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IT1264901B1 - Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina - Google Patents

Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina

Info

Publication number
IT1264901B1
IT1264901B1 IT93MI001396A ITMI931396A IT1264901B1 IT 1264901 B1 IT1264901 B1 IT 1264901B1 IT 93MI001396 A IT93MI001396 A IT 93MI001396A IT MI931396 A ITMI931396 A IT MI931396A IT 1264901 B1 IT1264901 B1 IT 1264901B1
Authority
IT
Italy
Prior art keywords
adenosine
receptor
pyrimidines
triazole
antagonist activity
Prior art date
Application number
IT93MI001396A
Other languages
English (en)
Inventor
Pier Giovanni Baraldi
Laura Zappaterra
Ennio Ongini
Original Assignee
Schering Plough S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough S P A filed Critical Schering Plough S P A
Priority to IT93MI001396A priority Critical patent/IT1264901B1/it
Publication of ITMI931396A0 publication Critical patent/ITMI931396A0/it
Priority to AU70723/94A priority patent/AU7072394A/en
Priority to PCT/EP1994/002031 priority patent/WO1995001356A1/en
Publication of ITMI931396A1 publication Critical patent/ITMI931396A1/it
Application granted granted Critical
Publication of IT1264901B1 publication Critical patent/IT1264901B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

I composti di formula I, dove R e A hanno i significati dati nella descrizione, sono dotati di selettiva attività antagonista sul recettore A2 dell'adenosina.
IT93MI001396A 1993-06-29 1993-06-29 Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina IT1264901B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT93MI001396A IT1264901B1 (it) 1993-06-29 1993-06-29 Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
AU70723/94A AU7072394A (en) 1993-06-29 1994-06-22 1,2,4-triazolo(1,5-c)pyrimidine heterocyclic analogues having antagonistic activity on adenosine a2 receptor
PCT/EP1994/002031 WO1995001356A1 (en) 1993-06-29 1994-06-22 1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES HAVING ANTAGONISTIC ACTIVITY ON ADENOSINE A2 RECEPTOR

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001396A IT1264901B1 (it) 1993-06-29 1993-06-29 Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina

Publications (3)

Publication Number Publication Date
ITMI931396A0 ITMI931396A0 (it) 1993-06-29
ITMI931396A1 ITMI931396A1 (it) 1994-12-29
IT1264901B1 true IT1264901B1 (it) 1996-10-17

Family

ID=11366495

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001396A IT1264901B1 (it) 1993-06-29 1993-06-29 Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina

Country Status (3)

Country Link
AU (1) AU7072394A (it)
IT (1) IT1264901B1 (it)
WO (1) WO1995001356A1 (it)

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IT1277392B1 (it) * 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
DE19629378A1 (de) * 1996-07-20 1998-01-29 Boehringer Ingelheim Kg Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6921825B2 (en) 1998-09-16 2005-07-26 King Pharmaceuticuals Research & Development, Inc. Adenosine A3 receptor modulators
US6448253B1 (en) 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
US6593078B1 (en) 1999-04-16 2003-07-15 Schering Corporation Use of azetidinone compounds
SI1283839T1 (it) * 2000-05-26 2005-08-31 Schering Corp
GB0100624D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VII
KR20040038899A (ko) * 2001-09-28 2004-05-08 교와 핫꼬 고교 가부시끼가이샤 수용체 길항제
US6653315B2 (en) * 2001-10-15 2003-11-25 Schering Corporation Adenosine A2a receptor antagonists
US6875772B2 (en) 2001-11-30 2005-04-05 Schering Corporation [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists
TW200300686A (en) 2001-11-30 2003-06-16 Schering Corp Adenosine A2a receptor antagonists
CA2468649C (en) 2001-11-30 2009-03-10 Schering Corporation Adenosine a2a receptor antagonists
US7064204B2 (en) 2002-05-30 2006-06-20 King Pharmacueticals Reserch And Development, Inc. Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use
TWI331036B (en) 2002-12-19 2010-10-01 Schering Corp Adenosine a2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
KR100831107B1 (ko) 2003-04-23 2008-05-20 쉐링 코포레이션 2-알키닐- 및 2-알케닐-피라졸로-[4,3-ｅ]-1,2,4-트리아졸로-[1,5-ｃ]-피리미딘 아데노신 Ａ2ａ 수용체 길항제 및 이를 포함하는 약제학적 조성물
CN1898246B (zh) * 2003-10-28 2010-10-27 先灵公司 制备取代的5-氨基-吡唑并[4，3-e]-1，2，4-三唑并[1，5-c]嘧啶的方法
ES2293380T3 (es) 2003-12-01 2008-03-16 Schering Corporation Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidos.
DE602005020127D1 (de) 2004-04-21 2010-05-06 Schering Corp Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors
ATE538123T1 (de) 2005-09-19 2012-01-15 Schering Corp 2-heteroarylpyrazoloä4,3-eü-1, 2, 4-triazolo-ä1,5-cü-pyrimidine als antagonisten des adenosin-a2a- rezeptors
AR056080A1 (es) 2005-09-23 2007-09-19 Schering Corp 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US7691869B2 (en) 2007-03-30 2010-04-06 King Pharmaceuticals Research And Development, Inc. Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity
JP2011513417A (ja) 2008-03-04 2011-04-28 シェーリング コーポレイション アデノシンＡ２ａ受容体アンタゴニストとして使用するための１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オンおよびピラゾロ［４，３−ｅ］−１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オン化合物
JP5843869B2 (ja) * 2010-09-24 2016-01-13 アドヴィナス・セラピューティックス・リミテッド アデノシン受容体拮抗薬としての縮合三環化合物
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
MX381180B (es) 2014-11-18 2025-03-12 Merck Sharp & Dohme Compuestos aminopirazina con propiedades antagonistas a2a.
US10138212B2 (en) 2015-02-06 2018-11-27 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as A2A antagonist
WO2016200717A1 (en) 2015-06-11 2016-12-15 Merck Sharp & Dohme Corp. Aminopyrazine compounds with a2a antagonist properties
WO2017008205A1 (en) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
US11498923B2 (en) 2017-12-13 2022-11-15 Merck Sharp & Dohme Llc Substituted imidazo[1,2-c]quinazolines as A2A antagonists
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
DE102019116986A1 (de) 2019-06-24 2020-12-24 Helmholtz-Zentrum Dresden-Rossendorf E. V. Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate
CN118812539B (zh) * 2024-06-19 2025-11-28 苏州大学 一种5-氨基三唑并嘧啶衍生物及其制备方法

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US4713383A (en) * 1984-10-01 1987-12-15 Ciba-Geigy Corporation Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
DE3677445D1 (de) * 1985-09-30 1991-03-14 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
JPH06104666B2 (ja) * 1986-09-30 1994-12-21 チバ―ガイギー アクチェンゲゼルシャフト ２―置換―ｅ―縮合―〔１，２，４〕トリアゾロ〔１，５―ｃ〕ピリミジン類及びそれを含有する医薬組成物

Also Published As

Publication number Publication date
ITMI931396A1 (it) 1994-12-29
AU7072394A (en) 1995-01-24
WO1995001356A1 (en) 1995-01-12
ITMI931396A0 (it) 1993-06-29

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Effective date: 19970530