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PE20030575A1 - Soluciones de meloxicam estables y muy concentradas para la inyeccion sin aguja - Google Patents

Soluciones de meloxicam estables y muy concentradas para la inyeccion sin aguja

Info

Publication number
PE20030575A1
PE20030575A1 PE2002001188A PE2002001188A PE20030575A1 PE 20030575 A1 PE20030575 A1 PE 20030575A1 PE 2002001188 A PE2002001188 A PE 2002001188A PE 2002001188 A PE2002001188 A PE 2002001188A PE 20030575 A1 PE20030575 A1 PE 20030575A1
Authority
PE
Peru
Prior art keywords
stable
highly concentrated
salt
glycine
dissolution
Prior art date
Application number
PE2002001188A
Other languages
English (en)
Inventor
Martin A Folger
Bernd Zierenberg
Stefan Henke
Bernhard Hassel
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Publication of PE20030575A1 publication Critical patent/PE20030575A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A SOLUCIONES DE MELOXICAM ACUOSAS, ESTABLES A LARGO PLAZO, EXENTAS DE CICLODEXTRINA Y APLICABLES SIN AGUJA POR VIA INTRACUTANEA O SUBCUTANEA PARA EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS E INFLAMACIONES EN MAMIFEROS, QUE CONTIENE: a)UNA SAL DE MELOXICAM FARMACOLOGICAMENTE COMPATIBLE DE UNA BASE ORGANICA O INORGANICA, QUE PUEDE SER SAL DE SODIO O MEGLUMINA; Y, b)UNO O VARIOS COADYUVANTES, TALES COMO TAMPONADORES, SELECCIONADOS DE GLICINA, MEZCLA DE GLICINA /HCl Y/O SUSTANCIAS CONSERVANTES, SELECCIONADAS DE: ETANOL, ACIDO BENZOICO, ENTRE OTROS O INDUCTORES DE DISOLUCION, TALES COMO: POLIETILENGLICOLES; POLIOXIETILENO-POLIOXIPROPILENO, GLICOFUROL; ENTRE OTROS; ADEMAS DE EDTA DISODICO. DONDE, EL CONTENIDO EN SAL DISUELTA DE MELOXICAM ES DE 35 mg/ml A 100 mg/ml; Y LA ESTABILIDAD A LARGO PLAZO DE LA SOLUCION A TEMPERATURA AMBIENTE ES DE 24 MESES O MAS
PE2002001188A 2001-12-12 2002-12-10 Soluciones de meloxicam estables y muy concentradas para la inyeccion sin aguja PE20030575A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10161077A DE10161077A1 (de) 2001-12-12 2001-12-12 Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion

Publications (1)

Publication Number Publication Date
PE20030575A1 true PE20030575A1 (es) 2003-08-29

Family

ID=7708961

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001188A PE20030575A1 (es) 2001-12-12 2002-12-10 Soluciones de meloxicam estables y muy concentradas para la inyeccion sin aguja

Country Status (17)

Country Link
US (5) US20030119825A1 (es)
EP (1) EP1455782B1 (es)
JP (1) JP5348818B2 (es)
AR (1) AR037789A1 (es)
AT (1) ATE357232T1 (es)
AU (1) AU2002361035A1 (es)
CA (1) CA2469588C (es)
CY (1) CY1106637T1 (es)
DE (2) DE10161077A1 (es)
DK (1) DK1455782T3 (es)
ES (1) ES2283634T3 (es)
PE (1) PE20030575A1 (es)
PT (1) PT1455782E (es)
SI (1) SI1455782T1 (es)
TW (1) TW200302720A (es)
UY (1) UY27575A1 (es)
WO (1) WO2003049733A1 (es)

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US8920820B2 (en) 2014-12-30
US20030119825A1 (en) 2003-06-26
ES2283634T3 (es) 2007-11-01
DE50209801D1 (de) 2007-05-03
DE10161077A1 (de) 2003-06-18
CA2469588C (en) 2014-03-18
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JP5348818B2 (ja) 2013-11-20
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US20140113893A1 (en) 2014-04-24
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US20080132493A1 (en) 2008-06-05
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US20140066440A1 (en) 2014-03-06
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US9993485B2 (en) 2018-06-12
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PT1455782E (pt) 2007-04-30
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