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MX9305768A - Nuevos derivados de taxano y procedimiento para su preparacion . - Google Patents

Nuevos derivados de taxano y procedimiento para su preparacion .

Info

Publication number
MX9305768A
MX9305768A MX9305768A MX9305768A MX9305768A MX 9305768 A MX9305768 A MX 9305768A MX 9305768 A MX9305768 A MX 9305768A MX 9305768 A MX9305768 A MX 9305768A MX 9305768 A MX9305768 A MX 9305768A
Authority
MX
Mexico
Prior art keywords
radical
formula
taxane
procedure
vii
Prior art date
Application number
MX9305768A
Other languages
English (en)
Inventor
Alain Commercon
Eric Didier
Elie Fouque
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of MX9305768A publication Critical patent/MX9305768A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a un procedimiento de preparación de los derivados del taxano de la fórmula (I) por la esterificación de la baccatina III o de la 10-desacetil baccatina III, protegida por un ácido de la fórmula (VII), a la eliminación de los grupos protectores y luego a la acilación de la función amina de la cadena lateral. Los productos de la fórmula (I) presentan propiedades antitumorígenas y antileucémicas remarcables. En las fórmulas (I) y (VII), Ar representa arilo, R representa hidrógeno o acetilo, R1 representa un radical benzoilo o un radical R2-O-CO- en el cual R2 representa alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquileno, bicicloalquilo, fenilo o heterciclilo, R3 representa un radical trihalometilo o fenilo sustituido por un radical trihalometilo, R4 representa un átomo de hidrógeno o es idéntico a R1.
MX9305768A 1992-10-05 1993-09-21 Nuevos derivados de taxano y procedimiento para su preparacion . MX9305768A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211743A FR2696460B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.

Publications (1)

Publication Number Publication Date
MX9305768A true MX9305768A (es) 1994-05-31

Family

ID=9434121

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9305768A MX9305768A (es) 1992-10-05 1993-09-21 Nuevos derivados de taxano y procedimiento para su preparacion .

Country Status (24)

Country Link
US (3) US5621121A (es)
EP (1) EP0663908B1 (es)
JP (1) JP3014762B2 (es)
KR (1) KR100301237B1 (es)
AT (1) ATE148882T1 (es)
AU (1) AU690080B2 (es)
CA (1) CA2146249A1 (es)
CZ (1) CZ283291B6 (es)
DE (1) DE69308154T2 (es)
DK (1) DK0663908T3 (es)
ES (1) ES2098060T3 (es)
FI (1) FI951592A7 (es)
FR (1) FR2696460B1 (es)
GR (1) GR3022616T3 (es)
HU (1) HUT72613A (es)
MX (1) MX9305768A (es)
NO (1) NO311255B1 (es)
NZ (1) NZ256447A (es)
PL (1) PL184556B1 (es)
RU (1) RU2115649C1 (es)
SK (1) SK280577B6 (es)
TW (1) TW393474B (es)
WO (1) WO1994007879A1 (es)
ZA (1) ZA937320B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2155304C (en) 1993-02-05 2010-07-20 Charles Swindell Syntheses of paclitaxel, analogs and intermediates with variable a-ring side chains
AU691804B2 (en) * 1993-03-22 1998-05-28 Florida State University Taxanes having furyl or thienyl substituted side-chain
AU7138894A (en) * 1993-06-11 1995-01-03 Pharmacia & Upjohn Company Delta 6,7--taxols antineoplastic use and pharmaceutical compositions containing them
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
EP0728130A1 (en) * 1993-11-12 1996-08-28 PHARMACIA & UPJOHN COMPANY Pyrimidine-thioalkyl and alkylether compounds
IL127597A (en) * 1994-01-28 2003-07-31 Upjohn Co Iso-taxol analogs
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
CZ293508B6 (cs) * 1996-05-08 2004-05-12 Pharmaciaá@Áupjohnácompany Fenylisoserinestery silylového baccatinu III
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
AU739303B2 (en) 1997-08-21 2001-10-11 Florida State University Method for the synthesis of taxanes
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
EP1318794A2 (en) 2000-09-22 2003-06-18 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
TWI293302B (en) * 2001-01-12 2008-02-11 Sod Conseils Rech Applic New derivatives of mikanolide, their preparation and their therapeutic uses
EP1383754B1 (en) * 2001-03-23 2011-02-23 ScinoPharm Taiwan, Ltd. Process for making taxane derivatives
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
DE102004034140A1 (de) * 2004-07-15 2006-02-23 Covion Organic Semiconductors Gmbh Verwendung von Polymeren für Up-conversion und Vorrichtungen zur Up-conversion
CN101534642A (zh) * 2006-10-20 2009-09-16 神隆药业新加坡私人有限公司 用于制备结晶无水多西紫杉醇的方法
KR100847331B1 (ko) * 2006-12-14 2008-07-21 한미약품 주식회사 도세탁셀의 제조방법 및 이에 사용되는 중간체
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
KR101003820B1 (ko) 2008-06-19 2010-12-27 주식회사 셀트리온화학연구소 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
JP2014079364A (ja) * 2012-10-16 2014-05-08 Tokai Medical Care Holdings Co Ltd 歩行訓練補助器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
AU7138894A (en) * 1993-06-11 1995-01-03 Pharmacia & Upjohn Company Delta 6,7--taxols antineoplastic use and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPH08501790A (ja) 1996-02-27
US5726318A (en) 1998-03-10
EP0663908A1 (fr) 1995-07-26
US5621121A (en) 1997-04-15
ZA937320B (en) 1994-04-25
NO951203L (no) 1995-03-29
JP3014762B2 (ja) 2000-02-28
FI951592L (fi) 1995-04-04
PL184556B1 (pl) 2002-11-29
NO311255B1 (no) 2001-11-05
ATE148882T1 (de) 1997-02-15
KR100301237B1 (ko) 2001-11-22
CZ84395A3 (en) 1995-09-13
NZ256447A (en) 1997-01-29
RU95110682A (ru) 1996-12-27
HU9500968D0 (en) 1995-06-28
PL308242A1 (en) 1995-07-24
EP0663908B1 (fr) 1997-02-12
FR2696460A1 (fr) 1994-04-08
FI951592A0 (fi) 1995-04-04
CA2146249A1 (fr) 1994-04-14
TW393474B (en) 2000-06-11
RU2115649C1 (ru) 1998-07-20
AU690080B2 (en) 1998-04-23
SK280577B6 (sk) 2000-04-10
FI951592A7 (fi) 1995-04-04
DE69308154T2 (de) 1997-09-25
FR2696460B1 (fr) 1994-11-25
AU5115293A (en) 1994-04-26
WO1994007879A1 (fr) 1994-04-14
KR950703548A (ko) 1995-09-20
HUT72613A (en) 1996-05-28
DK0663908T3 (es) 1997-03-17
US5861515A (en) 1999-01-19
NO951203D0 (no) 1995-03-29
ES2098060T3 (es) 1997-04-16
DE69308154D1 (de) 1997-03-27
CZ283291B6 (cs) 1998-02-18
SK43495A3 (en) 1995-08-09
GR3022616T3 (en) 1997-05-31

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: INEOS FLUOR HOLDINGS LIMITED

MM Annulment or lapse due to non-payment of fees