ATE208199T1 - Arzneimittel gegen parkinsonsche krankheit - Google Patents
Arzneimittel gegen parkinsonsche krankheitInfo
- Publication number
- ATE208199T1 ATE208199T1 AT94921793T AT94921793T ATE208199T1 AT E208199 T1 ATE208199 T1 AT E208199T1 AT 94921793 T AT94921793 T AT 94921793T AT 94921793 T AT94921793 T AT 94921793T AT E208199 T1 ATE208199 T1 AT E208199T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- heterocycle
- hydrogen
- represents hydrogen
- aryl
- Prior art date
Links
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910020008 S(O) Inorganic materials 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- -1 polycyclic compound Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18429593 | 1993-07-27 | ||
| PCT/JP1994/001196 WO1995003806A1 (en) | 1993-07-27 | 1994-07-20 | Remedy for parkinson's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE208199T1 true ATE208199T1 (de) | 2001-11-15 |
Family
ID=16150835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94921793T ATE208199T1 (de) | 1993-07-27 | 1994-07-20 | Arzneimittel gegen parkinsonsche krankheit |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5565460A (de) |
| EP (1) | EP0666079B1 (de) |
| AT (1) | ATE208199T1 (de) |
| AU (1) | AU7237294A (de) |
| CA (1) | CA2144330A1 (de) |
| DE (1) | DE69428977T2 (de) |
| ES (1) | ES2165393T3 (de) |
| WO (1) | WO1995003806A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1277392B1 (it) * | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| DE69820866T2 (de) | 1997-03-24 | 2004-12-30 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE |
| AU2639299A (en) * | 1998-02-24 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies/preventives for parkinson's disease |
| US6448253B1 (en) * | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
| US6506378B1 (en) | 1998-12-16 | 2003-01-14 | Arch Development Corporation | Vesicular monoamine transporter gene therapy in Parkinson's disease |
| SI1283839T1 (de) | 2000-05-26 | 2005-08-31 | Schering Corp | |
| GB0100624D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| JPWO2002079204A1 (ja) * | 2001-03-28 | 2004-07-22 | 協和醗酵工業株式会社 | ８−チアゾリル［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体 |
| JP5280597B2 (ja) * | 2001-03-30 | 2013-09-04 | サンスター技研株式会社 | 一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材 |
| CZ303808B6 (cs) * | 2001-05-24 | 2013-05-09 | Eli Lilly And Company | Nové pyrazolové deriváty jako farmaceutická cinidla |
| US6423844B1 (en) * | 2001-06-06 | 2002-07-23 | The United States Of America As Represented By The Secretary Of The Navy | Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine |
| JP2005516891A (ja) * | 2001-09-13 | 2005-06-09 | シェーリング コーポレイション | アデノシンＡ２ａレセプタアンタゴニストと抗鬱薬または抗不安薬との組合せ |
| US6653315B2 (en) * | 2001-10-15 | 2003-11-25 | Schering Corporation | Adenosine A2a receptor antagonists |
| TW200300686A (en) | 2001-11-30 | 2003-06-16 | Schering Corp | Adenosine A2a receptor antagonists |
| US6875772B2 (en) * | 2001-11-30 | 2005-04-05 | Schering Corporation | [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists |
| CA2468649C (en) | 2001-11-30 | 2009-03-10 | Schering Corporation | Adenosine a2a receptor antagonists |
| AU2003207734C1 (en) | 2002-01-28 | 2009-10-08 | Kyowa Kirin Co., Ltd. | Methods of treating patients suffering from movement disorders |
| FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| EP1544200A1 (de) * | 2002-09-24 | 2005-06-22 | Kyowa Hakko Kogyo Co., Ltd. | 1,2,4-TRIAZOLO 1,5-c PYRIMIDINDERIVAT |
| TWI331036B (en) | 2002-12-19 | 2010-10-01 | Schering Corp | Adenosine a2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| US20060106040A1 (en) * | 2002-12-19 | 2006-05-18 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| WO2004092177A1 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| EP1618109A2 (de) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Als a2a-adenosinrezeptorantagonisten geeignete triazolo[1,5-c]pyrimidine und pyrazolo[1,5-c]pyrimidine |
| WO2004092170A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
| US7834014B2 (en) | 2003-04-09 | 2010-11-16 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| KR100831107B1 (ko) * | 2003-04-23 | 2008-05-20 | 쉐링 코포레이션 | 2-알키닐- 및 2-알케닐-피라졸로-[4,3-ｅ]-1,2,4-트리아졸로-[1,5-ｃ]-피리미딘 아데노신 Ａ2ａ 수용체 길항제 및 이를 포함하는 약제학적 조성물 |
| DE602005020127D1 (de) * | 2004-04-21 | 2010-05-06 | Schering Corp | Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
| ATE538123T1 (de) | 2005-09-19 | 2012-01-15 | Schering Corp | 2-heteroarylpyrazoloä4,3-eü-1, 2, 4-triazolo-ä1,5-cü-pyrimidine als antagonisten des adenosin-a2a- rezeptors |
| AR056080A1 (es) * | 2005-09-23 | 2007-09-19 | Schering Corp | 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| US7691869B2 (en) | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
| JP2011513417A (ja) * | 2008-03-04 | 2011-04-28 | シェーリング コーポレイション | アデノシンＡ２ａ受容体アンタゴニストとして使用するための１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オンおよびピラゾロ［４，３−ｅ］−１，２，４−トリアゾロ［４，３−ｃ］ピリミジン−３−オン化合物 |
| WO2014101120A1 (en) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| WO2014172372A1 (en) | 2013-04-15 | 2014-10-23 | Northwestern University | Treatment for dopaminergic disorders |
| MX381180B (es) | 2014-11-18 | 2025-03-12 | Merck Sharp & Dohme | Compuestos aminopirazina con propiedades antagonistas a2a. |
| US10138212B2 (en) | 2015-02-06 | 2018-11-27 | Merck Sharp & Dohme Corp. | Aminoquinazoline compounds as A2A antagonist |
| WO2016200717A1 (en) | 2015-06-11 | 2016-12-15 | Merck Sharp & Dohme Corp. | Aminopyrazine compounds with a2a antagonist properties |
| WO2017008205A1 (en) | 2015-07-10 | 2017-01-19 | Merck Sharp & Dohme Corp. | Substituted aminoquinazoline compounds as a2a antagonist |
| US11498923B2 (en) | 2017-12-13 | 2022-11-15 | Merck Sharp & Dohme Llc | Substituted imidazo[1,2-c]quinazolines as A2A antagonists |
| WO2022029063A1 (en) | 2020-08-04 | 2022-02-10 | Bayer Aktiengesellschaft | Pyrido[1,2,4]triazolo[1,5-c]pyrimidin-5-amines |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0181282A1 (de) * | 1984-10-01 | 1986-05-14 | Ciba-Geigy Ag | Triazolochinazolinverbindungen |
| JPS62135475A (ja) * | 1985-09-30 | 1987-06-18 | チバ−ガイギ− アクチエンゲゼルシヤフト | ２−置換−ｅ−融合−〔１，２，４〕トリアゾロ−〔１，５−Ｃ〕ピリミジン |
| DE3677445D1 (de) * | 1985-09-30 | 1991-03-14 | Ciba Geigy Ag | 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung. |
| US4831013A (en) * | 1986-03-20 | 1989-05-16 | Ciba-Geigy Corporation | 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmaceutical compositions, and uses thereof |
| JPH06104666B2 (ja) * | 1986-09-30 | 1994-12-21 | チバ―ガイギー アクチェンゲゼルシャフト | ２―置換―ｅ―縮合―〔１，２，４〕トリアゾロ〔１，５―ｃ〕ピリミジン類及びそれを含有する医薬組成物 |
| EP0459702A1 (de) * | 1990-05-29 | 1991-12-04 | Zeneca Limited | Azolderivate |
| US5356894A (en) * | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
| GB9111130D0 (en) * | 1991-05-23 | 1991-07-17 | Ici Plc | Azole derivatives |
-
1994
- 1994-07-20 AT AT94921793T patent/ATE208199T1/de not_active IP Right Cessation
- 1994-07-20 EP EP94921793A patent/EP0666079B1/de not_active Expired - Lifetime
- 1994-07-20 WO PCT/JP1994/001196 patent/WO1995003806A1/ja not_active Ceased
- 1994-07-20 ES ES94921793T patent/ES2165393T3/es not_active Expired - Lifetime
- 1994-07-20 DE DE69428977T patent/DE69428977T2/de not_active Expired - Fee Related
- 1994-07-20 AU AU72372/94A patent/AU7237294A/en not_active Abandoned
- 1994-07-20 CA CA002144330A patent/CA2144330A1/en not_active Abandoned
- 1994-07-20 US US08/367,346 patent/US5565460A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995003806A1 (en) | 1995-02-09 |
| EP0666079B1 (de) | 2001-11-07 |
| EP0666079A1 (de) | 1995-08-09 |
| EP0666079A4 (de) | 1998-02-04 |
| CA2144330A1 (en) | 1995-02-09 |
| US5565460A (en) | 1996-10-15 |
| DE69428977T2 (de) | 2002-07-11 |
| AU7237294A (en) | 1995-02-28 |
| ES2165393T3 (es) | 2002-03-16 |
| DE69428977D1 (de) | 2001-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |