR20040084909A (de) |
| CN (1) | CN1756546A (de) |
| AR (1) | AR039556A1 (de) |
| AU (1) | AU2003245523A1 (de) |
| BR (1) | BR0307706A (de) |
| CA (1) | CA2475770A1 (de) |
| DE (1) | DE10207843A1 (de) |
| EC (1) | ECSP045297A (de) |
| MX (1) | MXPA04007943A (de) |
| NO (1) | NO20043840L (de) |
| PE (1) | PE20030906A1 (de) |
| PL (1) | PL371327A1 (de) |
| RS (1) | RS71304A (de) |
| RU (1) | RU2004127677A (de) |
| TW (1) | TW200306823A (de) |
| UA (1) | UA81111C2 (de) |
| UY (1) | UY27662A1 (de) |
| WO (1) | WO2003068225A1 (de) |
| ZA (1) | ZA200407382B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10207844A1 (de) * | 2002-02-15 | 2003-09-04 | Schering Ag | 1-Phenyl-2-heteroaryl-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
| DE602005016729D1 (de) * | 2005-03-17 | 2009-10-29 | Proyecto Biomedicina Cima Sl | Verwendung von 5'-methylthioadenosin zur prävention und/oder behandlung von autoimmunkrankheiten und/oder transplantatabstossung |
| WO2013186229A1 (en) * | 2012-06-11 | 2013-12-19 | Ucb Pharma S.A. | Tnf -alpha modulating benzimidazoles |
| US9586949B2 (en) | 2015-02-09 | 2017-03-07 | Incyte Corporation | Aza-heteroaryl compounds as PI3K-gamma inhibitors |
| LT3371190T (lt) | 2015-11-06 | 2022-08-10 | Incyte Corporation | Heterocikliniai junginiai, kaip pi3k-gama inhibitoriai |
| DK3390367T3 (da) * | 2015-12-15 | 2020-10-26 | Univ Leland Stanford Junior | Fremgangsmåde til forebyggelse og/eller behandling af aldersrelateret kognitiv funktionsnedsættelse og neuroinflammation |
| AR107293A1 (es) | 2016-01-05 | 2018-04-18 | Incyte Corp | COMPUESTOS DE PIRIDINA Y PIRIDIMINA COMO INHIBIDORES DE PI3K-g |
| US10138248B2 (en) | 2016-06-24 | 2018-11-27 | Incyte Corporation | Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors |
| WO2019079469A1 (en) | 2017-10-18 | 2019-04-25 | Incyte Corporation | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED WITH HYDROXY TERTIARY GROUPS AS INHIBITORS OF PI3K-GAMMA |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| PL3860998T3 (pl) | 2018-10-05 | 2024-06-17 | Annapurna Bio Inc. | Związki i kompozycje do leczenia schorzeń związanych z aktywnością receptora apj |
| CN112341450B (zh) * | 2019-08-09 | 2022-05-17 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112341451B (zh) * | 2019-08-09 | 2022-06-17 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| WO2021126923A1 (en) * | 2019-12-19 | 2021-06-24 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Cd206 modulators their use and methods for preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4330959A1 (de) * | 1993-09-09 | 1995-03-16 | Schering Ag | Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| CA2396227C (en) * | 2000-01-14 | 2012-03-20 | Schering Aktiengesellschaft | 1,2-diaryl benzimidazoles for treating illnesses associated with a microglia activation |
| DE10134775A1 (de) * | 2001-07-06 | 2003-01-30 | Schering Ag | 1-Alkyl-2.aryl-benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
| DE10135050A1 (de) * | 2001-07-09 | 2003-02-06 | Schering Ag | 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
-
2002
- 2002-02-15 DE DE10207843A patent/DE10207843A1/de not_active Ceased
-
2003
- 2003-01-17 KR KR10-2004-7012557A patent/KR20040084909A/ko not_active Ceased
- 2003-01-17 UA UA20040907401A patent/UA81111C2/uk unknown
- 2003-01-17 CN CNA038039923A patent/CN1756546A/zh active Pending
- 2003-01-17 RS YU71304A patent/RS71304A/sr unknown
- 2003-01-17 CA CA002475770A patent/CA2475770A1/en not_active Abandoned
- 2003-01-17 PL PL03371327A patent/PL371327A1/xx not_active Application Discontinuation
- 2003-01-17 WO PCT/EP2003/000467 patent/WO2003068225A1/de not_active Ceased
- 2003-01-17 RU RU2004127677/15A patent/RU2004127677A/ru unknown
- 2003-01-17 BR BR0307706-3A patent/BR0307706A/pt not_active IP Right Cessation
- 2003-01-17 EP EP03739380A patent/EP1474138A1/de not_active Withdrawn
- 2003-01-17 JP JP2003567407A patent/JP2005522447A/ja active Pending
- 2003-01-17 AU AU2003245523A patent/AU2003245523A1/en not_active Abandoned
- 2003-01-17 MX MXPA04007943A patent/MXPA04007943A/es unknown
- 2003-02-03 PE PE2003000119A patent/PE20030906A1/es not_active Application Discontinuation
- 2003-02-11 UY UY27662A patent/UY27662A1/es not_active Application Discontinuation
- 2003-02-12 AR ARP030100436A patent/AR039556A1/es unknown
- 2003-02-14 TW TW092103072A patent/TW200306823A/zh unknown
-
2004
- 2004-09-14 EC EC2004005297A patent/ECSP045297A/es unknown
- 2004-09-14 ZA ZA200407382A patent/ZA200407382B/en unknown
- 2004-09-14 NO NO20043840A patent/NO20043840L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2475770A1 (en) | 2003-08-21 |
| PL371327A1 (en) | 2005-06-13 |
| UY27662A1 (es) | 2003-09-30 |
| WO2003068225A1 (de) | 2003-08-21 |
| ECSP045297A (es) | 2004-10-26 |
| KR20040084909A (ko) | 2004-10-06 |
| BR0307706A (pt) | 2005-01-11 |
| AU2003245523A1 (en) | 2003-09-04 |
| ZA200407382B (en) | 2005-09-14 |
| CN1756546A (zh) | 2006-04-05 |
| AR039556A1 (es) | 2005-02-23 |
| RU2004127677A (ru) | 2005-06-10 |
| UA81111C2 (en) | 2007-12-10 |
| EP1474138A1 (de) | 2004-11-10 |
| DE10207843A1 (de) | 2003-09-04 |
| JP2005522447A (ja) | 2005-07-28 |
| TW200306823A (en) | 2003-12-01 |
| RS71304A (sr) | 2006-10-27 |
| MXPA04007943A (es) | 2004-11-26 |
| NO20043840L (no) | 2004-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030906A1 (es) | INHIBIDORES DE LA MICROGLIA PARA INTERRUMPIR REACCIONES INMUNES ASOCIADAS CON INTERLEUCINA 12 Y IFNy | |
| EA200401167A1 (ru) | Производные тропана в качестве модуляторов ccr5 | |
| ES2044878T3 (es) | Un proceso para la preparacion de derivados de benzimidazol. | |
| HUP0200895A2 (hu) | Alfa-helyettesített karbonsavak benzimidazolszármazékai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| MX9305768A (es) | Nuevos derivados de taxano y procedimiento para su preparacion . | |
| AR032679A1 (es) | Derivados del acido isoftalico como inhibidores de metaloproteinasas de la matriz | |
| YU46195B (sh) | Postupak za dobijanje antiaritmičkih agenasa | |
| AR017164A1 (es) | Derivados de la benzamidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, los medicamentos y laspreparaciones farmaceuticas que contienen estos derivados de la benzamidina, y un procedimiento para obtener estas preparaciones farmaceuticas. | |
| ATE301651T1 (de) | Substituierte benzimidazole | |
| ES8801193A1 (es) | Procedimiento para la preparacion de carbamatos de fenilo | |
| BRPI0313477B8 (pt) | derivados de purina, composição farmacêutica que os compreende, seu processo de preparação e uso | |
| AR016817A1 (es) | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento | |
| AR029215A1 (es) | Derivados de benzazol y tautomeros de los mismos utiles en el tratamiento de desordenes en los sistemas de autoinmunidad y neuronales, uso de dichos derivados en la preparacion de composiciones farmaceuticas aplicables en el tratamiento de dichos desordenes, metodo prar inhibir la expresion y/o acti | |
| TR200102399T2 (tr) | Tiyoamid türevleri | |
| ES8301225A1 (es) | Un procedimiento para la preparacion de un derivado de 3- aril-5-isotiazol | |
| ES2073398T3 (es) | Nuevos derivados substituidos del acido bencilideno- y cinamilideno-malonico con actividad como inhibidores de la proliferacion celular. | |
| FI810250L (fi) | Foerfarande foer framstaellning av nya terapeutiskt aktiva heterocykliska foereningar | |
| RU2006113371A (ru) | Производные бензимидазола, содержащие их композиции, их получение и применение | |
| AR011057A1 (es) | Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestos | |
| JP2005515976A5 (de) | ||
| JP2002535380A5 (de) | ||
| RU2019128534A (ru) | Химические соединения для лечения туберкулеза | |
| AR010984A1 (es) | Nuevos esteres de la pleuromutilina, y el acido 1-azabiciclo-4- carbanilcarbanico; procedimiento para su preparacion y composicionesfarmaceuticas que los contienen. | |
| BR0313480A (pt) | Derivados de purina | |
| FI894900A0 (fi) | Menetelmä farmaseuttisesti käyttökelpoisten -D-fenyylitioksylosidien valmistamiseksi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |