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AR022303A1 - Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion - Google Patents

Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion

Info

Publication number
AR022303A1
AR022303A1 ARP000100197A ARP000100197A AR022303A1 AR 022303 A1 AR022303 A1 AR 022303A1 AR P000100197 A ARP000100197 A AR P000100197A AR P000100197 A ARP000100197 A AR P000100197A AR 022303 A1 AR022303 A1 AR 022303A1
Authority
AR
Argentina
Prior art keywords
cr6r7
disorders
piperazine
piperidine
disorder
Prior art date
Application number
ARP000100197A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR022303A1 publication Critical patent/AR022303A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18Ethylenedioxybenzenes, not substituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Un derivado de piperidina, tetrahidropiridina o piperazina, que tiene la formula (1) cualquiera de sus enantiomeros o cualquier mezcla de los mismos, o unasal de adicion de ácido de los mismos, en la cual: B representa alquileno C1-10, alquenileno C2-10 o alquinileno C2-10; X es -O-, -S-, o CR4R5-; e Y es-CR6R7-, -CR6R7-CR8R9-, o -CR6=CR7; o X e Y forman conjuntamente un grupo -CR4=CR5-, o -CR4=CR5-CR6R7-; Z es -O- o -S-; W es N, C, o CH, y la línea de puntoses un enlace opcional; A es un anillobicíclico seleccionado de entre la formulas (2) o (3) siendo E1, E2, y E3, seleccionados de entre el grupo consistente enO, S, N, NR11, C, CR12 y CHR13, y la línea de puntos representa un enlace opcional, con la condicion que E2 y E1 y/o E3 no pueden ser simultáneamente O ni S;los restantes sustituyentes figuran definidos en la memoria descriptiva. Los compuestos de la presente son considerados utiles para el tratamiento de lostrastornos afectivos, tales como la depresion, sicosis, trastornos tipo ansiedad que incluyen el trastorno general de la ansiedad, el trastorno tipo pánico, eltrastorno de la compulsion obsesiva, y los trastornos de la alimentacion.
ARP000100197A 1999-01-22 2000-01-17 Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion AR022303A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199900084 1999-01-22

Publications (1)

Publication Number Publication Date
AR022303A1 true AR022303A1 (es) 2002-09-04

Family

ID=8089560

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100197A AR022303A1 (es) 1999-01-22 2000-01-17 Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion

Country Status (26)

Country Link
US (2) US6596722B2 (es)
EP (1) EP1149087B1 (es)
JP (1) JP2002535322A (es)
KR (1) KR20010101606A (es)
CN (1) CN1344265A (es)
AR (1) AR022303A1 (es)
AT (1) ATE263763T1 (es)
AU (1) AU767377B2 (es)
BG (1) BG105781A (es)
BR (1) BR0009007A (es)
CA (1) CA2361059A1 (es)
CZ (1) CZ20012657A3 (es)
DE (1) DE60009663T2 (es)
EA (1) EA200100798A1 (es)
HK (1) HK1045505A1 (es)
HU (1) HUP0105065A3 (es)
IL (1) IL144113A0 (es)
IS (1) IS5983A (es)
MX (1) MXPA01007226A (es)
NO (1) NO20013538L (es)
NZ (1) NZ512732A (es)
PL (1) PL349909A1 (es)
SK (1) SK10302001A3 (es)
TR (1) TR200102089T2 (es)
WO (1) WO2000043382A1 (es)
ZA (1) ZA200105548B (es)

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EP1007523B9 (en) * 1997-07-25 2004-09-08 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
US7067513B1 (en) * 1999-08-23 2006-06-27 Solvay Pharmaceuticals B.V. Phenylpiperazines
AR027133A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de heteroarilo, su preparacion y uso.
EP1408976B3 (en) * 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
JP2005504043A (ja) * 2001-08-10 2005-02-10 パラチン テクノロジーズ インク. 生物学的に活性な金属ペプチド類のペプチド模倣体類
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7507568B2 (en) * 2002-09-25 2009-03-24 The Proctor & Gamble Company Three dimensional coordinates of HPTPbeta
US7226755B1 (en) * 2002-09-25 2007-06-05 The Procter & Gamble Company HPTPbeta as a target in treatment of angiogenesis mediated disorders
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7235569B2 (en) 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20060122175A1 (en) * 2004-12-07 2006-06-08 Solvay Pharmaceuticals B.V. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20070072870A2 (en) 2004-12-08 2007-03-29 Solvay Pharmeceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
DE602005010902D1 (de) * 2004-12-08 2008-12-18 Solvay Pharm Bv Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
KR100589877B1 (ko) * 2005-12-20 2006-06-19 주식회사 픽슨이앤씨 파형강판 구조물의 보강라이너 설치용 거푸집
NZ571300A (en) 2006-04-07 2011-12-22 Warner Chilcott Co Llc Antibodies that bind human protein tyrosine phosphatase beta (HPTPBeta) and uses thereof
US7795444B2 (en) * 2006-06-27 2010-09-14 Warner Chilcott Company Human protein tyrosine phosphatase inhibitors and methods of use
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US7589212B2 (en) * 2006-06-27 2009-09-15 Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US8846685B2 (en) 2006-06-27 2014-09-30 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
US9096555B2 (en) 2009-01-12 2015-08-04 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome
US8367676B2 (en) 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
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CN103380129B (zh) 2010-12-20 2016-04-20 阿克图拉姆生命科学股份公司 2-甲酰胺-4-哌嗪基-苯并呋喃衍生物
CA2850830A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome and cancer
EP3027607B1 (en) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
CN104725363B (zh) * 2013-12-20 2019-03-01 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
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Publication number Priority date Publication date Assignee Title
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
IT1251144B (it) * 1991-07-30 1995-05-04 Boehringer Ingelheim Italia Derivati del benzimidazolone
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
RU2124511C1 (ru) * 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли

Also Published As

Publication number Publication date
PL349909A1 (en) 2002-10-07
BG105781A (en) 2002-05-31
HUP0105065A3 (en) 2003-06-30
CN1344265A (zh) 2002-04-10
US20020173512A1 (en) 2002-11-21
HK1045505A1 (zh) 2002-11-29
CZ20012657A3 (cs) 2002-02-13
US6596722B2 (en) 2003-07-22
AU767377B2 (en) 2003-11-06
JP2002535322A (ja) 2002-10-22
EP1149087A1 (en) 2001-10-31
EP1149087B1 (en) 2004-04-07
DE60009663D1 (de) 2004-05-13
US20020035113A1 (en) 2002-03-21
CA2361059A1 (en) 2000-07-27
IS5983A (is) 2001-06-28
BR0009007A (pt) 2001-11-27
HUP0105065A2 (hu) 2002-07-29
DE60009663T2 (de) 2005-04-14
TR200102089T2 (tr) 2002-07-22
NO20013538D0 (no) 2001-07-17
IL144113A0 (en) 2002-05-23
WO2000043382A1 (en) 2000-07-27
AU2278100A (en) 2000-08-07
NO20013538L (no) 2001-09-17
ZA200105548B (en) 2002-07-05
EA200100798A1 (ru) 2001-12-24
NZ512732A (en) 2003-10-31
MXPA01007226A (es) 2002-04-24
KR20010101606A (ko) 2001-11-14
SK10302001A3 (sk) 2002-01-07
ATE263763T1 (de) 2004-04-15

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