PE20020844A1 - Derivados de imidazolilo como inhibidores del factor de liberacion de la corticotropina - Google Patents
Derivados de imidazolilo como inhibidores del factor de liberacion de la corticotropinaInfo
- Publication number
- PE20020844A1 PE20020844A1 PE2002000063A PE2002000063A PE20020844A1 PE 20020844 A1 PE20020844 A1 PE 20020844A1 PE 2002000063 A PE2002000063 A PE 2002000063A PE 2002000063 A PE2002000063 A PE 2002000063A PE 20020844 A1 PE20020844 A1 PE 20020844A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- link
- compounds
- release factor
- corticotropin
- Prior art date
Links
- -1 IMIDAZOLYL Chemical class 0.000 title abstract 5
- 102400000739 Corticotropin Human genes 0.000 title abstract 2
- 101800000414 Corticotropin Proteins 0.000 title abstract 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title abstract 2
- 229960000258 corticotropin Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 abstract 2
- 101100439663 Arabidopsis thaliana CHR7 gene Proteins 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
Abstract
SE REFIERE A DERIVADOS DE IMIDAZOLILO DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS; R2 ES C(D)NR3R4, D'-D"R3R4, CH2NR3R4; D' ES CH2, UN ENLACE; D" ES C, COH, CH; D ES O, S R3 Y R4 SON H, ALQUILO C1-C6, HALOALQUILO C1-C6, HIDROXIALQUILO C1-C6 O JUNTO A N FORMAN UN HETEROCICLO, ENTRE OTROS; X ES C, Y ES C; A S, UN GRUPO a; X1 ES N Y ESTA UNIDO A X; Y1 ES N, ESTA UNIDO A Y; G ES Y2=J=Z1; Y2 ES N, CH, CH2, CO, CS, CR5, CHR5, CE1; J ES CH, CH2, CO, CS, CR6, ENTRE OTROS; Z1 ES CH, CH2, CO, CS, CR7, CHR7, ENTRE OTROS; R5, R6, R7 SON CN, ALQUILEN C1-C4-CN, HALO, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; E1 Y E2 FORMAN JUNTOS CHN(CH)2, N(CH)2N, ENTRE OTROS; E2 Y Z2 JUNTOS FORMAN N(CH)3, HCN(CH2)2, ENTRE OTROS; Z ES N-V, V ES FENILO, 3-PIRIDILO, ENTRE OTROS; SI Y2 ES N, J ES UN ENLACE, Z1 NO ES CE3; SI Y2 ES CE1, Z1 ES CE3, J ES UN ENLACE; SI Y2 NO ES CE1, Z1 NO ES CE3, J NO ES CE2, J ES CE2; ENTONCES CE1 Y Z1 NO SON CE3, CR7, CHR7; Z1 ES CE2, Y2 NO ES CE1, CR5, CHR5; SON COMPUESTOS PREFERIDOS CICLOPROPILMETIL-(2,2,2-TRIFLUORO-ETIL)-[2-TRIFLUOROMETIL-8-(2,4,6-TRIMETIL-FENIL)-5,6,7,8-TETRAHIDROIMIDAZOL[1,2-a]PIRIMIDIN-3-ILMETIL]-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTOS DE FORMULA WHH Y A PROCEDIMIENTOS PARA LA PREPARACION. LOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DEL FACTOR DE LIBERACION DE CORTICOTROPINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DEPRESION, ANSIEDAD, DESORDENES AFECTIVOS, DESORDENES DE TENSION POST-TRAUMATICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26457001P | 2001-01-26 | 2001-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020844A1 true PE20020844A1 (es) | 2002-09-27 |
Family
ID=23006646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000063A PE20020844A1 (es) | 2001-01-26 | 2002-01-25 | Derivados de imidazolilo como inhibidores del factor de liberacion de la corticotropina |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US6888004B2 (es) |
| EP (1) | EP1359916A4 (es) |
| JP (1) | JP2004531475A (es) |
| KR (1) | KR20040034594A (es) |
| CN (1) | CN1499972A (es) |
| BG (1) | BG107999A (es) |
| BR (1) | BR0206698A (es) |
| CA (1) | CA2434558A1 (es) |
| CZ (1) | CZ20032044A3 (es) |
| EE (1) | EE200300342A (es) |
| HR (1) | HRP20030675A2 (es) |
| HU (1) | HUP0303721A2 (es) |
| IL (1) | IL156813A0 (es) |
| IS (1) | IS6889A (es) |
| MX (1) | MXPA03006484A (es) |
| NO (1) | NO20033350L (es) |
| PE (1) | PE20020844A1 (es) |
| PL (1) | PL368555A1 (es) |
| RU (1) | RU2003126188A (es) |
| SK (1) | SK9222003A3 (es) |
| WO (1) | WO2002058704A1 (es) |
| ZA (1) | ZA200305531B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6888004B2 (en) * | 2001-01-26 | 2005-05-03 | Bristol-Myers Squibb Company | Imidazolyl derivatives as corticotropin releasing factor inhibitors |
| TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
| HUP0401292A3 (en) | 2001-04-27 | 2011-01-28 | Eisai R & D Man Co | Pyrazolo[1,5-a]pyridines, pharmaceutical compositions containing the same and process for preparation thereof |
| SI1555265T1 (sl) | 2002-10-22 | 2009-06-30 | Eisai R&D Man Co Ltd | 7-fenil pirazolopiridinske spojine |
| US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
| US20060128794A1 (en) * | 2004-12-13 | 2006-06-15 | Indevus Pharmaceuticals, Inc. | Treatment of interstitial cystitis using (6aR,10aR)-delta8-tetrahydrocannabinol-11-OIC acids |
| US7815905B2 (en) * | 2006-01-27 | 2010-10-19 | Research Development Foundation | Methods of increasing insulin sensitivity or decreasing insulin secretion by administering corticotropin releasing factor receptor-2 inhibitors |
| EP2167094A2 (en) | 2007-06-13 | 2010-03-31 | Research Development Foundation | Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating crf receptor signaling |
| RS53602B1 (sr) * | 2007-11-29 | 2015-02-27 | Boehringer Ingelheim International Gmbh | DERIVATI AMIDA 6,7-DIHIDRO-5H-IMIDAZO[1,2-α]IMIDAZOL-3-KARBOKSILNE KISELINE |
| MY152687A (en) | 2008-04-15 | 2014-10-31 | Eisai R&D Man Co Ltd | 3-phenylpyrazolo[5,1-b]thiazole compound |
| US7994203B2 (en) * | 2008-08-06 | 2011-08-09 | Novartis Ag | Organic compounds |
| AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| US20120295942A1 (en) * | 2010-02-01 | 2012-11-22 | Nicholas James Devereux | Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists |
| CN103517906B (zh) * | 2011-03-25 | 2016-08-24 | 巴斯夫欧洲公司 | 用于电子应用的4H-咪唑并[1,2-a]咪唑 |
| US9806270B2 (en) | 2011-03-25 | 2017-10-31 | Udc Ireland Limited | 4H-imidazo[1,2-a]imidazoles for electronic applications |
| CN108299439B (zh) | 2011-11-10 | 2021-02-09 | Udc 爱尔兰有限责任公司 | 用于电子应用的4H-咪唑并[1,2-a]咪唑 |
| CN109970707A (zh) * | 2012-02-07 | 2019-07-05 | 拜耳知识产权有限责任公司 | 取代的邻氨基苯甲酸衍生物的制备方法 |
| AU2013267594A1 (en) | 2012-05-25 | 2014-12-18 | Nutech Ventures | Amphiphilic cyclobutenes and cyclobutanes |
| KR102563117B1 (ko) | 2012-07-10 | 2023-08-04 | 유디씨 아일랜드 리미티드 | 전자 응용을 위한 벤즈이미다조[1,2-a]벤즈이미다졸 유도체 |
| BR112015001201B1 (pt) * | 2012-07-18 | 2022-02-22 | University Of Notre Dame Du Lac | Compostos anti-infecciosos 5,5-heteroaromáticos e composição |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| CN105384691B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂的制备方法及应用 |
| WO2019022873A1 (en) * | 2017-07-24 | 2019-01-31 | University Of South Florida | NEW BIS-CYCLIC GUANIDINES USEFUL AS ANTIBACTERIAL AGENTS |
| WO2019169113A1 (en) * | 2018-03-02 | 2019-09-06 | Ponce Medical School Foundation, Inc. | Compositions and methods for the treatment of endometriosis |
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|---|---|---|---|---|
| US3865836A (en) * | 1972-12-08 | 1975-02-11 | Janssen Pharmaceutica Nv | Bicyclic imidazoles |
| DE2827617A1 (de) * | 1978-06-23 | 1980-01-10 | Boehringer Sohn Ingelheim | Neue imidazo eckige klammer auf 1,2- alpha eckige klammer zu imidazole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| IL69417A (en) * | 1982-08-27 | 1987-12-20 | Roussel Uclaf | 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them |
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| EP0607076A1 (fr) * | 1993-01-15 | 1994-07-20 | Synthelabo | Dérivés de 9h-imidazo 1,2-a benzimidazole-3-acétamide à activité GABA |
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-
2002
- 2002-01-11 US US10/044,183 patent/US6888004B2/en not_active Expired - Lifetime
- 2002-01-11 MX MXPA03006484A patent/MXPA03006484A/es unknown
- 2002-01-11 JP JP2002559038A patent/JP2004531475A/ja active Pending
- 2002-01-11 CN CNA028071352A patent/CN1499972A/zh active Pending
- 2002-01-11 HU HU0303721A patent/HUP0303721A2/hu unknown
- 2002-01-11 RU RU2003126188/04A patent/RU2003126188A/ru not_active Application Discontinuation
- 2002-01-11 KR KR10-2003-7009883A patent/KR20040034594A/ko not_active Withdrawn
- 2002-01-11 PL PL02368555A patent/PL368555A1/xx unknown
- 2002-01-11 CZ CZ20032044A patent/CZ20032044A3/cs unknown
- 2002-01-11 EE EEP200300342A patent/EE200300342A/xx unknown
- 2002-01-11 IL IL15681302A patent/IL156813A0/xx unknown
- 2002-01-11 WO PCT/US2002/000841 patent/WO2002058704A1/en not_active Ceased
- 2002-01-11 BR BR0206698-0A patent/BR0206698A/pt not_active IP Right Cessation
- 2002-01-11 SK SK922-2003A patent/SK9222003A3/sk unknown
- 2002-01-11 CA CA002434558A patent/CA2434558A1/en not_active Abandoned
- 2002-01-11 HR HR20030675A patent/HRP20030675A2/hr not_active Application Discontinuation
- 2002-01-11 EP EP02705754A patent/EP1359916A4/en not_active Withdrawn
- 2002-01-25 PE PE2002000063A patent/PE20020844A1/es not_active Application Discontinuation
-
2003
- 2003-07-17 ZA ZA200305531A patent/ZA200305531B/en unknown
- 2003-07-17 BG BG107999A patent/BG107999A/xx unknown
- 2003-07-24 IS IS6889A patent/IS6889A/is unknown
- 2003-07-25 NO NO20033350A patent/NO20033350L/no not_active Application Discontinuation
-
2004
- 2004-01-29 US US10/767,645 patent/US7211669B2/en not_active Expired - Lifetime
- 2004-02-04 US US10/772,027 patent/US7244746B2/en not_active Expired - Lifetime
- 2004-02-04 US US10/771,766 patent/US7238699B2/en not_active Expired - Lifetime
- 2004-02-04 US US10/771,661 patent/US7125990B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20040254382A1 (en) | 2004-12-16 |
| PL368555A1 (en) | 2005-04-04 |
| US6888004B2 (en) | 2005-05-03 |
| ZA200305531B (en) | 2004-07-27 |
| IL156813A0 (en) | 2004-02-08 |
| IS6889A (is) | 2003-07-24 |
| WO2002058704A1 (en) | 2002-08-01 |
| US20040225001A1 (en) | 2004-11-11 |
| BR0206698A (pt) | 2004-04-20 |
| CN1499972A (zh) | 2004-05-26 |
| NO20033350D0 (no) | 2003-07-25 |
| BG107999A (en) | 2004-08-31 |
| US20040235924A1 (en) | 2004-11-25 |
| US7125990B2 (en) | 2006-10-24 |
| CZ20032044A3 (cs) | 2003-12-17 |
| US7238699B2 (en) | 2007-07-03 |
| NO20033350L (no) | 2003-09-22 |
| EP1359916A1 (en) | 2003-11-12 |
| CA2434558A1 (en) | 2002-08-01 |
| KR20040034594A (ko) | 2004-04-28 |
| SK9222003A3 (en) | 2004-05-04 |
| US20020183375A1 (en) | 2002-12-05 |
| JP2004531475A (ja) | 2004-10-14 |
| US7244746B2 (en) | 2007-07-17 |
| HUP0303721A2 (hu) | 2004-03-01 |
| EE200300342A (et) | 2003-12-15 |
| EP1359916A4 (en) | 2004-04-07 |
| RU2003126188A (ru) | 2005-03-27 |
| MXPA03006484A (es) | 2003-09-22 |
| HRP20030675A2 (en) | 2004-08-31 |
| US7211669B2 (en) | 2007-05-01 |
| US20040225130A1 (en) | 2004-11-11 |
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