PE20030653A1 - COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a - Google Patents
COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2aInfo
- Publication number
- PE20030653A1 PE20030653A1 PE2002001149A PE2002001149A PE20030653A1 PE 20030653 A1 PE20030653 A1 PE 20030653A1 PE 2002001149 A PE2002001149 A PE 2002001149A PE 2002001149 A PE2002001149 A PE 2002001149A PE 20030653 A1 PE20030653 A1 PE 20030653A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- group
- triazole
- cr3r3a
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title abstract 2
- 102000007471 Adenosine A2A receptor Human genes 0.000 title 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 125000006355 carbonyl methylene group Chemical group [H]C([H])([*:2])C([*:1])=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS BICICLICO DE [1,2,4]-TRIAZOL DE FORMULA I DONDE A ES A ES CR1, N; R1 Y R1a SON H, ALQUILO, HALO, CN, CF3; Y ES O, S, SO, SO2, R5-HETEROARILDIILO, R5-ARILENO, GRUPO a; p Y q SON 2-3; Q Y Q1 SON N, CH, C-CN, COH, C-COCH3; UNO DE Q Y Q1 ES N; R ES R5-ARILO; R5-HETEROARILO; R6-ALQUENILO, R6-ALQUINILO; R2 ES R5-ARILO; R5-HETEROARILO, R5-ARIL-ALQUILO, R5-HETEROARIL-ALQUILO; R2-Y ES UN GRUPO b; U, V, W ES N, CR1; UNO DE U, V, W ES CR1; n ES 1-3; a)A ES CR1; X ES CR3R3a, CO, O, S, SO, SO2; R4-ARILENO, R4-HETEROARILDIILO, NR9; A ES CR1; Y ES UN ENLACE; X ES CR3R3a, CO, O, S, SO, SO2; b)A ES N, X ES NR9; Y ES R5-ARILENO; R2 ES UN GRUPO c; n ES 2-3; c)A ES N, X ES CR3R3a, CO, S, SO, SO2, NR9, ENTRE OTROS; d)A ES N, Y ES UN ENLACE; X ES NR9, R2 ES PIPERIDINA OPCIONALMENTE SUSTITUIDA CON R10; e)A ES N, X ES NR9; Y, R2 JUNTOS FORMAN UN GRUPO d; Z ES COCH2, CO-CH2-ALQUILO, CH2-CH2-ALQUILO, -CH2-ALQUILO-CH2-; R3 Y R3a SON H, OH, ALQUILO, HIDROXIALQUILO, ALCOXI-ALQUILO, ENTRE OTROS; R4 ES H, ALQUILO, OH, ALCOXI, HALO, CF3, ENTRE OTROS; R5 ES H, ALQUILO, OH, ALCOXI, ENTRE OTROS; R6 ES H, OH, ALCOXI, HALO; R7 Y R7a SON H, ALQUILO, ALCOXI-ALQUILO; R10 ES H, COO-ALQUILO, R5-ALQUILO, ENTRE OTROS. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL O ATAQUE APOPLETICO, DEPRESION ENFERMEDADES COGNITIVAS, NEURODEGENERATIVAS; PARKINSON, DEMENCIA SENIL, PSICOSIS DE ORIGEN ORGANICO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33438501P | 2001-11-30 | 2001-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030653A1 true PE20030653A1 (es) | 2003-08-04 |
Family
ID=23306955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001149A PE20030653A1 (es) | 2001-11-30 | 2002-11-28 | COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6875772B2 (es) |
| EP (1) | EP1453836B1 (es) |
| JP (2) | JP4429724B2 (es) |
| KR (1) | KR20050044600A (es) |
| CN (1) | CN1688581A (es) |
| AR (1) | AR037681A1 (es) |
| AT (1) | ATE358130T1 (es) |
| AU (1) | AU2002352933A1 (es) |
| CA (1) | CA2468658C (es) |
| DE (1) | DE60219196T2 (es) |
| ES (1) | ES2283625T3 (es) |
| HU (1) | HUP0402324A3 (es) |
| IL (1) | IL161573A0 (es) |
| MX (1) | MXPA04005158A (es) |
| PE (1) | PE20030653A1 (es) |
| TW (1) | TW200300689A (es) |
| WO (1) | WO2003048163A1 (es) |
| ZA (1) | ZA200404168B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200300686A (en) | 2001-11-30 | 2003-06-16 | Schering Corp | Adenosine A2a receptor antagonists |
| US6875772B2 (en) * | 2001-11-30 | 2005-04-05 | Schering Corporation | [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists |
| US7019137B2 (en) * | 2002-03-12 | 2006-03-28 | Wyeth | Process for making chiral 1,4-disubstituted piperazines |
| EP1544200A1 (en) * | 2002-09-24 | 2005-06-22 | Kyowa Hakko Kogyo Co., Ltd. | 1,2,4 -TRIAZOLO 1,5-c PYRIMIDINE DERIVATIVE |
| TWI331036B (en) * | 2002-12-19 | 2010-10-01 | Schering Corp | Adenosine a2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| EP1618109A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
| US7834014B2 (en) | 2003-04-09 | 2010-11-16 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| WO2004092170A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
| WO2004092177A1 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| TW200507850A (en) * | 2003-07-25 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
| JPWO2006129626A1 (ja) * | 2005-05-30 | 2009-01-08 | 協和醗酵工業株式会社 | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法 |
| EP1902716A4 (en) | 2005-06-07 | 2009-05-13 | Kyowa Hakko Kirin Co Ltd | PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR MOTOR TROUBLESHOOTING |
| US20090124663A1 (en) * | 2005-06-08 | 2009-05-14 | Neurosearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2007027987A2 (en) | 2005-09-02 | 2007-03-08 | Mount Cook Biosciences, Inc. | Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| US7615556B2 (en) * | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| WO2009114533A2 (en) | 2008-03-10 | 2009-09-17 | Cornell University | Modulation of blood brain barrier permeability |
| WO2010008775A1 (en) * | 2008-06-23 | 2010-01-21 | Ligand Pharmaceuticals Inc. | Aminopyridopyrazinone derivatives for treating neurodegenerative diseases |
| GB201214106D0 (en) * | 2012-08-07 | 2012-09-19 | Univ Strathclyde | Immunomodulatory compounds |
| EP3436013A4 (en) | 2016-03-31 | 2019-11-13 | Versi Group, LLC | DELTA OPIOID AGONIST, MU OPIOID ANTAGONIST COMPOSITIONS AND METHOD FOR TREATING MORBUS PARKINSON |
| CN106866582A (zh) * | 2017-01-10 | 2017-06-20 | 广州隽沐生物科技有限公司 | 一种氟班色林中间体的制备方法 |
| CA3103068C (en) | 2018-06-26 | 2024-06-25 | Zhejiang Vimgreen Pharmaceuticals, Ltd | Triazolotriazine derivatives as a2a receptor antagonists |
| US12325708B2 (en) | 2019-05-03 | 2025-06-10 | Nektar Therapeutics | Adenosine 2 receptor antagonists |
| WO2021129843A1 (zh) * | 2019-12-26 | 2021-07-01 | 浙江春禾医药科技有限公司 | 三唑并三嗪衍生物在治疗疾病中的用途 |
| WO2022224180A1 (en) * | 2021-04-23 | 2022-10-27 | Chong Kun Dang Pharmaceutical Corp. | Compound as adenosine a2a receptor antagonist and pharmaceutical composition comprising same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| ATE208199T1 (de) * | 1993-07-27 | 2001-11-15 | Kyowa Hakko Kogyo Kk | Arzneimittel gegen parkinsonsche krankheit |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| DE69820866T2 (de) * | 1997-03-24 | 2004-12-30 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE |
| IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| AU2639299A (en) * | 1998-02-24 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies/preventives for parkinson's disease |
| EA200100265A1 (ru) * | 1998-09-22 | 2001-10-22 | Киова Хакко Когио Ко., Лтд. | Производные [1,2,4]триазоло[1,5-c]пиримидина |
| US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| JP2002037787A (ja) * | 2000-05-16 | 2002-02-06 | Kyowa Hakko Kogyo Co Ltd | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法 |
| SI1283839T1 (es) | 2000-05-26 | 2005-08-31 | Schering Corp | |
| US6653315B2 (en) * | 2001-10-15 | 2003-11-25 | Schering Corporation | Adenosine A2a receptor antagonists |
| US6875772B2 (en) * | 2001-11-30 | 2005-04-05 | Schering Corporation | [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists |
-
2002
- 2002-11-26 US US10/304,939 patent/US6875772B2/en not_active Expired - Lifetime
- 2002-11-26 DE DE60219196T patent/DE60219196T2/de not_active Expired - Lifetime
- 2002-11-26 CA CA002468658A patent/CA2468658C/en not_active Expired - Fee Related
- 2002-11-26 AU AU2002352933A patent/AU2002352933A1/en not_active Abandoned
- 2002-11-26 ES ES02789893T patent/ES2283625T3/es not_active Expired - Lifetime
- 2002-11-26 HU HU0402324A patent/HUP0402324A3/hu unknown
- 2002-11-26 KR KR1020047007953A patent/KR20050044600A/ko not_active Withdrawn
- 2002-11-26 AT AT02789893T patent/ATE358130T1/de not_active IP Right Cessation
- 2002-11-26 JP JP2003549353A patent/JP4429724B2/ja not_active Expired - Fee Related
- 2002-11-26 CN CNA028239679A patent/CN1688581A/zh active Pending
- 2002-11-26 WO PCT/US2002/037915 patent/WO2003048163A1/en not_active Ceased
- 2002-11-26 EP EP02789893A patent/EP1453836B1/en not_active Expired - Lifetime
- 2002-11-26 MX MXPA04005158A patent/MXPA04005158A/es active IP Right Grant
- 2002-11-26 IL IL16157302A patent/IL161573A0/xx unknown
- 2002-11-27 TW TW091134487A patent/TW200300689A/zh unknown
- 2002-11-27 AR ARP020104562A patent/AR037681A1/es unknown
- 2002-11-28 PE PE2002001149A patent/PE20030653A1/es not_active Application Discontinuation
-
2004
- 2004-05-27 ZA ZA200404168A patent/ZA200404168B/en unknown
- 2004-10-26 US US10/973,642 patent/US7078408B2/en not_active Expired - Lifetime
-
2009
- 2009-10-26 JP JP2009245977A patent/JP2010018634A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP4429724B2 (ja) | 2010-03-10 |
| CN1688581A (zh) | 2005-10-26 |
| JP2005511697A (ja) | 2005-04-28 |
| DE60219196T2 (de) | 2008-01-03 |
| AR037681A1 (es) | 2004-12-01 |
| HUP0402324A2 (hu) | 2005-02-28 |
| CA2468658A1 (en) | 2003-06-12 |
| MXPA04005158A (es) | 2004-08-11 |
| JP2010018634A (ja) | 2010-01-28 |
| US20050113380A1 (en) | 2005-05-26 |
| US20030191130A1 (en) | 2003-10-09 |
| US6875772B2 (en) | 2005-04-05 |
| EP1453836B1 (en) | 2007-03-28 |
| ZA200404168B (en) | 2005-09-02 |
| IL161573A0 (en) | 2004-09-27 |
| TW200300689A (en) | 2003-06-16 |
| HK1064097A1 (en) | 2005-01-21 |
| AU2002352933A1 (en) | 2003-06-17 |
| DE60219196D1 (de) | 2007-05-10 |
| ATE358130T1 (de) | 2007-04-15 |
| ES2283625T3 (es) | 2007-11-01 |
| WO2003048163A1 (en) | 2003-06-12 |
| US7078408B2 (en) | 2006-07-18 |
| KR20050044600A (ko) | 2005-05-12 |
| CA2468658C (en) | 2009-04-14 |
| EP1453836A1 (en) | 2004-09-08 |
| HUP0402324A3 (en) | 2008-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030653A1 (es) | COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a | |
| DE69628051D1 (de) | Phenylethanolamin-verbindungen und ihre anwendung als beta3 agonisten, verfahren zu ihrer herstellung und zwischenprodukte ihrer herstellung | |
| PE20080150A1 (es) | Derivados de piridinona n-aril y n-heteroaril sustituidos como antagonistas del receptor de la hormona concentradora de melanina (mch) | |
| PE20060873A1 (es) | Compuestos de quinolina heteroaromaticos | |
| NO953447L (no) | Nye 4-aminopyridiner, fremgangsmåte for deres fremstilling samt legemidler inneholdende disse | |
| AR052902A1 (es) | Derivados de piridazina, composicion farmaceutica que los contiene y su uso como agentes terapeuticos para enfermedades mediadas por la estearoil-coa desaturasa | |
| PE20020366A1 (es) | Derivados de piperazina como ligandos del receptor 5ht2 | |
| AR051090A1 (es) | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa | |
| PE106499A1 (es) | Antagonistas del receptor ccr-3 | |
| PE20030477A1 (es) | ANTAGONISTAS DEL RECEPTOR DE ADENOSINA A2a | |
| AR051095A1 (es) | Derivados heterociclicos y su uso comoinhibidores de la estearoil-coa desaturasa | |
| AR051092A1 (es) | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa | |
| CO6220949A2 (es) | Derivados pirazolicos como inhibidores de la 11 beta -hsd1 | |
| ES2184772T3 (es) | Derivados de bifenilo, procedimiento para su preparacion y su utilizacion como medicamentos. | |
| ES2148227T3 (es) | Derivados de 1-piperazino-1,2-dihidroindeno. | |
| AR022303A1 (es) | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion | |
| AR051093A1 (es) | Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa | |
| PE20030761A1 (es) | Derivados del 7-amino-benzotiazol | |
| SG47026A1 (en) | Serotonin antagonists | |
| AR060811A1 (es) | Moduladores de mglur5 v | |
| PE20050680A1 (es) | Derivados de ciclohexano espirociclicos | |
| AR064517A1 (es) | Pirimidinionas biciclicas y sus usos | |
| UY27179A1 (es) | Novedosos derivados heterociclicos de los carbonilos y sus usos como ligandos del receptor d3 de la dopamina | |
| PE20040757A1 (es) | Derivados de benzoxazina | |
| CO5210890A1 (es) | Compuestos quimicos del tipo benzodia - o tiazoles y su proceso de obtencion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |