[go: up one dir, main page]

ES8301225A1 - Un procedimiento para la preparacion de un derivado de 3- aril-5-isotiazol - Google Patents

Un procedimiento para la preparacion de un derivado de 3- aril-5-isotiazol

Info

Publication number
ES8301225A1
ES8301225A1 ES505678A ES505678A ES8301225A1 ES 8301225 A1 ES8301225 A1 ES 8301225A1 ES 505678 A ES505678 A ES 505678A ES 505678 A ES505678 A ES 505678A ES 8301225 A1 ES8301225 A1 ES 8301225A1
Authority
ES
Spain
Prior art keywords
aril
procedure
acid
isotiazole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505678A
Other languages
English (en)
Other versions
ES505678A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8301225A1 publication Critical patent/ES8301225A1/es
Publication of ES505678A0 publication Critical patent/ES505678A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE 3-ARIL-5-ISOTIAZOL. CONSISTE EN SOMETER A HIDROLISIS A UN COMPUESTO (I) EN QUE Q ES UN GRUPO ESTER AMIDO O NITRILO PARA FORMA EL ACIDO (II) EN QUE R ES HIDROXI. OPCIONALMENTE SE SALIFICA O ESTERIFICA DICHO ACIDO PARA FORMAR LA SAL O ESTER FARMACEUTICAMENTE ACEPTABLE. A<040> ES PIRIDILO, TIENILO, FENILO O EL RADICAL (III) EN QUE R , R Y R SON INDIVIDUALMENTE HIDROGENO, HALOALQUILO, HALOGENO, ALQUILO O ALCOXI; X ES AMINO, HIDROXI, HIDROGENO, HALOGENO O ALQUILAMINO. >ACTIVIDAD DE LA REDUCCION DE LOS NIVELES DE URATO (ACIDO URICO) EN MAMIFEROS.
ES505678A 1980-09-22 1981-09-21 Un procedimiento para la preparacion de un derivado de 3- aril-5-isotiazol Granted ES505678A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/189,435 US4346094A (en) 1980-09-22 1980-09-22 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels

Publications (2)

Publication Number Publication Date
ES8301225A1 true ES8301225A1 (es) 1982-12-01
ES505678A0 ES505678A0 (es) 1982-12-01

Family

ID=22697314

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505678A Granted ES505678A0 (es) 1980-09-22 1981-09-21 Un procedimiento para la preparacion de un derivado de 3- aril-5-isotiazol

Country Status (22)

Country Link
US (1) US4346094A (es)
EP (1) EP0048615B1 (es)
JP (1) JPS5785379A (es)
KR (1) KR830007597A (es)
AR (1) AR229103A1 (es)
AT (1) ATE7657T1 (es)
AU (1) AU7551681A (es)
CS (1) CS228536B2 (es)
DD (1) DD201790A5 (es)
DE (1) DE3163900D1 (es)
DK (1) DK417981A (es)
ES (1) ES505678A0 (es)
FI (1) FI812940A7 (es)
GB (1) GB2084573B (es)
GR (1) GR75046B (es)
IL (1) IL63890A0 (es)
NO (1) NO813208L (es)
PL (1) PL130497B1 (es)
PT (1) PT73711B (es)
RO (1) RO82216A (es)
YU (1) YU227181A (es)
ZA (1) ZA816549B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428956A (en) 1980-12-29 1984-01-31 Merck & Co., Inc. 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4431652A (en) * 1980-12-29 1984-02-14 Merck & Co., Inc. 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4539328A (en) * 1983-03-25 1985-09-03 Fmc Corporation Nematicidal isothiazole derivatives
US4620865A (en) * 1983-11-07 1986-11-04 Eli Lilly And Company Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
ZW21687A1 (en) * 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
DE69122084T2 (de) * 1990-11-30 1997-04-03 Teijin Ltd., Osaka 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
MY117352A (en) * 1995-10-31 2004-06-30 Ciba Sc Holding Ag Oximesulfonic acid esters and the use thereof as latent sulfonic acids.
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
AU1520699A (en) 1997-11-07 1999-05-31 Johns Hopkins University, The Methods for treatment of disorders of cardiac contractility
TW575792B (en) * 1998-08-19 2004-02-11 Ciba Sc Holding Ag New unsaturated oxime derivatives and the use thereof as latent acids
SG78412A1 (en) 1999-03-31 2001-02-20 Ciba Sc Holding Ag Oxime derivatives and the use thereof as latent acids
EP1472576B1 (en) 2002-02-06 2013-04-24 Basf Se Sulfonate derivatives and the use therof as latent acids
MX2007002160A (es) * 2004-08-27 2007-05-10 Astellas Pharma Inc Derivado de 2-fenilpiridina.
JPWO2006022375A1 (ja) * 2004-08-27 2008-05-08 アステラス製薬株式会社 ２−フェニルチオフェン誘導体
EP1932832B1 (en) 2005-10-07 2010-12-01 Astellas Pharma Inc. Triarylcarboxylic acid derivative
KR20080097456A (ko) 2006-02-24 2008-11-05 아스텔라스세이야쿠 가부시키가이샤 소화관 궤양의 치료제 또는 예방제
GB2450975B (en) 2007-07-12 2010-02-24 Ciba Holding Inc Yellow radiation curing inks
EP2668953A1 (en) * 2008-05-22 2013-12-04 Bristol-Myers Squibb Company Pharmaceutical compositions comprising an SGLT2 inhibitor with a supply of carbohydrate and/or an inhibitor of uric acid synthesis
PL2404908T3 (pl) 2009-02-27 2014-12-31 Teijin Ltd Sposób wytwarzania podstawionej fenylem pochodnej heterocyklicznej przez sprzężenie z użyciem katalizatora metalu przejściowego
KR20110137821A (ko) 2009-03-30 2011-12-23 바스프 에스이 Ｕｖ-조사량 인디케이터 필름
HUE030166T2 (en) 2010-08-27 2017-05-29 Teijin Pharma Ltd Process for the preparation of a phenyl-substituted heterocyclic derivative by coupling using a palladium compound
KR101897842B1 (ko) 2011-01-28 2018-09-12 바스프 에스이 열 경화제로서 옥심 술포네이트를 포함하는 중합성 조성물
CN105189476B (zh) 2013-03-29 2017-07-07 帝人制药株式会社 吡唑衍生物
CN106604912A (zh) 2014-08-29 2017-04-26 巴斯夫欧洲公司 肟磺酸酯衍生物
CA2984044A1 (en) 2015-04-29 2016-11-03 Bsn Medical Gmbh Steady-state no production via ph control
AU2016256577B2 (en) 2015-04-29 2019-04-04 Bsn Medical Gmbh Medical bathing device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178604A (en) * 1966-03-21 1970-01-21 American Cyanamid Co Novel Pyridinium Salts and Methods for Preparing Same
US3464999A (en) * 1967-07-27 1969-09-02 R & L Molecular Research Ltd Thiadiazolylisothiazoles
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1192701A (en) * 1968-03-22 1970-05-20 Ici Ltd Novel Thiazole Derivatives, the preparation thereof and Compositions containing the same
US3681498A (en) * 1970-10-19 1972-08-01 American Cyanamid Co Isothiazolyl pyridinium salts as hypoglycemic agents

Also Published As

Publication number Publication date
EP0048615A1 (en) 1982-03-31
DE3163900D1 (en) 1984-07-05
PT73711A (en) 1981-10-01
ZA816549B (en) 1983-04-27
PT73711B (en) 1982-12-20
YU227181A (en) 1983-10-31
DD201790A5 (de) 1983-08-10
KR830007597A (ko) 1983-11-04
US4346094A (en) 1982-08-24
JPS5785379A (en) 1982-05-28
NO813208L (no) 1982-03-23
CS228536B2 (en) 1984-05-14
PL130497B1 (en) 1984-08-31
PL233103A1 (es) 1982-12-20
ATE7657T1 (de) 1984-06-15
AR229103A1 (es) 1983-06-15
IL63890A0 (en) 1981-12-31
FI812940L (fi) 1982-03-23
RO82216A (ro) 1983-07-07
GB2084573B (en) 1984-09-12
ES505678A0 (es) 1982-12-01
GR75046B (es) 1984-07-12
FI812940A7 (fi) 1982-03-23
DK417981A (da) 1982-03-23
AU7551681A (en) 1982-04-01
RO82216B (ro) 1983-06-30
EP0048615B1 (en) 1984-05-30
GB2084573A (en) 1982-04-15

Similar Documents

Publication Publication Date Title
ES8301225A1 (es) Un procedimiento para la preparacion de un derivado de 3- aril-5-isotiazol
ES8307719A1 (es) &#34;procedimiento de preparar amidoaminoacidos n-substituidos&#34;.
ES505960A0 (es) Un procedimiento para la obtencion de un derivado acilico sustituido del compuesto acido 1,2,3,4-tetrahidro-3-isoqui- nolein-carboxilico
DE69711391D1 (de) Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern
ES449162A1 (es) Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico.
ATE161261T1 (de) Neue acylierte phospholipid-arzneimittel
ES518086A0 (es) Procedimiento para preparar acidos x-arilalcanoicos opticamente activos.
NO924949D0 (no) Piperidylsubstituerte indoler
SE9300013D0 (sv) Novel process and intermediates for the preparation of prodrugs
YU45810B (sh) Postupak za dobijanje hinolin karboksilnih kiselina
NO178025C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive (benzhydryloksyetylpiperidyl)alifatiske syrederivater
MX9201880A (es) Proceso para preparar fotoestabilizadores de amina impedida.
NL930100I2 (nl) Werkwijze en tussenprodukten voor het bereiden van3,3-azo-bis-(6-hydroxybenzoezuur).
SE8700913D0 (sv) Terapeutisk komposition innehallande adenosinderivat
ES478643A1 (es) Procedimiento de preparacion de nuevos derivados de la n-fe-nilalanina.
ES2167869T3 (es) Procedimiento para preparar acidos nicotinicos.
ES504208A0 (es) Procedimiento para la obtencion de amida de acido nicotinicopura a partir de amida de acido nicotinico bruta
ATE104281T1 (de) Salze von naphthalenpropionsaeure.
FR2669333B1 (fr) Procede de separation des enantiomeres des 5-aryl-5-alkylhydantouines.
PT98700A (pt) Processo para a preparacao de acidos aminometanofosfonico e de acidos aminometil-fosfinicos
DK342389A (da) Fremgangsmaade til syntese af optisk aktive aminosyrer, mellemprodukter til syntesen og disses fremstilling
ATE18208T1 (de) N-(4-hydroxyphenyl)essigsaeureamid-estern aus 5benzoyl-1-methylpyrrol-2-essigsaeure.
DK0971899T3 (da) Hexahydroindenopyridinforbindelser med antispermatogen virkning
ATE227289T1 (de) Verfahren zur herstellung von azyklischen nukleosiden
ES8308568A1 (es) Un procedimiento para la preparacion de nuevos derivados del 1,1-dioxido del acido penicilanico.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201